Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01285:Or4m1'

72686

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or4m1

Ensembl Gene

ENSMUSG00000045306

Gene Name

olfactory receptor family 4 subfamily M member 1

Synonyms

Olfr734, GA_x6K02T2PMLR-6013665-6012724, MOR242-1

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.495) question?

Stock #

IGL01285

Quality Score

Status

Chromosome

Chromosomal Location

50557293-50558325 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 50557713 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 193 (F193S)

Ref Sequence

ENSEMBL: ENSMUSP00000150732 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050928] [ENSMUST00000217152]

AlphaFold

Q8VFT4

Predicted Effect

possibly damaging
Transcript: ENSMUST00000050928
AA Change: F193S

PolyPhen 2 Score 0.878 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000057376
Gene: ENSMUSG00000045306
AA Change: F193S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	1.3e-39	PFAM
Pfam:7tm_1	41	302	4.1e-23	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216732

Predicted Effect

possibly damaging
Transcript: ENSMUST00000217152
AA Change: F193S

PolyPhen 2 Score 0.878 (Sensitivity: 0.82; Specificity: 0.94)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam5	T	C	8: 25,271,610 (GRCm39)	N599S	probably benign	Het
Adam6a	A	T	12: 113,509,893 (GRCm39)	*755Y	probably null	Het
Adgrb3	G	T	1: 25,132,868 (GRCm39)	T1166K	probably benign	Het
Ano1	T	C	7: 144,198,479 (GRCm39)	Y345C	probably benign	Het
Ano1	A	G	7: 144,149,275 (GRCm39)	V862A	probably damaging	Het
Asap2	C	T	12: 21,279,264 (GRCm39)	A382V	probably damaging	Het
Asb18	A	G	1: 89,923,963 (GRCm39)	V100A	probably benign	Het
Bdnf	G	A	2: 109,553,931 (GRCm39)	A102T	probably benign	Het
Ccser2	G	A	14: 36,660,626 (GRCm39)	T509M	probably damaging	Het
Cfap47	A	G	X: 78,532,764 (GRCm39)	I767T	possibly damaging	Het
Des	G	A	1: 75,339,227 (GRCm39)	A251T	probably benign	Het
Dmd	C	T	X: 84,153,590 (GRCm39)	Q3224*	probably null	Het
Endog	G	T	2: 30,061,975 (GRCm39)		probably null	Het
Ggt7	A	G	2: 155,342,691 (GRCm39)	V269A	probably damaging	Het
Gucy2c	A	G	6: 136,686,739 (GRCm39)	F808S	probably damaging	Het
Hira	A	G	16: 18,730,930 (GRCm39)	T210A	probably benign	Het
Ifitm5	C	A	7: 140,530,076 (GRCm39)	R16L	probably benign	Het
Igdcc4	T	C	9: 65,031,273 (GRCm39)	C404R	probably damaging	Het
Ints7	G	A	1: 191,347,890 (GRCm39)	R754H	probably benign	Het
Irf9	A	G	14: 55,845,058 (GRCm39)	E258G	probably damaging	Het
Megf11	T	C	9: 64,567,728 (GRCm39)	C406R	probably damaging	Het
Olfml1	A	G	7: 107,189,364 (GRCm39)	N143S	possibly damaging	Het
Or6c66b	T	A	10: 129,376,711 (GRCm39)	F102I	probably benign	Het
Or7g30	A	G	9: 19,352,266 (GRCm39)	D19G	probably benign	Het
Otof	G	T	5: 30,562,527 (GRCm39)	Q254K	probably damaging	Het
Pate7	A	T	9: 35,688,044 (GRCm39)	N65K	possibly damaging	Het
Plcd3	A	G	11: 102,968,696 (GRCm39)	F332L	probably benign	Het
Plxnc1	T	C	10: 94,635,230 (GRCm39)	D1332G	probably damaging	Het
Rnasel	A	T	1: 153,634,130 (GRCm39)	D521V	probably benign	Het
Sema5a	T	A	15: 32,575,143 (GRCm39)	V417D	possibly damaging	Het
Senp6	G	A	9: 80,044,000 (GRCm39)	R877Q	probably benign	Het
Shroom2	A	T	X: 151,442,353 (GRCm39)	D937E	probably damaging	Het
Slc35a3	A	G	3: 116,488,262 (GRCm39)	S142P	probably damaging	Het
Srpx	A	T	X: 9,905,298 (GRCm39)	V398E	probably damaging	Het
Stk10	A	T	11: 32,560,653 (GRCm39)	K669N	possibly damaging	Het
Sumf2	A	G	5: 129,878,811 (GRCm39)	D49G	probably damaging	Het
Syde1	T	A	10: 78,424,721 (GRCm39)	E370D	probably damaging	Het
Tas2r115	G	T	6: 132,714,641 (GRCm39)	S103R	probably damaging	Het
Top2a	G	A	11: 98,896,985 (GRCm39)		probably benign	Het
Ttn	T	A	2: 76,550,842 (GRCm39)	T23190S	probably damaging	Het
Ttyh3	C	A	5: 140,615,167 (GRCm39)	C407F	probably damaging	Het
Vmn2r27	G	T	6: 124,169,370 (GRCm39)	H587N	possibly damaging	Het
Vmn2r74	A	G	7: 85,606,692 (GRCm39)	I218T	possibly damaging	Het
Vsig10	A	G	5: 117,462,954 (GRCm39)	N60S	probably benign	Het
Zc3h7a	A	G	16: 10,956,979 (GRCm39)	S877P	probably damaging	Het
Zfp979	G	T	4: 147,699,853 (GRCm39)	T29N	probably damaging	Het
Znfx1	G	A	2: 166,880,615 (GRCm39)	R390C	possibly damaging	Het

Other mutations in Or4m1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01140:Or4m1	APN	14	50,557,732 (GRCm39)	missense	probably damaging	0.96
IGL02106:Or4m1	APN	14	50,557,617 (GRCm39)	missense	probably damaging	1.00
IGL02313:Or4m1	APN	14	50,557,473 (GRCm39)	missense	probably damaging	0.99
IGL03125:Or4m1	APN	14	50,558,149 (GRCm39)	missense	probably benign	0.01
R0276:Or4m1	UTSW	14	50,557,636 (GRCm39)	missense	probably benign	0.23
R0547:Or4m1	UTSW	14	50,557,575 (GRCm39)	missense	probably benign	0.06
R0567:Or4m1	UTSW	14	50,558,115 (GRCm39)	missense	probably damaging	0.99
R0927:Or4m1	UTSW	14	50,558,186 (GRCm39)	nonsense	probably null
R1506:Or4m1	UTSW	14	50,557,941 (GRCm39)	missense	probably benign	0.00
R4032:Or4m1	UTSW	14	50,557,767 (GRCm39)	missense	possibly damaging	0.91
R5179:Or4m1	UTSW	14	50,557,993 (GRCm39)	nonsense	probably null
R5401:Or4m1	UTSW	14	50,557,566 (GRCm39)	missense	probably damaging	1.00
R6240:Or4m1	UTSW	14	50,558,043 (GRCm39)	missense	probably benign	0.00
R7752:Or4m1	UTSW	14	50,557,573 (GRCm39)	missense	probably damaging	1.00
R7901:Or4m1	UTSW	14	50,557,573 (GRCm39)	missense	probably damaging	1.00
R8034:Or4m1	UTSW	14	50,558,023 (GRCm39)	missense	probably damaging	1.00
R8260:Or4m1	UTSW	14	50,557,615 (GRCm39)	missense	probably benign	0.09
R8420:Or4m1	UTSW	14	50,558,233 (GRCm39)	missense	probably benign
R9056:Or4m1	UTSW	14	50,557,999 (GRCm39)	missense	probably damaging	0.98
R9128:Or4m1	UTSW	14	50,558,214 (GRCm39)	missense	probably benign	0.08
R9618:Or4m1	UTSW	14	50,557,760 (GRCm39)	nonsense	probably null
R9659:Or4m1	UTSW	14	50,558,181 (GRCm39)	missense	probably benign	0.10
R9788:Or4m1	UTSW	14	50,558,181 (GRCm39)	missense	probably benign	0.10
X0064:Or4m1	UTSW	14	50,557,511 (GRCm39)	nonsense	probably null

Posted On

2013-10-07