Incidental Mutation 'IGL01285:Gm17727'
ID72702
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm17727
Ensembl Gene ENSMUSG00000090738
Gene Namepredicted gene, 17727
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.059) question?
Stock #IGL01285
Quality Score
Status
Chromosome9
Chromosomal Location35776524-35778109 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 35776748 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Lysine at position 65 (N65K)
Ref Sequence ENSEMBL: ENSMUSP00000129553 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171898] [ENSMUST00000184431]
Predicted Effect possibly damaging
Transcript: ENSMUST00000171898
AA Change: N65K

PolyPhen 2 Score 0.732 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000129553
Gene: ENSMUSG00000090738
AA Change: N65K

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000184431
SMART Domains Protein: ENSMUSP00000139380
Gene: ENSMUSG00000098847

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
low complexity region 32 43 N/A INTRINSIC
low complexity region 64 81 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam5 T C 8: 24,781,594 N599S probably benign Het
Adam6a A T 12: 113,546,273 *755Y probably null Het
Adgrb3 G T 1: 25,093,787 T1166K probably benign Het
Ano1 T C 7: 144,644,742 Y345C probably benign Het
Ano1 A G 7: 144,595,538 V862A probably damaging Het
Asap2 C T 12: 21,229,263 A382V probably damaging Het
Asb18 A G 1: 89,996,241 V100A probably benign Het
Bdnf G A 2: 109,723,586 A102T probably benign Het
Ccser2 G A 14: 36,938,669 T509M probably damaging Het
Des G A 1: 75,362,583 A251T probably benign Het
Dmd C T X: 85,109,984 Q3224* probably null Het
Endog G T 2: 30,171,963 probably null Het
Ggt7 A G 2: 155,500,771 V269A probably damaging Het
Gm7173 A G X: 79,489,158 I767T possibly damaging Het
Gucy2c A G 6: 136,709,741 F808S probably damaging Het
Hira A G 16: 18,912,180 T210A probably benign Het
Ifitm5 C A 7: 140,950,163 R16L probably benign Het
Igdcc4 T C 9: 65,123,991 C404R probably damaging Het
Ints7 G A 1: 191,615,778 R754H probably benign Het
Irf9 A G 14: 55,607,601 E258G probably damaging Het
Megf11 T C 9: 64,660,446 C406R probably damaging Het
Olfml1 A G 7: 107,590,157 N143S possibly damaging Het
Olfr734 A G 14: 50,320,256 F193S possibly damaging Het
Olfr792 T A 10: 129,540,842 F102I probably benign Het
Olfr849 A G 9: 19,440,970 D19G probably benign Het
Otof G T 5: 30,405,183 Q254K probably damaging Het
Plcd3 A G 11: 103,077,870 F332L probably benign Het
Plxnc1 T C 10: 94,799,368 D1332G probably damaging Het
Rnasel A T 1: 153,758,384 D521V probably benign Het
Sema5a T A 15: 32,574,997 V417D possibly damaging Het
Senp6 G A 9: 80,136,718 R877Q probably benign Het
Shroom2 A T X: 152,659,357 D937E probably damaging Het
Slc35a3 A G 3: 116,694,613 S142P probably damaging Het
Srpx A T X: 10,039,059 V398E probably damaging Het
Stk10 A T 11: 32,610,653 K669N possibly damaging Het
Sumf2 A G 5: 129,849,970 D49G probably damaging Het
Syde1 T A 10: 78,588,887 E370D probably damaging Het
Tas2r115 G T 6: 132,737,678 S103R probably damaging Het
Top2a G A 11: 99,006,159 probably benign Het
Ttn T A 2: 76,720,498 T23190S probably damaging Het
Ttyh3 C A 5: 140,629,412 C407F probably damaging Het
Vmn2r27 G T 6: 124,192,411 H587N possibly damaging Het
Vmn2r74 A G 7: 85,957,484 I218T possibly damaging Het
Vsig10 A G 5: 117,324,889 N60S probably benign Het
Zc3h7a A G 16: 11,139,115 S877P probably damaging Het
Zfp979 G T 4: 147,615,396 T29N probably damaging Het
Znfx1 G A 2: 167,038,695 R390C possibly damaging Het
Other mutations in Gm17727
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02044:Gm17727 APN 9 35776663 missense probably benign 0.19
IGL02352:Gm17727 APN 9 35777884 start codon destroyed probably null 0.04
IGL02359:Gm17727 APN 9 35777884 start codon destroyed probably null 0.04
R0827:Gm17727 UTSW 9 35777851 missense probably damaging 0.97
R1382:Gm17727 UTSW 9 35778094 start gained probably benign
R1591:Gm17727 UTSW 9 35776656 missense probably damaging 0.99
R1794:Gm17727 UTSW 9 35777122 missense probably benign 0.01
R5419:Gm17727 UTSW 9 35778111 unclassified probably null
R6110:Gm17727 UTSW 9 35777146 missense possibly damaging 0.90
R6379:Gm17727 UTSW 9 35778085 start gained probably benign
R6614:Gm17727 UTSW 9 35777125 missense probably damaging 0.99
R7698:Gm17727 UTSW 9 35777176 missense probably benign 0.27
R7833:Gm17727 UTSW 9 35777110 missense probably damaging 1.00
R7916:Gm17727 UTSW 9 35777110 missense probably damaging 1.00
Posted On2013-10-07