Incidental Mutation 'R9650:Nutm2'
ID 727058
Institutional Source Beutler Lab
Gene Symbol Nutm2
Ensembl Gene ENSMUSG00000071909
Gene Name NUT family member 2
Synonyms LOC328250, Gm806
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9650 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 50621343-50629391 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 50623755 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 151 (T151S)
Ref Sequence ENSEMBL: ENSMUSP00000094390 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096633]
AlphaFold Q3V0C3
Predicted Effect probably benign
Transcript: ENSMUST00000096633
AA Change: T151S

PolyPhen 2 Score 0.246 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000094390
Gene: ENSMUSG00000071909
AA Change: T151S

DomainStartEndE-ValueType
Pfam:NUT 27 733 9e-277 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 T A 11: 110,071,446 (GRCm39) N1469Y probably benign Het
Actl10 T A 2: 154,394,682 (GRCm39) N211K probably benign Het
Adam33 C T 2: 130,894,989 (GRCm39) V690M possibly damaging Het
Agap2 G A 10: 126,927,653 (GRCm39) R1178H unknown Het
Ank2 T A 3: 126,735,829 (GRCm39) T3352S unknown Het
BC005537 T A 13: 24,986,122 (GRCm39) D7E unknown Het
Bptf T C 11: 106,935,412 (GRCm39) M142V probably benign Het
Cox15 A G 19: 43,735,318 (GRCm39) Y150H probably benign Het
Cpq A T 15: 33,497,405 (GRCm39) I382F possibly damaging Het
Cps1 T C 1: 67,254,636 (GRCm39) F1275S Het
Cs T A 10: 128,196,856 (GRCm39) M417K probably benign Het
Cyp2b19 G A 7: 26,466,208 (GRCm39) R337Q possibly damaging Het
Dmgdh A T 13: 93,845,333 (GRCm39) Y442F probably benign Het
Dync2h1 A T 9: 7,174,849 (GRCm39) D131E possibly damaging Het
Epb41l2 A G 10: 25,369,495 (GRCm39) I605V probably benign Het
Evc G A 5: 37,458,162 (GRCm39) P963L probably damaging Het
Evl C A 12: 108,641,698 (GRCm39) T160N probably benign Het
Fam76a T C 4: 132,629,387 (GRCm39) Y255C probably damaging Het
Fras1 G T 5: 96,910,387 (GRCm39) R3272L probably damaging Het
Fry T C 5: 150,369,375 (GRCm39) V2283A probably damaging Het
Fzd6 A G 15: 38,894,941 (GRCm39) Y369C probably damaging Het
Hip1r T C 5: 124,135,357 (GRCm39) probably null Het
Hps5 A G 7: 46,425,354 (GRCm39) S449P probably damaging Het
Ighv1-34 G T 12: 114,814,885 (GRCm39) D92E possibly damaging Het
Iigp1c T G 18: 60,379,470 (GRCm39) V335G probably damaging Het
Ino80 C T 2: 119,277,464 (GRCm39) R337Q probably damaging Het
Itgax T C 7: 127,734,935 (GRCm39) I422T probably benign Het
Itk A T 11: 46,222,778 (GRCm39) Y564N probably damaging Het
Kcnh5 A C 12: 75,023,293 (GRCm39) S592A probably benign Het
Klhl40 T A 9: 121,609,083 (GRCm39) V416E possibly damaging Het
Lhfpl4 T C 6: 113,171,147 (GRCm39) E13G probably benign Het
Mid1 C G X: 168,768,003 (GRCm39) P384A probably benign Het
Muc16 A T 9: 18,553,762 (GRCm39) M4177K unknown Het
Ngef T A 1: 87,415,552 (GRCm39) T371S possibly damaging Het
Or4c109 A T 2: 88,818,006 (GRCm39) L180* probably null Het
Or51f2 T C 7: 102,526,987 (GRCm39) I220T probably damaging Het
Pate13 A C 9: 35,820,799 (GRCm39) M84L probably benign Het
Pcdhga8 T A 18: 37,860,519 (GRCm39) I525K probably benign Het
Pcx C T 19: 4,657,714 (GRCm39) R394C probably damaging Het
Pnmt A T 11: 98,278,262 (GRCm39) D112V probably damaging Het
Rnf115 C T 3: 96,665,337 (GRCm39) T69I probably damaging Het
Rrp7a A T 15: 83,004,091 (GRCm39) probably null Het
Senp1 A T 15: 97,946,248 (GRCm39) M499K probably damaging Het
Serpina3f G A 12: 104,186,519 (GRCm39) A362T possibly damaging Het
Slc29a3 T A 10: 60,586,302 (GRCm39) I55F possibly damaging Het
Stab2 ACC AC 10: 86,692,561 (GRCm39) probably null Het
Tln1 G A 4: 43,545,912 (GRCm39) T901I probably damaging Het
Tmem102 T C 11: 69,695,869 (GRCm39) K64R probably benign Het
Tmem135 G C 7: 88,797,186 (GRCm39) L357V probably benign Het
Tnxb G A 17: 34,930,629 (GRCm39) V2105I probably damaging Het
Traf2 A C 2: 25,410,454 (GRCm39) C391W probably damaging Het
Tubgcp3 A G 8: 12,705,974 (GRCm39) S183P probably benign Het
Unc13d AATGCCTCCCATGCC AATGCCTCCCATGCCTCCCATGCC 11: 115,958,998 (GRCm39) probably benign Het
Usp2 C A 9: 44,000,476 (GRCm39) N288K probably damaging Het
Utrn T C 10: 12,613,929 (GRCm39) T381A probably benign Het
Vil1 C T 1: 74,464,775 (GRCm39) P474L probably benign Het
Wasf2 T A 4: 132,917,457 (GRCm39) N185K unknown Het
Zfp865 A G 7: 5,037,683 (GRCm39) M45V unknown Het
Other mutations in Nutm2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00885:Nutm2 APN 13 50,628,896 (GRCm39) missense probably benign 0.18
IGL01087:Nutm2 APN 13 50,623,665 (GRCm39) missense probably damaging 1.00
IGL01707:Nutm2 APN 13 50,623,753 (GRCm39) missense probably damaging 0.96
IGL02085:Nutm2 APN 13 50,627,829 (GRCm39) splice site probably null
IGL02238:Nutm2 APN 13 50,625,075 (GRCm39) missense probably damaging 1.00
IGL02369:Nutm2 APN 13 50,623,944 (GRCm39) missense probably benign 0.16
IGL02429:Nutm2 APN 13 50,623,516 (GRCm39) missense probably benign 0.44
IGL03083:Nutm2 APN 13 50,621,480 (GRCm39) missense probably damaging 0.98
R0233:Nutm2 UTSW 13 50,621,441 (GRCm39) missense probably benign 0.41
R0233:Nutm2 UTSW 13 50,621,441 (GRCm39) missense probably benign 0.41
R0321:Nutm2 UTSW 13 50,626,991 (GRCm39) missense probably damaging 0.98
R1481:Nutm2 UTSW 13 50,623,517 (GRCm39) missense probably damaging 0.99
R1605:Nutm2 UTSW 13 50,623,955 (GRCm39) missense possibly damaging 0.68
R1679:Nutm2 UTSW 13 50,623,422 (GRCm39) missense probably benign 0.17
R1744:Nutm2 UTSW 13 50,623,390 (GRCm39) missense probably benign 0.03
R1768:Nutm2 UTSW 13 50,627,152 (GRCm39) missense probably damaging 1.00
R1969:Nutm2 UTSW 13 50,627,878 (GRCm39) missense probably damaging 1.00
R2026:Nutm2 UTSW 13 50,628,856 (GRCm39) missense probably benign 0.00
R2187:Nutm2 UTSW 13 50,621,453 (GRCm39) missense probably benign 0.00
R3912:Nutm2 UTSW 13 50,626,976 (GRCm39) missense possibly damaging 0.92
R4025:Nutm2 UTSW 13 50,623,389 (GRCm39) missense probably benign
R4367:Nutm2 UTSW 13 50,623,920 (GRCm39) missense probably benign 0.01
R4668:Nutm2 UTSW 13 50,627,033 (GRCm39) missense probably benign 0.18
R4940:Nutm2 UTSW 13 50,628,909 (GRCm39) missense possibly damaging 0.58
R4987:Nutm2 UTSW 13 50,626,379 (GRCm39) missense possibly damaging 0.93
R4988:Nutm2 UTSW 13 50,626,379 (GRCm39) missense possibly damaging 0.93
R5821:Nutm2 UTSW 13 50,623,891 (GRCm39) missense probably benign 0.01
R5986:Nutm2 UTSW 13 50,628,496 (GRCm39) missense probably damaging 1.00
R6189:Nutm2 UTSW 13 50,623,774 (GRCm39) missense possibly damaging 0.91
R7101:Nutm2 UTSW 13 50,626,934 (GRCm39) missense probably benign 0.00
R7192:Nutm2 UTSW 13 50,627,105 (GRCm39) missense probably damaging 1.00
R7394:Nutm2 UTSW 13 50,624,043 (GRCm39) missense probably damaging 1.00
R7591:Nutm2 UTSW 13 50,627,903 (GRCm39) missense probably damaging 0.98
R8217:Nutm2 UTSW 13 50,623,759 (GRCm39) missense probably benign 0.16
R8347:Nutm2 UTSW 13 50,626,373 (GRCm39) missense probably benign 0.05
R8811:Nutm2 UTSW 13 50,623,989 (GRCm39) missense probably benign 0.02
R9093:Nutm2 UTSW 13 50,628,964 (GRCm39) missense probably damaging 1.00
R9420:Nutm2 UTSW 13 50,626,964 (GRCm39) missense probably damaging 1.00
R9507:Nutm2 UTSW 13 50,621,455 (GRCm39) missense probably benign
R9532:Nutm2 UTSW 13 50,628,475 (GRCm39) missense probably benign 0.00
R9632:Nutm2 UTSW 13 50,628,901 (GRCm39) missense probably benign 0.10
R9683:Nutm2 UTSW 13 50,629,017 (GRCm39) missense possibly damaging 0.92
X0028:Nutm2 UTSW 13 50,626,990 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- TATCTGCCTTGCCTGGGATG -3'
(R):5'- GACACTGTCTGGTTTGGACAAG -3'

Sequencing Primer
(F):5'- TGGAAGCACTGCCCTGAGTG -3'
(R):5'- GGACAAGTAGTTTTCTGGGGAG -3'
Posted On 2022-10-06