Incidental Mutation 'R9654:Sult2a6'
ID 727261
Institutional Source Beutler Lab
Gene Symbol Sult2a6
Ensembl Gene ENSMUSG00000070810
Gene Name sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 6
Synonyms Gm6957
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R9654 (G1)
Quality Score 202.009
Status Not validated
Chromosome 7
Chromosomal Location 13956328-13988795 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 13956445 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Alanine at position 272 (D272A)
Ref Sequence ENSEMBL: ENSMUSP00000075884 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076576] [ENSMUST00000184731]
AlphaFold B2RVI8
Predicted Effect probably benign
Transcript: ENSMUST00000076576
AA Change: D272A

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000075884
Gene: ENSMUSG00000070810
AA Change: D272A

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 34 278 1.2e-81 PFAM
Pfam:Sulfotransfer_3 35 205 2.2e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000184731
SMART Domains Protein: ENSMUSP00000138842
Gene: ENSMUSG00000070810

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 34 116 4.7e-20 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik T C 15: 81,948,916 (GRCm39) S938P possibly damaging Het
Abca17 G T 17: 24,536,099 (GRCm39) H523N probably benign Het
Alx1 T A 10: 102,858,093 (GRCm39) H202L probably benign Het
Amotl1 T A 9: 14,462,981 (GRCm39) H744L probably benign Het
Ankrd50 A T 3: 38,511,018 (GRCm39) S450T probably benign Het
Aoc1l1 T C 6: 48,952,837 (GRCm39) L254P probably damaging Het
Arhgef25 C T 10: 127,021,955 (GRCm39) S200N probably damaging Het
Arl4c G T 1: 88,629,361 (GRCm39) S9* probably null Het
Bod1l A G 5: 41,975,707 (GRCm39) M1869T probably benign Het
Btnl6 G A 17: 34,733,140 (GRCm39) P241L probably damaging Het
Cacng8 C T 7: 3,443,002 (GRCm39) R88W probably damaging Het
Ccdc154 C T 17: 25,386,684 (GRCm39) T262I possibly damaging Het
Clmn C A 12: 104,748,193 (GRCm39) E451D probably damaging Het
Dnah14 A T 1: 181,593,904 (GRCm39) I3416L probably benign Het
Dnah17 A G 11: 117,927,156 (GRCm39) probably null Het
Dnah3 T A 7: 119,641,396 (GRCm39) K1175* probably null Het
Dock8 C T 19: 25,124,710 (GRCm39) R1009W probably damaging Het
Fhip1a G T 3: 85,579,532 (GRCm39) T891K probably damaging Het
Fkbp15 A G 4: 62,230,553 (GRCm39) V720A probably benign Het
Fryl G T 5: 73,275,801 (GRCm39) P121Q probably benign Het
H2-Q6 C T 17: 35,644,185 (GRCm39) R56C probably damaging Het
Hbs1l T C 10: 21,183,604 (GRCm39) V115A possibly damaging Het
Heatr5a G A 12: 52,005,778 (GRCm39) P66S probably damaging Het
Hsd17b4 A G 18: 50,272,533 (GRCm39) D44G probably benign Het
Idh3a T C 9: 54,497,182 (GRCm39) V41A probably benign Het
Itih1 T A 14: 30,664,870 (GRCm39) K37M probably damaging Het
Lama1 A G 17: 68,101,266 (GRCm39) T1920A Het
Ltn1 G C 16: 87,207,227 (GRCm39) D904E probably benign Het
Map6 T C 7: 98,986,166 (GRCm39) I893T probably damaging Het
Mcm5 C T 8: 75,844,168 (GRCm39) S313F probably benign Het
Mr1 T C 1: 155,013,430 (GRCm39) H49R possibly damaging Het
Myh2 T C 11: 67,088,171 (GRCm39) V1929A probably benign Het
Ncoa4 C A 14: 31,896,465 (GRCm39) P230Q probably benign Het
Npy4r T A 14: 33,869,081 (GRCm39) Q69L probably damaging Het
Nup210l C T 3: 90,107,173 (GRCm39) P1570L probably benign Het
Nus1 T G 10: 52,294,130 (GRCm39) L98R possibly damaging Het
Or10ag55-ps1 C T 2: 87,115,071 (GRCm39) L146F probably benign Het
Or14c42-ps1 T A 7: 86,210,950 (GRCm39) N3K unknown Het
Or2w4 T C 13: 21,795,915 (GRCm39) T75A possibly damaging Het
Or4c11b T C 2: 88,625,263 (GRCm39) L179S probably damaging Het
Or5k17 T A 16: 58,746,752 (GRCm39) I61F probably benign Het
Pcdha11 A C 18: 37,145,333 (GRCm39) T475P probably damaging Het
Pex5l C A 3: 33,010,827 (GRCm39) A384S probably benign Het
Pgk2 T A 17: 40,518,651 (GRCm39) D259V probably damaging Het
Rhbdf1 T C 11: 32,166,028 (GRCm39) M52V probably benign Het
Rsph6a T A 7: 18,799,332 (GRCm39) L321Q probably damaging Het
Sugp1 T A 8: 70,522,656 (GRCm39) M452K probably damaging Het
Tlr6 A T 5: 65,112,697 (GRCm39) L70Q probably damaging Het
Tmem178b A T 6: 40,222,534 (GRCm39) Y83F probably benign Het
Tmprss4 C T 9: 45,090,700 (GRCm39) probably null Het
Trpv4 A G 5: 114,764,887 (GRCm39) L709P probably benign Het
Utp15 G A 13: 98,385,668 (GRCm39) T519M probably benign Het
Vmn2r59 T C 7: 41,693,217 (GRCm39) N461S probably benign Het
Zap70 T C 1: 36,818,327 (GRCm39) V338A probably benign Het
Other mutations in Sult2a6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00959:Sult2a6 APN 7 13,988,634 (GRCm39) missense probably damaging 1.00
IGL01977:Sult2a6 APN 7 13,987,411 (GRCm39) missense probably benign 0.00
IGL02524:Sult2a6 APN 7 13,970,611 (GRCm39) missense possibly damaging 0.80
IGL03209:Sult2a6 APN 7 13,959,897 (GRCm39) missense probably benign 0.36
IGL03379:Sult2a6 APN 7 13,956,511 (GRCm39) missense probably benign 0.01
R1840:Sult2a6 UTSW 7 13,988,754 (GRCm39) missense probably benign 0.03
R1893:Sult2a6 UTSW 7 13,959,814 (GRCm39) missense probably benign 0.00
R2037:Sult2a6 UTSW 7 13,988,634 (GRCm39) missense probably damaging 0.99
R2331:Sult2a6 UTSW 7 13,959,795 (GRCm39) missense possibly damaging 0.94
R3871:Sult2a6 UTSW 7 13,988,701 (GRCm39) missense probably benign 0.16
R3921:Sult2a6 UTSW 7 13,988,668 (GRCm39) missense possibly damaging 0.83
R5599:Sult2a6 UTSW 7 13,988,629 (GRCm39) nonsense probably null
R5761:Sult2a6 UTSW 7 13,984,283 (GRCm39) missense probably damaging 0.97
R6744:Sult2a6 UTSW 7 13,956,470 (GRCm39) missense probably damaging 1.00
R6956:Sult2a6 UTSW 7 13,988,748 (GRCm39) missense possibly damaging 0.50
R7152:Sult2a6 UTSW 7 13,956,445 (GRCm39) missense probably benign 0.36
R7869:Sult2a6 UTSW 7 13,988,737 (GRCm39) missense not run
R7990:Sult2a6 UTSW 7 13,959,795 (GRCm39) missense possibly damaging 0.94
R8347:Sult2a6 UTSW 7 13,959,883 (GRCm39) missense probably benign 0.15
R8369:Sult2a6 UTSW 7 13,987,327 (GRCm39) critical splice donor site probably null
R8391:Sult2a6 UTSW 7 13,956,516 (GRCm39) critical splice acceptor site probably null
R8414:Sult2a6 UTSW 7 13,984,357 (GRCm39) missense probably damaging 1.00
R9317:Sult2a6 UTSW 7 13,970,615 (GRCm39) nonsense probably null
Z1088:Sult2a6 UTSW 7 13,959,819 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GACTTTTGGGATAGCATTGGAAATG -3'
(R):5'- GGTGGGACATAATTTTCACAGAGGG -3'

Sequencing Primer
(F):5'- TTGGGATAGCATTGGAAATGTAATG -3'
(R):5'- TTTTCACAGAGGGAGAAGTCTG -3'
Posted On 2022-10-06