Incidental Mutation 'R9654:Or5k17'
ID 727287
Institutional Source Beutler Lab
Gene Symbol Or5k17
Ensembl Gene ENSMUSG00000090951
Gene Name olfactory receptor family 5 subfamily K member 17
Synonyms Olfr181, MOR184-4, GA_x54KRFPKG5P-55145984-55145034
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R9654 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 58745920-58749007 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 58746752 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 61 (I61F)
Ref Sequence ENSEMBL: ENSMUSP00000074825 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075361] [ENSMUST00000205668] [ENSMUST00000205742] [ENSMUST00000205986] [ENSMUST00000206168]
AlphaFold Q8VGQ7
Predicted Effect probably benign
Transcript: ENSMUST00000075361
AA Change: I61F

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000074825
Gene: ENSMUSG00000090951
AA Change: I61F

DomainStartEndE-ValueType
Pfam:7tm_4 31 305 5.7e-52 PFAM
Pfam:7TM_GPCR_Srsx 35 308 6.1e-6 PFAM
Pfam:7tm_1 41 308 3.3e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205668
AA Change: I61F

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000205742
AA Change: I61F

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000205986
AA Change: I61F

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000206168
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI

All alleles(1) : Gene trapped(1) 

Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik T C 15: 81,948,916 (GRCm39) S938P possibly damaging Het
Abca17 G T 17: 24,536,099 (GRCm39) H523N probably benign Het
Alx1 T A 10: 102,858,093 (GRCm39) H202L probably benign Het
Amotl1 T A 9: 14,462,981 (GRCm39) H744L probably benign Het
Ankrd50 A T 3: 38,511,018 (GRCm39) S450T probably benign Het
Aoc1l1 T C 6: 48,952,837 (GRCm39) L254P probably damaging Het
Arhgef25 C T 10: 127,021,955 (GRCm39) S200N probably damaging Het
Arl4c G T 1: 88,629,361 (GRCm39) S9* probably null Het
Bod1l A G 5: 41,975,707 (GRCm39) M1869T probably benign Het
Btnl6 G A 17: 34,733,140 (GRCm39) P241L probably damaging Het
Cacng8 C T 7: 3,443,002 (GRCm39) R88W probably damaging Het
Ccdc154 C T 17: 25,386,684 (GRCm39) T262I possibly damaging Het
Clmn C A 12: 104,748,193 (GRCm39) E451D probably damaging Het
Dnah14 A T 1: 181,593,904 (GRCm39) I3416L probably benign Het
Dnah17 A G 11: 117,927,156 (GRCm39) probably null Het
Dnah3 T A 7: 119,641,396 (GRCm39) K1175* probably null Het
Dock8 C T 19: 25,124,710 (GRCm39) R1009W probably damaging Het
Fhip1a G T 3: 85,579,532 (GRCm39) T891K probably damaging Het
Fkbp15 A G 4: 62,230,553 (GRCm39) V720A probably benign Het
Fryl G T 5: 73,275,801 (GRCm39) P121Q probably benign Het
H2-Q6 C T 17: 35,644,185 (GRCm39) R56C probably damaging Het
Hbs1l T C 10: 21,183,604 (GRCm39) V115A possibly damaging Het
Heatr5a G A 12: 52,005,778 (GRCm39) P66S probably damaging Het
Hsd17b4 A G 18: 50,272,533 (GRCm39) D44G probably benign Het
Idh3a T C 9: 54,497,182 (GRCm39) V41A probably benign Het
Itih1 T A 14: 30,664,870 (GRCm39) K37M probably damaging Het
Lama1 A G 17: 68,101,266 (GRCm39) T1920A Het
Ltn1 G C 16: 87,207,227 (GRCm39) D904E probably benign Het
Map6 T C 7: 98,986,166 (GRCm39) I893T probably damaging Het
Mcm5 C T 8: 75,844,168 (GRCm39) S313F probably benign Het
Mr1 T C 1: 155,013,430 (GRCm39) H49R possibly damaging Het
Myh2 T C 11: 67,088,171 (GRCm39) V1929A probably benign Het
Ncoa4 C A 14: 31,896,465 (GRCm39) P230Q probably benign Het
Npy4r T A 14: 33,869,081 (GRCm39) Q69L probably damaging Het
Nup210l C T 3: 90,107,173 (GRCm39) P1570L probably benign Het
Nus1 T G 10: 52,294,130 (GRCm39) L98R possibly damaging Het
Or10ag55-ps1 C T 2: 87,115,071 (GRCm39) L146F probably benign Het
Or14c42-ps1 T A 7: 86,210,950 (GRCm39) N3K unknown Het
Or2w4 T C 13: 21,795,915 (GRCm39) T75A possibly damaging Het
Or4c11b T C 2: 88,625,263 (GRCm39) L179S probably damaging Het
Pcdha11 A C 18: 37,145,333 (GRCm39) T475P probably damaging Het
Pex5l C A 3: 33,010,827 (GRCm39) A384S probably benign Het
Pgk2 T A 17: 40,518,651 (GRCm39) D259V probably damaging Het
Rhbdf1 T C 11: 32,166,028 (GRCm39) M52V probably benign Het
Rsph6a T A 7: 18,799,332 (GRCm39) L321Q probably damaging Het
Sugp1 T A 8: 70,522,656 (GRCm39) M452K probably damaging Het
Sult2a6 T G 7: 13,956,445 (GRCm39) D272A probably benign Het
Tlr6 A T 5: 65,112,697 (GRCm39) L70Q probably damaging Het
Tmem178b A T 6: 40,222,534 (GRCm39) Y83F probably benign Het
Tmprss4 C T 9: 45,090,700 (GRCm39) probably null Het
Trpv4 A G 5: 114,764,887 (GRCm39) L709P probably benign Het
Utp15 G A 13: 98,385,668 (GRCm39) T519M probably benign Het
Vmn2r59 T C 7: 41,693,217 (GRCm39) N461S probably benign Het
Zap70 T C 1: 36,818,327 (GRCm39) V338A probably benign Het
Other mutations in Or5k17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01845:Or5k17 APN 16 58,746,929 (GRCm39) missense probably benign
IGL02477:Or5k17 APN 16 58,746,126 (GRCm39) missense probably benign 0.07
IGL02545:Or5k17 APN 16 58,746,833 (GRCm39) missense possibly damaging 0.88
IGL02690:Or5k17 APN 16 58,746,214 (GRCm39) missense possibly damaging 0.78
IGL02718:Or5k17 APN 16 58,746,459 (GRCm39) missense possibly damaging 0.57
IGL02945:Or5k17 APN 16 58,746,703 (GRCm39) missense probably damaging 1.00
IGL03349:Or5k17 APN 16 58,746,323 (GRCm39) missense probably benign 0.00
B5639:Or5k17 UTSW 16 58,746,889 (GRCm39) missense probably benign 0.00
R0550:Or5k17 UTSW 16 58,746,748 (GRCm39) missense probably damaging 1.00
R0659:Or5k17 UTSW 16 58,746,772 (GRCm39) missense possibly damaging 0.94
R1433:Or5k17 UTSW 16 58,746,049 (GRCm39) missense probably benign
R1957:Or5k17 UTSW 16 58,746,530 (GRCm39) missense probably benign
R2155:Or5k17 UTSW 16 58,746,486 (GRCm39) missense probably benign 0.01
R2404:Or5k17 UTSW 16 58,745,998 (GRCm39) missense probably benign 0.01
R2568:Or5k17 UTSW 16 58,746,286 (GRCm39) missense probably benign 0.27
R4022:Or5k17 UTSW 16 58,746,483 (GRCm39) missense possibly damaging 0.94
R4592:Or5k17 UTSW 16 58,746,455 (GRCm39) missense probably benign 0.00
R4673:Or5k17 UTSW 16 58,746,053 (GRCm39) missense possibly damaging 0.61
R4880:Or5k17 UTSW 16 58,746,463 (GRCm39) missense probably damaging 0.98
R5109:Or5k17 UTSW 16 58,746,422 (GRCm39) missense probably benign 0.10
R5231:Or5k17 UTSW 16 58,746,077 (GRCm39) missense possibly damaging 0.94
R5291:Or5k17 UTSW 16 58,746,764 (GRCm39) missense possibly damaging 0.96
R5477:Or5k17 UTSW 16 58,746,393 (GRCm39) missense possibly damaging 0.61
R5524:Or5k17 UTSW 16 58,746,172 (GRCm39) missense probably benign 0.00
R5809:Or5k17 UTSW 16 58,746,860 (GRCm39) missense probably benign
R5830:Or5k17 UTSW 16 58,746,457 (GRCm39) missense possibly damaging 0.64
R6119:Or5k17 UTSW 16 58,746,895 (GRCm39) missense possibly damaging 0.94
R6217:Or5k17 UTSW 16 58,746,877 (GRCm39) missense probably benign 0.03
R6861:Or5k17 UTSW 16 58,746,867 (GRCm39) missense probably benign
R6939:Or5k17 UTSW 16 58,746,648 (GRCm39) nonsense probably null
R7376:Or5k17 UTSW 16 58,746,121 (GRCm39) missense possibly damaging 0.82
R7650:Or5k17 UTSW 16 58,746,416 (GRCm39) nonsense probably null
R8153:Or5k17 UTSW 16 58,746,149 (GRCm39) missense possibly damaging 0.47
R8947:Or5k17 UTSW 16 58,746,433 (GRCm39) missense probably benign
R9205:Or5k17 UTSW 16 58,746,486 (GRCm39) missense probably benign 0.01
R9205:Or5k17 UTSW 16 58,746,485 (GRCm39) missense probably benign 0.00
R9318:Or5k17 UTSW 16 58,746,271 (GRCm39) missense probably damaging 1.00
R9678:Or5k17 UTSW 16 58,746,640 (GRCm39) missense probably benign 0.17
Predicted Primers PCR Primer
(F):5'- TTGCATATGGCCACATAGCG -3'
(R):5'- TCTCAGCACAGATCAAGCATG -3'

Sequencing Primer
(F):5'- CACATAGCGGTCATAGGCCATTG -3'
(R):5'- GATGAAGGCAAATCACTCTTTGACAG -3'
Posted On 2022-10-06