Mutagenetix > Incidental Mutation

Incidental Mutation 'R9657:Or9m2'

727367

Institutional Source

Beutler Lab

Gene Symbol

Or9m2

Ensembl Gene

ENSMUSG00000062793

Gene Name

olfactory receptor family 9 subfamily M member 2

Synonyms

GA_x6K02T2Q125-49480812-49481753, Olfr1158, MOR173-3

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.070) question?

Stock #

R9657 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

87820457-87821398 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 87821310 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Threonine at position 285 (N285T)

Ref Sequence

ENSEMBL: ENSMUSP00000099682 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000102622]

AlphaFold

A2BHP7

Predicted Effect

probably damaging
Transcript: ENSMUST00000102622
AA Change: N285T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000099682
Gene: ENSMUSG00000062793
AA Change: N285T

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	1.5e-45	PFAM
Pfam:7tm_1	41	289	4.5e-15	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 66 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	T	A	11: 9,243,379 (GRCm39)	D1747E	probably benign	Het
Acad11	T	A	9: 103,953,035 (GRCm39)	I88N	possibly damaging	Het
Atp2b4	T	C	1: 133,656,478 (GRCm39)	E724G	probably damaging	Het
Bcl2a1b	T	C	9: 89,081,599 (GRCm39)	S63P	probably damaging	Het
Blzf1	T	C	1: 164,134,023 (GRCm39)	S9G	probably benign	Het
Ccdc121rt1	T	C	1: 181,338,104 (GRCm39)	T283A	probably benign	Het
Cdh22	T	C	2: 164,965,715 (GRCm39)	D488G	probably benign	Het
Cep290	A	G	10: 100,351,003 (GRCm39)	E688G	possibly damaging	Het
Cldn10	A	C	14: 119,025,781 (GRCm39)	E71D	probably benign	Het
Clip2	C	T	5: 134,533,616 (GRCm39)	R487Q	probably benign	Het
Cyp3a16	T	C	5: 145,386,979 (GRCm39)	D337G	probably null	Het
Dnah5	A	T	15: 28,410,089 (GRCm39)	D3654V	probably damaging	Het
Dock1	T	C	7: 134,339,429 (GRCm39)	S100P	possibly damaging	Het
Hdgfl2	T	C	17: 56,405,978 (GRCm39)	V488A	unknown	Het
Itih2	T	C	2: 10,107,686 (GRCm39)	T627A	probably damaging	Het
Katnip	A	G	7: 125,441,956 (GRCm39)	S648G	probably benign	Het
Klhl33	T	C	14: 51,134,117 (GRCm39)	D144G	probably benign	Het
Lca5l	G	A	16: 95,974,953 (GRCm39)	Q324*	probably null	Het
Mcm5	C	T	8: 75,844,168 (GRCm39)	S313F	probably benign	Het
Mical2	A	G	7: 111,921,806 (GRCm39)	T542A	probably benign	Het
Moxd1	T	A	10: 24,128,485 (GRCm39)	V179E	probably benign	Het
Myh7b	A	G	2: 155,455,963 (GRCm39)	Y116C	probably damaging	Het
Myoc	C	T	1: 162,467,229 (GRCm39)	R133*	probably null	Het
Nol3	A	T	8: 106,005,641 (GRCm39)	I12F	probably damaging	Het
Nrap	A	G	19: 56,352,377 (GRCm39)	V605A	probably benign	Het
Or5w13	T	C	2: 87,524,121 (GRCm39)	Y35C	probably damaging	Het
Pag1	G	T	3: 9,769,791 (GRCm39)	S52R	probably damaging	Het
Pbxip1	A	G	3: 89,355,056 (GRCm39)	D525G	probably benign	Het
Pla2g4f	A	G	2: 120,135,138 (GRCm39)	F437L	probably benign	Het
Podn	A	C	4: 107,884,231 (GRCm39)	I86S	probably damaging	Het
Postn	A	G	3: 54,290,820 (GRCm39)	T676A	probably benign	Het
Ppp1r1c	A	G	2: 79,638,718 (GRCm39)	E104G	probably benign	Het
Prss53	T	C	7: 127,486,238 (GRCm39)	T436A	probably damaging	Het
Psme4	A	T	11: 30,788,980 (GRCm39)	E1127D	probably benign	Het
Ptpn18	C	A	1: 34,512,473 (GRCm39)	A426E	possibly damaging	Het
Ptprz1	T	G	6: 23,042,377 (GRCm39)	C2044G	possibly damaging	Het
Rad54l2	C	A	9: 106,581,372 (GRCm39)	V850L	probably damaging	Het
Ranbp9	A	G	13: 43,557,155 (GRCm39)	I28T	unknown	Het
Rapgef2	A	T	3: 78,999,191 (GRCm39)	V527E	probably damaging	Het
Rere	C	A	4: 150,699,390 (GRCm39)	P825T	unknown	Het
Rundc3a	A	G	11: 102,291,578 (GRCm39)	T349A	probably benign	Het
Scn2a	T	C	2: 65,566,032 (GRCm39)	F1352S	probably damaging	Het
Senp7	T	A	16: 55,944,295 (GRCm39)	C206*	probably null	Het
Serac1	C	T	17: 6,119,658 (GRCm39)	V91I	probably benign	Het
Serpina1f	G	A	12: 103,656,050 (GRCm39)	Q393*	probably null	Het
Slc8a1	T	C	17: 81,955,244 (GRCm39)	E598G	probably damaging	Het
Slmap	A	T	14: 26,151,013 (GRCm39)	H518Q	probably benign	Het
Spg11	G	A	2: 121,910,781 (GRCm39)	R1199C	probably damaging	Het
Tada1	T	C	1: 166,214,312 (GRCm39)	S104P	possibly damaging	Het
Tbck	A	G	3: 132,421,451 (GRCm39)	D186G	probably damaging	Het
Tdrd9	A	C	12: 112,002,824 (GRCm39)	R824S	possibly damaging	Het
Tmem161a	T	C	8: 70,630,260 (GRCm39)		probably null	Het
Trim55	G	A	3: 19,728,671 (GRCm39)	G494D	possibly damaging	Het
Ttc17	T	A	2: 94,237,010 (GRCm39)	M1L	probably benign	Het
Ttn	C	T	2: 76,715,357 (GRCm39)	E7912K	unknown	Het
Ugt3a1	A	C	15: 9,280,133 (GRCm39)	S32R	probably damaging	Het
Vgll3	T	C	16: 65,636,343 (GRCm39)	S220P	probably benign	Het
Virma	A	G	4: 11,544,898 (GRCm39)	E1569G	probably damaging	Het
Vmn1r54	C	G	6: 90,246,984 (GRCm39)	F299L	probably benign	Het
Vmn2r114	A	G	17: 23,510,690 (GRCm39)	S597P	probably damaging	Het
Wdr7	A	G	18: 64,057,918 (GRCm39)	D1249G	probably damaging	Het
Wdr97	A	G	15: 76,245,476 (GRCm39)	Y1271C		Het
Yju2b	T	C	8: 84,987,084 (GRCm39)	K138E	possibly damaging	Het
Ypel4	A	G	2: 84,568,068 (GRCm39)	Y108C	probably damaging	Het
Zfp770	A	G	2: 114,027,766 (GRCm39)	V101A	probably damaging	Het
Zfyve9	A	T	4: 108,575,729 (GRCm39)	C451S	probably damaging	Het

Other mutations in Or9m2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00272:Or9m2	APN	2	87,820,782 (GRCm39)	missense	probably damaging	1.00
IGL01287:Or9m2	APN	2	87,821,288 (GRCm39)	missense	probably benign	0.01
IGL01374:Or9m2	APN	2	87,820,892 (GRCm39)	missense	probably benign
IGL01821:Or9m2	APN	2	87,820,933 (GRCm39)	missense	probably benign	0.12
IGL01832:Or9m2	APN	2	87,820,513 (GRCm39)	missense	probably benign	0.02
IGL02327:Or9m2	APN	2	87,820,601 (GRCm39)	missense	probably damaging	1.00
IGL02580:Or9m2	APN	2	87,820,857 (GRCm39)	missense	probably benign	0.09
IGL03001:Or9m2	APN	2	87,820,493 (GRCm39)	missense	probably benign	0.43
IGL03196:Or9m2	APN	2	87,820,826 (GRCm39)	missense	possibly damaging	0.67
R0546:Or9m2	UTSW	2	87,820,816 (GRCm39)	nonsense	probably null
R1474:Or9m2	UTSW	2	87,821,334 (GRCm39)	missense	probably damaging	1.00
R1650:Or9m2	UTSW	2	87,821,145 (GRCm39)	missense	probably benign	0.01
R1757:Or9m2	UTSW	2	87,820,926 (GRCm39)	missense	probably damaging	0.99
R2992:Or9m2	UTSW	2	87,821,121 (GRCm39)	missense	probably benign	0.00
R4038:Or9m2	UTSW	2	87,821,262 (GRCm39)	missense	possibly damaging	0.88
R5190:Or9m2	UTSW	2	87,821,107 (GRCm39)	nonsense	probably null
R5871:Or9m2	UTSW	2	87,821,355 (GRCm39)	missense	possibly damaging	0.82
R8220:Or9m2	UTSW	2	87,820,496 (GRCm39)	missense	probably damaging	1.00
R8475:Or9m2	UTSW	2	87,820,536 (GRCm39)	missense	probably damaging	1.00
R8532:Or9m2	UTSW	2	87,820,913 (GRCm39)	missense	probably damaging	1.00
R9026:Or9m2	UTSW	2	87,820,568 (GRCm39)	missense	probably damaging	0.99
R9522:Or9m2	UTSW	2	87,821,175 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GGCCATTCTTAAAACAGGTTCTGC -3'
(R):5'- GACACAGTACTTTCTTTCTTAACGG -3'

Sequencing Primer
(F):5'- TTCTTAAAACAGGTTCTGCAGAGGG -3'
(R):5'- AGTACTTTCTTTCTTAACGGATTCTC -3'

Posted On

2022-10-06