Mutagenetix > Incidental Mutation

Incidental Mutation 'R9657:Vmn2r114'

727417

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r114

Ensembl Gene

ENSMUSG00000091945

Gene Name

vomeronasal 2, receptor 114

Synonyms

EG666002

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.129) question?

Stock #

R9657 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

23290934-23312313 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23291716 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 597 (S597P)

Ref Sequence

ENSEMBL: ENSMUSP00000127505 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168033]

AlphaFold

E9Q281

Predicted Effect

probably damaging
Transcript: ENSMUST00000168033
AA Change: S597P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000127505
Gene: ENSMUSG00000091945
AA Change: S597P

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	154	470	1.5e-24	PFAM
Pfam:NCD3G	511	564	1.5e-18	PFAM
Pfam:7tm_3	597	832	1.4e-55	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 66 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	T	A	11: 9,293,379	D1747E	probably benign	Het
Acad11	T	A	9: 104,075,836	I88N	possibly damaging	Het
Atp2b4	T	C	1: 133,728,740	E724G	probably damaging	Het
Bcl2a1b	T	C	9: 89,199,546	S63P	probably damaging	Het
Blzf1	T	C	1: 164,306,454	S9G	probably benign	Het
Ccdc121	T	C	1: 181,510,539	T283A	probably benign	Het
Ccdc130	T	C	8: 84,260,455	K138E	possibly damaging	Het
Cdh22	T	C	2: 165,123,795	D488G	probably benign	Het
Cep290	A	G	10: 100,515,141	E688G	possibly damaging	Het
Cldn10	A	C	14: 118,788,369	E71D	probably benign	Het
Clip2	C	T	5: 134,504,762	R487Q	probably benign	Het
Cyp3a16	T	C	5: 145,450,169	D337G	probably null	Het
D430042O09Rik	A	G	7: 125,842,784	S648G	probably benign	Het
Dnah5	A	T	15: 28,409,943	D3654V	probably damaging	Het
Dock1	T	C	7: 134,737,700	S100P	possibly damaging	Het
Gm35339	A	G	15: 76,361,276	Y1271C		Het
Hdgfl2	T	C	17: 56,098,978	V488A	unknown	Het
Itih2	T	C	2: 10,102,875	T627A	probably damaging	Het
Klhl33	T	C	14: 50,896,660	D144G	probably benign	Het
Lca5l	G	A	16: 96,173,753	Q324*	probably null	Het
Mcm5	C	T	8: 75,117,540	S313F	probably benign	Het
Mical2	A	G	7: 112,322,599	T542A	probably benign	Het
Moxd1	T	A	10: 24,252,587	V179E	probably benign	Het
Myh7b	A	G	2: 155,614,043	Y116C	probably damaging	Het
Myoc	C	T	1: 162,639,660	R133*	probably null	Het
Nol3	A	T	8: 105,279,009	I12F	probably damaging	Het
Nrap	A	G	19: 56,363,945	V605A	probably benign	Het
Olfr1136	T	C	2: 87,693,777	Y35C	probably damaging	Het
Olfr1158	A	C	2: 87,990,966	N285T	probably damaging	Het
Pag1	G	T	3: 9,704,731	S52R	probably damaging	Het
Pbxip1	A	G	3: 89,447,749	D525G	probably benign	Het
Pla2g4f	A	G	2: 120,304,657	F437L	probably benign	Het
Podn	A	C	4: 108,027,034	I86S	probably damaging	Het
Postn	A	G	3: 54,383,399	T676A	probably benign	Het
Ppp1r1c	A	G	2: 79,808,374	E104G	probably benign	Het
Prss53	T	C	7: 127,887,066	T436A	probably damaging	Het
Psme4	A	T	11: 30,838,980	E1127D	probably benign	Het
Ptpn18	C	A	1: 34,473,392	A426E	possibly damaging	Het
Ptprz1	T	G	6: 23,042,378	C2044G	possibly damaging	Het
Rad54l2	C	A	9: 106,704,173	V850L	probably damaging	Het
Ranbp9	A	G	13: 43,403,679	I28T	unknown	Het
Rapgef2	A	T	3: 79,091,884	V527E	probably damaging	Het
Rere	C	A	4: 150,614,933	P825T	unknown	Het
Rundc3a	A	G	11: 102,400,752	T349A	probably benign	Het
Scn2a	T	C	2: 65,735,688	F1352S	probably damaging	Het
Senp7	T	A	16: 56,123,932	C206*	probably null	Het
Serac1	C	T	17: 6,069,383	V91I	probably benign	Het
Serpina1f	G	A	12: 103,689,791	Q393*	probably null	Het
Slc8a1	T	C	17: 81,647,815	E598G	probably damaging	Het
Slmap	A	T	14: 26,429,858	H518Q	probably benign	Het
Spg11	G	A	2: 122,080,300	R1199C	probably damaging	Het
Tada1	T	C	1: 166,386,743	S104P	possibly damaging	Het
Tbck	A	G	3: 132,715,690	D186G	probably damaging	Het
Tdrd9	A	C	12: 112,036,390	R824S	possibly damaging	Het
Tmem161a	T	C	8: 70,177,610		probably null	Het
Trim55	G	A	3: 19,674,507	G494D	possibly damaging	Het
Ttc17	T	A	2: 94,406,665	M1L	probably benign	Het
Ttn	C	T	2: 76,885,013	E7912K	unknown	Het
Ugt3a1	A	C	15: 9,280,047	S32R	probably damaging	Het
Vgll3	T	C	16: 65,839,457	S220P	probably benign	Het
Virma	A	G	4: 11,544,898	E1569G	probably damaging	Het
Vmn1r54	C	G	6: 90,270,002	F299L	probably benign	Het
Wdr7	A	G	18: 63,924,847	D1249G	probably damaging	Het
Ypel4	A	G	2: 84,737,724	Y108C	probably damaging	Het
Zfp770	A	G	2: 114,197,285	V101A	probably damaging	Het
Zfyve9	A	T	4: 108,718,532	C451S	probably damaging	Het

Other mutations in Vmn2r114

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00157:Vmn2r114	APN	17	23291665	missense	probably damaging	1.00
IGL00990:Vmn2r114	APN	17	23290965	missense	probably benign
IGL00990:Vmn2r114	APN	17	23290983	missense	probably benign	0.23
IGL00990:Vmn2r114	APN	17	23291238	missense	probably damaging	1.00
IGL01838:Vmn2r114	APN	17	23296982	missense	probably benign	0.44
IGL01990:Vmn2r114	APN	17	23310381	missense	probably benign	0.22
IGL01994:Vmn2r114	APN	17	23310477	missense	probably damaging	1.00
IGL02153:Vmn2r114	APN	17	23291808	missense	probably benign	0.01
IGL02453:Vmn2r114	APN	17	23311134	missense	probably benign	0.00
IGL02621:Vmn2r114	APN	17	23310520	missense	probably damaging	0.98
IGL02938:Vmn2r114	APN	17	23291289	missense	probably benign	0.10
IGL03130:Vmn2r114	APN	17	23296996	splice site	probably benign
IGL03325:Vmn2r114	APN	17	23291678	missense	probably damaging	1.00
BB004:Vmn2r114	UTSW	17	23291645	missense	probably damaging	1.00
R0109:Vmn2r114	UTSW	17	23310575	nonsense	probably null
R0164:Vmn2r114	UTSW	17	23309826	critical splice donor site	probably null
R0310:Vmn2r114	UTSW	17	23290943	missense	probably benign	0.23
R0583:Vmn2r114	UTSW	17	23290932	makesense	probably null
R0677:Vmn2r114	UTSW	17	23310594	missense	probably damaging	1.00
R1127:Vmn2r114	UTSW	17	23290932	makesense	probably null
R1147:Vmn2r114	UTSW	17	23311063	missense	probably benign	0.00
R1147:Vmn2r114	UTSW	17	23311063	missense	probably benign	0.00
R1157:Vmn2r114	UTSW	17	23310340	missense	possibly damaging	0.60
R1323:Vmn2r114	UTSW	17	23290932	makesense	probably null
R1347:Vmn2r114	UTSW	17	23290932	makesense	probably null
R1435:Vmn2r114	UTSW	17	23290932	makesense	probably null
R1437:Vmn2r114	UTSW	17	23291211	missense	probably damaging	1.00
R1585:Vmn2r114	UTSW	17	23291701	missense	probably damaging	0.98
R1641:Vmn2r114	UTSW	17	23296988	missense	probably benign	0.00
R1748:Vmn2r114	UTSW	17	23308061	missense	probably benign	0.17
R1954:Vmn2r114	UTSW	17	23311112	missense	probably benign	0.32
R2081:Vmn2r114	UTSW	17	23291109	missense	possibly damaging	0.91
R2103:Vmn2r114	UTSW	17	23290932	makesense	probably null
R2113:Vmn2r114	UTSW	17	23290932	makesense	probably null
R2134:Vmn2r114	UTSW	17	23291763	missense	probably damaging	1.00
R2149:Vmn2r114	UTSW	17	23290932	makesense	probably null
R2424:Vmn2r114	UTSW	17	23296868	missense	possibly damaging	0.90
R2847:Vmn2r114	UTSW	17	23290974	missense	probably benign	0.00
R2848:Vmn2r114	UTSW	17	23290974	missense	probably benign	0.00
R2893:Vmn2r114	UTSW	17	23290932	makesense	probably null
R3017:Vmn2r114	UTSW	17	23290932	makesense	probably null
R3018:Vmn2r114	UTSW	17	23290932	makesense	probably null
R3019:Vmn2r114	UTSW	17	23290932	makesense	probably null
R3020:Vmn2r114	UTSW	17	23290932	makesense	probably null
R3021:Vmn2r114	UTSW	17	23290932	makesense	probably null
R4628:Vmn2r114	UTSW	17	23290932	makesense	probably null
R4668:Vmn2r114	UTSW	17	23310473	missense	possibly damaging	0.83
R4840:Vmn2r114	UTSW	17	23291379	missense	probably damaging	0.97
R4841:Vmn2r114	UTSW	17	23310362	missense	probably benign	0.04
R4842:Vmn2r114	UTSW	17	23310362	missense	probably benign	0.04
R4856:Vmn2r114	UTSW	17	23308034	missense	probably benign	0.11
R4886:Vmn2r114	UTSW	17	23308034	missense	probably benign	0.11
R4992:Vmn2r114	UTSW	17	23291791	missense	probably benign	0.03
R5182:Vmn2r114	UTSW	17	23291658	missense	probably damaging	0.96
R5223:Vmn2r114	UTSW	17	23290932	makesense	probably null
R5405:Vmn2r114	UTSW	17	23290932	makesense	probably null
R5449:Vmn2r114	UTSW	17	23290932	makesense	probably null
R5615:Vmn2r114	UTSW	17	23290932	makesense	probably null
R5834:Vmn2r114	UTSW	17	23310625	missense	possibly damaging	0.90
R6150:Vmn2r114	UTSW	17	23291295	missense	probably benign	0.03
R6277:Vmn2r114	UTSW	17	23290980	missense	possibly damaging	0.93
R6403:Vmn2r114	UTSW	17	23309965	missense	probably damaging	0.99
R6589:Vmn2r114	UTSW	17	23291668	missense	probably damaging	1.00
R6613:Vmn2r114	UTSW	17	23310246	missense	possibly damaging	0.82
R6747:Vmn2r114	UTSW	17	23309876	missense	probably benign	0.00
R6837:Vmn2r114	UTSW	17	23310202	missense	probably benign	0.10
R6911:Vmn2r114	UTSW	17	23291130	missense	probably damaging	0.98
R6950:Vmn2r114	UTSW	17	23310163	missense	probably benign	0.03
R7276:Vmn2r114	UTSW	17	23290960	missense	probably damaging	0.97
R7482:Vmn2r114	UTSW	17	23291494	missense	probably damaging	1.00
R7514:Vmn2r114	UTSW	17	23308061	missense	probably null	0.96
R7523:Vmn2r114	UTSW	17	23310637	missense	probably benign	0.01
R7563:Vmn2r114	UTSW	17	23291026	missense	probably benign	0.01
R7585:Vmn2r114	UTSW	17	23291265	missense	probably damaging	1.00
R7593:Vmn2r114	UTSW	17	23291843	nonsense	probably null
R7611:Vmn2r114	UTSW	17	23296970	missense	probably damaging	0.97
R7641:Vmn2r114	UTSW	17	23308203	missense	possibly damaging	0.53
R7651:Vmn2r114	UTSW	17	23291012	nonsense	probably null
R7970:Vmn2r114	UTSW	17	23311212	missense	probably benign	0.00
R8737:Vmn2r114	UTSW	17	23310168	missense	probably benign	0.36
R8802:Vmn2r114	UTSW	17	23309862	missense	possibly damaging	0.65
R8847:Vmn2r114	UTSW	17	23310012	missense	probably damaging	1.00
R8991:Vmn2r114	UTSW	17	23310312	missense	probably damaging	1.00
R9138:Vmn2r114	UTSW	17	23291604	missense	probably damaging	1.00
R9173:Vmn2r114	UTSW	17	23291553	missense	probably damaging	0.99
R9175:Vmn2r114	UTSW	17	23308238	missense	probably damaging	1.00
R9670:Vmn2r114	UTSW	17	23312124	missense
X0065:Vmn2r114	UTSW	17	23310957	missense	probably benign	0.34
Z1088:Vmn2r114	UTSW	17	23290932	makesense	probably null

Predicted Primers

PCR Primer
(F):5'- GTTTTAGCCAAGACAGTGGAAACAG -3'
(R):5'- TCCTGTCAGTAAAATTGCTAAAGC -3'

Sequencing Primer
(F):5'- CAACTCCAAATGTGATTTGCTGTAGG -3'
(R):5'- TGTCAGTAAAATTGCTAAAGCTACAC -3'

Posted On

2022-10-06