Incidental Mutation 'R9659:Ep300'
ID 727474
Institutional Source Beutler Lab
Gene Symbol Ep300
Ensembl Gene ENSMUSG00000055024
Gene Name E1A binding protein p300
Synonyms p300, KAT3B
MMRRC Submission
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R9659 (G1)
Quality Score 225.009
Status Not validated
Chromosome 15
Chromosomal Location 81470329-81536278 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 81505273 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 631 (Y631C)
Ref Sequence ENSEMBL: ENSMUSP00000066789 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068387] [ENSMUST00000206936]
AlphaFold B2RWS6
Predicted Effect unknown
Transcript: ENSMUST00000068387
AA Change: Y631C
SMART Domains Protein: ENSMUSP00000066789
Gene: ENSMUSG00000055024
AA Change: Y631C

DomainStartEndE-ValueType
low complexity region 18 28 N/A INTRINSIC
low complexity region 162 178 N/A INTRINSIC
low complexity region 223 242 N/A INTRINSIC
low complexity region 296 309 N/A INTRINSIC
ZnF_TAZ 333 418 2.85e-32 SMART
low complexity region 475 488 N/A INTRINSIC
low complexity region 492 503 N/A INTRINSIC
Pfam:KIX 567 647 7.2e-44 PFAM
low complexity region 722 735 N/A INTRINSIC
low complexity region 831 848 N/A INTRINSIC
low complexity region 852 882 N/A INTRINSIC
low complexity region 884 920 N/A INTRINSIC
low complexity region 924 943 N/A INTRINSIC
low complexity region 1024 1039 N/A INTRINSIC
BROMO 1047 1157 6.36e-42 SMART
Blast:KAT11 1227 1300 9e-22 BLAST
KAT11 1305 1610 1.19e-140 SMART
ZnF_ZZ 1663 1704 2.67e-15 SMART
ZnF_TAZ 1728 1806 5.53e-30 SMART
low complexity region 1810 1836 N/A INTRINSIC
low complexity region 1847 1881 N/A INTRINSIC
low complexity region 1902 1927 N/A INTRINSIC
low complexity region 1962 1979 N/A INTRINSIC
Pfam:Creb_binding 1993 2099 3.5e-37 PFAM
low complexity region 2146 2158 N/A INTRINSIC
low complexity region 2187 2203 N/A INTRINSIC
low complexity region 2205 2244 N/A INTRINSIC
low complexity region 2254 2265 N/A INTRINSIC
low complexity region 2303 2346 N/A INTRINSIC
low complexity region 2390 2405 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000185967
AA Change: Y108C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000206936
AA Change: Y4C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit defects of the heart, lung, and small intestine and die at midgestation; heterozygotes also show some embryonic loss. Heterozygotes for an acetyltransferase-negative mutation die by the neonatal period. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A330070K13Rik T C 5: 130,407,876 (GRCm39) I112V unknown Het
Adcy7 A G 8: 89,045,733 (GRCm39) T572A probably benign Het
Atad5 G T 11: 79,980,542 (GRCm39) probably benign Het
C2cd2 A G 16: 97,723,473 (GRCm39) S15P possibly damaging Het
Cabp1 T C 5: 115,311,187 (GRCm39) D289G possibly damaging Het
Ccdc14 A G 16: 34,541,913 (GRCm39) I545V probably damaging Het
Cep295 C A 9: 15,233,846 (GRCm39) A2317S probably benign Het
Cerkl T C 2: 79,223,322 (GRCm39) D133G possibly damaging Het
Cited4 T G 4: 120,524,543 (GRCm39) C182G probably damaging Het
Col6a5 T A 9: 105,811,034 (GRCm39) K828N unknown Het
Ear2 A G 14: 44,340,705 (GRCm39) Y121C probably damaging Het
Ect2l C T 10: 18,041,347 (GRCm39) C369Y possibly damaging Het
Elapor1 G A 3: 108,377,297 (GRCm39) T387I possibly damaging Het
Ephb4 T G 5: 137,363,743 (GRCm39) Y583D probably damaging Het
Fbn2 C G 18: 58,342,654 (GRCm39) R75P probably damaging Het
Gabra2 T C 5: 71,192,140 (GRCm39) D63G probably benign Het
Gfra1 A G 19: 58,441,652 (GRCm39) M93T probably damaging Het
Gm21886 AGAGGCCTGCAGACAGTAGGTGCTCACTAGGGCCTGCAGACAGCAGGTGCTCACTGAGGCCTG AGAGGCCTG 18: 80,132,776 (GRCm39) probably benign Het
Gm3604 A T 13: 62,519,724 (GRCm39) H10Q possibly damaging Het
Helz2 T C 2: 180,882,025 (GRCm39) D256G probably benign Het
Herc1 A C 9: 66,307,185 (GRCm39) I1002L probably benign Het
Hpgd C G 8: 56,772,075 (GRCm39) C182W probably damaging Het
Htr5b A G 1: 121,455,428 (GRCm39) L164P possibly damaging Het
Kmo T C 1: 175,486,085 (GRCm39) F403L probably damaging Het
Ly75 C A 2: 60,168,665 (GRCm39) D748Y probably damaging Het
Mcm5 C T 8: 75,844,168 (GRCm39) S313F probably benign Het
Mipep A G 14: 61,083,893 (GRCm39) T595A probably damaging Het
Muc6 T C 7: 141,232,100 (GRCm39) D968G probably damaging Het
Myo18b T C 5: 113,022,382 (GRCm39) T337A unknown Het
Nlrp1b T A 11: 71,073,132 (GRCm39) Q237L possibly damaging Het
Nr1h4 A G 10: 89,314,638 (GRCm39) probably null Het
Nxph1 A G 6: 9,247,418 (GRCm39) T130A probably damaging Het
Or10al6 T G 17: 38,082,880 (GRCm39) F112C probably damaging Het
Or1l4 T A 2: 37,091,897 (GRCm39) C215S possibly damaging Het
Or4m1 A G 14: 50,558,181 (GRCm39) F37S probably benign Het
Or5p4 T C 7: 107,680,745 (GRCm39) V248A probably damaging Het
Or8g21 A G 9: 38,906,296 (GRCm39) V145A possibly damaging Het
Pcsk5 A G 19: 17,455,245 (GRCm39) Y1062H probably benign Het
Plch1 T C 3: 63,681,136 (GRCm39) I164V probably benign Het
Plekhh2 T A 17: 84,854,892 (GRCm39) M42K possibly damaging Het
Polr2a T C 11: 69,625,654 (GRCm39) Y1832C unknown Het
Prpf4 G A 4: 62,334,296 (GRCm39) probably null Het
Psg16 T C 7: 16,824,524 (GRCm39) S12P possibly damaging Het
Ptpn14 T A 1: 189,587,174 (GRCm39) M528K probably benign Het
Rb1cc1 T A 1: 6,318,673 (GRCm39) H697Q probably benign Het
Reg3a T G 6: 78,360,574 (GRCm39) C171G possibly damaging Het
Slc22a26 G A 19: 7,763,798 (GRCm39) P412S probably benign Het
Spata31e5 G T 1: 28,816,536 (GRCm39) H499N probably benign Het
Tcstv2a T A 13: 120,725,754 (GRCm39) D139E probably damaging Het
Tlk2 T C 11: 105,131,263 (GRCm39) I203T probably benign Het
Tmem120b T G 5: 123,253,788 (GRCm39) H279Q probably damaging Het
Trip4 T C 9: 65,740,702 (GRCm39) E535G probably benign Het
Ttn C T 2: 76,715,357 (GRCm39) E7912K unknown Het
Ubr5 A T 15: 37,984,254 (GRCm39) L2298I Het
Utp20 A G 10: 88,653,171 (GRCm39) L303P probably damaging Het
Vcan A G 13: 89,839,860 (GRCm39) Y1895H probably damaging Het
Vmn2r2 T C 3: 64,041,942 (GRCm39) N258D possibly damaging Het
Wdr20rt A T 12: 65,273,343 (GRCm39) S269C probably damaging Het
Zfand4 T G 6: 116,282,588 (GRCm39) Y54D probably damaging Het
Zfp82 C T 7: 29,755,963 (GRCm39) R373H probably damaging Het
Zmiz2 A G 11: 6,346,814 (GRCm39) E141G probably benign Het
Other mutations in Ep300
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00236:Ep300 APN 15 81,525,619 (GRCm39) missense unknown
IGL01128:Ep300 APN 15 81,514,207 (GRCm39) unclassified probably benign
IGL01151:Ep300 APN 15 81,507,673 (GRCm39) intron probably benign
IGL01414:Ep300 APN 15 81,511,467 (GRCm39) unclassified probably benign
IGL01564:Ep300 APN 15 81,516,665 (GRCm39) unclassified probably benign
IGL01875:Ep300 APN 15 81,524,224 (GRCm39) missense unknown
IGL01945:Ep300 APN 15 81,500,310 (GRCm39) unclassified probably benign
IGL02022:Ep300 APN 15 81,495,638 (GRCm39) unclassified probably benign
IGL02115:Ep300 APN 15 81,533,019 (GRCm39) missense unknown
IGL02129:Ep300 APN 15 81,470,837 (GRCm39) missense unknown
IGL02145:Ep300 APN 15 81,485,367 (GRCm39) missense unknown
IGL02149:Ep300 APN 15 81,512,621 (GRCm39) unclassified probably benign
IGL02165:Ep300 APN 15 81,525,592 (GRCm39) missense probably benign 0.39
IGL02226:Ep300 APN 15 81,497,613 (GRCm39) missense unknown
IGL02610:Ep300 APN 15 81,485,723 (GRCm39) missense unknown
IGL02731:Ep300 APN 15 81,532,615 (GRCm39) missense unknown
IGL03239:Ep300 APN 15 81,525,589 (GRCm39) missense unknown
BB001:Ep300 UTSW 15 81,533,703 (GRCm39) missense unknown
BB011:Ep300 UTSW 15 81,533,703 (GRCm39) missense unknown
R0077:Ep300 UTSW 15 81,525,514 (GRCm39) missense unknown
R0145:Ep300 UTSW 15 81,500,328 (GRCm39) critical splice donor site probably null
R0244:Ep300 UTSW 15 81,524,329 (GRCm39) missense unknown
R0390:Ep300 UTSW 15 81,524,317 (GRCm39) missense unknown
R0534:Ep300 UTSW 15 81,485,097 (GRCm39) splice site probably benign
R0671:Ep300 UTSW 15 81,500,335 (GRCm39) unclassified probably benign
R0840:Ep300 UTSW 15 81,529,134 (GRCm39) missense unknown
R1166:Ep300 UTSW 15 81,514,265 (GRCm39) unclassified probably benign
R1737:Ep300 UTSW 15 81,510,548 (GRCm39) missense probably damaging 0.99
R1893:Ep300 UTSW 15 81,515,847 (GRCm39) unclassified probably benign
R2136:Ep300 UTSW 15 81,524,648 (GRCm39) missense unknown
R3427:Ep300 UTSW 15 81,485,480 (GRCm39) missense unknown
R3757:Ep300 UTSW 15 81,532,790 (GRCm39) missense unknown
R3892:Ep300 UTSW 15 81,504,198 (GRCm39) unclassified probably benign
R4554:Ep300 UTSW 15 81,485,631 (GRCm39) missense unknown
R4575:Ep300 UTSW 15 81,495,611 (GRCm39) unclassified probably benign
R4575:Ep300 UTSW 15 81,533,210 (GRCm39) missense unknown
R4577:Ep300 UTSW 15 81,495,611 (GRCm39) unclassified probably benign
R4577:Ep300 UTSW 15 81,533,210 (GRCm39) missense unknown
R4578:Ep300 UTSW 15 81,495,611 (GRCm39) unclassified probably benign
R4578:Ep300 UTSW 15 81,533,210 (GRCm39) missense unknown
R5021:Ep300 UTSW 15 81,524,224 (GRCm39) missense unknown
R5366:Ep300 UTSW 15 81,500,301 (GRCm39) missense probably benign 0.24
R5372:Ep300 UTSW 15 81,521,031 (GRCm39) missense unknown
R5393:Ep300 UTSW 15 81,515,819 (GRCm39) unclassified probably benign
R5410:Ep300 UTSW 15 81,533,055 (GRCm39) missense unknown
R5571:Ep300 UTSW 15 81,527,418 (GRCm39) intron probably benign
R5701:Ep300 UTSW 15 81,485,696 (GRCm39) missense unknown
R5772:Ep300 UTSW 15 81,524,115 (GRCm39) intron probably benign
R5825:Ep300 UTSW 15 81,495,673 (GRCm39) missense probably benign 0.39
R5917:Ep300 UTSW 15 81,512,808 (GRCm39) unclassified probably benign
R5991:Ep300 UTSW 15 81,532,667 (GRCm39) missense unknown
R6019:Ep300 UTSW 15 81,525,583 (GRCm39) missense unknown
R6144:Ep300 UTSW 15 81,485,435 (GRCm39) missense unknown
R6291:Ep300 UTSW 15 81,532,708 (GRCm39) missense unknown
R6292:Ep300 UTSW 15 81,500,935 (GRCm39) unclassified probably benign
R6599:Ep300 UTSW 15 81,470,914 (GRCm39) missense unknown
R6804:Ep300 UTSW 15 81,525,512 (GRCm39) nonsense probably null
R6925:Ep300 UTSW 15 81,534,182 (GRCm39) missense probably benign 0.32
R7327:Ep300 UTSW 15 81,511,515 (GRCm39) missense unknown
R7378:Ep300 UTSW 15 81,534,746 (GRCm39) missense probably damaging 0.97
R7388:Ep300 UTSW 15 81,532,567 (GRCm39) missense unknown
R7419:Ep300 UTSW 15 81,532,715 (GRCm39) missense unknown
R7498:Ep300 UTSW 15 81,524,044 (GRCm39) missense unknown
R7584:Ep300 UTSW 15 81,512,627 (GRCm39) missense unknown
R7605:Ep300 UTSW 15 81,505,353 (GRCm39) missense unknown
R7619:Ep300 UTSW 15 81,492,399 (GRCm39) missense unknown
R7699:Ep300 UTSW 15 81,470,594 (GRCm39) start gained probably benign
R7763:Ep300 UTSW 15 81,470,784 (GRCm39) start gained probably benign
R7775:Ep300 UTSW 15 81,470,887 (GRCm39) missense unknown
R7778:Ep300 UTSW 15 81,470,887 (GRCm39) missense unknown
R7862:Ep300 UTSW 15 81,534,954 (GRCm39) missense probably damaging 1.00
R7924:Ep300 UTSW 15 81,533,703 (GRCm39) missense unknown
R8155:Ep300 UTSW 15 81,505,269 (GRCm39) missense unknown
R8259:Ep300 UTSW 15 81,523,218 (GRCm39) missense unknown
R8276:Ep300 UTSW 15 81,534,229 (GRCm39) missense possibly damaging 0.85
R8331:Ep300 UTSW 15 81,485,411 (GRCm39) missense unknown
R8554:Ep300 UTSW 15 81,523,228 (GRCm39) missense unknown
R9019:Ep300 UTSW 15 81,532,730 (GRCm39) missense unknown
R9128:Ep300 UTSW 15 81,533,946 (GRCm39) missense unknown
R9379:Ep300 UTSW 15 81,532,760 (GRCm39) missense unknown
R9380:Ep300 UTSW 15 81,500,245 (GRCm39) missense unknown
R9484:Ep300 UTSW 15 81,521,026 (GRCm39) missense unknown
R9690:Ep300 UTSW 15 81,520,396 (GRCm39) missense unknown
R9721:Ep300 UTSW 15 81,492,516 (GRCm39) missense unknown
RF020:Ep300 UTSW 15 81,470,772 (GRCm39) start gained probably benign
Z1177:Ep300 UTSW 15 81,514,298 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- TGTTCTGCAGACCATGTTATACTC -3'
(R):5'- ACTTGGAAGGCTCCCTTGAG -3'

Sequencing Primer
(F):5'- TGTTATACTCAAACCCAGATCTGC -3'
(R):5'- TTTTTCCACTCGTTTTTAAAAGTGG -3'
Posted On 2022-10-06