Incidental Mutation 'R9661:Tut7'
ID 727600
Institutional Source Beutler Lab
Gene Symbol Tut7
Ensembl Gene ENSMUSG00000035248
Gene Name terminal uridylyl transferase 7
Synonyms Zcchc6, Tent3b, 6030448M23Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably essential (E-score: 0.761) question?
Stock # R9661 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 59919690-59971060 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 59937332 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 1155 (D1155G)
Ref Sequence ENSEMBL: ENSMUSP00000071623 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071703] [ENSMUST00000224480]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000071703
AA Change: D1155G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000071623
Gene: ENSMUSG00000035248
AA Change: D1155G

DomainStartEndE-ValueType
low complexity region 15 27 N/A INTRINSIC
low complexity region 176 190 N/A INTRINSIC
ZnF_C2H2 244 268 2.61e1 SMART
SCOP:d1f5aa2 284 497 4e-25 SMART
low complexity region 522 534 N/A INTRINSIC
Pfam:PAP_assoc 550 603 6.7e-14 PFAM
low complexity region 811 825 N/A INTRINSIC
low complexity region 846 857 N/A INTRINSIC
low complexity region 882 898 N/A INTRINSIC
ZnF_C2HC 960 976 3.3e-3 SMART
Pfam:NTP_transf_2 1022 1134 4e-8 PFAM
Pfam:PAP_assoc 1229 1282 1.7e-17 PFAM
ZnF_C2HC 1342 1358 2.09e-3 SMART
Pfam:TUTF7_u4 1359 1446 1.6e-42 PFAM
ZnF_C2HC 1448 1464 1.06e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000224480
AA Change: D753G

PolyPhen 2 Score 0.140 (Sensitivity: 0.92; Specificity: 0.86)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A430033K04Rik T A 5: 138,645,451 (GRCm39) H445Q possibly damaging Het
Aadacl4 C A 4: 144,340,287 (GRCm39) P4Q probably damaging Het
Adgre1 A G 17: 57,748,368 (GRCm39) T523A possibly damaging Het
Arhgap32 A G 9: 32,168,531 (GRCm39) E838G probably benign Het
Atad5 G T 11: 79,980,542 (GRCm39) probably benign Het
Card10 C T 15: 78,683,318 (GRCm39) R275H probably damaging Het
Cdh16 A G 8: 105,345,612 (GRCm39) V327A probably benign Het
Clip2 C T 5: 134,533,616 (GRCm39) R487Q probably benign Het
Cttnbp2 T A 6: 18,429,151 (GRCm39) Q159L Het
D630003M21Rik A G 2: 158,047,673 (GRCm39) L732P possibly damaging Het
Dgcr8 T C 16: 18,098,579 (GRCm39) I308V possibly damaging Het
Dhx9 A G 1: 153,340,393 (GRCm39) F702L probably damaging Het
Dpy19l1 T C 9: 24,386,730 (GRCm39) Y188C probably damaging Het
Eea1 T C 10: 95,862,742 (GRCm39) L888S probably benign Het
Elmo1 T C 13: 20,469,531 (GRCm39) probably null Het
Fam186a T A 15: 99,842,492 (GRCm39) I1251F possibly damaging Het
Fer1l4 G A 2: 155,862,336 (GRCm39) A1779V probably damaging Het
Fgfrl1 C T 5: 108,853,841 (GRCm39) T407I probably benign Het
Gkn1 T C 6: 87,325,173 (GRCm39) K79E probably damaging Het
Gm11564 C T 11: 99,706,247 (GRCm39) R61H unknown Het
Gpr107 T C 2: 31,057,075 (GRCm39) F56L probably benign Het
H2-T22 T C 17: 36,353,371 (GRCm39) probably benign Het
Hs1bp3 T C 12: 8,367,940 (GRCm39) V63A probably damaging Het
Htr6 A G 4: 138,801,963 (GRCm39) I37T probably damaging Het
Kifc5b T C 17: 27,140,836 (GRCm39) probably null Het
Lrfn2 T C 17: 49,403,650 (GRCm39) I591T probably benign Het
Lrrc49 A T 9: 60,573,582 (GRCm39) I300N probably damaging Het
Lyst A G 13: 13,808,779 (GRCm39) T150A probably benign Het
Myh11 T C 16: 14,041,857 (GRCm39) Q722R Het
Nek9 T C 12: 85,361,253 (GRCm39) Q484R possibly damaging Het
Nfs1 A T 2: 155,970,473 (GRCm39) V280E probably damaging Het
Notch3 T A 17: 32,373,792 (GRCm39) D472V probably damaging Het
Nt5c1b T C 12: 10,425,450 (GRCm39) V273A probably damaging Het
Nudt12 T C 17: 59,316,981 (GRCm39) D222G probably benign Het
Nup98 G A 7: 101,782,019 (GRCm39) Q1204* probably null Het
Nwd2 A T 5: 63,957,780 (GRCm39) Y370F probably damaging Het
Oas3 A T 5: 120,904,230 (GRCm39) I548N unknown Het
Ogfr A T 2: 180,233,431 (GRCm39) N78Y probably damaging Het
Or10ak11 A T 4: 118,687,526 (GRCm39) L36Q probably benign Het
Prkcq A T 2: 11,250,141 (GRCm39) K153* probably null Het
Ptpdc1 T A 13: 48,739,610 (GRCm39) N607I probably benign Het
Rab5c G T 11: 100,606,917 (GRCm39) Q221K probably benign Het
Ret G A 6: 118,150,437 (GRCm39) T693I probably benign Het
Rnf20 A G 4: 49,654,556 (GRCm39) E871G probably damaging Het
Rtl1 G T 12: 109,557,346 (GRCm39) P1498T possibly damaging Het
Septin9 C G 11: 117,245,751 (GRCm39) R458G possibly damaging Het
Sh2d2a T C 3: 87,756,788 (GRCm39) probably null Het
Slc14a1 C A 18: 78,152,807 (GRCm39) A367S probably damaging Het
Slc16a4 T A 3: 107,213,359 (GRCm39) D451E probably benign Het
Slc36a3 A G 11: 55,015,984 (GRCm39) F390S probably benign Het
Slc4a2 T A 5: 24,640,005 (GRCm39) M576K probably damaging Het
Smim14 T C 5: 65,610,533 (GRCm39) H88R possibly damaging Het
Spata31e5 G T 1: 28,816,536 (GRCm39) H499N probably benign Het
Sspo C T 6: 48,455,272 (GRCm39) Q3045* probably null Het
Supt7l C A 5: 31,680,403 (GRCm39) R3M probably damaging Het
Tjap1 A G 17: 46,571,092 (GRCm39) W132R probably damaging Het
Tmem26 T A 10: 68,559,838 (GRCm39) W37R probably damaging Het
Vmn1r119 C T 7: 20,746,224 (GRCm39) V53M possibly damaging Het
Vmn2r54 A T 7: 12,349,166 (GRCm39) N805K probably benign Het
Zfp638 T C 6: 83,923,320 (GRCm39) V706A probably damaging Het
Other mutations in Tut7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Tut7 APN 13 59,964,512 (GRCm39) missense probably damaging 1.00
IGL01361:Tut7 APN 13 59,933,614 (GRCm39) missense probably damaging 1.00
IGL02002:Tut7 APN 13 59,929,910 (GRCm39) missense possibly damaging 0.76
IGL02015:Tut7 APN 13 59,937,072 (GRCm39) missense probably damaging 1.00
IGL02029:Tut7 APN 13 59,932,702 (GRCm39) unclassified probably benign
IGL02216:Tut7 APN 13 59,948,237 (GRCm39) missense probably benign 0.01
IGL02705:Tut7 APN 13 59,937,017 (GRCm39) missense probably damaging 1.00
IGL02742:Tut7 APN 13 59,964,156 (GRCm39) missense probably damaging 0.99
IGL02810:Tut7 APN 13 59,929,830 (GRCm39) critical splice donor site probably null
IGL02942:Tut7 APN 13 59,959,335 (GRCm39) missense probably damaging 0.98
IGL03104:Tut7 APN 13 59,962,717 (GRCm39) missense probably benign 0.04
R0025:Tut7 UTSW 13 59,953,142 (GRCm39) missense probably benign 0.08
R0025:Tut7 UTSW 13 59,953,142 (GRCm39) missense probably benign 0.08
R0153:Tut7 UTSW 13 59,930,150 (GRCm39) nonsense probably null
R0269:Tut7 UTSW 13 59,964,669 (GRCm39) splice site probably null
R0358:Tut7 UTSW 13 59,929,918 (GRCm39) missense probably damaging 0.99
R0555:Tut7 UTSW 13 59,948,131 (GRCm39) missense probably benign 0.00
R0599:Tut7 UTSW 13 59,957,301 (GRCm39) missense probably damaging 1.00
R0609:Tut7 UTSW 13 59,947,596 (GRCm39) nonsense probably null
R0617:Tut7 UTSW 13 59,964,669 (GRCm39) splice site probably null
R0680:Tut7 UTSW 13 59,948,413 (GRCm39) missense possibly damaging 0.79
R0699:Tut7 UTSW 13 59,929,828 (GRCm39) splice site probably benign
R1214:Tut7 UTSW 13 59,953,140 (GRCm39) missense possibly damaging 0.76
R1271:Tut7 UTSW 13 59,969,669 (GRCm39) missense probably damaging 0.99
R1556:Tut7 UTSW 13 59,948,054 (GRCm39) missense probably benign 0.02
R1662:Tut7 UTSW 13 59,947,717 (GRCm39) missense possibly damaging 0.93
R1777:Tut7 UTSW 13 59,939,635 (GRCm39) missense probably damaging 1.00
R1834:Tut7 UTSW 13 59,962,749 (GRCm39) nonsense probably null
R1928:Tut7 UTSW 13 59,964,548 (GRCm39) missense probably damaging 1.00
R2012:Tut7 UTSW 13 59,959,352 (GRCm39) missense probably damaging 0.99
R2045:Tut7 UTSW 13 59,948,470 (GRCm39) missense probably damaging 1.00
R2336:Tut7 UTSW 13 59,946,868 (GRCm39) missense probably damaging 1.00
R3764:Tut7 UTSW 13 59,948,194 (GRCm39) missense probably damaging 0.98
R3899:Tut7 UTSW 13 59,937,069 (GRCm39) nonsense probably null
R3918:Tut7 UTSW 13 59,929,838 (GRCm39) missense probably damaging 1.00
R4423:Tut7 UTSW 13 59,969,863 (GRCm39) missense probably damaging 0.96
R4664:Tut7 UTSW 13 59,948,413 (GRCm39) missense possibly damaging 0.79
R4673:Tut7 UTSW 13 59,944,659 (GRCm39) missense probably damaging 1.00
R4770:Tut7 UTSW 13 59,920,698 (GRCm39) unclassified probably benign
R4884:Tut7 UTSW 13 59,937,266 (GRCm39) missense probably damaging 1.00
R5186:Tut7 UTSW 13 59,964,470 (GRCm39) critical splice donor site probably null
R5337:Tut7 UTSW 13 59,939,666 (GRCm39) missense probably damaging 1.00
R5385:Tut7 UTSW 13 59,937,660 (GRCm39) critical splice donor site probably null
R5452:Tut7 UTSW 13 59,948,471 (GRCm39) missense probably damaging 1.00
R5534:Tut7 UTSW 13 59,936,367 (GRCm39) missense probably damaging 1.00
R5566:Tut7 UTSW 13 59,936,443 (GRCm39) nonsense probably null
R5928:Tut7 UTSW 13 59,969,880 (GRCm39) missense probably benign 0.16
R5994:Tut7 UTSW 13 59,937,023 (GRCm39) missense probably damaging 1.00
R6415:Tut7 UTSW 13 59,964,110 (GRCm39) splice site probably null
R6495:Tut7 UTSW 13 59,947,753 (GRCm39) missense possibly damaging 0.95
R6577:Tut7 UTSW 13 59,955,975 (GRCm39) missense probably damaging 1.00
R7205:Tut7 UTSW 13 59,936,364 (GRCm39) missense probably damaging 1.00
R7286:Tut7 UTSW 13 59,969,463 (GRCm39) missense probably benign 0.18
R7355:Tut7 UTSW 13 59,969,616 (GRCm39) missense probably benign 0.00
R7369:Tut7 UTSW 13 59,929,867 (GRCm39) missense possibly damaging 0.71
R7455:Tut7 UTSW 13 59,969,871 (GRCm39) missense probably benign 0.03
R7557:Tut7 UTSW 13 59,936,280 (GRCm39) missense possibly damaging 0.89
R7635:Tut7 UTSW 13 59,947,904 (GRCm39) missense probably benign 0.03
R7727:Tut7 UTSW 13 59,947,496 (GRCm39) missense probably benign 0.00
R7798:Tut7 UTSW 13 59,963,389 (GRCm39) missense possibly damaging 0.81
R7912:Tut7 UTSW 13 59,946,819 (GRCm39) missense probably damaging 1.00
R7915:Tut7 UTSW 13 59,932,628 (GRCm39) missense probably benign 0.12
R8035:Tut7 UTSW 13 59,937,004 (GRCm39) missense probably benign 0.00
R8531:Tut7 UTSW 13 59,937,074 (GRCm39) missense probably damaging 1.00
R8777:Tut7 UTSW 13 59,933,597 (GRCm39) missense probably benign 0.15
R8777-TAIL:Tut7 UTSW 13 59,933,597 (GRCm39) missense probably benign 0.15
R8850:Tut7 UTSW 13 59,937,011 (GRCm39) missense possibly damaging 0.83
R8929:Tut7 UTSW 13 59,947,942 (GRCm39) missense probably benign
R9254:Tut7 UTSW 13 59,936,288 (GRCm39) missense possibly damaging 0.48
R9313:Tut7 UTSW 13 59,947,798 (GRCm39) missense probably benign 0.01
R9373:Tut7 UTSW 13 59,944,681 (GRCm39) missense probably damaging 1.00
R9379:Tut7 UTSW 13 59,936,288 (GRCm39) missense possibly damaging 0.48
R9404:Tut7 UTSW 13 59,947,701 (GRCm39) missense probably benign 0.00
R9461:Tut7 UTSW 13 59,963,512 (GRCm39) missense probably damaging 1.00
R9462:Tut7 UTSW 13 59,929,957 (GRCm39) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- TTCCAGCCATCAACAAGTATTTCTG -3'
(R):5'- TGACCGACAATCCACTTCTTTG -3'

Sequencing Primer
(F):5'- TGTCCAGGAAAAGTTACAAGATGTC -3'
(R):5'- GACAATCCACTTCTTTGTTGAATTC -3'
Posted On 2022-10-06