Incidental Mutation 'R9662:Exog'
ID 727633
Institutional Source Beutler Lab
Gene Symbol Exog
Ensembl Gene ENSMUSG00000042787
Gene Name exo/endonuclease G
Synonyms Endogl1, ENGL-B, ENDOGL2, ENGL-a
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.128) question?
Stock # R9662 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 119274026-119294584 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 119281376 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 229 (R229G)
Ref Sequence ENSEMBL: ENSMUSP00000129273 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035094] [ENSMUST00000164213] [ENSMUST00000214140] [ENSMUST00000214462]
AlphaFold Q8C163
Predicted Effect probably benign
Transcript: ENSMUST00000035094
AA Change: R205G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000035094
Gene: ENSMUSG00000042787
AA Change: R205G

DomainStartEndE-ValueType
Blast:Endonuclease_NS 1 53 1e-5 BLAST
Endonuclease_NS 76 287 2.01e-74 SMART
NUC 77 287 2.25e-103 SMART
low complexity region 348 363 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000164213
AA Change: R229G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000129273
Gene: ENSMUSG00000042787
AA Change: R229G

DomainStartEndE-ValueType
low complexity region 34 49 N/A INTRINSIC
Endonuclease_NS 100 311 2.01e-74 SMART
NUC 101 311 2.25e-103 SMART
low complexity region 372 387 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000214140
Predicted Effect probably benign
Transcript: ENSMUST00000214462
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agbl3 T A 6: 34,809,468 (GRCm39) Y698* probably null Het
Arhgef28 C A 13: 98,065,969 (GRCm39) G1628V probably benign Het
Bcr T C 10: 75,011,152 (GRCm39) V1018A probably benign Het
Cadps T A 14: 12,411,567 (GRCm38) E1263V probably benign Het
Cdc14a T A 3: 116,088,484 (GRCm39) K446M probably damaging Het
Celf6 C T 9: 59,485,668 (GRCm39) A3V unknown Het
Clip2 C T 5: 134,533,616 (GRCm39) R487Q probably benign Het
Col1a1 A G 11: 94,836,667 (GRCm39) S709G probably benign Het
Dnah17 A T 11: 117,925,166 (GRCm39) L3889H probably damaging Het
Dnah2 T C 11: 69,343,763 (GRCm39) T2849A probably benign Het
Fnbp1 T A 2: 30,986,042 (GRCm39) K114N probably damaging Het
Gm21149 A T 5: 15,681,357 (GRCm39) N35K probably damaging Het
Gm7324 A T 14: 43,952,434 (GRCm39) D359V unknown Het
Grin3a A T 4: 49,792,432 (GRCm39) S434T possibly damaging Het
H2-Q6 C T 17: 35,644,185 (GRCm39) R56C probably damaging Het
Hmgcll1 A T 9: 75,922,397 (GRCm39) Y14F probably benign Het
Kcna6 T G 6: 126,715,380 (GRCm39) E503A probably benign Het
Kmt2a A G 9: 44,731,428 (GRCm39) V2963A unknown Het
Ltk G T 2: 119,582,330 (GRCm39) S807* probably null Het
Mars1 A G 10: 127,136,349 (GRCm39) L492P probably damaging Het
Mcm5 C T 8: 75,844,168 (GRCm39) S313F probably benign Het
Myo7a T A 7: 97,747,499 (GRCm39) Y111F possibly damaging Het
Ndst3 T A 3: 123,465,115 (GRCm39) I286L probably benign Het
Nup210l C T 3: 90,107,173 (GRCm39) P1570L probably benign Het
Parg T C 14: 31,971,976 (GRCm39) L657S probably damaging Het
Ppip5k1 T C 2: 121,174,054 (GRCm39) T356A probably benign Het
Ppp3ca T C 3: 136,583,501 (GRCm39) S203P probably damaging Het
Raver1 C T 9: 20,992,550 (GRCm39) R293H probably benign Het
Robo2 C T 16: 73,758,566 (GRCm39) probably null Het
Sgsm1 G A 5: 113,427,097 (GRCm39) P398L probably benign Het
Slc6a19 A T 13: 73,839,822 (GRCm39) C153* probably null Het
Tbx1 T C 16: 18,400,882 (GRCm39) H434R unknown Het
Tmem151a C A 19: 5,132,717 (GRCm39) R163L probably damaging Het
Ttn A G 2: 76,671,604 (GRCm39) V11320A unknown Het
Zfp207 G A 11: 80,286,029 (GRCm39) M423I unknown Het
Zfp251 A T 15: 76,737,520 (GRCm39) H524Q possibly damaging Het
Zfp318 C T 17: 46,724,383 (GRCm39) R2129W probably damaging Het
Zfp763 T A 17: 33,240,787 (GRCm39) D14V probably damaging Het
Other mutations in Exog
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01470:Exog APN 9 119,291,592 (GRCm39) missense probably damaging 0.98
IGL03013:Exog APN 9 119,291,679 (GRCm39) missense possibly damaging 0.86
IGL03399:Exog APN 9 119,276,017 (GRCm39) missense possibly damaging 0.83
R0014:Exog UTSW 9 119,281,344 (GRCm39) missense probably damaging 0.96
R0102:Exog UTSW 9 119,281,319 (GRCm39) missense possibly damaging 0.83
R0102:Exog UTSW 9 119,281,319 (GRCm39) missense possibly damaging 0.83
R0508:Exog UTSW 9 119,277,444 (GRCm39) splice site probably benign
R0754:Exog UTSW 9 119,291,572 (GRCm39) missense probably benign 0.15
R1389:Exog UTSW 9 119,291,572 (GRCm39) missense probably benign 0.15
R1552:Exog UTSW 9 119,274,176 (GRCm39) missense unknown
R1777:Exog UTSW 9 119,278,884 (GRCm39) missense probably damaging 1.00
R1961:Exog UTSW 9 119,281,332 (GRCm39) missense possibly damaging 0.92
R3085:Exog UTSW 9 119,291,518 (GRCm39) missense probably benign 0.42
R3799:Exog UTSW 9 119,278,876 (GRCm39) missense probably damaging 1.00
R5618:Exog UTSW 9 119,291,817 (GRCm39) missense probably damaging 0.99
R7310:Exog UTSW 9 119,274,069 (GRCm39) missense unknown
R7320:Exog UTSW 9 119,291,544 (GRCm39) missense possibly damaging 0.63
R8528:Exog UTSW 9 119,291,686 (GRCm39) missense probably damaging 1.00
R8693:Exog UTSW 9 119,276,108 (GRCm39) missense possibly damaging 0.51
R9326:Exog UTSW 9 119,291,554 (GRCm39) missense probably damaging 1.00
R9733:Exog UTSW 9 119,291,586 (GRCm39) missense possibly damaging 0.82
Z1177:Exog UTSW 9 119,277,564 (GRCm39) missense probably damaging 0.99
Z1177:Exog UTSW 9 119,274,146 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- ACTCATTCAAGAGTCTTTCCTAGGG -3'
(R):5'- AGTCTTCAACACAGCTGGGTG -3'

Sequencing Primer
(F):5'- CAAGAGTCTTTCCTAGGGACTGG -3'
(R):5'- GGTGAGTGCCTCCCTTTAACTG -3'
Posted On 2022-10-06