Mutagenetix > Incidental Mutation

Incidental Mutation 'R9662:Zfp763'

727648

Institutional Source

Beutler Lab

Gene Symbol

Zfp763

Ensembl Gene

ENSMUSG00000067430

Gene Name

zinc finger protein 763

Synonyms

1700065O13Rik

MMRRC Submission

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R9662 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

33235838-33252355 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 33240787 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Valine at position 14 (D14V)

Ref Sequence

ENSEMBL: ENSMUSP00000084936 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000087654]

AlphaFold

Q8BIC7

Predicted Effect

probably damaging
Transcript: ENSMUST00000087654
AA Change: D14V

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000084936
Gene: ENSMUSG00000067430
AA Change: D14V

Domain	Start	End	E-Value	Type
KRAB	10	60	7.47e-14	SMART
ZnF_C2H2	223	245	2.53e-2	SMART
ZnF_C2H2	251	273	4.54e-4	SMART
ZnF_C2H2	279	301	1.69e-3	SMART
ZnF_C2H2	307	329	5.72e-1	SMART
ZnF_C2H2	335	357	1.64e-1	SMART
ZnF_C2H2	363	385	1.56e-2	SMART
ZnF_C2H2	391	413	1.82e-3	SMART
ZnF_C2H2	419	441	1.64e-1	SMART
ZnF_C2H2	447	469	5.9e-3	SMART
ZnF_C2H2	475	497	2.02e-1	SMART
ZnF_C2H2	503	525	7.15e-2	SMART
ZnF_C2H2	531	553	1.79e-2	SMART
ZnF_C2H2	559	581	5.14e-3	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agbl3	T	A	6: 34,809,468 (GRCm39)	Y698*	probably null	Het
Arhgef28	C	A	13: 98,065,969 (GRCm39)	G1628V	probably benign	Het
Bcr	T	C	10: 75,011,152 (GRCm39)	V1018A	probably benign	Het
Cadps	T	A	14: 12,411,567 (GRCm38)	E1263V	probably benign	Het
Cdc14a	T	A	3: 116,088,484 (GRCm39)	K446M	probably damaging	Het
Celf6	C	T	9: 59,485,668 (GRCm39)	A3V	unknown	Het
Clip2	C	T	5: 134,533,616 (GRCm39)	R487Q	probably benign	Het
Col1a1	A	G	11: 94,836,667 (GRCm39)	S709G	probably benign	Het
Dnah17	A	T	11: 117,925,166 (GRCm39)	L3889H	probably damaging	Het
Dnah2	T	C	11: 69,343,763 (GRCm39)	T2849A	probably benign	Het
Exog	A	G	9: 119,281,376 (GRCm39)	R229G	probably benign	Het
Fnbp1	T	A	2: 30,986,042 (GRCm39)	K114N	probably damaging	Het
Gm21149	A	T	5: 15,681,357 (GRCm39)	N35K	probably damaging	Het
Gm7324	A	T	14: 43,952,434 (GRCm39)	D359V	unknown	Het
Grin3a	A	T	4: 49,792,432 (GRCm39)	S434T	possibly damaging	Het
H2-Q6	C	T	17: 35,644,185 (GRCm39)	R56C	probably damaging	Het
Hmgcll1	A	T	9: 75,922,397 (GRCm39)	Y14F	probably benign	Het
Kcna6	T	G	6: 126,715,380 (GRCm39)	E503A	probably benign	Het
Kmt2a	A	G	9: 44,731,428 (GRCm39)	V2963A	unknown	Het
Ltk	G	T	2: 119,582,330 (GRCm39)	S807*	probably null	Het
Mars1	A	G	10: 127,136,349 (GRCm39)	L492P	probably damaging	Het
Mcm5	C	T	8: 75,844,168 (GRCm39)	S313F	probably benign	Het
Myo7a	T	A	7: 97,747,499 (GRCm39)	Y111F	possibly damaging	Het
Ndst3	T	A	3: 123,465,115 (GRCm39)	I286L	probably benign	Het
Nup210l	C	T	3: 90,107,173 (GRCm39)	P1570L	probably benign	Het
Parg	T	C	14: 31,971,976 (GRCm39)	L657S	probably damaging	Het
Ppip5k1	T	C	2: 121,174,054 (GRCm39)	T356A	probably benign	Het
Ppp3ca	T	C	3: 136,583,501 (GRCm39)	S203P	probably damaging	Het
Raver1	C	T	9: 20,992,550 (GRCm39)	R293H	probably benign	Het
Robo2	C	T	16: 73,758,566 (GRCm39)		probably null	Het
Sgsm1	G	A	5: 113,427,097 (GRCm39)	P398L	probably benign	Het
Slc6a19	A	T	13: 73,839,822 (GRCm39)	C153*	probably null	Het
Tbx1	T	C	16: 18,400,882 (GRCm39)	H434R	unknown	Het
Tmem151a	C	A	19: 5,132,717 (GRCm39)	R163L	probably damaging	Het
Ttn	A	G	2: 76,671,604 (GRCm39)	V11320A	unknown	Het
Zfp207	G	A	11: 80,286,029 (GRCm39)	M423I	unknown	Het
Zfp251	A	T	15: 76,737,520 (GRCm39)	H524Q	possibly damaging	Het
Zfp318	C	T	17: 46,724,383 (GRCm39)	R2129W	probably damaging	Het

Other mutations in Zfp763

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02638:Zfp763	APN	17	33,238,908 (GRCm39)	missense	probably benign	0.41
IGL03291:Zfp763	APN	17	33,238,860 (GRCm39)	missense	probably damaging	0.96
R0346:Zfp763	UTSW	17	33,238,721 (GRCm39)	missense	probably benign	0.26
R0675:Zfp763	UTSW	17	33,238,774 (GRCm39)	missense	possibly damaging	0.92
R0683:Zfp763	UTSW	17	33,237,892 (GRCm39)	missense	probably damaging	1.00
R1494:Zfp763	UTSW	17	33,240,477 (GRCm39)	missense	probably damaging	0.99
R1521:Zfp763	UTSW	17	33,252,276 (GRCm39)	start codon destroyed	probably benign	0.03
R1607:Zfp763	UTSW	17	33,238,881 (GRCm39)	missense	probably benign	0.08
R1627:Zfp763	UTSW	17	33,240,758 (GRCm39)	missense	probably damaging	1.00
R1714:Zfp763	UTSW	17	33,238,591 (GRCm39)	missense	probably damaging	0.99
R1993:Zfp763	UTSW	17	33,237,413 (GRCm39)	missense	probably damaging	1.00
R2109:Zfp763	UTSW	17	33,238,752 (GRCm39)	missense	probably benign
R4420:Zfp763	UTSW	17	33,237,455 (GRCm39)	missense	probably benign	0.43
R4612:Zfp763	UTSW	17	33,237,922 (GRCm39)	missense	probably benign	0.05
R5114:Zfp763	UTSW	17	33,237,949 (GRCm39)	missense	probably damaging	0.99
R5426:Zfp763	UTSW	17	33,238,569 (GRCm39)	missense	probably benign
R5503:Zfp763	UTSW	17	33,238,507 (GRCm39)	missense	possibly damaging	0.95
R5534:Zfp763	UTSW	17	33,240,768 (GRCm39)	missense	probably damaging	0.97
R6133:Zfp763	UTSW	17	33,237,675 (GRCm39)	missense	possibly damaging	0.75
R7141:Zfp763	UTSW	17	33,237,769 (GRCm39)	missense	probably damaging	0.97
R7365:Zfp763	UTSW	17	33,252,352 (GRCm39)	start gained	probably benign
R7430:Zfp763	UTSW	17	33,238,506 (GRCm39)	missense	possibly damaging	0.68
R7552:Zfp763	UTSW	17	33,237,625 (GRCm39)	missense	probably benign
R8277:Zfp763	UTSW	17	33,252,294 (GRCm39)	start gained	probably benign
R8446:Zfp763	UTSW	17	33,238,473 (GRCm39)	missense	probably benign	0.28
R8964:Zfp763	UTSW	17	33,240,710 (GRCm39)	missense	probably benign	0.25

Predicted Primers

PCR Primer
(F):5'- AGTGTGATTTGACCTGCTCC -3'
(R):5'- AGACTTTAAGATTGCACACTCTCC -3'

Sequencing Primer
(F):5'- ATTCATGAAACTACACAGGTGAGC -3'
(R):5'- CATTGAGGATCTTAAGCCCTGAGC -3'

Posted On

2022-10-06