Incidental Mutation 'IGL01287:Myo1g'
ID 72783
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Myo1g
Ensembl Gene ENSMUSG00000020437
Gene Name myosin IG
Synonyms E430002D17Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01287
Quality Score
Status
Chromosome 11
Chromosomal Location 6456548-6470960 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 6465856 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Phenylalanine at position 410 (V410F)
Ref Sequence ENSEMBL: ENSMUSP00000003459 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000003459] [ENSMUST00000134489] [ENSMUST00000144725] [ENSMUST00000146536]
AlphaFold Q5SUA5
Predicted Effect possibly damaging
Transcript: ENSMUST00000003459
AA Change: V410F

PolyPhen 2 Score 0.702 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000003459
Gene: ENSMUSG00000020437
AA Change: V410F

DomainStartEndE-ValueType
MYSc 9 714 N/A SMART
IQ 715 737 2.79e0 SMART
Pfam:Myosin_TH1 821 1024 2.8e-42 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131823
Predicted Effect probably benign
Transcript: ENSMUST00000134489
SMART Domains Protein: ENSMUSP00000122356
Gene: ENSMUSG00000020437

DomainStartEndE-ValueType
Pfam:Myosin_head 51 99 5.9e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000144725
SMART Domains Protein: ENSMUSP00000120975
Gene: ENSMUSG00000020437

DomainStartEndE-ValueType
Blast:MYSc 9 43 8e-14 BLAST
low complexity region 48 60 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000146536
SMART Domains Protein: ENSMUSP00000122438
Gene: ENSMUSG00000020437

DomainStartEndE-ValueType
Blast:MYSc 9 38 2e-13 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156878
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced B cell spreading, migration and homing and impaired T cell motility. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017B05Rik T C 9: 57,165,040 (GRCm39) K445E probably damaging Het
Abca15 A T 7: 119,932,081 (GRCm39) probably benign Het
Acsbg3 C T 17: 57,189,203 (GRCm39) Q204* probably null Het
Acvr1c A T 2: 58,170,254 (GRCm39) C371* probably null Het
Brs3 T C X: 56,092,727 (GRCm39) probably benign Het
Car14 C T 3: 95,806,871 (GRCm39) V198M possibly damaging Het
Cenpc1 G A 5: 86,170,313 (GRCm39) R704* probably null Het
Crybg1 C T 10: 43,868,490 (GRCm39) R1396H possibly damaging Het
Cubn A G 2: 13,315,377 (GRCm39) S3019P probably damaging Het
Cyp2j9 T C 4: 96,471,665 (GRCm39) E222G probably benign Het
Defb50 C A 8: 22,321,187 (GRCm39) T59K probably benign Het
Dlg3 T C X: 99,850,848 (GRCm39) I587T possibly damaging Het
Doc2a C T 7: 126,450,173 (GRCm39) R204C probably damaging Het
Galc T C 12: 98,212,503 (GRCm39) probably benign Het
Gm8257 A T 14: 44,892,800 (GRCm39) F67I probably damaging Het
Hnrnpul1 A T 7: 25,426,323 (GRCm39) N509K probably damaging Het
Iars2 T A 1: 185,028,625 (GRCm39) I678F possibly damaging Het
Ifit1 A G 19: 34,625,533 (GRCm39) E223G possibly damaging Het
Krt81 G A 15: 101,361,269 (GRCm39) H104Y probably benign Het
Lrp4 C A 2: 91,304,293 (GRCm39) D157E probably damaging Het
Ltk T A 2: 119,586,186 (GRCm39) T21S probably benign Het
Lvrn A T 18: 46,997,733 (GRCm39) probably benign Het
Maob G A X: 16,578,881 (GRCm39) A424V probably damaging Het
Myorg T A 4: 41,498,923 (GRCm39) I236F possibly damaging Het
Naxe T C 3: 87,963,981 (GRCm39) H250R probably damaging Het
Nek5 T C 8: 22,601,199 (GRCm39) N174S possibly damaging Het
Or2y3 G T 17: 38,392,998 (GRCm39) N290K probably damaging Het
Or51l14 C T 7: 103,101,002 (GRCm39) R153W probably damaging Het
Or9m2 A G 2: 87,821,288 (GRCm39) T278A probably benign Het
Pex1 A G 5: 3,656,027 (GRCm39) T285A probably benign Het
Pfas A G 11: 68,892,086 (GRCm39) S141P probably benign Het
Pmm1 T C 15: 81,839,945 (GRCm39) T127A probably damaging Het
Proc C A 18: 32,256,873 (GRCm39) probably benign Het
Ranbp9 T C 13: 43,633,980 (GRCm39) E142G probably damaging Het
Recql4 C A 15: 76,594,112 (GRCm39) probably benign Het
Robo4 C T 9: 37,324,336 (GRCm39) P955S possibly damaging Het
Ryr3 T A 2: 112,539,418 (GRCm39) N3274I probably damaging Het
Serpinb10 T C 1: 107,468,612 (GRCm39) probably benign Het
Slc9c1 A T 16: 45,404,811 (GRCm39) K848* probably null Het
Slfn5 A G 11: 82,847,807 (GRCm39) T231A probably damaging Het
Syncrip T C 9: 88,338,660 (GRCm39) probably benign Het
Syt16 A T 12: 74,313,513 (GRCm39) T480S probably damaging Het
Taf1c G A 8: 120,327,931 (GRCm39) T293M probably benign Het
Tbc1d5 T C 17: 51,120,826 (GRCm39) D430G possibly damaging Het
Tbx18 T C 9: 87,606,384 (GRCm39) T254A probably damaging Het
Tpm1 C T 9: 66,943,337 (GRCm39) R105H probably damaging Het
Usp17la T C 7: 104,510,522 (GRCm39) S376P probably benign Het
Vmn1r19 A G 6: 57,382,179 (GRCm39) D244G probably damaging Het
Vmn1r58 A T 7: 5,414,054 (GRCm39) F59I probably benign Het
Vmn2r45 A T 7: 8,488,622 (GRCm39) M136K probably benign Het
Vmn2r70 T A 7: 85,218,227 (GRCm39) R24* probably null Het
Vmn2r75 T A 7: 85,797,801 (GRCm39) I671F probably damaging Het
Other mutations in Myo1g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01608:Myo1g APN 11 6,466,780 (GRCm39) missense possibly damaging 0.61
IGL01679:Myo1g APN 11 6,468,006 (GRCm39) missense possibly damaging 0.90
IGL01830:Myo1g APN 11 6,464,522 (GRCm39) nonsense probably null
IGL02332:Myo1g APN 11 6,470,766 (GRCm39) missense possibly damaging 0.61
IGL02813:Myo1g APN 11 6,468,743 (GRCm39) makesense probably null
IGL02988:Myo1g APN 11 6,458,183 (GRCm39) splice site probably benign
IGL03178:Myo1g APN 11 6,462,181 (GRCm39) missense probably damaging 1.00
R0004:Myo1g UTSW 11 6,465,901 (GRCm39) missense probably damaging 1.00
R0334:Myo1g UTSW 11 6,461,084 (GRCm39) splice site probably benign
R0513:Myo1g UTSW 11 6,460,203 (GRCm39) missense probably benign 0.00
R0730:Myo1g UTSW 11 6,470,794 (GRCm39) missense probably damaging 1.00
R1054:Myo1g UTSW 11 6,468,987 (GRCm39) missense probably damaging 1.00
R1434:Myo1g UTSW 11 6,459,372 (GRCm39) missense probably benign 0.00
R1500:Myo1g UTSW 11 6,470,811 (GRCm39) missense probably benign
R1513:Myo1g UTSW 11 6,465,140 (GRCm39) missense probably damaging 0.99
R1720:Myo1g UTSW 11 6,462,490 (GRCm39) missense probably benign 0.44
R1774:Myo1g UTSW 11 6,465,988 (GRCm39) missense probably damaging 1.00
R1809:Myo1g UTSW 11 6,462,283 (GRCm39) missense probably benign 0.02
R1957:Myo1g UTSW 11 6,462,159 (GRCm39) critical splice donor site probably null
R1978:Myo1g UTSW 11 6,470,829 (GRCm39) missense possibly damaging 0.53
R2212:Myo1g UTSW 11 6,467,870 (GRCm39) missense possibly damaging 0.88
R2438:Myo1g UTSW 11 6,461,542 (GRCm39) missense probably damaging 1.00
R2566:Myo1g UTSW 11 6,462,539 (GRCm39) critical splice acceptor site probably null
R3158:Myo1g UTSW 11 6,464,527 (GRCm39) missense possibly damaging 0.62
R3159:Myo1g UTSW 11 6,464,527 (GRCm39) missense possibly damaging 0.62
R3413:Myo1g UTSW 11 6,467,870 (GRCm39) missense possibly damaging 0.88
R3816:Myo1g UTSW 11 6,460,926 (GRCm39) missense probably benign 0.02
R3872:Myo1g UTSW 11 6,464,886 (GRCm39) missense possibly damaging 0.94
R3946:Myo1g UTSW 11 6,470,760 (GRCm39) missense possibly damaging 0.89
R4551:Myo1g UTSW 11 6,467,874 (GRCm39) missense probably damaging 1.00
R4625:Myo1g UTSW 11 6,462,240 (GRCm39) missense probably damaging 1.00
R4630:Myo1g UTSW 11 6,469,047 (GRCm39) missense probably damaging 1.00
R4700:Myo1g UTSW 11 6,466,785 (GRCm39) splice site probably null
R4713:Myo1g UTSW 11 6,466,080 (GRCm39) missense probably null 1.00
R4964:Myo1g UTSW 11 6,465,976 (GRCm39) missense probably damaging 1.00
R5183:Myo1g UTSW 11 6,458,243 (GRCm39) missense probably damaging 1.00
R5191:Myo1g UTSW 11 6,465,105 (GRCm39) missense probably benign
R5192:Myo1g UTSW 11 6,464,816 (GRCm39) missense probably damaging 1.00
R5726:Myo1g UTSW 11 6,459,420 (GRCm39) missense probably benign 0.06
R5841:Myo1g UTSW 11 6,457,000 (GRCm39) missense probably benign 0.05
R5942:Myo1g UTSW 11 6,464,888 (GRCm39) missense probably damaging 1.00
R6225:Myo1g UTSW 11 6,469,168 (GRCm39) missense probably damaging 1.00
R6517:Myo1g UTSW 11 6,462,509 (GRCm39) missense probably damaging 0.99
R6563:Myo1g UTSW 11 6,467,146 (GRCm39) missense possibly damaging 0.91
R7214:Myo1g UTSW 11 6,461,055 (GRCm39) missense probably damaging 1.00
R7258:Myo1g UTSW 11 6,459,416 (GRCm39) missense possibly damaging 0.92
R7265:Myo1g UTSW 11 6,460,933 (GRCm39) missense possibly damaging 0.92
R7750:Myo1g UTSW 11 6,464,849 (GRCm39) missense probably damaging 1.00
R8683:Myo1g UTSW 11 6,467,569 (GRCm39) critical splice donor site probably null
R8910:Myo1g UTSW 11 6,468,009 (GRCm39) missense possibly damaging 0.66
R9035:Myo1g UTSW 11 6,464,916 (GRCm39) missense probably damaging 1.00
R9103:Myo1g UTSW 11 6,466,153 (GRCm39) missense possibly damaging 0.88
R9162:Myo1g UTSW 11 6,460,897 (GRCm39) missense probably damaging 0.98
R9487:Myo1g UTSW 11 6,456,913 (GRCm39) missense probably benign
X0017:Myo1g UTSW 11 6,466,077 (GRCm39) critical splice donor site probably null
X0061:Myo1g UTSW 11 6,467,967 (GRCm39) missense probably damaging 1.00
Z1176:Myo1g UTSW 11 6,469,045 (GRCm39) missense probably damaging 1.00
Z1177:Myo1g UTSW 11 6,467,935 (GRCm39) missense probably damaging 1.00
Posted On 2013-10-07