Incidental Mutation 'R9668:Tars1'
ID 727950
Institutional Source Beutler Lab
Gene Symbol Tars1
Ensembl Gene ENSMUSG00000022241
Gene Name threonyl-tRNA synthetase 1
Synonyms D15Wsu59e, Tars, ThrRS
MMRRC Submission
Accession Numbers
Essential gene? Probably essential (E-score: 0.962) question?
Stock # R9668 (G1)
Quality Score 225.009
Status Not validated
Chromosome 15
Chromosomal Location 11383749-11399744 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 11394446 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 64 (K64*)
Ref Sequence ENSEMBL: ENSMUSP00000022849 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022849] [ENSMUST00000228814]
AlphaFold Q9D0R2
Predicted Effect probably null
Transcript: ENSMUST00000022849
AA Change: K64*
SMART Domains Protein: ENSMUSP00000022849
Gene: ENSMUSG00000022241
AA Change: K64*

DomainStartEndE-ValueType
low complexity region 21 45 N/A INTRINSIC
Pfam:TGS 82 142 7.5e-18 PFAM
tRNA_SAD 248 297 1.91e-16 SMART
Pfam:tRNA-synt_2b 396 607 5e-38 PFAM
Pfam:HGTP_anticodon 619 710 6.5e-21 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000228814
AA Change: K64*
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acox1 G T 11: 116,089,137 (GRCm39) Y60* probably null Het
Acp7 T A 7: 28,314,562 (GRCm39) probably null Het
Adamts17 G A 7: 66,797,438 (GRCm39) V1052I possibly damaging Het
Ankrd13b T A 11: 77,368,594 (GRCm39) E42V possibly damaging Het
Ano1 C A 7: 144,164,579 (GRCm39) probably null Het
Atp5pb C T 3: 105,863,356 (GRCm39) V27I probably benign Het
C2cd2 A G 16: 97,671,418 (GRCm39) S494P probably damaging Het
Cd320 G A 17: 34,065,113 (GRCm39) C82Y probably damaging Het
Cdc16 T A 8: 13,817,552 (GRCm39) S288T possibly damaging Het
Chrne A G 11: 70,507,779 (GRCm39) probably null Het
Col12a1 G A 9: 79,546,960 (GRCm39) Q2291* probably null Het
Cps1 A G 1: 67,213,649 (GRCm39) S794G probably benign Het
Csmd1 A T 8: 16,261,772 (GRCm39) D908E probably benign Het
Dpf1 C T 7: 29,009,084 (GRCm39) Q70* probably null Het
Fam227a A T 15: 79,526,444 (GRCm39) N129K probably benign Het
Fcho2 T A 13: 98,913,965 (GRCm39) I211F probably benign Het
Fezf1 T C 6: 23,247,574 (GRCm39) D167G probably benign Het
Flt3 G A 5: 147,293,694 (GRCm39) P461S probably benign Het
Fry G T 5: 150,282,318 (GRCm39) A314S probably damaging Het
Gm6309 A G 5: 146,105,026 (GRCm39) S296P probably benign Het
Gmppb T G 9: 107,928,362 (GRCm39) V291G probably damaging Het
Hmcn1 G T 1: 150,619,492 (GRCm39) S1207R probably benign Het
Iars1 C T 13: 49,840,885 (GRCm39) P6L probably damaging Het
Kdm5d T A Y: 943,075 (GRCm39) S1519R possibly damaging Het
Kpna2 G A 11: 106,881,541 (GRCm39) T363I probably damaging Het
Lrp1b A T 2: 41,075,982 (GRCm39) H1886Q Het
Meak7 T C 8: 120,488,514 (GRCm39) E436G probably damaging Het
Mettl5 C T 2: 69,711,723 (GRCm39) D48N probably benign Het
Mfsd4a C T 1: 131,969,628 (GRCm39) G442S probably damaging Het
Mief2 A G 11: 60,622,074 (GRCm39) T215A probably damaging Het
Myt1 C T 2: 181,452,135 (GRCm39) T824I probably damaging Het
Naprt C A 15: 75,765,281 (GRCm39) V148L possibly damaging Het
Nckap1l C T 15: 103,382,277 (GRCm39) R491C probably damaging Het
Nr1i2 A G 16: 38,071,573 (GRCm39) M321T possibly damaging Het
Nup107 A T 10: 117,610,383 (GRCm39) I355N possibly damaging Het
Or10j2 G A 1: 173,098,183 (GRCm39) G147D possibly damaging Het
Or10x4 A T 1: 174,218,898 (GRCm39) N88Y probably benign Het
Or1e28-ps1 A G 11: 73,615,658 (GRCm39) I64T probably benign Het
Or1l4b T G 2: 37,036,518 (GRCm39) M98R probably damaging Het
Or4a80 T G 2: 89,582,636 (GRCm39) I179L probably benign Het
Or4k35 T G 2: 111,100,287 (GRCm39) I142L probably benign Het
Pccb T C 9: 100,876,634 (GRCm39) D320G possibly damaging Het
Pcdhgb6 A T 18: 37,875,561 (GRCm39) I90L probably benign Het
Pik3r2 A G 8: 71,221,459 (GRCm39) S682P probably damaging Het
Pkd1l3 GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA 8: 110,350,827 (GRCm39) probably benign Het
Plagl1 A G 10: 13,004,466 (GRCm39) Q578R unknown Het
Ppp1r42 A G 1: 10,073,563 (GRCm39) I9T probably benign Het
Ptcd3 A T 6: 71,871,275 (GRCm39) I315K possibly damaging Het
Rnf217 A G 10: 31,484,402 (GRCm39) L260P probably damaging Het
Selp A T 1: 163,968,975 (GRCm39) H525L possibly damaging Het
Sh3rf2 T A 18: 42,244,347 (GRCm39) M303K probably benign Het
Shprh A T 10: 11,082,076 (GRCm39) I1549F probably damaging Het
Slc38a7 G T 8: 96,570,772 (GRCm39) A244D probably benign Het
Stxbp6 G T 12: 44,949,740 (GRCm39) T63K probably damaging Het
Syne3 A G 12: 104,898,468 (GRCm39) S962P probably damaging Het
Syt10 T C 15: 89,711,135 (GRCm39) I133V probably damaging Het
Tcaf3 A T 6: 42,566,636 (GRCm39) W818R probably damaging Het
Tekt2 C T 4: 126,217,444 (GRCm39) R207H probably damaging Het
Tmem70 A C 1: 16,735,659 (GRCm39) E43A probably benign Het
Trim72 C A 7: 127,609,092 (GRCm39) A298E probably damaging Het
Washc5 C T 15: 59,218,062 (GRCm39) probably null Het
Zfp707 C A 15: 75,847,085 (GRCm39) F378L possibly damaging Het
Zfp839 G A 12: 110,822,280 (GRCm39) A365T probably damaging Het
Other mutations in Tars1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00551:Tars1 APN 15 11,388,307 (GRCm39) splice site probably null
IGL00642:Tars1 APN 15 11,394,458 (GRCm39) missense probably damaging 1.00
IGL01315:Tars1 APN 15 11,389,820 (GRCm39) nonsense probably null
IGL01459:Tars1 APN 15 11,391,940 (GRCm39) missense possibly damaging 0.76
IGL02141:Tars1 APN 15 11,391,280 (GRCm39) missense probably damaging 0.96
IGL03292:Tars1 APN 15 11,384,107 (GRCm39) missense probably benign 0.22
R0383:Tars1 UTSW 15 11,390,411 (GRCm39) missense probably benign
R0517:Tars1 UTSW 15 11,394,452 (GRCm39) nonsense probably null
R0685:Tars1 UTSW 15 11,385,259 (GRCm39) missense probably benign
R1589:Tars1 UTSW 15 11,388,261 (GRCm39) missense probably benign 0.32
R1753:Tars1 UTSW 15 11,394,329 (GRCm39) nonsense probably null
R2051:Tars1 UTSW 15 11,393,280 (GRCm39) nonsense probably null
R2060:Tars1 UTSW 15 11,394,459 (GRCm39) missense probably benign 0.03
R2216:Tars1 UTSW 15 11,389,794 (GRCm39) missense probably benign 0.00
R3610:Tars1 UTSW 15 11,392,990 (GRCm39) missense probably damaging 0.99
R4656:Tars1 UTSW 15 11,394,350 (GRCm39) missense probably damaging 1.00
R4844:Tars1 UTSW 15 11,385,281 (GRCm39) missense possibly damaging 0.85
R4974:Tars1 UTSW 15 11,390,477 (GRCm39) missense probably damaging 1.00
R5551:Tars1 UTSW 15 11,392,068 (GRCm39) missense probably damaging 0.97
R5992:Tars1 UTSW 15 11,397,282 (GRCm39) missense probably damaging 1.00
R6742:Tars1 UTSW 15 11,394,427 (GRCm39) missense probably damaging 0.98
R6778:Tars1 UTSW 15 11,389,785 (GRCm39) missense probably benign 0.06
R6850:Tars1 UTSW 15 11,392,885 (GRCm39) missense probably benign
R7270:Tars1 UTSW 15 11,392,105 (GRCm39) missense probably benign 0.00
R7401:Tars1 UTSW 15 11,392,095 (GRCm39) nonsense probably null
R7743:Tars1 UTSW 15 11,399,458 (GRCm39) splice site probably null
R8062:Tars1 UTSW 15 11,388,400 (GRCm39) missense possibly damaging 0.78
R8852:Tars1 UTSW 15 11,393,348 (GRCm39) missense probably benign 0.02
R8942:Tars1 UTSW 15 11,384,183 (GRCm39) missense probably benign 0.27
R9205:Tars1 UTSW 15 11,397,265 (GRCm39) critical splice donor site probably null
R9362:Tars1 UTSW 15 11,387,616 (GRCm39) missense probably damaging 1.00
Z1088:Tars1 UTSW 15 11,391,970 (GRCm39) missense probably benign 0.24
Predicted Primers PCR Primer
(F):5'- AATACTATCAGGATGTGCTGGC -3'
(R):5'- ATGCCAGTGACCATTGTGATC -3'

Sequencing Primer
(F):5'- ATACTATCAGGATGTGCTGGCATGAC -3'
(R):5'- GACCATTGTGATCTGTGAAGCAATC -3'
Posted On 2022-10-06