Incidental Mutation 'R9672:Oxgr1'
ID 728117
Institutional Source Beutler Lab
Gene Symbol Oxgr1
Ensembl Gene ENSMUSG00000044819
Gene Name oxoglutarate (alpha-ketoglutarate) receptor 1
Synonyms P2Y15, Cysltr3, LOC239283, Gpr99, Gpr80
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9672 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 120256997-120279847 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 120259454 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 251 (Y251F)
Ref Sequence ENSEMBL: ENSMUSP00000055137 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058213]
AlphaFold Q6IYF8
Predicted Effect probably damaging
Transcript: ENSMUST00000058213
AA Change: Y251F

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000055137
Gene: ENSMUSG00000044819
AA Change: Y251F

DomainStartEndE-ValueType
Pfam:7tm_1 50 302 3.8e-35 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-coupled receptor (GPCR) that belongs to the oxoglutarate receptor family within the GPCR superfamily. The encoded protein is activated by the citric acid intermediate, oxoglutarate, as well as several cysteinyl leukotrienes, including leukotrienes E4, C4 and D4, which are implicated in many inflammatory disorders. In mice, a knock-out of this gene leads to middle ear inflammation, changes in the mucosal epithelium, and an increase in fluid behind the eardrum, and is associated with hearing loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced leukotriene E4 ligand (LTE4)-induced ear edema at low and intermediate doses and abnormal acid-base balance. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 G T 10: 79,838,563 (GRCm39) K612N probably null Het
Atrnl1 G A 19: 57,618,695 (GRCm39) A138T possibly damaging Het
Bicc1 T C 10: 70,794,666 (GRCm39) T164A probably damaging Het
Bnip3l G A 14: 67,246,214 (GRCm39) P7L possibly damaging Het
Ccdc7a A G 8: 129,671,016 (GRCm39) S497P unknown Het
Cd209d C G 8: 3,922,036 (GRCm39) G212A probably damaging Het
Cog8 A G 8: 107,780,658 (GRCm39) I200T probably damaging Het
Cuzd1 T A 7: 130,919,847 (GRCm39) I90F possibly damaging Het
Cyp4a30b T A 4: 115,316,576 (GRCm39) C401S probably benign Het
Cyp4a31 T A 4: 115,427,422 (GRCm39) N209K probably benign Het
D6Ertd527e G C 6: 87,088,839 (GRCm39) S334T unknown Het
Dcaf11 T A 14: 55,806,484 (GRCm39) Y468* probably null Het
Dennd4a A G 9: 64,800,640 (GRCm39) D926G probably benign Het
Dph7 T C 2: 24,855,606 (GRCm39) L135P probably benign Het
Fcho2 A T 13: 98,869,178 (GRCm39) C564* probably null Het
Gabrb2 G A 11: 42,312,207 (GRCm39) G11R probably benign Het
Gas6 A G 8: 13,528,273 (GRCm39) S187P probably benign Het
Gemin5 C T 11: 58,058,585 (GRCm39) V93I probably benign Het
Gldn A T 9: 54,245,780 (GRCm39) I444F probably damaging Het
Gmps T C 3: 63,897,750 (GRCm39) V234A probably damaging Het
Hand1 A G 11: 57,722,516 (GRCm39) S33P possibly damaging Het
Ice2 G A 9: 69,322,899 (GRCm39) A465T probably benign Het
Irf9 T C 14: 55,842,129 (GRCm39) S2P probably benign Het
Kpna7 C T 5: 144,944,776 (GRCm39) M21I probably benign Het
Lig4 A G 8: 10,023,213 (GRCm39) M189T probably damaging Het
Lrp1b T C 2: 40,779,291 (GRCm39) T2698A Het
Med10 A G 13: 69,963,711 (GRCm39) K104R probably benign Het
Mfsd14b A G 13: 65,260,320 (GRCm39) W38R probably benign Het
Mrgpra2a A G 7: 47,076,490 (GRCm39) F256S probably benign Het
Myo9a A G 9: 59,687,332 (GRCm39) K146E probably benign Het
Pabpc4 T C 4: 123,184,133 (GRCm39) probably null Het
Pde8a A G 7: 80,942,014 (GRCm39) N151S probably damaging Het
Pdilt A G 7: 119,100,824 (GRCm39) F176L possibly damaging Het
Plekhg5 C A 4: 152,187,541 (GRCm39) D115E probably benign Het
Plxnd1 C T 6: 115,940,274 (GRCm39) R1370Q possibly damaging Het
Ppp1r9a T C 6: 5,007,889 (GRCm39) C532R unknown Het
Rasa2 A G 9: 96,427,781 (GRCm39) W695R probably damaging Het
Rbpms2 A G 9: 65,538,118 (GRCm39) N3S probably benign Het
Rsph6a A G 7: 18,799,842 (GRCm39) Y491C probably damaging Het
Scel T A 14: 103,836,838 (GRCm39) N495K possibly damaging Het
Setd1a T C 7: 127,385,237 (GRCm39) L648P possibly damaging Het
Snx29 A T 16: 11,478,515 (GRCm39) R333S probably benign Het
Sppl2c A G 11: 104,077,344 (GRCm39) Y48C probably damaging Het
Uba2 A T 7: 33,856,749 (GRCm39) N230K probably benign Het
Utrn T C 10: 12,603,613 (GRCm39) Q589R possibly damaging Het
Vmn1r51 T A 6: 90,106,549 (GRCm39) L155H probably damaging Het
Vmn2r97 A G 17: 19,149,442 (GRCm39) N277D probably benign Het
Wdr97 T A 15: 76,240,377 (GRCm39) V355E Het
Yy1 C A 12: 108,759,584 (GRCm39) H82Q unknown Het
Other mutations in Oxgr1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02167:Oxgr1 APN 14 120,259,342 (GRCm39) missense probably damaging 0.97
IGL02678:Oxgr1 APN 14 120,259,580 (GRCm39) missense probably damaging 1.00
IGL03387:Oxgr1 APN 14 120,260,199 (GRCm39) nonsense probably null
IGL03394:Oxgr1 APN 14 120,260,022 (GRCm39) missense possibly damaging 0.65
R1615:Oxgr1 UTSW 14 120,260,185 (GRCm39) missense probably benign 0.25
R2919:Oxgr1 UTSW 14 120,260,221 (GRCm39) start gained probably benign
R4223:Oxgr1 UTSW 14 120,260,025 (GRCm39) missense probably damaging 1.00
R4409:Oxgr1 UTSW 14 120,259,572 (GRCm39) missense possibly damaging 0.67
R4783:Oxgr1 UTSW 14 120,259,776 (GRCm39) missense probably benign
R5213:Oxgr1 UTSW 14 120,259,552 (GRCm39) nonsense probably null
R5226:Oxgr1 UTSW 14 120,259,665 (GRCm39) missense probably damaging 1.00
R6416:Oxgr1 UTSW 14 120,259,860 (GRCm39) missense probably damaging 0.99
R6491:Oxgr1 UTSW 14 120,259,419 (GRCm39) missense probably benign 0.01
R6670:Oxgr1 UTSW 14 120,259,669 (GRCm39) missense probably damaging 1.00
R6904:Oxgr1 UTSW 14 120,259,431 (GRCm39) missense possibly damaging 0.90
R7089:Oxgr1 UTSW 14 120,259,614 (GRCm39) missense probably damaging 1.00
R7819:Oxgr1 UTSW 14 120,260,281 (GRCm39) critical splice acceptor site probably null
R9731:Oxgr1 UTSW 14 120,260,094 (GRCm39) missense probably benign 0.00
R9803:Oxgr1 UTSW 14 120,259,563 (GRCm39) missense possibly damaging 0.91
Predicted Primers PCR Primer
(F):5'- TGCTGGAAGTTATTGCTGACCAC -3'
(R):5'- CCAATAGGTCTGCTTGCCTTG -3'

Sequencing Primer
(F):5'- TGACCACAACATATAACAGCAGGTTG -3'
(R):5'- GATGACCTCACTACTATCAAGTGG -3'
Posted On 2022-10-06