Incidental Mutation 'R9673:Vmn2r77'
| ID |
728154 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r77
|
| Ensembl Gene |
ENSMUSG00000090949 |
| Gene Name |
vomeronasal 2, receptor 77 |
| Synonyms |
EG546983 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.079)
|
| Stock # |
R9673 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
86444349-86461240 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 86450171 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 139
(V139A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129540
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164996]
|
| AlphaFold |
L7N2B7 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000164996
AA Change: V139A
PolyPhen 2
Score 0.753 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000129540
Gene: ENSMUSG00000090949
AA Change: V139A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
78 |
467 |
1.4e-30 |
PFAM |
|
Pfam:NCD3G
|
510 |
562 |
1e-20 |
PFAM |
|
Pfam:7tm_3
|
594 |
830 |
2.6e-52 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930568D16Rik |
T |
C |
2: 35,244,399 (GRCm39) |
K318E |
probably benign |
Het |
| Ap5z1 |
T |
C |
5: 142,463,113 (GRCm39) |
F766L |
probably benign |
Het |
| Atrnl1 |
A |
G |
19: 57,599,786 (GRCm39) |
M1V |
probably null |
Het |
| Atxn1 |
T |
C |
13: 45,710,622 (GRCm39) |
E770G |
probably benign |
Het |
| Brwd1 |
T |
G |
16: 95,813,096 (GRCm39) |
I1471L |
probably benign |
Het |
| Bud23 |
T |
C |
5: 135,082,571 (GRCm39) |
E66G |
probably benign |
Het |
| Cdh8 |
T |
A |
8: 99,757,367 (GRCm39) |
I744L |
possibly damaging |
Het |
| Celsr1 |
G |
T |
15: 85,917,286 (GRCm39) |
S229* |
probably null |
Het |
| Cep95 |
C |
A |
11: 106,703,322 (GRCm39) |
H467Q |
probably benign |
Het |
| Chd1 |
A |
G |
17: 15,989,023 (GRCm39) |
Y1592C |
probably benign |
Het |
| Chkb |
C |
G |
15: 89,313,628 (GRCm39) |
G59A |
probably damaging |
Het |
| Copa |
A |
G |
1: 171,945,648 (GRCm39) |
S915G |
probably benign |
Het |
| Creb3 |
G |
T |
4: 43,563,191 (GRCm39) |
V97F |
probably damaging |
Het |
| Csmd2 |
T |
A |
4: 128,308,062 (GRCm39) |
H1273Q |
|
Het |
| Cxcr1 |
T |
C |
1: 74,231,074 (GRCm39) |
N316S |
probably benign |
Het |
| Cyct |
A |
T |
2: 76,184,523 (GRCm39) |
I76N |
probably damaging |
Het |
| Dmxl2 |
G |
T |
9: 54,294,840 (GRCm39) |
R2412S |
probably damaging |
Het |
| Dnah11 |
A |
G |
12: 117,982,513 (GRCm39) |
M2552T |
possibly damaging |
Het |
| Dnph1 |
G |
A |
17: 46,809,901 (GRCm39) |
E148K |
possibly damaging |
Het |
| Ecpas |
T |
C |
4: 58,822,060 (GRCm39) |
N1169S |
probably benign |
Het |
| Esp16 |
T |
A |
17: 39,848,731 (GRCm39) |
Y8* |
probably null |
Het |
| Fam186a |
T |
C |
15: 99,841,024 (GRCm39) |
D1740G |
possibly damaging |
Het |
| Fam76a |
C |
A |
4: 132,628,557 (GRCm39) |
K300N |
probably damaging |
Het |
| Fcgbpl1 |
A |
G |
7: 27,856,044 (GRCm39) |
T1944A |
probably benign |
Het |
| Frrs1l |
A |
C |
4: 56,990,191 (GRCm39) |
D27E |
|
Het |
| G6pc1 |
T |
C |
11: 101,267,380 (GRCm39) |
S277P |
probably damaging |
Het |
| Gabrg3 |
T |
A |
7: 56,973,422 (GRCm39) |
I82F |
probably damaging |
Het |
| Gm3604 |
G |
T |
13: 62,517,969 (GRCm39) |
Q130K |
probably benign |
Het |
| Hhip |
T |
A |
8: 80,719,108 (GRCm39) |
D473V |
probably damaging |
Het |
| Ifi209 |
T |
C |
1: 173,470,332 (GRCm39) |
S307P |
probably damaging |
Het |
| Ino80c |
C |
T |
18: 24,254,856 (GRCm39) |
M1I |
probably null |
Het |
| Jag2 |
G |
T |
12: 112,875,416 (GRCm39) |
C872* |
probably null |
Het |
| Kcnma1 |
A |
C |
14: 23,558,123 (GRCm39) |
H474Q |
probably benign |
Het |
| Krr1 |
G |
A |
10: 111,818,963 (GRCm39) |
|
probably null |
Het |
| Lats1 |
T |
G |
10: 7,588,387 (GRCm39) |
D1001E |
probably benign |
Het |
| Lilrb4b |
T |
C |
10: 51,357,753 (GRCm39) |
L149P |
probably benign |
Het |
| Lrrk2 |
T |
A |
15: 91,649,884 (GRCm39) |
S1674T |
probably damaging |
Het |
| Magi2 |
A |
G |
5: 20,670,582 (GRCm39) |
I309V |
possibly damaging |
Het |
| Mtmr4 |
T |
C |
11: 87,504,916 (GRCm39) |
V1137A |
probably damaging |
Het |
| Mtmr4 |
A |
G |
11: 87,503,138 (GRCm39) |
D1064G |
probably damaging |
Het |
| Neb |
C |
T |
2: 52,133,853 (GRCm39) |
|
probably null |
Het |
| Nhsl1 |
T |
A |
10: 18,402,665 (GRCm39) |
V1297E |
possibly damaging |
Het |
| Nlrp3 |
T |
A |
11: 59,440,148 (GRCm39) |
V575D |
probably damaging |
Het |
| Nptx2 |
T |
C |
5: 144,492,159 (GRCm39) |
I312T |
possibly damaging |
Het |
| Osm |
A |
G |
11: 4,189,926 (GRCm39) |
T237A |
probably benign |
Het |
| Pcdha12 |
T |
C |
18: 37,155,234 (GRCm39) |
V651A |
possibly damaging |
Het |
| Pclo |
A |
G |
5: 14,908,758 (GRCm39) |
|
probably null |
Het |
| Pdlim3 |
C |
T |
8: 46,368,195 (GRCm39) |
S183L |
possibly damaging |
Het |
| Peg10 |
GC |
GCTCC |
6: 4,756,452 (GRCm39) |
|
probably benign |
Het |
| Pgm2 |
T |
A |
5: 64,273,671 (GRCm39) |
M552K |
probably damaging |
Het |
| Pkhd1l1 |
T |
C |
15: 44,386,901 (GRCm39) |
L1258S |
probably benign |
Het |
| Proser3 |
T |
G |
7: 30,248,530 (GRCm39) |
T55P |
probably damaging |
Het |
| Ranbp2 |
C |
A |
10: 58,300,963 (GRCm39) |
P611Q |
probably damaging |
Het |
| Rangap1 |
T |
C |
15: 81,590,637 (GRCm39) |
D485G |
probably benign |
Het |
| Rp1 |
G |
A |
1: 4,337,792 (GRCm39) |
T421I |
unknown |
Het |
| Ryr3 |
G |
A |
2: 112,486,883 (GRCm39) |
L3862F |
possibly damaging |
Het |
| Sbf1 |
C |
T |
15: 89,179,675 (GRCm39) |
G1337R |
possibly damaging |
Het |
| Setd2 |
A |
G |
9: 110,378,138 (GRCm39) |
E651G |
probably damaging |
Het |
| Shmt1 |
A |
G |
11: 60,692,769 (GRCm39) |
W105R |
probably damaging |
Het |
| Skor2 |
C |
T |
18: 76,946,376 (GRCm39) |
H33Y |
unknown |
Het |
| Slc22a29 |
T |
C |
19: 8,140,104 (GRCm39) |
I434V |
probably benign |
Het |
| Sord |
C |
T |
2: 122,090,712 (GRCm39) |
T221I |
probably benign |
Het |
| Speer1g |
T |
A |
5: 11,178,990 (GRCm39) |
N55K |
probably benign |
Het |
| Tbcd |
T |
C |
11: 121,464,647 (GRCm39) |
Y561H |
probably damaging |
Het |
| Tcaf1 |
G |
A |
6: 42,663,808 (GRCm39) |
S24F |
probably benign |
Het |
| Tenm4 |
A |
T |
7: 96,517,196 (GRCm39) |
D1429V |
probably damaging |
Het |
| Tesk1 |
A |
G |
4: 43,444,574 (GRCm39) |
Y126C |
probably damaging |
Het |
| Tmem176a |
G |
A |
6: 48,820,952 (GRCm39) |
V141I |
probably benign |
Het |
| Tmem204 |
A |
T |
17: 25,299,243 (GRCm39) |
V92D |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,572,605 (GRCm39) |
D26096V |
probably damaging |
Het |
| Vmn1r70 |
T |
A |
7: 10,368,364 (GRCm39) |
L284Q |
probably damaging |
Het |
| Wdpcp |
A |
G |
11: 21,671,285 (GRCm39) |
R509G |
possibly damaging |
Het |
| Wee1 |
C |
T |
7: 109,725,210 (GRCm39) |
T284I |
probably damaging |
Het |
| Wfs1 |
A |
G |
5: 37,125,113 (GRCm39) |
S593P |
probably damaging |
Het |
| Zbtb11 |
A |
G |
16: 55,827,336 (GRCm39) |
H934R |
probably damaging |
Het |
| Zfp277 |
A |
T |
12: 40,370,611 (GRCm39) |
V446E |
probably benign |
Het |
| Zfp874a |
C |
A |
13: 67,591,156 (GRCm39) |
R176L |
probably benign |
Het |
| Znrf2 |
A |
T |
6: 54,840,978 (GRCm39) |
N184I |
probably damaging |
Het |
| Zp2 |
T |
A |
7: 119,733,238 (GRCm39) |
T568S |
probably damaging |
Het |
|
| Other mutations in Vmn2r77 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00954:Vmn2r77
|
APN |
7 |
86,449,975 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01105:Vmn2r77
|
APN |
7 |
86,460,872 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01367:Vmn2r77
|
APN |
7 |
86,461,124 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01634:Vmn2r77
|
APN |
7 |
86,460,857 (GRCm39) |
missense |
probably benign |
|
|
IGL01805:Vmn2r77
|
APN |
7 |
86,460,395 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01868:Vmn2r77
|
APN |
7 |
86,452,224 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01980:Vmn2r77
|
APN |
7 |
86,450,678 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL02055:Vmn2r77
|
APN |
7 |
86,450,763 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02066:Vmn2r77
|
APN |
7 |
86,452,836 (GRCm39) |
nonsense |
probably null |
|
|
IGL02185:Vmn2r77
|
APN |
7 |
86,444,360 (GRCm39) |
missense |
unknown |
|
|
IGL02200:Vmn2r77
|
APN |
7 |
86,451,187 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02336:Vmn2r77
|
APN |
7 |
86,451,224 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02445:Vmn2r77
|
APN |
7 |
86,452,848 (GRCm39) |
nonsense |
probably null |
|
|
IGL02557:Vmn2r77
|
APN |
7 |
86,444,342 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02659:Vmn2r77
|
APN |
7 |
86,449,979 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL02978:Vmn2r77
|
APN |
7 |
86,460,555 (GRCm39) |
missense |
probably benign |
|
|
IGL03180:Vmn2r77
|
APN |
7 |
86,450,843 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL03255:Vmn2r77
|
APN |
7 |
86,461,131 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL03273:Vmn2r77
|
APN |
7 |
86,460,494 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0046:Vmn2r77
|
UTSW |
7 |
86,451,146 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0047:Vmn2r77
|
UTSW |
7 |
86,460,858 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0066:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0066:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0389:Vmn2r77
|
UTSW |
7 |
86,450,702 (GRCm39) |
missense |
probably benign |
0.29 |
|
R0635:Vmn2r77
|
UTSW |
7 |
86,460,383 (GRCm39) |
missense |
probably benign |
|
|
R0689:Vmn2r77
|
UTSW |
7 |
86,460,872 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0827:Vmn2r77
|
UTSW |
7 |
86,451,224 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1167:Vmn2r77
|
UTSW |
7 |
86,450,954 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1228:Vmn2r77
|
UTSW |
7 |
86,450,242 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1353:Vmn2r77
|
UTSW |
7 |
86,451,394 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1392:Vmn2r77
|
UTSW |
7 |
86,450,830 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1392:Vmn2r77
|
UTSW |
7 |
86,450,830 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1613:Vmn2r77
|
UTSW |
7 |
86,460,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1654:Vmn2r77
|
UTSW |
7 |
86,461,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1742:Vmn2r77
|
UTSW |
7 |
86,444,543 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1827:Vmn2r77
|
UTSW |
7 |
86,450,821 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1911:Vmn2r77
|
UTSW |
7 |
86,461,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1974:Vmn2r77
|
UTSW |
7 |
86,449,964 (GRCm39) |
missense |
probably benign |
0.17 |
|
R2008:Vmn2r77
|
UTSW |
7 |
86,450,921 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2093:Vmn2r77
|
UTSW |
7 |
86,450,702 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2143:Vmn2r77
|
UTSW |
7 |
86,461,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2269:Vmn2r77
|
UTSW |
7 |
86,460,897 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2972:Vmn2r77
|
UTSW |
7 |
86,452,893 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2974:Vmn2r77
|
UTSW |
7 |
86,452,893 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3037:Vmn2r77
|
UTSW |
7 |
86,450,191 (GRCm39) |
missense |
probably benign |
|
|
R3694:Vmn2r77
|
UTSW |
7 |
86,450,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3695:Vmn2r77
|
UTSW |
7 |
86,450,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3805:Vmn2r77
|
UTSW |
7 |
86,444,368 (GRCm39) |
nonsense |
probably null |
|
|
R3870:Vmn2r77
|
UTSW |
7 |
86,461,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4732:Vmn2r77
|
UTSW |
7 |
86,450,195 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4733:Vmn2r77
|
UTSW |
7 |
86,450,195 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5009:Vmn2r77
|
UTSW |
7 |
86,451,015 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5201:Vmn2r77
|
UTSW |
7 |
86,460,846 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5218:Vmn2r77
|
UTSW |
7 |
86,451,341 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5469:Vmn2r77
|
UTSW |
7 |
86,451,271 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5673:Vmn2r77
|
UTSW |
7 |
86,461,214 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5771:Vmn2r77
|
UTSW |
7 |
86,461,235 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5832:Vmn2r77
|
UTSW |
7 |
86,460,670 (GRCm39) |
nonsense |
probably null |
|
|
R5899:Vmn2r77
|
UTSW |
7 |
86,460,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6151:Vmn2r77
|
UTSW |
7 |
86,450,878 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6182:Vmn2r77
|
UTSW |
7 |
86,460,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6326:Vmn2r77
|
UTSW |
7 |
86,451,031 (GRCm39) |
missense |
probably benign |
|
|
R6419:Vmn2r77
|
UTSW |
7 |
86,460,767 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6549:Vmn2r77
|
UTSW |
7 |
86,450,065 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6874:Vmn2r77
|
UTSW |
7 |
86,451,286 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6972:Vmn2r77
|
UTSW |
7 |
86,452,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7056:Vmn2r77
|
UTSW |
7 |
86,451,023 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7185:Vmn2r77
|
UTSW |
7 |
86,451,035 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7261:Vmn2r77
|
UTSW |
7 |
86,460,518 (GRCm39) |
nonsense |
probably null |
|
|
R7298:Vmn2r77
|
UTSW |
7 |
86,449,979 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7662:Vmn2r77
|
UTSW |
7 |
86,460,492 (GRCm39) |
nonsense |
probably null |
|
|
R8182:Vmn2r77
|
UTSW |
7 |
86,460,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8327:Vmn2r77
|
UTSW |
7 |
86,450,680 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8387:Vmn2r77
|
UTSW |
7 |
86,450,947 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8825:Vmn2r77
|
UTSW |
7 |
86,452,855 (GRCm39) |
missense |
probably benign |
|
|
R8898:Vmn2r77
|
UTSW |
7 |
86,444,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8973:Vmn2r77
|
UTSW |
7 |
86,452,150 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9258:Vmn2r77
|
UTSW |
7 |
86,452,302 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9338:Vmn2r77
|
UTSW |
7 |
86,460,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9358:Vmn2r77
|
UTSW |
7 |
86,452,236 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9377:Vmn2r77
|
UTSW |
7 |
86,444,442 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9404:Vmn2r77
|
UTSW |
7 |
86,451,247 (GRCm39) |
missense |
probably benign |
|
|
R9679:Vmn2r77
|
UTSW |
7 |
86,460,741 (GRCm39) |
missense |
probably benign |
0.07 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACCCGTATCCTCCATGATTGG -3'
(R):5'- CTGTCATAAAGATGTTGTGTTTGCC -3'
Sequencing Primer
(F):5'- GCTCTCTTTTCAGAGTTACACTTAAG -3'
(R):5'- GATGTTGTGTTTGCCAAAGAAAG -3'
|
| Posted On |
2022-10-06 |
Incidental Mutation