Incidental Mutation 'R9673:Cep95'
ID 728175
Institutional Source Beutler Lab
Gene Symbol Cep95
Ensembl Gene ENSMUSG00000018372
Gene Name centrosomal protein 95
Synonyms 4732496G21Rik, Ccdc45, F630025I20Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.170) question?
Stock # R9673 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 106679466-106709687 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 106703322 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 467 (H467Q)
Ref Sequence ENSEMBL: ENSMUSP00000018516 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000018516] [ENSMUST00000103068]
AlphaFold Q8BVV7
Predicted Effect probably benign
Transcript: ENSMUST00000018516
AA Change: H467Q

PolyPhen 2 Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000018516
Gene: ENSMUSG00000018372
AA Change: H467Q

DomainStartEndE-ValueType
low complexity region 389 407 N/A INTRINSIC
coiled coil region 584 633 N/A INTRINSIC
coiled coil region 701 793 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000103068
AA Change: H424Q

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000099357
Gene: ENSMUSG00000018372
AA Change: H424Q

DomainStartEndE-ValueType
low complexity region 346 364 N/A INTRINSIC
coiled coil region 541 590 N/A INTRINSIC
coiled coil region 658 750 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930568D16Rik T C 2: 35,244,399 (GRCm39) K318E probably benign Het
Ap5z1 T C 5: 142,463,113 (GRCm39) F766L probably benign Het
Atrnl1 A G 19: 57,599,786 (GRCm39) M1V probably null Het
Atxn1 T C 13: 45,710,622 (GRCm39) E770G probably benign Het
Brwd1 T G 16: 95,813,096 (GRCm39) I1471L probably benign Het
Bud23 T C 5: 135,082,571 (GRCm39) E66G probably benign Het
Cdh8 T A 8: 99,757,367 (GRCm39) I744L possibly damaging Het
Celsr1 G T 15: 85,917,286 (GRCm39) S229* probably null Het
Chd1 A G 17: 15,989,023 (GRCm39) Y1592C probably benign Het
Chkb C G 15: 89,313,628 (GRCm39) G59A probably damaging Het
Copa A G 1: 171,945,648 (GRCm39) S915G probably benign Het
Creb3 G T 4: 43,563,191 (GRCm39) V97F probably damaging Het
Csmd2 T A 4: 128,308,062 (GRCm39) H1273Q Het
Cxcr1 T C 1: 74,231,074 (GRCm39) N316S probably benign Het
Cyct A T 2: 76,184,523 (GRCm39) I76N probably damaging Het
Dmxl2 G T 9: 54,294,840 (GRCm39) R2412S probably damaging Het
Dnah11 A G 12: 117,982,513 (GRCm39) M2552T possibly damaging Het
Dnph1 G A 17: 46,809,901 (GRCm39) E148K possibly damaging Het
Ecpas T C 4: 58,822,060 (GRCm39) N1169S probably benign Het
Esp16 T A 17: 39,848,731 (GRCm39) Y8* probably null Het
Fam186a T C 15: 99,841,024 (GRCm39) D1740G possibly damaging Het
Fam76a C A 4: 132,628,557 (GRCm39) K300N probably damaging Het
Fcgbpl1 A G 7: 27,856,044 (GRCm39) T1944A probably benign Het
Frrs1l A C 4: 56,990,191 (GRCm39) D27E Het
G6pc1 T C 11: 101,267,380 (GRCm39) S277P probably damaging Het
Gabrg3 T A 7: 56,973,422 (GRCm39) I82F probably damaging Het
Gm3604 G T 13: 62,517,969 (GRCm39) Q130K probably benign Het
Hhip T A 8: 80,719,108 (GRCm39) D473V probably damaging Het
Ifi209 T C 1: 173,470,332 (GRCm39) S307P probably damaging Het
Ino80c C T 18: 24,254,856 (GRCm39) M1I probably null Het
Jag2 G T 12: 112,875,416 (GRCm39) C872* probably null Het
Kcnma1 A C 14: 23,558,123 (GRCm39) H474Q probably benign Het
Krr1 G A 10: 111,818,963 (GRCm39) probably null Het
Lats1 T G 10: 7,588,387 (GRCm39) D1001E probably benign Het
Lilrb4b T C 10: 51,357,753 (GRCm39) L149P probably benign Het
Lrrk2 T A 15: 91,649,884 (GRCm39) S1674T probably damaging Het
Magi2 A G 5: 20,670,582 (GRCm39) I309V possibly damaging Het
Mtmr4 A G 11: 87,503,138 (GRCm39) D1064G probably damaging Het
Mtmr4 T C 11: 87,504,916 (GRCm39) V1137A probably damaging Het
Neb C T 2: 52,133,853 (GRCm39) probably null Het
Nhsl1 T A 10: 18,402,665 (GRCm39) V1297E possibly damaging Het
Nlrp3 T A 11: 59,440,148 (GRCm39) V575D probably damaging Het
Nptx2 T C 5: 144,492,159 (GRCm39) I312T possibly damaging Het
Osm A G 11: 4,189,926 (GRCm39) T237A probably benign Het
Pcdha12 T C 18: 37,155,234 (GRCm39) V651A possibly damaging Het
Pclo A G 5: 14,908,758 (GRCm39) probably null Het
Pdlim3 C T 8: 46,368,195 (GRCm39) S183L possibly damaging Het
Peg10 GC GCTCC 6: 4,756,452 (GRCm39) probably benign Het
Pgm2 T A 5: 64,273,671 (GRCm39) M552K probably damaging Het
Pkhd1l1 T C 15: 44,386,901 (GRCm39) L1258S probably benign Het
Proser3 T G 7: 30,248,530 (GRCm39) T55P probably damaging Het
Ranbp2 C A 10: 58,300,963 (GRCm39) P611Q probably damaging Het
Rangap1 T C 15: 81,590,637 (GRCm39) D485G probably benign Het
Rp1 G A 1: 4,337,792 (GRCm39) T421I unknown Het
Ryr3 G A 2: 112,486,883 (GRCm39) L3862F possibly damaging Het
Sbf1 C T 15: 89,179,675 (GRCm39) G1337R possibly damaging Het
Setd2 A G 9: 110,378,138 (GRCm39) E651G probably damaging Het
Shmt1 A G 11: 60,692,769 (GRCm39) W105R probably damaging Het
Skor2 C T 18: 76,946,376 (GRCm39) H33Y unknown Het
Slc22a29 T C 19: 8,140,104 (GRCm39) I434V probably benign Het
Sord C T 2: 122,090,712 (GRCm39) T221I probably benign Het
Speer1g T A 5: 11,178,990 (GRCm39) N55K probably benign Het
Tbcd T C 11: 121,464,647 (GRCm39) Y561H probably damaging Het
Tcaf1 G A 6: 42,663,808 (GRCm39) S24F probably benign Het
Tenm4 A T 7: 96,517,196 (GRCm39) D1429V probably damaging Het
Tesk1 A G 4: 43,444,574 (GRCm39) Y126C probably damaging Het
Tmem176a G A 6: 48,820,952 (GRCm39) V141I probably benign Het
Tmem204 A T 17: 25,299,243 (GRCm39) V92D probably damaging Het
Ttn T A 2: 76,572,605 (GRCm39) D26096V probably damaging Het
Vmn1r70 T A 7: 10,368,364 (GRCm39) L284Q probably damaging Het
Vmn2r77 T C 7: 86,450,171 (GRCm39) V139A possibly damaging Het
Wdpcp A G 11: 21,671,285 (GRCm39) R509G possibly damaging Het
Wee1 C T 7: 109,725,210 (GRCm39) T284I probably damaging Het
Wfs1 A G 5: 37,125,113 (GRCm39) S593P probably damaging Het
Zbtb11 A G 16: 55,827,336 (GRCm39) H934R probably damaging Het
Zfp277 A T 12: 40,370,611 (GRCm39) V446E probably benign Het
Zfp874a C A 13: 67,591,156 (GRCm39) R176L probably benign Het
Znrf2 A T 6: 54,840,978 (GRCm39) N184I probably damaging Het
Zp2 T A 7: 119,733,238 (GRCm39) T568S probably damaging Het
Other mutations in Cep95
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00834:Cep95 APN 11 106,709,043 (GRCm39) missense probably damaging 0.98
IGL00988:Cep95 APN 11 106,697,220 (GRCm39) missense probably benign 0.00
IGL01306:Cep95 APN 11 106,704,641 (GRCm39) missense probably benign 0.00
IGL01995:Cep95 APN 11 106,697,197 (GRCm39) missense probably damaging 1.00
IGL02541:Cep95 APN 11 106,706,407 (GRCm39) missense probably damaging 0.99
ANU23:Cep95 UTSW 11 106,704,641 (GRCm39) missense probably benign 0.00
R0071:Cep95 UTSW 11 106,681,554 (GRCm39) unclassified probably benign
R0071:Cep95 UTSW 11 106,681,554 (GRCm39) unclassified probably benign
R0255:Cep95 UTSW 11 106,702,097 (GRCm39) missense probably benign 0.10
R0427:Cep95 UTSW 11 106,681,578 (GRCm39) missense probably benign 0.18
R0436:Cep95 UTSW 11 106,709,511 (GRCm39) missense probably null 0.98
R0583:Cep95 UTSW 11 106,705,449 (GRCm39) missense probably benign
R0831:Cep95 UTSW 11 106,705,530 (GRCm39) missense probably benign 0.00
R1459:Cep95 UTSW 11 106,708,781 (GRCm39) missense probably damaging 1.00
R1589:Cep95 UTSW 11 106,690,930 (GRCm39) missense probably benign 0.00
R1627:Cep95 UTSW 11 106,700,531 (GRCm39) missense probably damaging 1.00
R1768:Cep95 UTSW 11 106,697,177 (GRCm39) nonsense probably null
R1914:Cep95 UTSW 11 106,705,464 (GRCm39) missense probably damaging 1.00
R1915:Cep95 UTSW 11 106,705,464 (GRCm39) missense probably damaging 1.00
R1928:Cep95 UTSW 11 106,681,554 (GRCm39) unclassified probably benign
R2495:Cep95 UTSW 11 106,700,108 (GRCm39) missense possibly damaging 0.73
R3157:Cep95 UTSW 11 106,700,013 (GRCm39) splice site probably benign
R3158:Cep95 UTSW 11 106,700,013 (GRCm39) splice site probably benign
R3712:Cep95 UTSW 11 106,702,112 (GRCm39) nonsense probably null
R3881:Cep95 UTSW 11 106,697,118 (GRCm39) missense probably damaging 0.98
R4739:Cep95 UTSW 11 106,706,560 (GRCm39) missense probably benign 0.34
R4908:Cep95 UTSW 11 106,702,172 (GRCm39) missense probably damaging 1.00
R4989:Cep95 UTSW 11 106,707,480 (GRCm39) splice site probably null
R5913:Cep95 UTSW 11 106,709,335 (GRCm39) unclassified probably benign
R5925:Cep95 UTSW 11 106,703,227 (GRCm39) missense probably benign 0.00
R6291:Cep95 UTSW 11 106,706,422 (GRCm39) missense probably damaging 1.00
R6540:Cep95 UTSW 11 106,692,328 (GRCm39) missense probably damaging 0.97
R6924:Cep95 UTSW 11 106,702,023 (GRCm39) missense probably damaging 0.99
R6985:Cep95 UTSW 11 106,709,529 (GRCm39) missense probably damaging 0.99
R7156:Cep95 UTSW 11 106,700,050 (GRCm39) missense possibly damaging 0.84
R7940:Cep95 UTSW 11 106,686,974 (GRCm39) missense probably benign
R8348:Cep95 UTSW 11 106,704,593 (GRCm39) missense possibly damaging 0.81
R8509:Cep95 UTSW 11 106,695,876 (GRCm39) missense probably benign 0.08
R8849:Cep95 UTSW 11 106,707,630 (GRCm39) missense
R9284:Cep95 UTSW 11 106,704,624 (GRCm39) missense probably benign
R9532:Cep95 UTSW 11 106,687,042 (GRCm39) missense probably damaging 0.98
X0028:Cep95 UTSW 11 106,703,236 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ACTTAGCACAAGAGCTAGCC -3'
(R):5'- TCACGACCGTATCTCTAGTGAG -3'

Sequencing Primer
(F):5'- AAGAGCTAGCCACCCCC -3'
(R):5'- CAGTGGTGTGTTCACTGTA -3'
Posted On 2022-10-06