Incidental Mutation 'R9673:Atrnl1'
| ID |
728201 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Atrnl1
|
| Ensembl Gene |
ENSMUSG00000054843 |
| Gene Name |
attractin like 1 |
| Synonyms |
Alp |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.182)
|
| Stock # |
R9673 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
19 |
| Chromosomal Location |
57599466-58121775 bp(+) (GRCm39) |
| Type of Mutation |
start codon destroyed |
| DNA Base Change (assembly) |
A to G
at 57599786 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Valine
at position 1
(M1V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000076514
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000077282]
|
| AlphaFold |
Q6A051 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000077282
AA Change: M1V
PolyPhen 2
Score 0.037 (Sensitivity: 0.94; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000076514
Gene: ENSMUSG00000054843
AA Change: M1V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
25 |
32 |
N/A |
INTRINSIC |
|
EGF
|
61 |
90 |
5.71e-1 |
SMART |
|
CUB
|
92 |
208 |
1.43e-11 |
SMART |
|
EGF
|
209 |
244 |
1.95e1 |
SMART |
|
Pfam:EGF_2
|
248 |
279 |
5.8e-7 |
PFAM |
|
Pfam:Kelch_5
|
350 |
391 |
2.1e-9 |
PFAM |
|
Pfam:Kelch_6
|
354 |
401 |
5.8e-8 |
PFAM |
|
Pfam:Kelch_4
|
465 |
517 |
4.3e-7 |
PFAM |
|
Pfam:Kelch_1
|
519 |
573 |
2.7e-6 |
PFAM |
|
PSI
|
613 |
656 |
3.38e-1 |
SMART |
|
PSI
|
665 |
708 |
2e-3 |
SMART |
|
PSI
|
714 |
759 |
1.72e-2 |
SMART |
|
CLECT
|
747 |
872 |
2.86e-20 |
SMART |
|
PSI
|
888 |
938 |
6.26e-5 |
SMART |
|
PSI
|
941 |
1011 |
1.73e-7 |
SMART |
|
EGF_Lam
|
1013 |
1056 |
1.07e-5 |
SMART |
|
low complexity region
|
1157 |
1173 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1229 |
1251 |
N/A |
INTRINSIC |
|
low complexity region
|
1261 |
1272 |
N/A |
INTRINSIC |
|
low complexity region
|
1326 |
1339 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele exhibit normal coat coloring and normal brain morphology. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930568D16Rik |
T |
C |
2: 35,244,399 (GRCm39) |
K318E |
probably benign |
Het |
| Ap5z1 |
T |
C |
5: 142,463,113 (GRCm39) |
F766L |
probably benign |
Het |
| Atxn1 |
T |
C |
13: 45,710,622 (GRCm39) |
E770G |
probably benign |
Het |
| Brwd1 |
T |
G |
16: 95,813,096 (GRCm39) |
I1471L |
probably benign |
Het |
| Bud23 |
T |
C |
5: 135,082,571 (GRCm39) |
E66G |
probably benign |
Het |
| Cdh8 |
T |
A |
8: 99,757,367 (GRCm39) |
I744L |
possibly damaging |
Het |
| Celsr1 |
G |
T |
15: 85,917,286 (GRCm39) |
S229* |
probably null |
Het |
| Cep95 |
C |
A |
11: 106,703,322 (GRCm39) |
H467Q |
probably benign |
Het |
| Chd1 |
A |
G |
17: 15,989,023 (GRCm39) |
Y1592C |
probably benign |
Het |
| Chkb |
C |
G |
15: 89,313,628 (GRCm39) |
G59A |
probably damaging |
Het |
| Copa |
A |
G |
1: 171,945,648 (GRCm39) |
S915G |
probably benign |
Het |
| Creb3 |
G |
T |
4: 43,563,191 (GRCm39) |
V97F |
probably damaging |
Het |
| Csmd2 |
T |
A |
4: 128,308,062 (GRCm39) |
H1273Q |
|
Het |
| Cxcr1 |
T |
C |
1: 74,231,074 (GRCm39) |
N316S |
probably benign |
Het |
| Cyct |
A |
T |
2: 76,184,523 (GRCm39) |
I76N |
probably damaging |
Het |
| Dmxl2 |
G |
T |
9: 54,294,840 (GRCm39) |
R2412S |
probably damaging |
Het |
| Dnah11 |
A |
G |
12: 117,982,513 (GRCm39) |
M2552T |
possibly damaging |
Het |
| Dnph1 |
G |
A |
17: 46,809,901 (GRCm39) |
E148K |
possibly damaging |
Het |
| Ecpas |
T |
C |
4: 58,822,060 (GRCm39) |
N1169S |
probably benign |
Het |
| Esp16 |
T |
A |
17: 39,848,731 (GRCm39) |
Y8* |
probably null |
Het |
| Fam186a |
T |
C |
15: 99,841,024 (GRCm39) |
D1740G |
possibly damaging |
Het |
| Fam76a |
C |
A |
4: 132,628,557 (GRCm39) |
K300N |
probably damaging |
Het |
| Fcgbpl1 |
A |
G |
7: 27,856,044 (GRCm39) |
T1944A |
probably benign |
Het |
| Frrs1l |
A |
C |
4: 56,990,191 (GRCm39) |
D27E |
|
Het |
| G6pc1 |
T |
C |
11: 101,267,380 (GRCm39) |
S277P |
probably damaging |
Het |
| Gabrg3 |
T |
A |
7: 56,973,422 (GRCm39) |
I82F |
probably damaging |
Het |
| Gm3604 |
G |
T |
13: 62,517,969 (GRCm39) |
Q130K |
probably benign |
Het |
| Hhip |
T |
A |
8: 80,719,108 (GRCm39) |
D473V |
probably damaging |
Het |
| Ifi209 |
T |
C |
1: 173,470,332 (GRCm39) |
S307P |
probably damaging |
Het |
| Ino80c |
C |
T |
18: 24,254,856 (GRCm39) |
M1I |
probably null |
Het |
| Jag2 |
G |
T |
12: 112,875,416 (GRCm39) |
C872* |
probably null |
Het |
| Kcnma1 |
A |
C |
14: 23,558,123 (GRCm39) |
H474Q |
probably benign |
Het |
| Krr1 |
G |
A |
10: 111,818,963 (GRCm39) |
|
probably null |
Het |
| Lats1 |
T |
G |
10: 7,588,387 (GRCm39) |
D1001E |
probably benign |
Het |
| Lilrb4b |
T |
C |
10: 51,357,753 (GRCm39) |
L149P |
probably benign |
Het |
| Lrrk2 |
T |
A |
15: 91,649,884 (GRCm39) |
S1674T |
probably damaging |
Het |
| Magi2 |
A |
G |
5: 20,670,582 (GRCm39) |
I309V |
possibly damaging |
Het |
| Mtmr4 |
A |
G |
11: 87,503,138 (GRCm39) |
D1064G |
probably damaging |
Het |
| Mtmr4 |
T |
C |
11: 87,504,916 (GRCm39) |
V1137A |
probably damaging |
Het |
| Neb |
C |
T |
2: 52,133,853 (GRCm39) |
|
probably null |
Het |
| Nhsl1 |
T |
A |
10: 18,402,665 (GRCm39) |
V1297E |
possibly damaging |
Het |
| Nlrp3 |
T |
A |
11: 59,440,148 (GRCm39) |
V575D |
probably damaging |
Het |
| Nptx2 |
T |
C |
5: 144,492,159 (GRCm39) |
I312T |
possibly damaging |
Het |
| Osm |
A |
G |
11: 4,189,926 (GRCm39) |
T237A |
probably benign |
Het |
| Pcdha12 |
T |
C |
18: 37,155,234 (GRCm39) |
V651A |
possibly damaging |
Het |
| Pclo |
A |
G |
5: 14,908,758 (GRCm39) |
|
probably null |
Het |
| Pdlim3 |
C |
T |
8: 46,368,195 (GRCm39) |
S183L |
possibly damaging |
Het |
| Peg10 |
GC |
GCTCC |
6: 4,756,452 (GRCm39) |
|
probably benign |
Het |
| Pgm2 |
T |
A |
5: 64,273,671 (GRCm39) |
M552K |
probably damaging |
Het |
| Pkhd1l1 |
T |
C |
15: 44,386,901 (GRCm39) |
L1258S |
probably benign |
Het |
| Proser3 |
T |
G |
7: 30,248,530 (GRCm39) |
T55P |
probably damaging |
Het |
| Ranbp2 |
C |
A |
10: 58,300,963 (GRCm39) |
P611Q |
probably damaging |
Het |
| Rangap1 |
T |
C |
15: 81,590,637 (GRCm39) |
D485G |
probably benign |
Het |
| Rp1 |
G |
A |
1: 4,337,792 (GRCm39) |
T421I |
unknown |
Het |
| Ryr3 |
G |
A |
2: 112,486,883 (GRCm39) |
L3862F |
possibly damaging |
Het |
| Sbf1 |
C |
T |
15: 89,179,675 (GRCm39) |
G1337R |
possibly damaging |
Het |
| Setd2 |
A |
G |
9: 110,378,138 (GRCm39) |
E651G |
probably damaging |
Het |
| Shmt1 |
A |
G |
11: 60,692,769 (GRCm39) |
W105R |
probably damaging |
Het |
| Skor2 |
C |
T |
18: 76,946,376 (GRCm39) |
H33Y |
unknown |
Het |
| Slc22a29 |
T |
C |
19: 8,140,104 (GRCm39) |
I434V |
probably benign |
Het |
| Sord |
C |
T |
2: 122,090,712 (GRCm39) |
T221I |
probably benign |
Het |
| Speer1g |
T |
A |
5: 11,178,990 (GRCm39) |
N55K |
probably benign |
Het |
| Tbcd |
T |
C |
11: 121,464,647 (GRCm39) |
Y561H |
probably damaging |
Het |
| Tcaf1 |
G |
A |
6: 42,663,808 (GRCm39) |
S24F |
probably benign |
Het |
| Tenm4 |
A |
T |
7: 96,517,196 (GRCm39) |
D1429V |
probably damaging |
Het |
| Tesk1 |
A |
G |
4: 43,444,574 (GRCm39) |
Y126C |
probably damaging |
Het |
| Tmem176a |
G |
A |
6: 48,820,952 (GRCm39) |
V141I |
probably benign |
Het |
| Tmem204 |
A |
T |
17: 25,299,243 (GRCm39) |
V92D |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,572,605 (GRCm39) |
D26096V |
probably damaging |
Het |
| Vmn1r70 |
T |
A |
7: 10,368,364 (GRCm39) |
L284Q |
probably damaging |
Het |
| Vmn2r77 |
T |
C |
7: 86,450,171 (GRCm39) |
V139A |
possibly damaging |
Het |
| Wdpcp |
A |
G |
11: 21,671,285 (GRCm39) |
R509G |
possibly damaging |
Het |
| Wee1 |
C |
T |
7: 109,725,210 (GRCm39) |
T284I |
probably damaging |
Het |
| Wfs1 |
A |
G |
5: 37,125,113 (GRCm39) |
S593P |
probably damaging |
Het |
| Zbtb11 |
A |
G |
16: 55,827,336 (GRCm39) |
H934R |
probably damaging |
Het |
| Zfp277 |
A |
T |
12: 40,370,611 (GRCm39) |
V446E |
probably benign |
Het |
| Zfp874a |
C |
A |
13: 67,591,156 (GRCm39) |
R176L |
probably benign |
Het |
| Znrf2 |
A |
T |
6: 54,840,978 (GRCm39) |
N184I |
probably damaging |
Het |
| Zp2 |
T |
A |
7: 119,733,238 (GRCm39) |
T568S |
probably damaging |
Het |
|
| Other mutations in Atrnl1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00323:Atrnl1
|
APN |
19 |
57,680,249 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL00707:Atrnl1
|
APN |
19 |
57,661,697 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00921:Atrnl1
|
APN |
19 |
57,690,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01410:Atrnl1
|
APN |
19 |
58,119,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01468:Atrnl1
|
APN |
19 |
57,688,144 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01756:Atrnl1
|
APN |
19 |
57,641,380 (GRCm39) |
missense |
probably benign |
|
|
IGL01971:Atrnl1
|
APN |
19 |
57,741,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02019:Atrnl1
|
APN |
19 |
57,680,195 (GRCm39) |
splice site |
probably benign |
|
|
IGL02580:Atrnl1
|
APN |
19 |
57,703,008 (GRCm39) |
splice site |
probably benign |
|
|
IGL02649:Atrnl1
|
APN |
19 |
57,638,873 (GRCm39) |
splice site |
probably benign |
|
|
IGL02676:Atrnl1
|
APN |
19 |
57,680,316 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03276:Atrnl1
|
APN |
19 |
57,641,359 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03379:Atrnl1
|
APN |
19 |
57,630,973 (GRCm39) |
missense |
probably benign |
0.02 |
|
Magnetogorsk
|
UTSW |
19 |
57,618,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
polar
|
UTSW |
19 |
57,641,382 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4812001:Atrnl1
|
UTSW |
19 |
57,720,055 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0109:Atrnl1
|
UTSW |
19 |
57,743,949 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0308:Atrnl1
|
UTSW |
19 |
57,741,720 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0394:Atrnl1
|
UTSW |
19 |
57,661,608 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0734:Atrnl1
|
UTSW |
19 |
57,643,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0811:Atrnl1
|
UTSW |
19 |
57,661,573 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0812:Atrnl1
|
UTSW |
19 |
57,661,573 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1183:Atrnl1
|
UTSW |
19 |
57,638,725 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1213:Atrnl1
|
UTSW |
19 |
57,626,894 (GRCm39) |
missense |
probably benign |
0.25 |
|
R1344:Atrnl1
|
UTSW |
19 |
57,924,137 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1418:Atrnl1
|
UTSW |
19 |
57,924,137 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1707:Atrnl1
|
UTSW |
19 |
57,675,169 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1748:Atrnl1
|
UTSW |
19 |
57,703,134 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2051:Atrnl1
|
UTSW |
19 |
57,680,281 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2113:Atrnl1
|
UTSW |
19 |
57,744,048 (GRCm39) |
nonsense |
probably null |
|
|
R2130:Atrnl1
|
UTSW |
19 |
57,643,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3710:Atrnl1
|
UTSW |
19 |
57,645,546 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3916:Atrnl1
|
UTSW |
19 |
57,924,084 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4524:Atrnl1
|
UTSW |
19 |
57,618,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4707:Atrnl1
|
UTSW |
19 |
57,617,590 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4712:Atrnl1
|
UTSW |
19 |
57,641,382 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4784:Atrnl1
|
UTSW |
19 |
57,617,590 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4785:Atrnl1
|
UTSW |
19 |
57,617,590 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4798:Atrnl1
|
UTSW |
19 |
58,030,793 (GRCm39) |
missense |
probably benign |
|
|
R5172:Atrnl1
|
UTSW |
19 |
57,673,945 (GRCm39) |
nonsense |
probably null |
|
|
R5226:Atrnl1
|
UTSW |
19 |
57,638,767 (GRCm39) |
missense |
probably benign |
|
|
R5289:Atrnl1
|
UTSW |
19 |
57,645,514 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5372:Atrnl1
|
UTSW |
19 |
57,743,968 (GRCm39) |
missense |
probably benign |
|
|
R5737:Atrnl1
|
UTSW |
19 |
57,766,320 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5782:Atrnl1
|
UTSW |
19 |
57,741,718 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5826:Atrnl1
|
UTSW |
19 |
57,618,724 (GRCm39) |
nonsense |
probably null |
|
|
R6169:Atrnl1
|
UTSW |
19 |
57,630,895 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6242:Atrnl1
|
UTSW |
19 |
57,630,910 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6342:Atrnl1
|
UTSW |
19 |
57,626,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6372:Atrnl1
|
UTSW |
19 |
57,638,764 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6811:Atrnl1
|
UTSW |
19 |
57,643,393 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6897:Atrnl1
|
UTSW |
19 |
58,030,800 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7024:Atrnl1
|
UTSW |
19 |
57,626,882 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7085:Atrnl1
|
UTSW |
19 |
57,680,289 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7144:Atrnl1
|
UTSW |
19 |
58,030,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7259:Atrnl1
|
UTSW |
19 |
57,924,038 (GRCm39) |
nonsense |
probably null |
|
|
R7289:Atrnl1
|
UTSW |
19 |
57,638,846 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7310:Atrnl1
|
UTSW |
19 |
57,630,856 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R7372:Atrnl1
|
UTSW |
19 |
57,924,078 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7432:Atrnl1
|
UTSW |
19 |
57,743,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7478:Atrnl1
|
UTSW |
19 |
57,684,744 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7556:Atrnl1
|
UTSW |
19 |
57,643,278 (GRCm39) |
missense |
probably benign |
|
|
R7567:Atrnl1
|
UTSW |
19 |
57,687,955 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7608:Atrnl1
|
UTSW |
19 |
57,703,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7632:Atrnl1
|
UTSW |
19 |
57,618,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7655:Atrnl1
|
UTSW |
19 |
57,599,811 (GRCm39) |
nonsense |
probably null |
|
|
R7656:Atrnl1
|
UTSW |
19 |
57,599,811 (GRCm39) |
nonsense |
probably null |
|
|
R7718:Atrnl1
|
UTSW |
19 |
57,728,615 (GRCm39) |
nonsense |
probably null |
|
|
R7721:Atrnl1
|
UTSW |
19 |
57,684,763 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7726:Atrnl1
|
UTSW |
19 |
57,690,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7733:Atrnl1
|
UTSW |
19 |
57,690,420 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7774:Atrnl1
|
UTSW |
19 |
57,688,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8010:Atrnl1
|
UTSW |
19 |
57,670,878 (GRCm39) |
missense |
probably benign |
0.14 |
|
R8119:Atrnl1
|
UTSW |
19 |
57,630,895 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9242:Atrnl1
|
UTSW |
19 |
57,645,660 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9265:Atrnl1
|
UTSW |
19 |
57,766,359 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9272:Atrnl1
|
UTSW |
19 |
57,643,420 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9480:Atrnl1
|
UTSW |
19 |
57,690,420 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R9526:Atrnl1
|
UTSW |
19 |
57,617,551 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9672:Atrnl1
|
UTSW |
19 |
57,618,695 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
RF021:Atrnl1
|
UTSW |
19 |
57,630,905 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATCTCAGGCTAGCAGGAGTAC -3'
(R):5'- TGGGACACCTGAGCATAGAG -3'
Sequencing Primer
(F):5'- ATGCCCGAGTGTGACTGGAG -3'
(R):5'- GCATAGAGCGCCAGGTAG -3'
|
| Posted On |
2022-10-06 |
Incidental Mutation