Incidental Mutation 'R9674:Wnk4'
| ID |
728251 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Wnk4
|
| Ensembl Gene |
ENSMUSG00000035112 |
| Gene Name |
WNK lysine deficient protein kinase 4 |
| Synonyms |
2010002J11Rik, Prkwnk4 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.318)
|
| Stock # |
R9674 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
101151393-101168235 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 101166874 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Glutamine
at position 1010
(L1010Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000099397
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000017332]
[ENSMUST00000103107]
[ENSMUST00000103108]
[ENSMUST00000139487]
[ENSMUST00000147741]
[ENSMUST00000168089]
[ENSMUST00000170056]
|
| AlphaFold |
Q80UE6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000017332
|
| SMART Domains |
Protein: ENSMUSP00000017332
Gene: ENSMUSG00000017188
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Coiled-coil_56
|
1 |
106 |
1.8e-56 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000103107
|
| SMART Domains |
Protein: ENSMUSP00000099396
Gene: ENSMUSG00000078653
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Cyclin_N
|
111 |
180 |
1.8e-6 |
PFAM |
|
low complexity region
|
212 |
221 |
N/A |
INTRINSIC |
|
low complexity region
|
319 |
330 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000103108
AA Change: L1010Q
|
| SMART Domains |
Protein: ENSMUSP00000099397
Gene: ENSMUSG00000035112
AA Change: L1010Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
31 |
45 |
N/A |
INTRINSIC |
|
low complexity region
|
52 |
64 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
92 |
N/A |
INTRINSIC |
|
low complexity region
|
95 |
105 |
N/A |
INTRINSIC |
|
low complexity region
|
126 |
155 |
N/A |
INTRINSIC |
|
Pfam:Pkinase_Tyr
|
171 |
427 |
4.7e-42 |
PFAM |
|
Pfam:Pkinase
|
171 |
429 |
9e-55 |
PFAM |
|
Pfam:OSR1_C
|
450 |
486 |
3e-18 |
PFAM |
|
low complexity region
|
503 |
513 |
N/A |
INTRINSIC |
|
low complexity region
|
516 |
530 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
560 |
N/A |
INTRINSIC |
|
low complexity region
|
627 |
638 |
N/A |
INTRINSIC |
|
low complexity region
|
660 |
678 |
N/A |
INTRINSIC |
|
low complexity region
|
757 |
778 |
N/A |
INTRINSIC |
|
low complexity region
|
793 |
808 |
N/A |
INTRINSIC |
|
low complexity region
|
841 |
877 |
N/A |
INTRINSIC |
|
low complexity region
|
882 |
915 |
N/A |
INTRINSIC |
|
low complexity region
|
921 |
951 |
N/A |
INTRINSIC |
|
low complexity region
|
1014 |
1033 |
N/A |
INTRINSIC |
|
low complexity region
|
1093 |
1112 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000139487
|
| SMART Domains |
Protein: ENSMUSP00000129666
Gene: ENSMUSG00000035112
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
31 |
45 |
N/A |
INTRINSIC |
|
low complexity region
|
52 |
64 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
92 |
N/A |
INTRINSIC |
|
low complexity region
|
95 |
105 |
N/A |
INTRINSIC |
|
low complexity region
|
126 |
155 |
N/A |
INTRINSIC |
|
Pfam:Pkinase_Tyr
|
171 |
242 |
4e-8 |
PFAM |
|
Pfam:Pkinase
|
171 |
252 |
1.9e-10 |
PFAM |
|
low complexity region
|
269 |
283 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000147741
|
| SMART Domains |
Protein: ENSMUSP00000131298
Gene: ENSMUSG00000035112
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
31 |
45 |
N/A |
INTRINSIC |
|
low complexity region
|
52 |
64 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
92 |
N/A |
INTRINSIC |
|
low complexity region
|
95 |
105 |
N/A |
INTRINSIC |
|
low complexity region
|
126 |
155 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
171 |
394 |
9.3e-50 |
PFAM |
|
Pfam:Pkinase_Tyr
|
171 |
399 |
3.7e-38 |
PFAM |
|
low complexity region
|
401 |
413 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168089
|
| SMART Domains |
Protein: ENSMUSP00000130367
Gene: ENSMUSG00000017188
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Coiled-coil_56
|
1 |
74 |
2.7e-35 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170056
|
| SMART Domains |
Protein: ENSMUSP00000132123
Gene: ENSMUSG00000035112
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:OSR1_C
|
13 |
49 |
8.6e-20 |
PFAM |
|
low complexity region
|
66 |
76 |
N/A |
INTRINSIC |
|
low complexity region
|
79 |
93 |
N/A |
INTRINSIC |
|
low complexity region
|
107 |
123 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170372
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009]
PHENOTYPE: Mice homozygous for a null allele display increased Na+, K+ and Cl- urinary excretion, alkalosis and decreased plasma Cl-, K+, Mg2+ and renin levels. Mice homozygous for a point mutation exhibit acidosis, hypertension, increased circulating potassium levels and decreased potassium excretion. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadacl2 |
A |
T |
3: 59,914,472 (GRCm39) |
D25V |
possibly damaging |
Het |
| Abca16 |
A |
G |
7: 120,074,668 (GRCm39) |
|
probably null |
Het |
| Adam9 |
T |
A |
8: 25,441,014 (GRCm39) |
T820S |
possibly damaging |
Het |
| Adamts6 |
G |
A |
13: 104,563,448 (GRCm39) |
V647I |
probably benign |
Het |
| Afap1l2 |
T |
A |
19: 56,922,195 (GRCm39) |
R14S |
probably damaging |
Het |
| Aff3 |
C |
T |
1: 38,248,864 (GRCm39) |
V748I |
probably damaging |
Het |
| Aldh5a1 |
T |
C |
13: 25,110,038 (GRCm39) |
I166V |
probably benign |
Het |
| Alx4 |
G |
T |
2: 93,507,858 (GRCm39) |
L384F |
probably damaging |
Het |
| Ank3 |
T |
A |
10: 69,824,549 (GRCm39) |
S1073T |
|
Het |
| Ankrd50 |
A |
G |
3: 38,506,574 (GRCm39) |
C275R |
unknown |
Het |
| Apol11a |
G |
A |
15: 77,401,347 (GRCm39) |
S278N |
possibly damaging |
Het |
| Astn2 |
T |
A |
4: 65,460,963 (GRCm39) |
D1057V |
probably damaging |
Het |
| Atp11a |
T |
C |
8: 12,877,525 (GRCm39) |
V317A |
probably benign |
Het |
| Cacna1i |
A |
G |
15: 80,264,629 (GRCm39) |
T1486A |
probably damaging |
Het |
| Cadps |
A |
G |
14: 12,454,291 (GRCm38) |
F1076L |
probably damaging |
Het |
| Cct6b |
T |
C |
11: 82,645,838 (GRCm39) |
T154A |
probably damaging |
Het |
| Cfap69 |
A |
G |
5: 5,697,021 (GRCm39) |
F92L |
possibly damaging |
Het |
| Cyp19a1 |
A |
T |
9: 54,074,141 (GRCm39) |
I471K |
possibly damaging |
Het |
| Cyp26a1 |
T |
A |
19: 37,689,726 (GRCm39) |
M474K |
probably damaging |
Het |
| Cyp4a12a |
T |
C |
4: 115,186,156 (GRCm39) |
S439P |
probably benign |
Het |
| Cyp4f37 |
T |
A |
17: 32,846,841 (GRCm39) |
|
probably null |
Het |
| Dgki |
A |
G |
6: 37,027,157 (GRCm39) |
Y395H |
probably damaging |
Het |
| Dlg1 |
T |
C |
16: 31,610,580 (GRCm39) |
V287A |
probably damaging |
Het |
| Dlx2 |
C |
T |
2: 71,376,496 (GRCm39) |
G81S |
possibly damaging |
Het |
| Dnah8 |
G |
T |
17: 30,998,112 (GRCm39) |
K3448N |
possibly damaging |
Het |
| Dnhd1 |
C |
T |
7: 105,363,429 (GRCm39) |
P3997L |
probably damaging |
Het |
| Drosha |
C |
G |
15: 12,890,170 (GRCm39) |
D910E |
probably damaging |
Het |
| Dscam |
A |
G |
16: 96,442,036 (GRCm39) |
V1597A |
probably benign |
Het |
| Eif1b |
A |
G |
9: 120,323,265 (GRCm39) |
K42E |
possibly damaging |
Het |
| Enpp2 |
C |
A |
15: 54,816,135 (GRCm39) |
G10W |
unknown |
Het |
| Exd2 |
A |
G |
12: 80,536,372 (GRCm39) |
N334S |
probably benign |
Het |
| Glt6d1 |
T |
A |
2: 25,684,382 (GRCm39) |
N208I |
probably benign |
Het |
| Grin2a |
T |
A |
16: 9,471,265 (GRCm39) |
K668* |
probably null |
Het |
| Grm1 |
A |
G |
10: 10,609,028 (GRCm39) |
V535A |
possibly damaging |
Het |
| H2ac7 |
A |
G |
13: 23,758,862 (GRCm39) |
D73G |
possibly damaging |
Het |
| Hey2 |
A |
T |
10: 30,710,413 (GRCm39) |
D113E |
probably benign |
Het |
| Ighm |
T |
A |
12: 113,385,139 (GRCm39) |
I274F |
|
Het |
| Ighv1-58 |
G |
T |
12: 115,275,847 (GRCm39) |
T97K |
probably damaging |
Het |
| Igkv6-20 |
T |
C |
6: 70,312,852 (GRCm39) |
H107R |
possibly damaging |
Het |
| Il15 |
C |
T |
8: 83,069,938 (GRCm39) |
G42D |
probably damaging |
Het |
| Jakmip2 |
T |
A |
18: 43,704,961 (GRCm39) |
M347L |
probably benign |
Het |
| Kcnh7 |
T |
C |
2: 62,595,060 (GRCm39) |
Y670C |
probably damaging |
Het |
| Ktn1 |
G |
C |
14: 47,922,213 (GRCm39) |
C458S |
possibly damaging |
Het |
| Lama5 |
C |
T |
2: 179,840,267 (GRCm39) |
|
probably null |
Het |
| Lce1i |
T |
C |
3: 92,685,113 (GRCm39) |
Q21R |
unknown |
Het |
| Lmo7 |
A |
T |
14: 102,078,340 (GRCm39) |
E81D |
probably damaging |
Het |
| Lrrc4b |
A |
T |
7: 44,111,852 (GRCm39) |
I575F |
probably damaging |
Het |
| Mmrn1 |
C |
T |
6: 60,948,072 (GRCm39) |
Q272* |
probably null |
Het |
| Nbea |
A |
T |
3: 55,966,183 (GRCm39) |
D426E |
probably damaging |
Het |
| Neto1 |
G |
A |
18: 86,491,827 (GRCm39) |
V243M |
probably damaging |
Het |
| Notch1 |
G |
A |
2: 26,361,308 (GRCm39) |
R1061C |
probably damaging |
Het |
| Or5g25 |
T |
G |
2: 85,478,593 (GRCm39) |
Q24P |
possibly damaging |
Het |
| Or5p67 |
A |
T |
7: 107,922,271 (GRCm39) |
I204N |
probably benign |
Het |
| Osgin1 |
A |
G |
8: 120,172,499 (GRCm39) |
D431G |
possibly damaging |
Het |
| Ppp4r1 |
A |
G |
17: 66,140,127 (GRCm39) |
D675G |
probably damaging |
Het |
| Pramel25 |
T |
A |
4: 143,520,162 (GRCm39) |
H135Q |
probably benign |
Het |
| Prkdc |
T |
A |
16: 15,533,819 (GRCm39) |
H1552Q |
probably damaging |
Het |
| Rbfox1 |
T |
C |
16: 7,170,885 (GRCm39) |
F282L |
probably benign |
Het |
| Ret |
T |
C |
6: 118,130,830 (GRCm39) |
D1111G |
probably damaging |
Het |
| Rnf224 |
A |
T |
2: 25,126,330 (GRCm39) |
Y8N |
probably benign |
Het |
| Rtl1 |
G |
T |
12: 109,559,024 (GRCm39) |
H938Q |
possibly damaging |
Het |
| Sec23ip |
T |
G |
7: 128,380,187 (GRCm39) |
D867E |
probably damaging |
Het |
| Sema3f |
A |
T |
9: 107,566,947 (GRCm39) |
L194Q |
possibly damaging |
Het |
| Sfmbt1 |
C |
T |
14: 30,495,851 (GRCm39) |
R45C |
probably damaging |
Het |
| Slc7a4 |
T |
C |
16: 17,392,208 (GRCm39) |
I409V |
probably benign |
Het |
| Slco6c1 |
T |
A |
1: 97,047,565 (GRCm39) |
D246V |
probably damaging |
Het |
| Smap2 |
C |
T |
4: 120,826,745 (GRCm39) |
M426I |
probably benign |
Het |
| Spata31h1 |
C |
T |
10: 82,120,030 (GRCm39) |
V4327I |
possibly damaging |
Het |
| Tmem184b |
T |
A |
15: 79,249,524 (GRCm39) |
T315S |
probably benign |
Het |
| Trpm4 |
A |
T |
7: 44,982,811 (GRCm39) |
D30E |
possibly damaging |
Het |
| Ttc7b |
T |
A |
12: 100,432,553 (GRCm39) |
K154N |
probably benign |
Het |
| Vps13b |
T |
A |
15: 35,607,380 (GRCm39) |
H1104Q |
probably damaging |
Het |
| Xpo6 |
T |
A |
7: 125,723,700 (GRCm39) |
H537L |
probably benign |
Het |
| Xrn1 |
A |
T |
9: 95,855,645 (GRCm39) |
Y314F |
probably damaging |
Het |
| Xrn1 |
A |
T |
9: 95,855,647 (GRCm39) |
I315F |
possibly damaging |
Het |
| Zap70 |
T |
C |
1: 36,810,150 (GRCm39) |
Y87H |
probably benign |
Het |
| Zbtb4 |
T |
C |
11: 69,669,973 (GRCm39) |
Y899H |
probably damaging |
Het |
| Zcchc7 |
T |
A |
4: 44,931,418 (GRCm39) |
H202Q |
possibly damaging |
Het |
| Zeb2 |
A |
G |
2: 44,891,725 (GRCm39) |
Y276H |
probably damaging |
Het |
| Zfp867 |
T |
G |
11: 59,355,850 (GRCm39) |
Q68P |
probably benign |
Het |
|
| Other mutations in Wnk4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00231:Wnk4
|
APN |
11 |
101,159,574 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL00535:Wnk4
|
APN |
11 |
101,155,175 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01401:Wnk4
|
APN |
11 |
101,167,509 (GRCm39) |
splice site |
probably benign |
|
|
IGL01931:Wnk4
|
APN |
11 |
101,159,310 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01977:Wnk4
|
APN |
11 |
101,156,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02165:Wnk4
|
APN |
11 |
101,166,117 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02197:Wnk4
|
APN |
11 |
101,154,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02457:Wnk4
|
APN |
11 |
101,160,389 (GRCm39) |
splice site |
probably benign |
|
|
IGL02963:Wnk4
|
APN |
11 |
101,167,039 (GRCm39) |
unclassified |
probably benign |
|
|
ashamed
|
UTSW |
11 |
101,156,257 (GRCm39) |
missense |
probably damaging |
1.00 |
|
blushing
|
UTSW |
11 |
101,156,203 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Caught_dead
|
UTSW |
11 |
101,155,156 (GRCm39) |
missense |
probably damaging |
1.00 |
|
lowered
|
UTSW |
11 |
101,159,318 (GRCm39) |
critical splice donor site |
probably null |
|
|
mortification
|
UTSW |
11 |
101,154,720 (GRCm39) |
makesense |
probably null |
|
|
shame
|
UTSW |
11 |
101,153,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0066:Wnk4
|
UTSW |
11 |
101,156,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0317:Wnk4
|
UTSW |
11 |
101,159,630 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0628:Wnk4
|
UTSW |
11 |
101,165,849 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0630:Wnk4
|
UTSW |
11 |
101,156,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0710:Wnk4
|
UTSW |
11 |
101,164,932 (GRCm39) |
missense |
probably benign |
0.22 |
|
R1290:Wnk4
|
UTSW |
11 |
101,167,166 (GRCm39) |
unclassified |
probably benign |
|
|
R1482:Wnk4
|
UTSW |
11 |
101,160,462 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1775:Wnk4
|
UTSW |
11 |
101,167,166 (GRCm39) |
unclassified |
probably benign |
|
|
R2005:Wnk4
|
UTSW |
11 |
101,154,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2229:Wnk4
|
UTSW |
11 |
101,166,467 (GRCm39) |
unclassified |
probably benign |
|
|
R2258:Wnk4
|
UTSW |
11 |
101,165,861 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2323:Wnk4
|
UTSW |
11 |
101,159,307 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3081:Wnk4
|
UTSW |
11 |
101,167,717 (GRCm39) |
splice site |
probably benign |
|
|
R3763:Wnk4
|
UTSW |
11 |
101,160,114 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4196:Wnk4
|
UTSW |
11 |
101,160,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4447:Wnk4
|
UTSW |
11 |
101,159,277 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4614:Wnk4
|
UTSW |
11 |
101,164,937 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4751:Wnk4
|
UTSW |
11 |
101,167,188 (GRCm39) |
unclassified |
probably benign |
|
|
R4948:Wnk4
|
UTSW |
11 |
101,159,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5067:Wnk4
|
UTSW |
11 |
101,153,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5073:Wnk4
|
UTSW |
11 |
101,152,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5107:Wnk4
|
UTSW |
11 |
101,166,364 (GRCm39) |
unclassified |
probably benign |
|
|
R5181:Wnk4
|
UTSW |
11 |
101,156,203 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5205:Wnk4
|
UTSW |
11 |
101,155,964 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5252:Wnk4
|
UTSW |
11 |
101,159,574 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5273:Wnk4
|
UTSW |
11 |
101,154,695 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5293:Wnk4
|
UTSW |
11 |
101,166,023 (GRCm39) |
unclassified |
probably benign |
|
|
R5609:Wnk4
|
UTSW |
11 |
101,166,462 (GRCm39) |
unclassified |
probably benign |
|
|
R5915:Wnk4
|
UTSW |
11 |
101,154,720 (GRCm39) |
makesense |
probably null |
|
|
R5931:Wnk4
|
UTSW |
11 |
101,152,047 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6126:Wnk4
|
UTSW |
11 |
101,167,174 (GRCm39) |
unclassified |
probably benign |
|
|
R6164:Wnk4
|
UTSW |
11 |
101,165,894 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6191:Wnk4
|
UTSW |
11 |
101,155,156 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6267:Wnk4
|
UTSW |
11 |
101,164,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6274:Wnk4
|
UTSW |
11 |
101,156,257 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6296:Wnk4
|
UTSW |
11 |
101,164,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7132:Wnk4
|
UTSW |
11 |
101,152,026 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7251:Wnk4
|
UTSW |
11 |
101,155,979 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7352:Wnk4
|
UTSW |
11 |
101,155,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7404:Wnk4
|
UTSW |
11 |
101,159,318 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7624:Wnk4
|
UTSW |
11 |
101,155,180 (GRCm39) |
nonsense |
probably null |
|
|
R7634:Wnk4
|
UTSW |
11 |
101,153,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7780:Wnk4
|
UTSW |
11 |
101,160,403 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8006:Wnk4
|
UTSW |
11 |
101,159,182 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8046:Wnk4
|
UTSW |
11 |
101,164,918 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8143:Wnk4
|
UTSW |
11 |
101,153,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8458:Wnk4
|
UTSW |
11 |
101,166,147 (GRCm39) |
nonsense |
probably null |
|
|
R8735:Wnk4
|
UTSW |
11 |
101,167,092 (GRCm39) |
missense |
unknown |
|
|
R9025:Wnk4
|
UTSW |
11 |
101,153,641 (GRCm39) |
nonsense |
probably null |
|
|
R9206:Wnk4
|
UTSW |
11 |
101,164,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9295:Wnk4
|
UTSW |
11 |
101,160,078 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9610:Wnk4
|
UTSW |
11 |
101,159,250 (GRCm39) |
nonsense |
probably null |
|
|
R9611:Wnk4
|
UTSW |
11 |
101,159,250 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGCCCCAGTGCCTTACATTC -3'
(R):5'- TTTCATCATCGACCGCAACC -3'
Sequencing Primer
(F):5'- AGTGCCTTACATTCTGCTAGATC -3'
(R):5'- AACCCCCAGGCCTTCGG -3'
|
| Posted On |
2022-10-06 |
Incidental Mutation