Incidental Mutation 'R9674:Dlg1'
| ID |
728274 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dlg1
|
| Ensembl Gene |
ENSMUSG00000022770 |
| Gene Name |
discs large MAGUK scaffold protein 1 |
| Synonyms |
B130052P05Rik, SAP97, Dlgh1 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R9674 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
16 |
| Chromosomal Location |
31482261-31692174 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 31610580 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 287
(V287A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000064280
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023454]
[ENSMUST00000064477]
[ENSMUST00000100001]
[ENSMUST00000115196]
[ENSMUST00000115201]
[ENSMUST00000115205]
[ENSMUST00000132176]
|
| AlphaFold |
Q811D0 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000023454
AA Change: V254A
PolyPhen 2
Score 0.930 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000023454
Gene: ENSMUSG00000022770
AA Change: V254A
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
7 |
67 |
7.33e-12 |
SMART |
|
MAGUK_N_PEST
|
106 |
190 |
4.33e-44 |
SMART |
|
PDZ
|
199 |
278 |
5.98e-22 |
SMART |
|
PDZ
|
294 |
373 |
1.94e-21 |
SMART |
|
PDZ
|
441 |
514 |
1.84e-22 |
SMART |
|
low complexity region
|
534 |
542 |
N/A |
INTRINSIC |
|
SH3
|
551 |
617 |
1.27e-9 |
SMART |
|
GuKc
|
681 |
860 |
1.54e-75 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000064477
AA Change: V287A
PolyPhen 2
Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000064280
Gene: ENSMUSG00000022770
AA Change: V287A
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
7 |
67 |
7.33e-12 |
SMART |
|
MAGUK_N_PEST
|
106 |
223 |
6.07e-57 |
SMART |
|
PDZ
|
232 |
311 |
5.98e-22 |
SMART |
|
PDZ
|
327 |
406 |
1.94e-21 |
SMART |
|
PDZ
|
474 |
547 |
1.84e-22 |
SMART |
|
low complexity region
|
567 |
575 |
N/A |
INTRINSIC |
|
SH3
|
584 |
650 |
1.27e-9 |
SMART |
|
GuKc
|
736 |
915 |
1.54e-75 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000100001
AA Change: V287A
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000097581
Gene: ENSMUSG00000022770
AA Change: V287A
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
7 |
67 |
7.33e-12 |
SMART |
|
MAGUK_N_PEST
|
106 |
223 |
6.07e-57 |
SMART |
|
PDZ
|
232 |
311 |
5.98e-22 |
SMART |
|
PDZ
|
327 |
406 |
1.94e-21 |
SMART |
|
PDZ
|
474 |
547 |
1.84e-22 |
SMART |
|
low complexity region
|
567 |
575 |
N/A |
INTRINSIC |
|
SH3
|
584 |
650 |
1.27e-9 |
SMART |
|
GuKc
|
714 |
893 |
1.54e-75 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000115196
AA Change: V204A
PolyPhen 2
Score 0.675 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000110850
Gene: ENSMUSG00000022770
AA Change: V204A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
13 |
27 |
N/A |
INTRINSIC |
|
MAGUK_N_PEST
|
30 |
140 |
1.81e-14 |
SMART |
|
PDZ
|
149 |
228 |
5.98e-22 |
SMART |
|
PDZ
|
244 |
323 |
1.94e-21 |
SMART |
|
PDZ
|
391 |
464 |
1.84e-22 |
SMART |
|
low complexity region
|
484 |
492 |
N/A |
INTRINSIC |
|
SH3
|
501 |
567 |
1.27e-9 |
SMART |
|
GuKc
|
643 |
822 |
1.54e-75 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115201
AA Change: V287A
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000110855
Gene: ENSMUSG00000022770
AA Change: V287A
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
7 |
67 |
7.33e-12 |
SMART |
|
MAGUK_N_PEST
|
106 |
223 |
6.07e-57 |
SMART |
|
PDZ
|
232 |
311 |
5.98e-22 |
SMART |
|
PDZ
|
327 |
406 |
1.94e-21 |
SMART |
|
PDZ
|
474 |
547 |
1.84e-22 |
SMART |
|
low complexity region
|
567 |
575 |
N/A |
INTRINSIC |
|
SH3
|
584 |
650 |
1.27e-9 |
SMART |
|
GuKc
|
721 |
900 |
1.54e-75 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115205
AA Change: V287A
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000110859
Gene: ENSMUSG00000022770
AA Change: V287A
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
7 |
67 |
7.33e-12 |
SMART |
|
MAGUK_N_PEST
|
106 |
223 |
6.07e-57 |
SMART |
|
PDZ
|
232 |
311 |
5.98e-22 |
SMART |
|
PDZ
|
327 |
406 |
1.94e-21 |
SMART |
|
PDZ
|
474 |
547 |
1.84e-22 |
SMART |
|
low complexity region
|
567 |
575 |
N/A |
INTRINSIC |
|
SH3
|
584 |
650 |
1.27e-9 |
SMART |
|
GuKc
|
714 |
893 |
1.54e-75 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000131136
|
| SMART Domains |
Protein: ENSMUSP00000115954
Gene: ENSMUSG00000022770
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
38 |
117 |
1.94e-21 |
SMART |
|
PDZ
|
170 |
243 |
1.84e-22 |
SMART |
|
low complexity region
|
263 |
271 |
N/A |
INTRINSIC |
|
SH3
|
280 |
346 |
1.27e-9 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000132176
AA Change: V254A
PolyPhen 2
Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000138782
Gene: ENSMUSG00000022770
AA Change: V254A
| Domain | Start | End | E-Value | Type |
|---|
|
L27
|
7 |
67 |
7.33e-12 |
SMART |
|
MAGUK_N_PEST
|
106 |
190 |
4.33e-44 |
SMART |
|
PDZ
|
199 |
278 |
5.98e-22 |
SMART |
|
PDZ
|
294 |
373 |
1.94e-21 |
SMART |
|
PDZ
|
426 |
499 |
1.84e-22 |
SMART |
|
low complexity region
|
519 |
527 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known. [provided by RefSeq, Feb 2011]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit neonatal lethality, craniofacial defects, and abnormal eye morphology. Mice homozygous for knock-out alleles exhibit neonatal lethality, kidney defects, reproductive organ morphology, and cleft palate. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadacl2 |
A |
T |
3: 59,914,472 (GRCm39) |
D25V |
possibly damaging |
Het |
| Abca16 |
A |
G |
7: 120,074,668 (GRCm39) |
|
probably null |
Het |
| Adam9 |
T |
A |
8: 25,441,014 (GRCm39) |
T820S |
possibly damaging |
Het |
| Adamts6 |
G |
A |
13: 104,563,448 (GRCm39) |
V647I |
probably benign |
Het |
| Afap1l2 |
T |
A |
19: 56,922,195 (GRCm39) |
R14S |
probably damaging |
Het |
| Aff3 |
C |
T |
1: 38,248,864 (GRCm39) |
V748I |
probably damaging |
Het |
| Aldh5a1 |
T |
C |
13: 25,110,038 (GRCm39) |
I166V |
probably benign |
Het |
| Alx4 |
G |
T |
2: 93,507,858 (GRCm39) |
L384F |
probably damaging |
Het |
| Ank3 |
T |
A |
10: 69,824,549 (GRCm39) |
S1073T |
|
Het |
| Ankrd50 |
A |
G |
3: 38,506,574 (GRCm39) |
C275R |
unknown |
Het |
| Apol11a |
G |
A |
15: 77,401,347 (GRCm39) |
S278N |
possibly damaging |
Het |
| Astn2 |
T |
A |
4: 65,460,963 (GRCm39) |
D1057V |
probably damaging |
Het |
| Atp11a |
T |
C |
8: 12,877,525 (GRCm39) |
V317A |
probably benign |
Het |
| Cacna1i |
A |
G |
15: 80,264,629 (GRCm39) |
T1486A |
probably damaging |
Het |
| Cadps |
A |
G |
14: 12,454,291 (GRCm38) |
F1076L |
probably damaging |
Het |
| Cct6b |
T |
C |
11: 82,645,838 (GRCm39) |
T154A |
probably damaging |
Het |
| Cfap69 |
A |
G |
5: 5,697,021 (GRCm39) |
F92L |
possibly damaging |
Het |
| Cyp19a1 |
A |
T |
9: 54,074,141 (GRCm39) |
I471K |
possibly damaging |
Het |
| Cyp26a1 |
T |
A |
19: 37,689,726 (GRCm39) |
M474K |
probably damaging |
Het |
| Cyp4a12a |
T |
C |
4: 115,186,156 (GRCm39) |
S439P |
probably benign |
Het |
| Cyp4f37 |
T |
A |
17: 32,846,841 (GRCm39) |
|
probably null |
Het |
| Dgki |
A |
G |
6: 37,027,157 (GRCm39) |
Y395H |
probably damaging |
Het |
| Dlx2 |
C |
T |
2: 71,376,496 (GRCm39) |
G81S |
possibly damaging |
Het |
| Dnah8 |
G |
T |
17: 30,998,112 (GRCm39) |
K3448N |
possibly damaging |
Het |
| Dnhd1 |
C |
T |
7: 105,363,429 (GRCm39) |
P3997L |
probably damaging |
Het |
| Drosha |
C |
G |
15: 12,890,170 (GRCm39) |
D910E |
probably damaging |
Het |
| Dscam |
A |
G |
16: 96,442,036 (GRCm39) |
V1597A |
probably benign |
Het |
| Eif1b |
A |
G |
9: 120,323,265 (GRCm39) |
K42E |
possibly damaging |
Het |
| Enpp2 |
C |
A |
15: 54,816,135 (GRCm39) |
G10W |
unknown |
Het |
| Exd2 |
A |
G |
12: 80,536,372 (GRCm39) |
N334S |
probably benign |
Het |
| Glt6d1 |
T |
A |
2: 25,684,382 (GRCm39) |
N208I |
probably benign |
Het |
| Grin2a |
T |
A |
16: 9,471,265 (GRCm39) |
K668* |
probably null |
Het |
| Grm1 |
A |
G |
10: 10,609,028 (GRCm39) |
V535A |
possibly damaging |
Het |
| H2ac7 |
A |
G |
13: 23,758,862 (GRCm39) |
D73G |
possibly damaging |
Het |
| Hey2 |
A |
T |
10: 30,710,413 (GRCm39) |
D113E |
probably benign |
Het |
| Ighm |
T |
A |
12: 113,385,139 (GRCm39) |
I274F |
|
Het |
| Ighv1-58 |
G |
T |
12: 115,275,847 (GRCm39) |
T97K |
probably damaging |
Het |
| Igkv6-20 |
T |
C |
6: 70,312,852 (GRCm39) |
H107R |
possibly damaging |
Het |
| Il15 |
C |
T |
8: 83,069,938 (GRCm39) |
G42D |
probably damaging |
Het |
| Jakmip2 |
T |
A |
18: 43,704,961 (GRCm39) |
M347L |
probably benign |
Het |
| Kcnh7 |
T |
C |
2: 62,595,060 (GRCm39) |
Y670C |
probably damaging |
Het |
| Ktn1 |
G |
C |
14: 47,922,213 (GRCm39) |
C458S |
possibly damaging |
Het |
| Lama5 |
C |
T |
2: 179,840,267 (GRCm39) |
|
probably null |
Het |
| Lce1i |
T |
C |
3: 92,685,113 (GRCm39) |
Q21R |
unknown |
Het |
| Lmo7 |
A |
T |
14: 102,078,340 (GRCm39) |
E81D |
probably damaging |
Het |
| Lrrc4b |
A |
T |
7: 44,111,852 (GRCm39) |
I575F |
probably damaging |
Het |
| Mmrn1 |
C |
T |
6: 60,948,072 (GRCm39) |
Q272* |
probably null |
Het |
| Nbea |
A |
T |
3: 55,966,183 (GRCm39) |
D426E |
probably damaging |
Het |
| Neto1 |
G |
A |
18: 86,491,827 (GRCm39) |
V243M |
probably damaging |
Het |
| Notch1 |
G |
A |
2: 26,361,308 (GRCm39) |
R1061C |
probably damaging |
Het |
| Or5g25 |
T |
G |
2: 85,478,593 (GRCm39) |
Q24P |
possibly damaging |
Het |
| Or5p67 |
A |
T |
7: 107,922,271 (GRCm39) |
I204N |
probably benign |
Het |
| Osgin1 |
A |
G |
8: 120,172,499 (GRCm39) |
D431G |
possibly damaging |
Het |
| Ppp4r1 |
A |
G |
17: 66,140,127 (GRCm39) |
D675G |
probably damaging |
Het |
| Pramel25 |
T |
A |
4: 143,520,162 (GRCm39) |
H135Q |
probably benign |
Het |
| Prkdc |
T |
A |
16: 15,533,819 (GRCm39) |
H1552Q |
probably damaging |
Het |
| Rbfox1 |
T |
C |
16: 7,170,885 (GRCm39) |
F282L |
probably benign |
Het |
| Ret |
T |
C |
6: 118,130,830 (GRCm39) |
D1111G |
probably damaging |
Het |
| Rnf224 |
A |
T |
2: 25,126,330 (GRCm39) |
Y8N |
probably benign |
Het |
| Rtl1 |
G |
T |
12: 109,559,024 (GRCm39) |
H938Q |
possibly damaging |
Het |
| Sec23ip |
T |
G |
7: 128,380,187 (GRCm39) |
D867E |
probably damaging |
Het |
| Sema3f |
A |
T |
9: 107,566,947 (GRCm39) |
L194Q |
possibly damaging |
Het |
| Sfmbt1 |
C |
T |
14: 30,495,851 (GRCm39) |
R45C |
probably damaging |
Het |
| Slc7a4 |
T |
C |
16: 17,392,208 (GRCm39) |
I409V |
probably benign |
Het |
| Slco6c1 |
T |
A |
1: 97,047,565 (GRCm39) |
D246V |
probably damaging |
Het |
| Smap2 |
C |
T |
4: 120,826,745 (GRCm39) |
M426I |
probably benign |
Het |
| Spata31h1 |
C |
T |
10: 82,120,030 (GRCm39) |
V4327I |
possibly damaging |
Het |
| Tmem184b |
T |
A |
15: 79,249,524 (GRCm39) |
T315S |
probably benign |
Het |
| Trpm4 |
A |
T |
7: 44,982,811 (GRCm39) |
D30E |
possibly damaging |
Het |
| Ttc7b |
T |
A |
12: 100,432,553 (GRCm39) |
K154N |
probably benign |
Het |
| Vps13b |
T |
A |
15: 35,607,380 (GRCm39) |
H1104Q |
probably damaging |
Het |
| Wnk4 |
T |
A |
11: 101,166,874 (GRCm39) |
L1010Q |
unknown |
Het |
| Xpo6 |
T |
A |
7: 125,723,700 (GRCm39) |
H537L |
probably benign |
Het |
| Xrn1 |
A |
T |
9: 95,855,645 (GRCm39) |
Y314F |
probably damaging |
Het |
| Xrn1 |
A |
T |
9: 95,855,647 (GRCm39) |
I315F |
possibly damaging |
Het |
| Zap70 |
T |
C |
1: 36,810,150 (GRCm39) |
Y87H |
probably benign |
Het |
| Zbtb4 |
T |
C |
11: 69,669,973 (GRCm39) |
Y899H |
probably damaging |
Het |
| Zcchc7 |
T |
A |
4: 44,931,418 (GRCm39) |
H202Q |
possibly damaging |
Het |
| Zeb2 |
A |
G |
2: 44,891,725 (GRCm39) |
Y276H |
probably damaging |
Het |
| Zfp867 |
T |
G |
11: 59,355,850 (GRCm39) |
Q68P |
probably benign |
Het |
|
| Other mutations in Dlg1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01604:Dlg1
|
APN |
16 |
31,675,256 (GRCm39) |
splice site |
probably benign |
|
|
IGL02277:Dlg1
|
APN |
16 |
31,609,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02897:Dlg1
|
APN |
16 |
31,590,674 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03025:Dlg1
|
APN |
16 |
31,624,545 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03271:Dlg1
|
APN |
16 |
31,676,710 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
PIT4812001:Dlg1
|
UTSW |
16 |
31,665,703 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0068:Dlg1
|
UTSW |
16 |
31,655,018 (GRCm39) |
unclassified |
probably benign |
|
|
R0115:Dlg1
|
UTSW |
16 |
31,624,508 (GRCm39) |
nonsense |
probably null |
|
|
R0128:Dlg1
|
UTSW |
16 |
31,676,883 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0257:Dlg1
|
UTSW |
16 |
31,661,671 (GRCm39) |
splice site |
probably benign |
|
|
R0268:Dlg1
|
UTSW |
16 |
31,503,011 (GRCm39) |
missense |
probably benign |
|
|
R0312:Dlg1
|
UTSW |
16 |
31,609,085 (GRCm39) |
missense |
probably benign |
|
|
R0321:Dlg1
|
UTSW |
16 |
31,676,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0355:Dlg1
|
UTSW |
16 |
31,502,992 (GRCm39) |
nonsense |
probably null |
|
|
R0538:Dlg1
|
UTSW |
16 |
31,615,682 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0540:Dlg1
|
UTSW |
16 |
31,656,992 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0607:Dlg1
|
UTSW |
16 |
31,656,992 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0607:Dlg1
|
UTSW |
16 |
31,484,398 (GRCm39) |
missense |
probably benign |
0.37 |
|
R0894:Dlg1
|
UTSW |
16 |
31,561,965 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1107:Dlg1
|
UTSW |
16 |
31,665,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1349:Dlg1
|
UTSW |
16 |
31,631,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1372:Dlg1
|
UTSW |
16 |
31,631,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Dlg1
|
UTSW |
16 |
31,661,640 (GRCm39) |
splice site |
probably null |
|
|
R1468:Dlg1
|
UTSW |
16 |
31,661,640 (GRCm39) |
splice site |
probably null |
|
|
R1696:Dlg1
|
UTSW |
16 |
31,600,616 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1772:Dlg1
|
UTSW |
16 |
31,484,485 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1795:Dlg1
|
UTSW |
16 |
31,561,965 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2106:Dlg1
|
UTSW |
16 |
31,631,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2206:Dlg1
|
UTSW |
16 |
31,672,664 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2207:Dlg1
|
UTSW |
16 |
31,672,664 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2846:Dlg1
|
UTSW |
16 |
31,682,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3954:Dlg1
|
UTSW |
16 |
31,676,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4714:Dlg1
|
UTSW |
16 |
31,609,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4758:Dlg1
|
UTSW |
16 |
31,610,570 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4898:Dlg1
|
UTSW |
16 |
31,676,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4964:Dlg1
|
UTSW |
16 |
31,573,626 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4966:Dlg1
|
UTSW |
16 |
31,573,626 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4985:Dlg1
|
UTSW |
16 |
31,606,953 (GRCm39) |
splice site |
probably null |
|
|
R5068:Dlg1
|
UTSW |
16 |
31,503,113 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5069:Dlg1
|
UTSW |
16 |
31,503,113 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5078:Dlg1
|
UTSW |
16 |
31,675,287 (GRCm39) |
nonsense |
probably null |
|
|
R5090:Dlg1
|
UTSW |
16 |
31,656,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5225:Dlg1
|
UTSW |
16 |
31,655,085 (GRCm39) |
missense |
probably benign |
0.21 |
|
R5888:Dlg1
|
UTSW |
16 |
31,610,704 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5950:Dlg1
|
UTSW |
16 |
31,484,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6029:Dlg1
|
UTSW |
16 |
31,612,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6132:Dlg1
|
UTSW |
16 |
31,655,059 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6246:Dlg1
|
UTSW |
16 |
31,484,468 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6294:Dlg1
|
UTSW |
16 |
31,656,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6322:Dlg1
|
UTSW |
16 |
31,675,297 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7147:Dlg1
|
UTSW |
16 |
31,610,672 (GRCm39) |
missense |
probably benign |
|
|
R7216:Dlg1
|
UTSW |
16 |
31,615,736 (GRCm39) |
frame shift |
probably null |
|
|
R7963:Dlg1
|
UTSW |
16 |
31,609,119 (GRCm39) |
missense |
probably null |
0.92 |
|
R7985:Dlg1
|
UTSW |
16 |
31,606,923 (GRCm39) |
nonsense |
probably null |
|
|
R8041:Dlg1
|
UTSW |
16 |
31,656,885 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8111:Dlg1
|
UTSW |
16 |
31,661,620 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R8751:Dlg1
|
UTSW |
16 |
31,600,648 (GRCm39) |
missense |
probably benign |
|
|
R9052:Dlg1
|
UTSW |
16 |
31,656,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9725:Dlg1
|
UTSW |
16 |
31,665,683 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9741:Dlg1
|
UTSW |
16 |
31,676,735 (GRCm39) |
nonsense |
probably null |
|
|
X0021:Dlg1
|
UTSW |
16 |
31,484,526 (GRCm39) |
critical splice donor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CTAAGTACCTAGCATGTGGTTAATG -3'
(R):5'- ACTCAGATTCTGTAGAGGATAACAG -3'
Sequencing Primer
(F):5'- TGCTGGCTTTTGAGAAATGTATAC -3'
(R):5'- TTCTGTAGAGGATAACAGGATGAC -3'
|
| Posted On |
2022-10-06 |
Incidental Mutation