Incidental Mutation 'IGL01288:Il36b'
ID 72830
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Il36b
Ensembl Gene ENSMUSG00000026985
Gene Name interleukin 36B
Synonyms If36b, Il1f8, 2310043N20Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # IGL01288
Quality Score
Status
Chromosome 2
Chromosomal Location 24043184-24050115 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 24049925 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 179 (I179L)
Ref Sequence ENSEMBL: ENSMUSP00000028363 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028363]
AlphaFold Q9D6Z6
Predicted Effect probably benign
Transcript: ENSMUST00000028363
AA Change: I179L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000028363
Gene: ENSMUSG00000026985
AA Change: I179L

DomainStartEndE-ValueType
IL1 33 180 3.19e-22 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsf3 G T 8: 123,507,381 (GRCm39) probably benign Het
Acsl3 G T 1: 78,677,476 (GRCm39) W490L possibly damaging Het
Ahnak A G 19: 8,979,858 (GRCm39) I381V possibly damaging Het
Aox1 A G 1: 58,333,566 (GRCm39) Y261C probably damaging Het
Ap3m2 T C 8: 23,293,931 (GRCm39) T40A probably benign Het
Arfgef1 C T 1: 10,283,436 (GRCm39) A158T possibly damaging Het
Atp1a4 T C 1: 172,085,474 (GRCm39) E43G possibly damaging Het
Cog5 C T 12: 31,936,205 (GRCm39) T584I probably benign Het
Cpa1 G A 6: 30,640,582 (GRCm39) V75M probably damaging Het
Cul7 A G 17: 46,968,733 (GRCm39) probably benign Het
Dennd2b A G 7: 109,139,029 (GRCm39) I668T probably damaging Het
Dop1b T C 16: 93,536,181 (GRCm39) I93T possibly damaging Het
Dyrk2 T C 10: 118,696,604 (GRCm39) Y218C probably damaging Het
Efr3b T C 12: 4,032,865 (GRCm39) Y164C probably damaging Het
Etos1 C A 7: 130,373,935 (GRCm39) probably benign Het
Fam13a A G 6: 58,933,712 (GRCm39) Y293H probably damaging Het
Gde1 A T 7: 118,290,863 (GRCm39) V154D possibly damaging Het
Glyat A G 19: 12,627,719 (GRCm39) T105A possibly damaging Het
Kif21b C T 1: 136,099,922 (GRCm39) T1492M probably benign Het
Kmt2d G T 15: 98,762,925 (GRCm39) P282T probably damaging Het
Lgi4 A G 7: 30,768,468 (GRCm39) E489G probably benign Het
Lipn A C 19: 34,056,435 (GRCm39) E260D probably benign Het
Mdn1 A G 4: 32,730,864 (GRCm39) D2911G probably benign Het
Nab2 C T 10: 127,500,978 (GRCm39) R38Q probably damaging Het
Or1e35 A T 11: 73,798,139 (GRCm39) Y60N probably damaging Het
Or4c1 A T 2: 89,133,816 (GRCm39) V40E possibly damaging Het
Or4p22 T A 2: 88,317,592 (GRCm39) I172K probably damaging Het
Or52i2 A G 7: 102,319,858 (GRCm39) T244A probably damaging Het
Or5t16 C A 2: 86,818,598 (GRCm39) M307I probably benign Het
Or6f2 T C 7: 139,756,528 (GRCm39) L165P probably damaging Het
Osbpl6 T C 2: 76,395,167 (GRCm39) S337P probably damaging Het
Phf8 T C X: 150,330,921 (GRCm39) probably null Het
Pik3c2b C T 1: 133,022,543 (GRCm39) H1162Y probably damaging Het
Plek2 T C 12: 78,941,727 (GRCm39) D134G possibly damaging Het
Rnf139 G A 15: 58,771,028 (GRCm39) R351H probably damaging Het
Shld2 A T 14: 33,981,600 (GRCm39) Y513N probably benign Het
Skint5 T C 4: 113,381,332 (GRCm39) probably benign Het
Slc12a9 C T 5: 137,329,200 (GRCm39) probably null Het
Stradb C A 1: 59,031,460 (GRCm39) H216N possibly damaging Het
Tex15 C T 8: 34,061,412 (GRCm39) H281Y probably benign Het
Tg G T 15: 66,608,125 (GRCm39) V237L possibly damaging Het
Tns1 T A 1: 73,992,969 (GRCm39) T570S probably damaging Het
Tpm1 C T 9: 66,943,337 (GRCm39) R105H probably damaging Het
Wdfy3 G T 5: 102,049,857 (GRCm39) probably null Het
Zc3h12c A G 9: 52,028,951 (GRCm39) probably benign Het
Zmynd8 T A 2: 165,654,734 (GRCm39) S584C probably damaging Het
Other mutations in Il36b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01944:Il36b APN 2 24,045,291 (GRCm39) missense probably damaging 1.00
IGL02379:Il36b APN 2 24,044,650 (GRCm39) missense probably benign 0.01
R0035:Il36b UTSW 2 24,049,890 (GRCm39) missense probably benign 0.19
R0035:Il36b UTSW 2 24,049,890 (GRCm39) missense probably benign 0.19
R2137:Il36b UTSW 2 24,044,672 (GRCm39) missense probably benign 0.00
R2139:Il36b UTSW 2 24,044,672 (GRCm39) missense probably benign 0.00
R4052:Il36b UTSW 2 24,049,844 (GRCm39) missense probably damaging 1.00
R4096:Il36b UTSW 2 24,048,826 (GRCm39) missense possibly damaging 0.66
R4705:Il36b UTSW 2 24,044,630 (GRCm39) missense probably benign 0.00
R5785:Il36b UTSW 2 24,044,661 (GRCm39) missense probably benign 0.00
R6541:Il36b UTSW 2 24,049,827 (GRCm39) missense probably damaging 1.00
R7517:Il36b UTSW 2 24,049,890 (GRCm39) missense probably benign 0.02
R7752:Il36b UTSW 2 24,048,826 (GRCm39) missense possibly damaging 0.66
R7858:Il36b UTSW 2 24,044,626 (GRCm39) missense probably benign 0.00
R8252:Il36b UTSW 2 24,048,825 (GRCm39) missense possibly damaging 0.46
R8820:Il36b UTSW 2 24,049,892 (GRCm39) nonsense probably null
Posted On 2013-10-07