Incidental Mutation 'R9680:Olfr767'
ID 728498
Institutional Source Beutler Lab
Gene Symbol Olfr767
Ensembl Gene ENSMUSG00000059762
Gene Name olfactory receptor 767
Synonyms MOR115-1, GA_x6K02T2PULF-10765431-10764502
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R9680 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 129074825-129082910 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 129079489 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 158 (I158N)
Ref Sequence ENSEMBL: ENSMUSP00000150151 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082131] [ENSMUST00000213579]
AlphaFold Q8VG33
Predicted Effect probably benign
Transcript: ENSMUST00000082131
AA Change: I158N

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000080775
Gene: ENSMUSG00000059762
AA Change: I158N

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.9e-49 PFAM
Pfam:7tm_1 39 288 3.6e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213579
AA Change: I158N

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik A G 15: 8,202,301 N1077S possibly damaging Het
Adam25 T A 8: 40,755,202 Y502N probably damaging Het
Adam6a T A 12: 113,545,864 L619* probably null Het
Akap9 A T 5: 3,961,587 R763S probably benign Het
Akt3 G A 1: 177,131,073 P24S probably damaging Het
Ano2 A T 6: 125,880,419 probably null Het
B4galnt4 G A 7: 141,068,044 R491Q possibly damaging Het
Bahcc1 A G 11: 120,272,460 D528G possibly damaging Het
Camk1g G T 1: 193,348,175 Q409K probably benign Het
Cdh3 T A 8: 106,547,764 N638K probably benign Het
Cgnl1 T A 9: 71,655,350 E882D possibly damaging Het
Cpxm2 C T 7: 132,059,922 E379K probably damaging Het
Cyp3a16 A G 5: 145,452,880 L225P probably damaging Het
Dchs1 T C 7: 105,762,418 E1497G probably damaging Het
Denr T A 5: 123,927,054 S157T possibly damaging Het
Disp3 A G 4: 148,271,644 I253T probably damaging Het
Dlgap2 C T 8: 14,846,653 T1043M probably damaging Het
Epb41l5 T C 1: 119,608,074 T355A probably damaging Het
Etv6 G A 6: 134,036,099 probably benign Het
Fbn1 T C 2: 125,468,564 I141V probably benign Het
Fsip2 T G 2: 82,988,928 S5002A probably benign Het
Gbf1 T G 19: 46,283,398 V1576G probably damaging Het
Gm853 A G 4: 130,221,734 V7A probably benign Het
Gmfg T A 7: 28,441,308 probably null Het
Gsdmc4 T C 15: 63,902,857 E25G possibly damaging Het
Igkv6-23 A T 6: 70,260,900 L12M possibly damaging Het
Kank1 G A 19: 25,410,774 V604M probably damaging Het
Kctd1 A G 18: 15,007,765 V40A probably damaging Het
Krt222 T C 11: 99,236,239 K185R possibly damaging Het
Lipm T C 19: 34,112,094 F151L probably damaging Het
Lrrc2 A T 9: 110,962,642 N154I probably damaging Het
Map1a T A 2: 121,302,384 M1227K probably damaging Het
Med1 T C 11: 98,180,288 T78A probably damaging Het
Mrm1 A G 11: 84,819,318 S19P possibly damaging Het
Naf1 GCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAACTGGGATGCGGGCGGAAGACCACCACCGCCGCCAGCCCCGAACTCGGATCCCGGCGGAAGACC GCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAACTGGGATGCGGGCGGAAGACCACCACCGCCGCCAGCCCCGAACTCGGATCCCGGCGGAAGACC 8: 66,860,548 probably benign Het
Nap1l1 A G 10: 111,494,796 Y354C probably damaging Het
Npr1 A G 3: 90,461,141 V474A probably benign Het
Nyap1 A T 5: 137,735,578 S398T probably damaging Het
Obox7 C T 7: 14,664,142 Q36* probably null Het
Olfr1109 A T 2: 87,093,046 M117K possibly damaging Het
P3h1 T A 4: 119,233,231 L92H probably benign Het
Pappa2 T C 1: 158,782,248 T1548A possibly damaging Het
Pnisr A G 4: 21,873,586 E443G probably damaging Het
Prdm2 A G 4: 143,132,509 S1404P possibly damaging Het
Prom1 A T 5: 44,032,942 probably null Het
Rbm27 A T 18: 42,322,121 Q646H probably damaging Het
Scamp3 C T 3: 89,180,254 R134* probably null Het
Scrt2 T C 2: 152,082,098 C17R probably benign Het
Setbp1 A G 18: 78,859,283 S390P probably benign Het
Shank2 A T 7: 144,411,100 D815V probably damaging Het
Sirt7 G A 11: 120,620,470 T285M Het
Sis T G 3: 72,956,288 S206R probably benign Het
Slc24a4 T G 12: 102,227,075 D206E possibly damaging Het
Slc26a4 C A 12: 31,535,293 G501C probably damaging Het
Sptb T C 12: 76,630,715 N115S probably damaging Het
Srprb T C 9: 103,197,608 T112A possibly damaging Het
Tbk1 G T 10: 121,553,936 A537E probably benign Het
Tbx19 T A 1: 165,142,498 H274L probably damaging Het
Tmem130 A G 5: 144,737,423 S394P probably damaging Het
Tmem40 A G 6: 115,741,556 S104P possibly damaging Het
Tmprss2 T A 16: 97,578,626 Q158L probably damaging Het
Tnip1 A T 11: 54,938,050 V97D possibly damaging Het
Tpr T A 1: 150,439,136 S1985T probably benign Het
Traf7 CA CAA 17: 24,527,763 probably benign Het
Trio G T 15: 27,744,072 N2591K possibly damaging Het
Ushbp1 A T 8: 71,385,929 C618S possibly damaging Het
Usp34 A G 11: 23,367,385 S834G possibly damaging Het
Vmn2r103 C A 17: 19,799,263 C536* probably null Het
Vmn2r124 T A 17: 18,073,496 V615D probably damaging Het
Zbtb38 G A 9: 96,688,344 T229I probably benign Het
Zfhx4 T A 3: 5,400,596 V1963E probably damaging Het
Zfp142 G A 1: 74,571,774 T954M probably benign Het
Zgrf1 A G 3: 127,615,567 Y1730C probably benign Het
Other mutations in Olfr767
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01784:Olfr767 APN 10 129079355 missense probably benign 0.13
IGL01945:Olfr767 APN 10 129079303 missense probably damaging 1.00
IGL02341:Olfr767 APN 10 129079461 nonsense probably null
IGL02389:Olfr767 APN 10 129079230 missense probably damaging 0.97
IGL02516:Olfr767 APN 10 129079793 missense possibly damaging 0.95
IGL02755:Olfr767 APN 10 129079196 missense probably benign 0.00
R0145:Olfr767 UTSW 10 129079363 missense probably damaging 0.97
R0453:Olfr767 UTSW 10 129079771 missense probably damaging 0.97
R0578:Olfr767 UTSW 10 129079193 missense probably damaging 1.00
R1034:Olfr767 UTSW 10 129079961 start codon destroyed probably benign 0.43
R1494:Olfr767 UTSW 10 129079615 missense probably damaging 1.00
R1941:Olfr767 UTSW 10 129079954 missense probably damaging 0.99
R3707:Olfr767 UTSW 10 129079385 missense probably benign 0.31
R5405:Olfr767 UTSW 10 129079396 missense probably damaging 0.99
R5716:Olfr767 UTSW 10 129079555 missense probably benign 0.00
R8224:Olfr767 UTSW 10 129079435 missense possibly damaging 0.90
Z1177:Olfr767 UTSW 10 129080052 critical splice acceptor site probably benign
Predicted Primers PCR Primer
(F):5'- AAAGCCTTTGTCCTTTGCTGG -3'
(R):5'- CCATCTTTCTTGGAGCAACAG -3'

Sequencing Primer
(F):5'- CTGAAGGGAGCTTGAGAATTGTC -3'
(R):5'- GAGCAACAGAGTTTTATCTCCTGGC -3'
Posted On 2022-10-06