Incidental Mutation 'R9680:Med1'
| ID |
728502 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Med1
|
| Ensembl Gene |
ENSMUSG00000018160 |
| Gene Name |
mediator complex subunit 1 |
| Synonyms |
DRIP205, TRAP220, PBP, Pparbp, CRSP210, l11Jus15, TRAP 220 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R9680 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
98042980-98084119 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 98071114 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 78
(T78A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000103169
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000018304]
[ENSMUST00000092735]
[ENSMUST00000107545]
|
| AlphaFold |
Q925J9 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000018304
AA Change: T63A
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000018304
Gene: ENSMUSG00000018160
AA Change: T63A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Med1
|
18 |
414 |
3.7e-112 |
PFAM |
|
low complexity region
|
536 |
559 |
N/A |
INTRINSIC |
|
low complexity region
|
595 |
619 |
N/A |
INTRINSIC |
|
low complexity region
|
667 |
678 |
N/A |
INTRINSIC |
|
low complexity region
|
960 |
981 |
N/A |
INTRINSIC |
|
low complexity region
|
989 |
999 |
N/A |
INTRINSIC |
|
low complexity region
|
1015 |
1036 |
N/A |
INTRINSIC |
|
low complexity region
|
1042 |
1054 |
N/A |
INTRINSIC |
|
low complexity region
|
1063 |
1138 |
N/A |
INTRINSIC |
|
low complexity region
|
1170 |
1183 |
N/A |
INTRINSIC |
|
low complexity region
|
1205 |
1243 |
N/A |
INTRINSIC |
|
low complexity region
|
1250 |
1281 |
N/A |
INTRINSIC |
|
low complexity region
|
1344 |
1364 |
N/A |
INTRINSIC |
|
low complexity region
|
1482 |
1503 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000092735
AA Change: T78A
PolyPhen 2
Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000090411
Gene: ENSMUSG00000018160
AA Change: T78A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Med1
|
33 |
429 |
1.2e-113 |
PFAM |
|
transmembrane domain
|
585 |
607 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000107545
AA Change: T78A
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000103169
Gene: ENSMUSG00000018160
AA Change: T78A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Med1
|
59 |
426 |
2.9e-74 |
PFAM |
|
low complexity region
|
551 |
574 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
634 |
N/A |
INTRINSIC |
|
low complexity region
|
682 |
693 |
N/A |
INTRINSIC |
|
low complexity region
|
975 |
996 |
N/A |
INTRINSIC |
|
low complexity region
|
1004 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1030 |
1051 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1078 |
1153 |
N/A |
INTRINSIC |
|
low complexity region
|
1185 |
1198 |
N/A |
INTRINSIC |
|
low complexity region
|
1220 |
1258 |
N/A |
INTRINSIC |
|
low complexity region
|
1265 |
1296 |
N/A |
INTRINSIC |
|
low complexity region
|
1359 |
1379 |
N/A |
INTRINSIC |
|
low complexity region
|
1497 |
1518 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for targeted null mutations have defects of placental vasculature, heart, and lens, arrested erythrocytic differentiation, impaired neuronal development, and die by embryonic day 11.5. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 73 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam25 |
T |
A |
8: 41,208,239 (GRCm39) |
Y502N |
probably damaging |
Het |
| Adam6a |
T |
A |
12: 113,509,484 (GRCm39) |
L619* |
probably null |
Het |
| Akap9 |
A |
T |
5: 4,011,587 (GRCm39) |
R763S |
probably benign |
Het |
| Akt3 |
G |
A |
1: 176,958,639 (GRCm39) |
P24S |
probably damaging |
Het |
| Ano2 |
A |
T |
6: 125,857,382 (GRCm39) |
|
probably null |
Het |
| B4galnt4 |
G |
A |
7: 140,647,957 (GRCm39) |
R491Q |
possibly damaging |
Het |
| Bahcc1 |
A |
G |
11: 120,163,286 (GRCm39) |
D528G |
possibly damaging |
Het |
| Camk1g |
G |
T |
1: 193,030,483 (GRCm39) |
Q409K |
probably benign |
Het |
| Cdh3 |
T |
A |
8: 107,274,396 (GRCm39) |
N638K |
probably benign |
Het |
| Cgnl1 |
T |
A |
9: 71,562,632 (GRCm39) |
E882D |
possibly damaging |
Het |
| Cplane1 |
A |
G |
15: 8,231,785 (GRCm39) |
N1077S |
possibly damaging |
Het |
| Cpxm2 |
C |
T |
7: 131,661,651 (GRCm39) |
E379K |
probably damaging |
Het |
| Cyp3a16 |
A |
G |
5: 145,389,690 (GRCm39) |
L225P |
probably damaging |
Het |
| Dchs1 |
T |
C |
7: 105,411,625 (GRCm39) |
E1497G |
probably damaging |
Het |
| Denr |
T |
A |
5: 124,065,117 (GRCm39) |
S157T |
possibly damaging |
Het |
| Disp3 |
A |
G |
4: 148,356,101 (GRCm39) |
I253T |
probably damaging |
Het |
| Dlgap2 |
C |
T |
8: 14,896,653 (GRCm39) |
T1043M |
probably damaging |
Het |
| Epb41l5 |
T |
C |
1: 119,535,804 (GRCm39) |
T355A |
probably damaging |
Het |
| Etv6 |
G |
A |
6: 134,013,062 (GRCm39) |
|
probably benign |
Het |
| Fbn1 |
T |
C |
2: 125,310,484 (GRCm39) |
I141V |
probably benign |
Het |
| Fsip2 |
T |
G |
2: 82,819,272 (GRCm39) |
S5002A |
probably benign |
Het |
| Gbf1 |
T |
G |
19: 46,271,837 (GRCm39) |
V1576G |
probably damaging |
Het |
| Gmfg |
T |
A |
7: 28,140,733 (GRCm39) |
|
probably null |
Het |
| Gsdmc4 |
T |
C |
15: 63,774,706 (GRCm39) |
E25G |
possibly damaging |
Het |
| Igkv6-23 |
A |
T |
6: 70,237,884 (GRCm39) |
L12M |
possibly damaging |
Het |
| Kank1 |
G |
A |
19: 25,388,138 (GRCm39) |
V604M |
probably damaging |
Het |
| Kctd1 |
A |
G |
18: 15,140,822 (GRCm39) |
V40A |
probably damaging |
Het |
| Krt222 |
T |
C |
11: 99,127,065 (GRCm39) |
K185R |
possibly damaging |
Het |
| Ldc1 |
A |
G |
4: 130,115,527 (GRCm39) |
V7A |
probably benign |
Het |
| Lipm |
T |
C |
19: 34,089,494 (GRCm39) |
F151L |
probably damaging |
Het |
| Lrrc2 |
A |
T |
9: 110,791,710 (GRCm39) |
N154I |
probably damaging |
Het |
| Map1a |
T |
A |
2: 121,132,865 (GRCm39) |
M1227K |
probably damaging |
Het |
| Mrm1 |
A |
G |
11: 84,710,144 (GRCm39) |
S19P |
possibly damaging |
Het |
| Naf1 |
GCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAACTGGGATGCGGGCGGAAGACCACCACCGCCGCCAGCCCCGAACTCGGATCCCGGCGGAAGACC |
GCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAACTGGGATGCGGGCGGAAGACCACCACCGCCGCCAGCCCCGAACTCGGATCCCGGCGGAAGACC |
8: 67,313,200 (GRCm39) |
|
probably benign |
Het |
| Nap1l1 |
A |
G |
10: 111,330,657 (GRCm39) |
Y354C |
probably damaging |
Het |
| Npr1 |
A |
G |
3: 90,368,448 (GRCm39) |
V474A |
probably benign |
Het |
| Nyap1 |
A |
T |
5: 137,733,840 (GRCm39) |
S398T |
probably damaging |
Het |
| Obox7 |
C |
T |
7: 14,398,067 (GRCm39) |
Q36* |
probably null |
Het |
| Or5aq6 |
A |
T |
2: 86,923,390 (GRCm39) |
M117K |
possibly damaging |
Het |
| Or6c8 |
A |
T |
10: 128,915,358 (GRCm39) |
I158N |
probably benign |
Het |
| P3h1 |
T |
A |
4: 119,090,428 (GRCm39) |
L92H |
probably benign |
Het |
| Pappa2 |
T |
C |
1: 158,609,818 (GRCm39) |
T1548A |
possibly damaging |
Het |
| Pnisr |
A |
G |
4: 21,873,586 (GRCm39) |
E443G |
probably damaging |
Het |
| Prdm2 |
A |
G |
4: 142,859,079 (GRCm39) |
S1404P |
possibly damaging |
Het |
| Prom1 |
A |
T |
5: 44,190,284 (GRCm39) |
|
probably null |
Het |
| Rbm27 |
A |
T |
18: 42,455,186 (GRCm39) |
Q646H |
probably damaging |
Het |
| Scamp3 |
C |
T |
3: 89,087,561 (GRCm39) |
R134* |
probably null |
Het |
| Scrt2 |
T |
C |
2: 151,924,018 (GRCm39) |
C17R |
probably benign |
Het |
| Setbp1 |
A |
G |
18: 78,902,498 (GRCm39) |
S390P |
probably benign |
Het |
| Shank2 |
A |
T |
7: 143,964,837 (GRCm39) |
D815V |
probably damaging |
Het |
| Sirt7 |
G |
A |
11: 120,511,296 (GRCm39) |
T285M |
|
Het |
| Sis |
T |
G |
3: 72,863,621 (GRCm39) |
S206R |
probably benign |
Het |
| Slc24a4 |
T |
G |
12: 102,193,334 (GRCm39) |
D206E |
possibly damaging |
Het |
| Slc26a4 |
C |
A |
12: 31,585,292 (GRCm39) |
G501C |
probably damaging |
Het |
| Sptb |
T |
C |
12: 76,677,489 (GRCm39) |
N115S |
probably damaging |
Het |
| Srprb |
T |
C |
9: 103,074,807 (GRCm39) |
T112A |
possibly damaging |
Het |
| Tbk1 |
G |
T |
10: 121,389,841 (GRCm39) |
A537E |
probably benign |
Het |
| Tbx19 |
T |
A |
1: 164,970,067 (GRCm39) |
H274L |
probably damaging |
Het |
| Tmem130 |
A |
G |
5: 144,674,233 (GRCm39) |
S394P |
probably damaging |
Het |
| Tmem40 |
A |
G |
6: 115,718,517 (GRCm39) |
S104P |
possibly damaging |
Het |
| Tmprss2 |
T |
A |
16: 97,379,826 (GRCm39) |
Q158L |
probably damaging |
Het |
| Tnip1 |
A |
T |
11: 54,828,876 (GRCm39) |
V97D |
possibly damaging |
Het |
| Tpr |
T |
A |
1: 150,314,887 (GRCm39) |
S1985T |
probably benign |
Het |
| Traf7 |
CA |
CAA |
17: 24,746,737 (GRCm39) |
|
probably benign |
Het |
| Trio |
G |
T |
15: 27,744,158 (GRCm39) |
N2591K |
possibly damaging |
Het |
| Ushbp1 |
A |
T |
8: 71,838,573 (GRCm39) |
C618S |
possibly damaging |
Het |
| Usp34 |
A |
G |
11: 23,317,385 (GRCm39) |
S834G |
possibly damaging |
Het |
| Vmn2r103 |
C |
A |
17: 20,019,525 (GRCm39) |
C536* |
probably null |
Het |
| Vmn2r124 |
T |
A |
17: 18,293,758 (GRCm39) |
V615D |
probably damaging |
Het |
| Zbtb38 |
G |
A |
9: 96,570,397 (GRCm39) |
T229I |
probably benign |
Het |
| Zfhx4 |
T |
A |
3: 5,465,656 (GRCm39) |
V1963E |
probably damaging |
Het |
| Zfp142 |
G |
A |
1: 74,610,933 (GRCm39) |
T954M |
probably benign |
Het |
| Zgrf1 |
A |
G |
3: 127,409,216 (GRCm39) |
Y1730C |
probably benign |
Het |
|
| Other mutations in Med1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00556:Med1
|
APN |
11 |
98,046,510 (GRCm39) |
intron |
probably benign |
|
|
IGL00690:Med1
|
APN |
11 |
98,060,226 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01087:Med1
|
APN |
11 |
98,071,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01133:Med1
|
APN |
11 |
98,048,812 (GRCm39) |
nonsense |
probably null |
|
|
IGL02223:Med1
|
APN |
11 |
98,048,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02257:Med1
|
APN |
11 |
98,071,096 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02699:Med1
|
APN |
11 |
98,070,851 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
IGL02706:Med1
|
APN |
11 |
98,047,533 (GRCm39) |
intron |
probably benign |
|
|
IGL02902:Med1
|
APN |
11 |
98,047,335 (GRCm39) |
intron |
probably benign |
|
|
IGL02986:Med1
|
APN |
11 |
98,047,086 (GRCm39) |
intron |
probably benign |
|
|
IGL03011:Med1
|
APN |
11 |
98,051,859 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL03282:Med1
|
APN |
11 |
98,047,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03303:Med1
|
APN |
11 |
98,049,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03342:Med1
|
APN |
11 |
98,080,006 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03410:Med1
|
APN |
11 |
98,080,009 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
PIT4453001:Med1
|
UTSW |
11 |
98,049,243 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0040:Med1
|
UTSW |
11 |
98,057,081 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0206:Med1
|
UTSW |
11 |
98,046,515 (GRCm39) |
intron |
probably benign |
|
|
R0206:Med1
|
UTSW |
11 |
98,046,515 (GRCm39) |
intron |
probably benign |
|
|
R0208:Med1
|
UTSW |
11 |
98,046,515 (GRCm39) |
intron |
probably benign |
|
|
R0310:Med1
|
UTSW |
11 |
98,058,400 (GRCm39) |
missense |
probably benign |
0.38 |
|
R0505:Med1
|
UTSW |
11 |
98,047,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0597:Med1
|
UTSW |
11 |
98,060,264 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0680:Med1
|
UTSW |
11 |
98,070,992 (GRCm39) |
splice site |
probably null |
|
|
R0686:Med1
|
UTSW |
11 |
98,049,230 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0698:Med1
|
UTSW |
11 |
98,046,515 (GRCm39) |
intron |
probably benign |
|
|
R1293:Med1
|
UTSW |
11 |
98,047,862 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1302:Med1
|
UTSW |
11 |
98,048,275 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R1365:Med1
|
UTSW |
11 |
98,046,821 (GRCm39) |
intron |
probably benign |
|
|
R1537:Med1
|
UTSW |
11 |
98,051,772 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1609:Med1
|
UTSW |
11 |
98,051,996 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1631:Med1
|
UTSW |
11 |
98,046,452 (GRCm39) |
intron |
probably benign |
|
|
R1792:Med1
|
UTSW |
11 |
98,048,109 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1831:Med1
|
UTSW |
11 |
98,047,437 (GRCm39) |
intron |
probably benign |
|
|
R1837:Med1
|
UTSW |
11 |
98,060,238 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2366:Med1
|
UTSW |
11 |
98,052,008 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3754:Med1
|
UTSW |
11 |
98,057,548 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R3762:Med1
|
UTSW |
11 |
98,046,341 (GRCm39) |
intron |
probably benign |
|
|
R4012:Med1
|
UTSW |
11 |
98,062,532 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4112:Med1
|
UTSW |
11 |
98,070,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4384:Med1
|
UTSW |
11 |
98,043,688 (GRCm39) |
unclassified |
probably benign |
|
|
R4579:Med1
|
UTSW |
11 |
98,049,248 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R4740:Med1
|
UTSW |
11 |
98,071,090 (GRCm39) |
nonsense |
probably null |
|
|
R4819:Med1
|
UTSW |
11 |
98,046,258 (GRCm39) |
intron |
probably benign |
|
|
R4879:Med1
|
UTSW |
11 |
98,046,186 (GRCm39) |
unclassified |
probably benign |
|
|
R4993:Med1
|
UTSW |
11 |
98,054,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5040:Med1
|
UTSW |
11 |
98,046,230 (GRCm39) |
intron |
probably benign |
|
|
R5249:Med1
|
UTSW |
11 |
98,048,066 (GRCm39) |
missense |
probably benign |
0.43 |
|
R5373:Med1
|
UTSW |
11 |
98,054,789 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5374:Med1
|
UTSW |
11 |
98,054,789 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5552:Med1
|
UTSW |
11 |
98,057,157 (GRCm39) |
nonsense |
probably null |
|
|
R5692:Med1
|
UTSW |
11 |
98,047,206 (GRCm39) |
intron |
probably benign |
|
|
R6010:Med1
|
UTSW |
11 |
98,049,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6149:Med1
|
UTSW |
11 |
98,074,679 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R6417:Med1
|
UTSW |
11 |
98,048,054 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7301:Med1
|
UTSW |
11 |
98,043,634 (GRCm39) |
missense |
probably benign |
0.23 |
|
R7507:Med1
|
UTSW |
11 |
98,048,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7529:Med1
|
UTSW |
11 |
98,046,791 (GRCm39) |
missense |
unknown |
|
|
R7588:Med1
|
UTSW |
11 |
98,046,398 (GRCm39) |
missense |
unknown |
|
|
R7654:Med1
|
UTSW |
11 |
98,060,189 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7662:Med1
|
UTSW |
11 |
98,046,218 (GRCm39) |
missense |
unknown |
|
|
R7679:Med1
|
UTSW |
11 |
98,046,887 (GRCm39) |
missense |
unknown |
|
|
R7862:Med1
|
UTSW |
11 |
98,052,036 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8447:Med1
|
UTSW |
11 |
98,060,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8693:Med1
|
UTSW |
11 |
98,046,599 (GRCm39) |
missense |
unknown |
|
|
R8843:Med1
|
UTSW |
11 |
98,080,102 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9072:Med1
|
UTSW |
11 |
98,080,009 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R9284:Med1
|
UTSW |
11 |
98,046,366 (GRCm39) |
missense |
unknown |
|
|
R9428:Med1
|
UTSW |
11 |
98,080,049 (GRCm39) |
nonsense |
probably null |
|
|
R9465:Med1
|
UTSW |
11 |
98,049,144 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9531:Med1
|
UTSW |
11 |
98,048,321 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9537:Med1
|
UTSW |
11 |
98,062,586 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R9548:Med1
|
UTSW |
11 |
98,070,884 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9696:Med1
|
UTSW |
11 |
98,061,772 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1176:Med1
|
UTSW |
11 |
98,052,009 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGATCTAACTGCACTTCCAC -3'
(R):5'- TGTCCTTTACCTGACTACTGGG -3'
Sequencing Primer
(F):5'- CTGACGTGATGTAACACTCAGTGC -3'
(R):5'- TGGGTCACAGCCAAGCCTC -3'
|
| Posted On |
2022-10-06 |
Incidental Mutation