Incidental Mutation 'R9680:Vmn2r103'
| ID |
728515 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r103
|
| Ensembl Gene |
ENSMUSG00000091771 |
| Gene Name |
vomeronasal 2, receptor 103 |
| Synonyms |
EG627636 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.059)
|
| Stock # |
R9680 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
19773363-19812536 bp(+) (GRCm38) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to A
at 19799263 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Stop codon
at position 536
(C536*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126756
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172203]
|
| AlphaFold |
E9PWW0 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000172203
AA Change: C536*
|
| SMART Domains |
Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: C536*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
449 |
1.3e-37 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
3.5e-22 |
PFAM |
|
Pfam:7tm_3
|
595 |
830 |
1.1e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 73 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2410089E03Rik |
A |
G |
15: 8,202,301 (GRCm38) |
N1077S |
possibly damaging |
Het |
| Adam25 |
T |
A |
8: 40,755,202 (GRCm38) |
Y502N |
probably damaging |
Het |
| Adam6a |
T |
A |
12: 113,545,864 (GRCm38) |
L619* |
probably null |
Het |
| Akap9 |
A |
T |
5: 3,961,587 (GRCm38) |
R763S |
probably benign |
Het |
| Akt3 |
G |
A |
1: 177,131,073 (GRCm38) |
P24S |
probably damaging |
Het |
| Ano2 |
A |
T |
6: 125,880,419 (GRCm38) |
|
probably null |
Het |
| B4galnt4 |
G |
A |
7: 141,068,044 (GRCm38) |
R491Q |
possibly damaging |
Het |
| Bahcc1 |
A |
G |
11: 120,272,460 (GRCm38) |
D528G |
possibly damaging |
Het |
| Camk1g |
G |
T |
1: 193,348,175 (GRCm38) |
Q409K |
probably benign |
Het |
| Cdh3 |
T |
A |
8: 106,547,764 (GRCm38) |
N638K |
probably benign |
Het |
| Cgnl1 |
T |
A |
9: 71,655,350 (GRCm38) |
E882D |
possibly damaging |
Het |
| Cpxm2 |
C |
T |
7: 132,059,922 (GRCm38) |
E379K |
probably damaging |
Het |
| Cyp3a16 |
A |
G |
5: 145,452,880 (GRCm38) |
L225P |
probably damaging |
Het |
| Dchs1 |
T |
C |
7: 105,762,418 (GRCm38) |
E1497G |
probably damaging |
Het |
| Denr |
T |
A |
5: 123,927,054 (GRCm38) |
S157T |
possibly damaging |
Het |
| Disp3 |
A |
G |
4: 148,271,644 (GRCm38) |
I253T |
probably damaging |
Het |
| Dlgap2 |
C |
T |
8: 14,846,653 (GRCm38) |
T1043M |
probably damaging |
Het |
| Epb41l5 |
T |
C |
1: 119,608,074 (GRCm38) |
T355A |
probably damaging |
Het |
| Etv6 |
G |
A |
6: 134,036,099 (GRCm38) |
|
probably benign |
Het |
| Fbn1 |
T |
C |
2: 125,468,564 (GRCm38) |
I141V |
probably benign |
Het |
| Fsip2 |
T |
G |
2: 82,988,928 (GRCm38) |
S5002A |
probably benign |
Het |
| Gbf1 |
T |
G |
19: 46,283,398 (GRCm38) |
V1576G |
probably damaging |
Het |
| Gm853 |
A |
G |
4: 130,221,734 (GRCm38) |
V7A |
probably benign |
Het |
| Gmfg |
T |
A |
7: 28,441,308 (GRCm38) |
|
probably null |
Het |
| Gsdmc4 |
T |
C |
15: 63,902,857 (GRCm38) |
E25G |
possibly damaging |
Het |
| Igkv6-23 |
A |
T |
6: 70,260,900 (GRCm38) |
L12M |
possibly damaging |
Het |
| Kank1 |
G |
A |
19: 25,410,774 (GRCm38) |
V604M |
probably damaging |
Het |
| Kctd1 |
A |
G |
18: 15,007,765 (GRCm38) |
V40A |
probably damaging |
Het |
| Krt222 |
T |
C |
11: 99,236,239 (GRCm38) |
K185R |
possibly damaging |
Het |
| Lipm |
T |
C |
19: 34,112,094 (GRCm38) |
F151L |
probably damaging |
Het |
| Lrrc2 |
A |
T |
9: 110,962,642 (GRCm38) |
N154I |
probably damaging |
Het |
| Map1a |
T |
A |
2: 121,302,384 (GRCm38) |
M1227K |
probably damaging |
Het |
| Med1 |
T |
C |
11: 98,180,288 (GRCm38) |
T78A |
probably damaging |
Het |
| Mrm1 |
A |
G |
11: 84,819,318 (GRCm38) |
S19P |
possibly damaging |
Het |
| Naf1 |
GCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAACTGGGATGCGGGCGGAAGACCACCACCGCCGCCAGCCCCGAACTCGGATCCCGGCGGAAGACC |
GCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCTGCCAGCCCCGAACTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAGCTCGGATCCCGGCGGAAGACCACCGCCGCCGCCAGCCCCGAACTGGGATGCGGGCGGAAGACCACCACCGCCGCCAGCCCCGAACTCGGATCCCGGCGGAAGACC |
8: 66,860,548 (GRCm38) |
|
probably benign |
Het |
| Nap1l1 |
A |
G |
10: 111,494,796 (GRCm38) |
Y354C |
probably damaging |
Het |
| Npr1 |
A |
G |
3: 90,461,141 (GRCm38) |
V474A |
probably benign |
Het |
| Nyap1 |
A |
T |
5: 137,735,578 (GRCm38) |
S398T |
probably damaging |
Het |
| Obox7 |
C |
T |
7: 14,664,142 (GRCm38) |
Q36* |
probably null |
Het |
| Olfr1109 |
A |
T |
2: 87,093,046 (GRCm38) |
M117K |
possibly damaging |
Het |
| Olfr767 |
A |
T |
10: 129,079,489 (GRCm38) |
I158N |
probably benign |
Het |
| P3h1 |
T |
A |
4: 119,233,231 (GRCm38) |
L92H |
probably benign |
Het |
| Pappa2 |
T |
C |
1: 158,782,248 (GRCm38) |
T1548A |
possibly damaging |
Het |
| Pnisr |
A |
G |
4: 21,873,586 (GRCm38) |
E443G |
probably damaging |
Het |
| Prdm2 |
A |
G |
4: 143,132,509 (GRCm38) |
S1404P |
possibly damaging |
Het |
| Prom1 |
A |
T |
5: 44,032,942 (GRCm38) |
|
probably null |
Het |
| Rbm27 |
A |
T |
18: 42,322,121 (GRCm38) |
Q646H |
probably damaging |
Het |
| Scamp3 |
C |
T |
3: 89,180,254 (GRCm38) |
R134* |
probably null |
Het |
| Scrt2 |
T |
C |
2: 152,082,098 (GRCm38) |
C17R |
probably benign |
Het |
| Setbp1 |
A |
G |
18: 78,859,283 (GRCm38) |
S390P |
probably benign |
Het |
| Shank2 |
A |
T |
7: 144,411,100 (GRCm38) |
D815V |
probably damaging |
Het |
| Sirt7 |
G |
A |
11: 120,620,470 (GRCm38) |
T285M |
|
Het |
| Sis |
T |
G |
3: 72,956,288 (GRCm38) |
S206R |
probably benign |
Het |
| Slc24a4 |
T |
G |
12: 102,227,075 (GRCm38) |
D206E |
possibly damaging |
Het |
| Slc26a4 |
C |
A |
12: 31,535,293 (GRCm38) |
G501C |
probably damaging |
Het |
| Sptb |
T |
C |
12: 76,630,715 (GRCm38) |
N115S |
probably damaging |
Het |
| Srprb |
T |
C |
9: 103,197,608 (GRCm38) |
T112A |
possibly damaging |
Het |
| Tbk1 |
G |
T |
10: 121,553,936 (GRCm38) |
A537E |
probably benign |
Het |
| Tbx19 |
T |
A |
1: 165,142,498 (GRCm38) |
H274L |
probably damaging |
Het |
| Tmem130 |
A |
G |
5: 144,737,423 (GRCm38) |
S394P |
probably damaging |
Het |
| Tmem40 |
A |
G |
6: 115,741,556 (GRCm38) |
S104P |
possibly damaging |
Het |
| Tmprss2 |
T |
A |
16: 97,578,626 (GRCm38) |
Q158L |
probably damaging |
Het |
| Tnip1 |
A |
T |
11: 54,938,050 (GRCm38) |
V97D |
possibly damaging |
Het |
| Tpr |
T |
A |
1: 150,439,136 (GRCm38) |
S1985T |
probably benign |
Het |
| Traf7 |
CA |
CAA |
17: 24,527,763 (GRCm38) |
|
probably benign |
Het |
| Trio |
G |
T |
15: 27,744,072 (GRCm38) |
N2591K |
possibly damaging |
Het |
| Ushbp1 |
A |
T |
8: 71,385,929 (GRCm38) |
C618S |
possibly damaging |
Het |
| Usp34 |
A |
G |
11: 23,367,385 (GRCm38) |
S834G |
possibly damaging |
Het |
| Vmn2r124 |
T |
A |
17: 18,073,496 (GRCm38) |
V615D |
probably damaging |
Het |
| Zbtb38 |
G |
A |
9: 96,688,344 (GRCm38) |
T229I |
probably benign |
Het |
| Zfhx4 |
T |
A |
3: 5,400,596 (GRCm38) |
V1963E |
probably damaging |
Het |
| Zfp142 |
G |
A |
1: 74,571,774 (GRCm38) |
T954M |
probably benign |
Het |
| Zgrf1 |
A |
G |
3: 127,615,567 (GRCm38) |
Y1730C |
probably benign |
Het |
|
| Other mutations in Vmn2r103 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00333:Vmn2r103
|
APN |
17 |
19,793,102 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL00939:Vmn2r103
|
APN |
17 |
19,794,965 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01120:Vmn2r103
|
APN |
17 |
19,792,997 (GRCm38) |
missense |
probably benign |
0.06 |
|
IGL01403:Vmn2r103
|
APN |
17 |
19,792,967 (GRCm38) |
missense |
probably benign |
|
|
IGL01404:Vmn2r103
|
APN |
17 |
19,812,434 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01713:Vmn2r103
|
APN |
17 |
19,794,068 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01802:Vmn2r103
|
APN |
17 |
19,799,208 (GRCm38) |
missense |
probably benign |
|
|
IGL02251:Vmn2r103
|
APN |
17 |
19,793,969 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
IGL02466:Vmn2r103
|
APN |
17 |
19,773,369 (GRCm38) |
missense |
probably benign |
|
|
IGL02555:Vmn2r103
|
APN |
17 |
19,811,611 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02668:Vmn2r103
|
APN |
17 |
19,794,127 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL02715:Vmn2r103
|
APN |
17 |
19,793,956 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL02735:Vmn2r103
|
APN |
17 |
19,812,248 (GRCm38) |
missense |
probably benign |
0.27 |
|
IGL03101:Vmn2r103
|
APN |
17 |
19,773,520 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0003:Vmn2r103
|
UTSW |
17 |
19,811,979 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0052:Vmn2r103
|
UTSW |
17 |
19,811,641 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0375:Vmn2r103
|
UTSW |
17 |
19,793,464 (GRCm38) |
missense |
probably benign |
0.12 |
|
R0375:Vmn2r103
|
UTSW |
17 |
19,792,859 (GRCm38) |
missense |
probably benign |
0.06 |
|
R0755:Vmn2r103
|
UTSW |
17 |
19,773,568 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0837:Vmn2r103
|
UTSW |
17 |
19,793,927 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1345:Vmn2r103
|
UTSW |
17 |
19,794,247 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1396:Vmn2r103
|
UTSW |
17 |
19,792,968 (GRCm38) |
missense |
probably benign |
|
|
R1488:Vmn2r103
|
UTSW |
17 |
19,793,660 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1533:Vmn2r103
|
UTSW |
17 |
19,773,400 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1590:Vmn2r103
|
UTSW |
17 |
19,794,234 (GRCm38) |
missense |
probably benign |
|
|
R1928:Vmn2r103
|
UTSW |
17 |
19,811,767 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1942:Vmn2r103
|
UTSW |
17 |
19,812,300 (GRCm38) |
missense |
probably benign |
0.02 |
|
R2071:Vmn2r103
|
UTSW |
17 |
19,793,794 (GRCm38) |
missense |
probably benign |
|
|
R2219:Vmn2r103
|
UTSW |
17 |
19,793,647 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2442:Vmn2r103
|
UTSW |
17 |
19,773,531 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2889:Vmn2r103
|
UTSW |
17 |
19,793,600 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3762:Vmn2r103
|
UTSW |
17 |
19,812,149 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4014:Vmn2r103
|
UTSW |
17 |
19,793,604 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R4331:Vmn2r103
|
UTSW |
17 |
19,794,233 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4630:Vmn2r103
|
UTSW |
17 |
19,793,696 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4631:Vmn2r103
|
UTSW |
17 |
19,793,696 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4632:Vmn2r103
|
UTSW |
17 |
19,793,696 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4660:Vmn2r103
|
UTSW |
17 |
19,811,815 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4801:Vmn2r103
|
UTSW |
17 |
19,795,076 (GRCm38) |
missense |
probably benign |
0.06 |
|
R4802:Vmn2r103
|
UTSW |
17 |
19,795,076 (GRCm38) |
missense |
probably benign |
0.06 |
|
R4931:Vmn2r103
|
UTSW |
17 |
19,811,769 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4995:Vmn2r103
|
UTSW |
17 |
19,773,511 (GRCm38) |
missense |
probably benign |
0.14 |
|
R5309:Vmn2r103
|
UTSW |
17 |
19,793,034 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5312:Vmn2r103
|
UTSW |
17 |
19,793,034 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5329:Vmn2r103
|
UTSW |
17 |
19,812,171 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5611:Vmn2r103
|
UTSW |
17 |
19,793,642 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5684:Vmn2r103
|
UTSW |
17 |
19,792,989 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5715:Vmn2r103
|
UTSW |
17 |
19,794,939 (GRCm38) |
missense |
probably benign |
0.17 |
|
R5907:Vmn2r103
|
UTSW |
17 |
19,812,453 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R6029:Vmn2r103
|
UTSW |
17 |
19,794,216 (GRCm38) |
nonsense |
probably null |
|
|
R6114:Vmn2r103
|
UTSW |
17 |
19,812,325 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6285:Vmn2r103
|
UTSW |
17 |
19,812,144 (GRCm38) |
missense |
probably benign |
|
|
R6292:Vmn2r103
|
UTSW |
17 |
19,793,604 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R6334:Vmn2r103
|
UTSW |
17 |
19,794,082 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R6501:Vmn2r103
|
UTSW |
17 |
19,811,904 (GRCm38) |
missense |
probably benign |
0.29 |
|
R6710:Vmn2r103
|
UTSW |
17 |
19,811,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6774:Vmn2r103
|
UTSW |
17 |
19,773,511 (GRCm38) |
missense |
probably benign |
0.14 |
|
R6981:Vmn2r103
|
UTSW |
17 |
19,793,477 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7768:Vmn2r103
|
UTSW |
17 |
19,812,052 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7816:Vmn2r103
|
UTSW |
17 |
19,794,214 (GRCm38) |
missense |
probably benign |
0.06 |
|
R7885:Vmn2r103
|
UTSW |
17 |
19,793,123 (GRCm38) |
missense |
probably benign |
0.25 |
|
R8002:Vmn2r103
|
UTSW |
17 |
19,799,249 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8031:Vmn2r103
|
UTSW |
17 |
19,793,497 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8140:Vmn2r103
|
UTSW |
17 |
19,811,796 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8186:Vmn2r103
|
UTSW |
17 |
19,811,943 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8559:Vmn2r103
|
UTSW |
17 |
19,812,384 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9413:Vmn2r103
|
UTSW |
17 |
19,811,896 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R9591:Vmn2r103
|
UTSW |
17 |
19,811,659 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R9652:Vmn2r103
|
UTSW |
17 |
19,793,765 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9743:Vmn2r103
|
UTSW |
17 |
19,812,213 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r103
|
UTSW |
17 |
19,795,047 (GRCm38) |
missense |
probably benign |
0.08 |
|
| Predicted Primers |
PCR Primer
(F):5'- AACAATACTCCTGCCTTCTGTGTAT -3'
(R):5'- TACACAGAAAACCCTTGTCTCAA -3'
Sequencing Primer
(F):5'- GCCTTCTGTGTATGACCTTCAAAAAC -3'
(R):5'- GGATGTTTCTGGAGAATAACAACC -3'
|
| Posted On |
2022-10-06 |
Incidental Mutation