Incidental Mutation 'R9682:Fer1l6'
ID 728649
Institutional Source Beutler Lab
Gene Symbol Fer1l6
Ensembl Gene ENSMUSG00000037106
Gene Name fer-1 like family member 6
Synonyms EG631797
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R9682 (G1)
Quality Score 225.009
Status Not validated
Chromosome 15
Chromosomal Location 58381897-58536936 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 58422113 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 104 (T104A)
Ref Sequence ENSEMBL: ENSMUSP00000125718 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000161028]
AlphaFold E0CZ42
Predicted Effect probably benign
Transcript: ENSMUST00000161028
AA Change: T104A

PolyPhen 2 Score 0.031 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000125718
Gene: ENSMUSG00000037106
AA Change: T104A

DomainStartEndE-ValueType
low complexity region 4 20 N/A INTRINSIC
C2 83 179 4.09e-12 SMART
FerI 165 235 2.06e-36 SMART
C2 243 354 5.19e-14 SMART
low complexity region 412 449 N/A INTRINSIC
FerB 714 787 2.53e-45 SMART
C2 829 936 8.84e-8 SMART
C2 1000 1099 3.05e0 SMART
low complexity region 1189 1203 N/A INTRINSIC
low complexity region 1256 1270 N/A INTRINSIC
C2 1361 1460 5.78e-12 SMART
low complexity region 1518 1529 N/A INTRINSIC
C2 1601 1731 1.01e-2 SMART
Pfam:Ferlin_C 1765 1857 2.3e-40 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1a A T 5: 8,752,507 (GRCm39) M493L probably benign Het
Abcb5 T A 12: 118,896,328 (GRCm39) I334F probably damaging Het
Acad9 C T 3: 36,136,268 (GRCm39) A351V possibly damaging Het
Adgrg6 A T 10: 14,316,128 (GRCm39) N536K possibly damaging Het
Alk A T 17: 72,182,058 (GRCm39) L1322M possibly damaging Het
Atp2b1 T C 10: 98,815,662 (GRCm39) V102A possibly damaging Het
Atp8b3 T C 10: 80,371,230 (GRCm39) N48S probably damaging Het
B3gnt4 A T 5: 123,649,516 (GRCm39) I294L probably benign Het
Bnip3 A G 7: 138,496,445 (GRCm39) S88P probably damaging Het
Ccr2 A G 9: 123,906,176 (GRCm39) Y152C probably damaging Het
Cd28 T C 1: 60,804,505 (GRCm39) L161P probably damaging Het
Clcn4 C T 7: 7,299,797 (GRCm39) V11M probably benign Het
Clec4g T A 8: 3,757,713 (GRCm39) S79C unknown Het
Cux1 A T 5: 136,337,116 (GRCm39) S799T probably benign Het
Cyp2t4 A T 7: 26,857,611 (GRCm39) H408L probably damaging Het
Cyp3a41a A T 5: 145,652,326 (GRCm39) W58R possibly damaging Het
Dicer1 A G 12: 104,672,484 (GRCm39) V921A probably damaging Het
Dpysl3 A G 18: 43,491,313 (GRCm39) L268P probably damaging Het
Dus3l G A 17: 57,076,770 (GRCm39) V626I probably benign Het
Epb41 C A 4: 131,655,820 (GRCm39) D337Y Het
Fgd4 T C 16: 16,302,202 (GRCm39) T118A probably benign Het
Gabra4 T A 5: 71,798,415 (GRCm39) Y188F possibly damaging Het
Gm28168 A T 1: 117,875,824 (GRCm39) H151L probably damaging Het
Gm7995 A G 14: 42,133,395 (GRCm39) I91V Het
Heg1 A G 16: 33,541,298 (GRCm39) E485G probably benign Het
Hirip3 A G 7: 126,462,021 (GRCm39) D73G probably benign Het
Igdcc3 A G 9: 65,091,332 (GRCm39) D684G probably benign Het
Kif15 A G 9: 122,815,712 (GRCm39) E502G probably damaging Het
Lrrc31 C T 3: 30,743,423 (GRCm39) V181I probably damaging Het
Lrrc7 G T 3: 157,882,954 (GRCm39) S446R possibly damaging Het
Lyst A G 13: 13,831,526 (GRCm39) E1650G probably benign Het
Map3k6 A G 4: 132,975,419 (GRCm39) Y718C possibly damaging Het
Mta1 T C 12: 113,095,384 (GRCm39) probably null Het
Muc16 C T 9: 18,553,874 (GRCm39) G4140R unknown Het
Nfe2l1 A C 11: 96,710,944 (GRCm39) I428M probably benign Het
Nup210l T A 3: 90,051,469 (GRCm39) Y538N possibly damaging Het
Nxpe4 G A 9: 48,304,248 (GRCm39) V112M probably benign Het
Or1e16 C T 11: 73,286,025 (GRCm39) M274I probably benign Het
Or4c112 T A 2: 88,854,296 (GRCm39) Q17L possibly damaging Het
Or4k40 T A 2: 111,250,737 (GRCm39) K186N probably benign Het
Or52d3 G T 7: 104,229,434 (GRCm39) A194S probably damaging Het
Or8g24 G A 9: 38,989,874 (GRCm39) H56Y possibly damaging Het
Palm A G 10: 79,655,039 (GRCm39) T266A possibly damaging Het
Pdzph1 T G 17: 59,257,262 (GRCm39) K925N probably damaging Het
Pfkfb3 G T 2: 11,491,058 (GRCm39) Q179K probably benign Het
Phtf1 A G 3: 103,901,214 (GRCm39) Q421R possibly damaging Het
Pip5k1b A T 19: 24,356,318 (GRCm39) S207T probably damaging Het
Pkd2 T C 5: 104,626,790 (GRCm39) V324A probably damaging Het
Plcxd1 A T 5: 110,251,477 (GRCm39) N351I probably damaging Het
Prr14l G A 5: 32,988,023 (GRCm39) P491S probably benign Het
Rxfp2 A T 5: 149,966,564 (GRCm39) R101* probably null Het
Saxo2 T G 7: 82,292,881 (GRCm39) K72T probably benign Het
Sema3b T A 9: 107,481,013 (GRCm39) D108V probably damaging Het
Sh3gl2 A G 4: 85,295,748 (GRCm39) D150G probably damaging Het
Slc6a12 G A 6: 121,340,704 (GRCm39) M544I probably benign Het
Spag6l T C 16: 16,646,981 (GRCm39) probably null Het
Stat3 A G 11: 100,785,593 (GRCm39) F512L probably benign Het
Stk39 A G 2: 68,196,449 (GRCm39) S327P probably damaging Het
Tjp3 C T 10: 81,109,645 (GRCm39) E853K probably benign Het
Tmem30c A T 16: 57,111,180 (GRCm39) S31T probably benign Het
Tpte A T 8: 22,841,493 (GRCm39) D495V probably damaging Het
Ugt2b5 A T 5: 87,287,522 (GRCm39) M215K probably damaging Het
Vinac1 T C 2: 128,875,529 (GRCm39) S1246G unknown Het
Vsig2 T C 9: 37,451,771 (GRCm39) L135S probably benign Het
Other mutations in Fer1l6
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0009:Fer1l6 UTSW 15 58,534,636 (GRCm39) missense probably damaging 1.00
R0141:Fer1l6 UTSW 15 58,430,251 (GRCm39) missense probably damaging 1.00
R0178:Fer1l6 UTSW 15 58,509,763 (GRCm39) splice site probably null
R0304:Fer1l6 UTSW 15 58,462,411 (GRCm39) missense probably benign 0.08
R0379:Fer1l6 UTSW 15 58,420,187 (GRCm39) missense probably benign 0.05
R0457:Fer1l6 UTSW 15 58,509,943 (GRCm39) critical splice donor site probably null
R0546:Fer1l6 UTSW 15 58,430,257 (GRCm39) splice site probably null
R0602:Fer1l6 UTSW 15 58,449,794 (GRCm39) missense probably damaging 0.98
R0619:Fer1l6 UTSW 15 58,534,784 (GRCm39) splice site probably null
R0669:Fer1l6 UTSW 15 58,425,573 (GRCm39) splice site probably null
R0854:Fer1l6 UTSW 15 58,431,037 (GRCm39) missense probably benign 0.00
R0948:Fer1l6 UTSW 15 58,435,924 (GRCm39) missense probably benign 0.00
R1180:Fer1l6 UTSW 15 58,474,160 (GRCm39) splice site probably benign
R1483:Fer1l6 UTSW 15 58,509,819 (GRCm39) missense possibly damaging 0.84
R1627:Fer1l6 UTSW 15 58,513,728 (GRCm39) missense probably benign 0.41
R1635:Fer1l6 UTSW 15 58,518,930 (GRCm39) missense probably damaging 1.00
R1834:Fer1l6 UTSW 15 58,429,718 (GRCm39) missense possibly damaging 0.58
R1921:Fer1l6 UTSW 15 58,497,080 (GRCm39) missense probably damaging 1.00
R2000:Fer1l6 UTSW 15 58,474,160 (GRCm39) splice site probably benign
R2041:Fer1l6 UTSW 15 58,430,155 (GRCm39) missense probably damaging 1.00
R2144:Fer1l6 UTSW 15 58,499,383 (GRCm39) missense probably benign
R2145:Fer1l6 UTSW 15 58,499,383 (GRCm39) missense probably benign
R2981:Fer1l6 UTSW 15 58,435,926 (GRCm39) missense probably damaging 0.99
R4164:Fer1l6 UTSW 15 58,431,087 (GRCm39) missense possibly damaging 0.83
R4192:Fer1l6 UTSW 15 58,518,998 (GRCm39) missense probably damaging 1.00
R4273:Fer1l6 UTSW 15 58,499,371 (GRCm39) missense probably benign 0.41
R4573:Fer1l6 UTSW 15 58,498,129 (GRCm39) critical splice donor site probably null
R4581:Fer1l6 UTSW 15 58,512,075 (GRCm39) missense probably damaging 1.00
R4624:Fer1l6 UTSW 15 58,425,554 (GRCm39) missense probably damaging 1.00
R4755:Fer1l6 UTSW 15 58,512,060 (GRCm39) missense probably benign 0.09
R4774:Fer1l6 UTSW 15 58,449,798 (GRCm39) missense probably damaging 0.99
R4894:Fer1l6 UTSW 15 58,490,751 (GRCm39) missense probably damaging 1.00
R4896:Fer1l6 UTSW 15 58,509,869 (GRCm39) missense probably damaging 1.00
R4921:Fer1l6 UTSW 15 58,472,160 (GRCm39) critical splice acceptor site probably null
R4962:Fer1l6 UTSW 15 58,443,250 (GRCm39) missense probably benign 0.03
R5029:Fer1l6 UTSW 15 58,515,769 (GRCm39) missense probably benign 0.00
R5134:Fer1l6 UTSW 15 58,512,003 (GRCm39) missense probably damaging 1.00
R5175:Fer1l6 UTSW 15 58,422,126 (GRCm39) missense probably damaging 1.00
R5227:Fer1l6 UTSW 15 58,453,752 (GRCm39) nonsense probably null
R5561:Fer1l6 UTSW 15 58,532,674 (GRCm39) missense probably damaging 0.97
R5621:Fer1l6 UTSW 15 58,430,175 (GRCm39) missense probably damaging 1.00
R5670:Fer1l6 UTSW 15 58,494,331 (GRCm39) missense probably benign 0.00
R5745:Fer1l6 UTSW 15 58,443,238 (GRCm39) missense probably benign 0.01
R5807:Fer1l6 UTSW 15 58,462,399 (GRCm39) nonsense probably null
R5823:Fer1l6 UTSW 15 58,462,352 (GRCm39) nonsense probably null
R5892:Fer1l6 UTSW 15 58,435,917 (GRCm39) missense probably benign
R6006:Fer1l6 UTSW 15 58,518,893 (GRCm39) missense probably damaging 1.00
R6137:Fer1l6 UTSW 15 58,431,055 (GRCm39) missense probably damaging 0.97
R6195:Fer1l6 UTSW 15 58,509,806 (GRCm39) missense probably damaging 1.00
R6234:Fer1l6 UTSW 15 58,432,488 (GRCm39) missense probably damaging 1.00
R6237:Fer1l6 UTSW 15 58,509,855 (GRCm39) missense probably damaging 1.00
R6237:Fer1l6 UTSW 15 58,497,026 (GRCm39) nonsense probably null
R6271:Fer1l6 UTSW 15 58,513,767 (GRCm39) missense probably benign 0.01
R6336:Fer1l6 UTSW 15 58,431,081 (GRCm39) nonsense probably null
R6784:Fer1l6 UTSW 15 58,443,275 (GRCm39) missense possibly damaging 0.63
R6852:Fer1l6 UTSW 15 58,466,727 (GRCm39) missense probably damaging 1.00
R7030:Fer1l6 UTSW 15 58,501,227 (GRCm39) missense probably damaging 1.00
R7088:Fer1l6 UTSW 15 58,435,899 (GRCm39) missense possibly damaging 0.69
R7181:Fer1l6 UTSW 15 58,447,146 (GRCm39) missense probably benign 0.00
R7226:Fer1l6 UTSW 15 58,462,384 (GRCm39) missense probably benign 0.00
R7266:Fer1l6 UTSW 15 58,499,446 (GRCm39) missense probably benign
R7463:Fer1l6 UTSW 15 58,445,450 (GRCm39) nonsense probably null
R7464:Fer1l6 UTSW 15 58,445,096 (GRCm39) splice site probably null
R7469:Fer1l6 UTSW 15 58,462,419 (GRCm39) splice site probably null
R7483:Fer1l6 UTSW 15 58,513,794 (GRCm39) missense possibly damaging 0.83
R7491:Fer1l6 UTSW 15 58,472,281 (GRCm39) missense probably damaging 1.00
R7534:Fer1l6 UTSW 15 58,509,875 (GRCm39) missense probably damaging 1.00
R7562:Fer1l6 UTSW 15 58,432,331 (GRCm39) missense probably benign 0.00
R7580:Fer1l6 UTSW 15 58,430,245 (GRCm39) missense probably benign 0.41
R7599:Fer1l6 UTSW 15 58,499,438 (GRCm39) missense probably benign
R7607:Fer1l6 UTSW 15 58,534,581 (GRCm39) nonsense probably null
R7677:Fer1l6 UTSW 15 58,474,139 (GRCm39) missense probably benign 0.00
R8202:Fer1l6 UTSW 15 58,502,486 (GRCm39) missense probably damaging 1.00
R8261:Fer1l6 UTSW 15 58,432,345 (GRCm39) missense possibly damaging 0.84
R8847:Fer1l6 UTSW 15 58,414,012 (GRCm39) missense possibly damaging 0.72
R9022:Fer1l6 UTSW 15 58,455,329 (GRCm39) missense probably damaging 0.99
R9030:Fer1l6 UTSW 15 58,502,594 (GRCm39) missense probably damaging 1.00
R9160:Fer1l6 UTSW 15 58,515,715 (GRCm39) missense possibly damaging 0.94
R9180:Fer1l6 UTSW 15 58,494,230 (GRCm39) missense probably benign 0.19
R9289:Fer1l6 UTSW 15 58,490,766 (GRCm39) missense probably damaging 1.00
R9559:Fer1l6 UTSW 15 58,429,759 (GRCm39) missense possibly damaging 0.88
R9562:Fer1l6 UTSW 15 58,490,370 (GRCm39) missense possibly damaging 0.70
R9775:Fer1l6 UTSW 15 58,497,098 (GRCm39) missense probably benign
X0021:Fer1l6 UTSW 15 58,441,051 (GRCm39) nonsense probably null
X0027:Fer1l6 UTSW 15 58,501,189 (GRCm39) missense probably damaging 1.00
X0063:Fer1l6 UTSW 15 58,490,423 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AACTGCTGACTAAGATCCATGATGG -3'
(R):5'- TGTAAAATGGGCTGTTGGTCCC -3'

Sequencing Primer
(F):5'- TCCATGATGGAGAGATCAAATCTC -3'
(R):5'- GGTCCCTTCCTTCACTGTGGG -3'
Posted On 2022-10-06