Incidental Mutation 'R9685:Olfr1008'
ID 728778
Institutional Source Beutler Lab
Gene Symbol Olfr1008
Ensembl Gene ENSMUSG00000050603
Gene Name olfactory receptor 1008
Synonyms MOR187-3, GA_x6K02T2Q125-47170431-47171372
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R9685 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 85689431-85690372 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 85689522 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 31 (F31S)
Ref Sequence ENSEMBL: ENSMUSP00000061191 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054868]
AlphaFold Q8VGC7
Predicted Effect probably damaging
Transcript: ENSMUST00000054868
AA Change: F31S

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000061191
Gene: ENSMUSG00000050603
AA Change: F31S

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.9e-46 PFAM
Pfam:7tm_1 41 290 2.4e-14 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930453N24Rik G T 16: 64,766,460 N300K possibly damaging Het
A130010J15Rik G A 1: 193,174,757 R139H probably benign Het
Aanat A C 11: 116,596,855 T127P possibly damaging Het
Acp4 G A 7: 44,257,309 probably benign Het
Arhgef5 T G 6: 43,273,593 I426S probably benign Het
Bcl2a1a T C 9: 88,957,132 S28P probably benign Het
Cd163 T C 6: 124,311,425 S272P possibly damaging Het
Cdk13 C A 13: 17,803,957 R232L unknown Het
Clrn2 A G 5: 45,453,989 D60G possibly damaging Het
Cnot6l A G 5: 96,082,890 L406P probably damaging Het
Cspg4 T G 9: 56,890,338 V1362G probably benign Het
Cspp1 C T 1: 10,126,414 S939L probably benign Het
Dcaf1 C T 9: 106,836,619 T145I probably benign Het
Ddx28 T C 8: 106,010,101 S442G probably benign Het
Dnajc3 A T 14: 118,972,363 R283S probably benign Het
Dsc1 G A 18: 20,099,030 T307I possibly damaging Het
Elovl5 T C 9: 77,961,009 Y68H probably damaging Het
Fam25c G A 14: 34,355,309 T17I probably damaging Het
Fryl T C 5: 73,059,536 E2137G probably damaging Het
Gm10142 A G 10: 77,715,928 Q41R unknown Het
Gm21671 AACT A 5: 25,950,851 probably benign Het
Grm1 T C 10: 10,689,031 T1178A possibly damaging Het
Hhip A T 8: 79,996,734 H430Q probably damaging Het
Hip1 A G 5: 135,449,822 F178L probably damaging Het
Impa1 T A 3: 10,328,370 I58L probably benign Het
Irak4 T A 15: 94,553,931 V135E probably benign Het
Jup A C 11: 100,383,411 L151R probably damaging Het
Lrrn4cl T A 19: 8,852,055 N132K probably damaging Het
Mapkbp1 C A 2: 120,021,183 R863S probably benign Het
Pramef17 T A 4: 143,992,950 M282L probably benign Het
Rasa4 A G 5: 136,095,529 D144G probably benign Het
Rrs1 T A 1: 9,546,165 S214R probably benign Het
Rsf1 CGGC CGGCGGCGGGGGC 7: 97,579,932 probably benign Het
Rtca T A 3: 116,499,576 R195S probably benign Het
Scaper A T 9: 55,864,551 S360R probably benign Het
Scarb1 A T 5: 125,294,130 F293I possibly damaging Het
Snapc1 T C 12: 73,970,341 probably null Het
Spta1 T C 1: 174,205,359 V994A probably damaging Het
Synpo2 T C 3: 123,117,717 E93G probably damaging Het
Ubr4 A G 4: 139,464,030 T985A unknown Het
Vmn1r18 T C 6: 57,390,478 I30M possibly damaging Het
Vmn2r15 A G 5: 109,292,732 V420A probably benign Het
Vmn2r6 A G 3: 64,556,660 V251A probably benign Het
Zfyve16 A T 13: 92,522,803 I200N possibly damaging Het
Other mutations in Olfr1008
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00969:Olfr1008 APN 2 85689663 missense probably benign 0.01
IGL02192:Olfr1008 APN 2 85690128 missense possibly damaging 0.80
IGL02560:Olfr1008 APN 2 85689519 missense possibly damaging 0.79
IGL02726:Olfr1008 APN 2 85690210 missense possibly damaging 0.94
IGL02756:Olfr1008 APN 2 85690058 missense probably damaging 0.99
R0463:Olfr1008 UTSW 2 85689839 missense possibly damaging 0.94
R0961:Olfr1008 UTSW 2 85689446 missense probably benign 0.00
R0964:Olfr1008 UTSW 2 85690365 missense probably benign
R1259:Olfr1008 UTSW 2 85689531 missense probably damaging 0.98
R1756:Olfr1008 UTSW 2 85690083 missense probably damaging 1.00
R1871:Olfr1008 UTSW 2 85690311 missense probably damaging 1.00
R1882:Olfr1008 UTSW 2 85689606 missense probably damaging 1.00
R6573:Olfr1008 UTSW 2 85689999 missense probably damaging 0.99
R6640:Olfr1008 UTSW 2 85689935 missense probably damaging 1.00
R6746:Olfr1008 UTSW 2 85689608 missense probably damaging 1.00
R7045:Olfr1008 UTSW 2 85689911 missense possibly damaging 0.49
R7347:Olfr1008 UTSW 2 85689837 missense probably damaging 0.99
R7875:Olfr1008 UTSW 2 85689494 missense probably benign 0.14
R8030:Olfr1008 UTSW 2 85689719 missense probably damaging 1.00
R9161:Olfr1008 UTSW 2 85689887 missense probably benign 0.01
R9193:Olfr1008 UTSW 2 85690300 nonsense probably null
R9399:Olfr1008 UTSW 2 85690051 missense probably damaging 0.97
R9460:Olfr1008 UTSW 2 85690015 missense probably benign 0.02
R9467:Olfr1008 UTSW 2 85690282 missense
Z1177:Olfr1008 UTSW 2 85689680 missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- TGTGCAAATTTTGTCTGTGACC -3'
(R):5'- TGACATCTGTGTGGCACATG -3'

Sequencing Primer
(F):5'- GCAAATTTTGTCTGTGACCATTTAC -3'
(R):5'- CATCTGTGTGGCACATGCATAAAAAG -3'
Posted On 2022-10-06