Incidental Mutation 'R9685:Fam25a'
ID 728813
Institutional Source Beutler Lab
Gene Symbol Fam25a
Ensembl Gene ENSMUSG00000043681
Gene Name family with sequence similarity 25, member A
Synonyms Fam25c, 2200001I15Rik
MMRRC Submission
Accession Numbers
Essential gene? Not available question?
Stock # R9685 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 34073838-34077390 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 34077266 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 17 (T17I)
Ref Sequence ENSEMBL: ENSMUSP00000063140 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052126]
AlphaFold Q8CF02
Predicted Effect probably damaging
Transcript: ENSMUST00000052126
AA Change: T17I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000063140
Gene: ENSMUSG00000043681
AA Change: T17I

DomainStartEndE-ValueType
low complexity region 2 14 N/A INTRINSIC
Pfam:FAM25 24 88 1.1e-39 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930453N24Rik G T 16: 64,586,823 (GRCm39) N300K possibly damaging Het
A130010J15Rik G A 1: 192,857,065 (GRCm39) R139H probably benign Het
Aanat A C 11: 116,487,681 (GRCm39) T127P possibly damaging Het
Acp4 G A 7: 43,906,733 (GRCm39) probably benign Het
Arhgef5 T G 6: 43,250,527 (GRCm39) I426S probably benign Het
Bcl2a1a T C 9: 88,839,185 (GRCm39) S28P probably benign Het
Cd163 T C 6: 124,288,384 (GRCm39) S272P possibly damaging Het
Cdk13 C A 13: 17,978,542 (GRCm39) R232L unknown Het
Clrn2 A G 5: 45,611,331 (GRCm39) D60G possibly damaging Het
Cnot6l A G 5: 96,230,749 (GRCm39) L406P probably damaging Het
Cspg4 T G 9: 56,797,622 (GRCm39) V1362G probably benign Het
Cspp1 C T 1: 10,196,639 (GRCm39) S939L probably benign Het
Dcaf1 C T 9: 106,713,818 (GRCm39) T145I probably benign Het
Ddx28 T C 8: 106,736,733 (GRCm39) S442G probably benign Het
Dnajc3 A T 14: 119,209,775 (GRCm39) R283S probably benign Het
Dsc1 G A 18: 20,232,087 (GRCm39) T307I possibly damaging Het
Elovl5 T C 9: 77,868,291 (GRCm39) Y68H probably damaging Het
Fryl T C 5: 73,216,879 (GRCm39) E2137G probably damaging Het
Gm10142 A G 10: 77,551,762 (GRCm39) Q41R unknown Het
Grm1 T C 10: 10,564,775 (GRCm39) T1178A possibly damaging Het
Hhip A T 8: 80,723,363 (GRCm39) H430Q probably damaging Het
Hip1 A G 5: 135,478,676 (GRCm39) F178L probably damaging Het
Impa1 T A 3: 10,393,430 (GRCm39) I58L probably benign Het
Irak4 T A 15: 94,451,812 (GRCm39) V135E probably benign Het
Jup A C 11: 100,274,237 (GRCm39) L151R probably damaging Het
Lrrn4cl T A 19: 8,829,419 (GRCm39) N132K probably damaging Het
Mapkbp1 C A 2: 119,851,664 (GRCm39) R863S probably benign Het
Or8k16 T C 2: 85,519,866 (GRCm39) F31S probably damaging Het
Pramel14 T A 4: 143,719,520 (GRCm39) M282L probably benign Het
Rasa4 A G 5: 136,124,383 (GRCm39) D144G probably benign Het
Rrs1 T A 1: 9,616,390 (GRCm39) S214R probably benign Het
Rsf1 CGGC CGGCGGCGGGGGC 7: 97,229,139 (GRCm39) probably benign Het
Rtca T A 3: 116,293,225 (GRCm39) R195S probably benign Het
Scaper A T 9: 55,771,835 (GRCm39) S360R probably benign Het
Scarb1 A T 5: 125,371,194 (GRCm39) F293I possibly damaging Het
Snapc1 T C 12: 74,017,115 (GRCm39) probably null Het
Speer4a3 AACT A 5: 26,155,849 (GRCm39) probably benign Het
Spta1 T C 1: 174,032,925 (GRCm39) V994A probably damaging Het
Synpo2 T C 3: 122,911,366 (GRCm39) E93G probably damaging Het
Ubr4 A G 4: 139,191,341 (GRCm39) T985A unknown Het
Vmn1r18 T C 6: 57,367,463 (GRCm39) I30M possibly damaging Het
Vmn2r15 A G 5: 109,440,598 (GRCm39) V420A probably benign Het
Vmn2r6 A G 3: 64,464,081 (GRCm39) V251A probably benign Het
Zfyve16 A T 13: 92,659,311 (GRCm39) I200N possibly damaging Het
Other mutations in Fam25a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01380:Fam25a APN 14 34,075,655 (GRCm39) missense probably null 0.98
R9380:Fam25a UTSW 14 34,073,957 (GRCm39) missense possibly damaging 0.64
Predicted Primers PCR Primer
(F):5'- TTTCTGAGCAACTACCCCAG -3'
(R):5'- GACTCATCTGCTCAGCCTAC -3'

Sequencing Primer
(F):5'- GCAACTACCCCAGCCTCTGTG -3'
(R):5'- GCCTACTACTGGCTAGGTAAGG -3'
Posted On 2022-10-06