Mutagenetix > Incidental Mutation

Incidental Mutation 'R9686:Taar7a'

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Institutional Source

Beutler Lab

Gene Symbol

Taar7a

Ensembl Gene

ENSMUSG00000095647

Gene Name

trace amine-associated receptor 7A

Synonyms

Taar7a, LOC215856

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.138) question?

Stock #

R9686 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

23992405-23993481 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 23993411 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 24 (T24I)

Ref Sequence

ENSEMBL: ENSMUSP00000077616 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078532]

AlphaFold

Q5QD12

Predicted Effect

probably benign
Transcript: ENSMUST00000078532
AA Change: T24I

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000077616
Gene: ENSMUSG00000095647
AA Change: T24I

Domain	Start	End	E-Value	Type
Pfam:7tm_4	54	344	9.2e-10	PFAM
Pfam:7TM_GPCR_Srx	56	261	5.2e-9	PFAM
Pfam:7tm_1	64	326	3.2e-58	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc3	A	G	11: 94,357,041	F1209L	probably benign	Het
Adamts19	A	G	18: 58,838,021	T226A	probably benign	Het
Akap13	A	G	7: 75,586,336	T220A	probably damaging	Het
Ank2	T	A	3: 126,946,901	E1778V	unknown	Het
Aspn	T	C	13: 49,557,353	I158T	probably damaging	Het
Btbd1	A	G	7: 81,805,850	C258R	probably damaging	Het
Btla	A	G	16: 45,250,509	N278S	probably damaging	Het
Cap2	A	G	13: 46,525,450	E12G	probably damaging	Het
Ccdc171	A	G	4: 83,549,682	Y88C	probably damaging	Het
Ceacam3	C	T	7: 17,158,198	L289F		Het
Cenpj	G	A	14: 56,552,591	A667V	probably benign	Het
Clu	G	T	14: 65,975,005	G136C	probably damaging	Het
Col4a4	A	T	1: 82,497,241	F626I	unknown	Het
Csf2ra	A	G	19: 61,225,191	F360S	probably damaging	Het
Cyp27b1	T	A	10: 127,050,316	S289T	probably benign	Het
Dnah17	G	T	11: 118,088,222	H1781Q	possibly damaging	Het
Epha8	G	T	4: 136,938,586	L420M	probably damaging	Het
Fap	T	C	2: 62,573,513	K6R	possibly damaging	Het
Fcer1a	A	G	1: 173,225,413	V72A	possibly damaging	Het
Flnc	T	C	6: 29,456,435	S2211P	possibly damaging	Het
Gm20939	A	T	17: 94,877,460	H512L	probably damaging	Het
Gm21964	T	A	8: 110,109,931	W180R	probably damaging	Het
Gng12	T	C	6: 67,017,545	S59P	probably damaging	Het
Grin1	A	C	2: 25,313,510	I163S	probably benign	Het
Haus5	A	G	7: 30,661,973	I74T	probably benign	Het
Hmcn1	G	A	1: 150,737,605	P1357L	probably damaging	Het
Kcnv1	A	G	15: 45,109,104	I461T	probably benign	Het
Kmo	A	G	1: 175,632,220	M1V	probably null	Het
Krt80	G	A	15: 101,364,400	R107C	probably damaging	Het
Macf1	A	G	4: 123,483,698	V1481A	possibly damaging	Het
Masp1	A	G	16: 23,496,137	S125P	probably damaging	Het
Mroh2b	C	T	15: 4,945,123	P1195L	probably benign	Het
Neurl3	A	T	1: 36,266,458	W223R	probably benign	Het
Olfr1034	A	T	2: 86,046,991	I170F	probably benign	Het
Olfr172	T	C	16: 58,760,763	K138E	possibly damaging	Het
Olfr63	A	G	17: 33,268,879	T52A	probably benign	Het
Olfr996	T	A	2: 85,579,996	Y252*	probably null	Het
Pcdhb4	A	C	18: 37,309,890	Y751S	probably damaging	Het
Pcnx2	C	A	8: 125,866,027	A733S	probably benign	Het
Pde4a	A	G	9: 21,206,266	E608G	probably benign	Het
Pfdn2	G	A	1: 171,357,809	E98K	unknown	Het
Pikfyve	T	A	1: 65,252,456	V1278D	probably damaging	Het
Ptprb	A	T	10: 116,368,789	T1843S	probably damaging	Het
Rab12	G	T	17: 66,519,518	A66E	probably benign	Het
Ralyl	T	C	3: 13,776,827		probably benign	Het
Rbm47	A	T	5: 66,022,626		probably null	Het
Rev3l	T	A	10: 39,867,388	D3038E	possibly damaging	Het
Rhobtb2	A	G	14: 69,796,556	F407L	probably benign	Het
S100pbp	A	T	4: 129,155,478	D332E	probably damaging	Het
Slc9c1	T	C	16: 45,580,214	V729A	possibly damaging	Het
Slfn5	A	T	11: 82,957,175	E295D	probably benign	Het
Smarcc2	A	G	10: 128,480,906	S518G	probably damaging	Het
Sorbs1	T	C	19: 40,393,510	D29G	probably damaging	Het
Spata13	G	A	14: 60,751,659	E925K	probably damaging	Het
Spen	A	G	4: 141,472,635	S2894P	probably benign	Het
Taf4b	C	A	18: 14,799,158	T189N	possibly damaging	Het
Ube2o	A	T	11: 116,543,953	C561S	probably benign	Het
Usp34	T	A	11: 23,474,351	I3213N		Het
Vmn1r103	A	G	7: 20,510,428	V36A	possibly damaging	Het
Vmn2r65	G	A	7: 84,940,876	L611F	probably benign	Het
Zfp51	C	T	17: 21,463,609	S162F	probably damaging	Het
Zfp518b	G	A	5: 38,674,114	H183Y	probably damaging	Het
Zfp622	A	G	15: 25,985,055	E169G	probably benign	Het
Zfp703	A	G	8: 26,979,016	D236G	probably damaging	Het
Zfp839	A	T	12: 110,855,498	I249F	probably damaging	Het

Other mutations in Taar7a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00476:Taar7a	APN	10	23992396	unclassified	probably benign
IGL02408:Taar7a	APN	10	23992602	missense	probably benign
PIT4434001:Taar7a	UTSW	10	23993421	missense	probably benign
R0422:Taar7a	UTSW	10	23993274	missense	probably benign	0.02
R1029:Taar7a	UTSW	10	23992541	missense	possibly damaging	0.65
R1742:Taar7a	UTSW	10	23993219	missense	probably damaging	0.98
R2104:Taar7a	UTSW	10	23993061	missense	probably damaging	0.99
R2421:Taar7a	UTSW	10	23992517	missense	probably damaging	1.00
R3907:Taar7a	UTSW	10	23992559	missense	probably benign	0.25
R4021:Taar7a	UTSW	10	23993386	missense	probably benign	0.00
R5180:Taar7a	UTSW	10	23993148	missense	probably damaging	1.00
R5486:Taar7a	UTSW	10	23992458	missense	probably benign	0.00
R5507:Taar7a	UTSW	10	23992631	missense	probably damaging	0.98
R5587:Taar7a	UTSW	10	23992828	missense	probably benign	0.00
R5766:Taar7a	UTSW	10	23993362	missense	probably benign	0.01
R5861:Taar7a	UTSW	10	23992439	missense	probably benign
R7201:Taar7a	UTSW	10	23992460	missense	probably benign	0.04
R7506:Taar7a	UTSW	10	23992994	missense	possibly damaging	0.50
R8810:Taar7a	UTSW	10	23993381	missense	probably benign	0.20
R9015:Taar7a	UTSW	10	23992835	missense	probably damaging	0.97
R9172:Taar7a	UTSW	10	23992779	missense	probably benign	0.16
R9717:Taar7a	UTSW	10	23992901	missense	probably benign	0.01
R9720:Taar7a	UTSW	10	23992835	missense	probably benign	0.10
X0064:Taar7a	UTSW	10	23992617	missense	probably damaging	1.00
Z1177:Taar7a	UTSW	10	23992892	missense	probably benign	0.01

Predicted Primers

Posted On

2022-10-06