Incidental Mutation 'R9686:Taar7a'
ID 728851
Institutional Source Beutler Lab
Gene Symbol Taar7a
Ensembl Gene ENSMUSG00000095647
Gene Name trace amine-associated receptor 7A
Synonyms Taar7a, LOC215856
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.138) question?
Stock # R9686 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 23992405-23993481 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 23993411 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 24 (T24I)
Ref Sequence ENSEMBL: ENSMUSP00000077616 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078532]
AlphaFold Q5QD12
Predicted Effect probably benign
Transcript: ENSMUST00000078532
AA Change: T24I

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000077616
Gene: ENSMUSG00000095647
AA Change: T24I

DomainStartEndE-ValueType
Pfam:7tm_4 54 344 9.2e-10 PFAM
Pfam:7TM_GPCR_Srx 56 261 5.2e-9 PFAM
Pfam:7tm_1 64 326 3.2e-58 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc3 A G 11: 94,357,041 F1209L probably benign Het
Adamts19 A G 18: 58,838,021 T226A probably benign Het
Akap13 A G 7: 75,586,336 T220A probably damaging Het
Ank2 T A 3: 126,946,901 E1778V unknown Het
Aspn T C 13: 49,557,353 I158T probably damaging Het
Btbd1 A G 7: 81,805,850 C258R probably damaging Het
Btla A G 16: 45,250,509 N278S probably damaging Het
Cap2 A G 13: 46,525,450 E12G probably damaging Het
Ccdc171 A G 4: 83,549,682 Y88C probably damaging Het
Ceacam3 C T 7: 17,158,198 L289F Het
Cenpj G A 14: 56,552,591 A667V probably benign Het
Clu G T 14: 65,975,005 G136C probably damaging Het
Col4a4 A T 1: 82,497,241 F626I unknown Het
Csf2ra A G 19: 61,225,191 F360S probably damaging Het
Cyp27b1 T A 10: 127,050,316 S289T probably benign Het
Dnah17 G T 11: 118,088,222 H1781Q possibly damaging Het
Epha8 G T 4: 136,938,586 L420M probably damaging Het
Fap T C 2: 62,573,513 K6R possibly damaging Het
Fcer1a A G 1: 173,225,413 V72A possibly damaging Het
Flnc T C 6: 29,456,435 S2211P possibly damaging Het
Gm20939 A T 17: 94,877,460 H512L probably damaging Het
Gm21964 T A 8: 110,109,931 W180R probably damaging Het
Gng12 T C 6: 67,017,545 S59P probably damaging Het
Grin1 A C 2: 25,313,510 I163S probably benign Het
Haus5 A G 7: 30,661,973 I74T probably benign Het
Hmcn1 G A 1: 150,737,605 P1357L probably damaging Het
Kcnv1 A G 15: 45,109,104 I461T probably benign Het
Kmo A G 1: 175,632,220 M1V probably null Het
Krt80 G A 15: 101,364,400 R107C probably damaging Het
Macf1 A G 4: 123,483,698 V1481A possibly damaging Het
Masp1 A G 16: 23,496,137 S125P probably damaging Het
Mroh2b C T 15: 4,945,123 P1195L probably benign Het
Neurl3 A T 1: 36,266,458 W223R probably benign Het
Olfr1034 A T 2: 86,046,991 I170F probably benign Het
Olfr172 T C 16: 58,760,763 K138E possibly damaging Het
Olfr63 A G 17: 33,268,879 T52A probably benign Het
Olfr996 T A 2: 85,579,996 Y252* probably null Het
Pcdhb4 A C 18: 37,309,890 Y751S probably damaging Het
Pcnx2 C A 8: 125,866,027 A733S probably benign Het
Pde4a A G 9: 21,206,266 E608G probably benign Het
Pfdn2 G A 1: 171,357,809 E98K unknown Het
Pikfyve T A 1: 65,252,456 V1278D probably damaging Het
Ptprb A T 10: 116,368,789 T1843S probably damaging Het
Rab12 G T 17: 66,519,518 A66E probably benign Het
Ralyl T C 3: 13,776,827 probably benign Het
Rbm47 A T 5: 66,022,626 probably null Het
Rev3l T A 10: 39,867,388 D3038E possibly damaging Het
Rhobtb2 A G 14: 69,796,556 F407L probably benign Het
S100pbp A T 4: 129,155,478 D332E probably damaging Het
Slc9c1 T C 16: 45,580,214 V729A possibly damaging Het
Slfn5 A T 11: 82,957,175 E295D probably benign Het
Smarcc2 A G 10: 128,480,906 S518G probably damaging Het
Sorbs1 T C 19: 40,393,510 D29G probably damaging Het
Spata13 G A 14: 60,751,659 E925K probably damaging Het
Spen A G 4: 141,472,635 S2894P probably benign Het
Taf4b C A 18: 14,799,158 T189N possibly damaging Het
Ube2o A T 11: 116,543,953 C561S probably benign Het
Usp34 T A 11: 23,474,351 I3213N Het
Vmn1r103 A G 7: 20,510,428 V36A possibly damaging Het
Vmn2r65 G A 7: 84,940,876 L611F probably benign Het
Zfp51 C T 17: 21,463,609 S162F probably damaging Het
Zfp518b G A 5: 38,674,114 H183Y probably damaging Het
Zfp622 A G 15: 25,985,055 E169G probably benign Het
Zfp703 A G 8: 26,979,016 D236G probably damaging Het
Zfp839 A T 12: 110,855,498 I249F probably damaging Het
Other mutations in Taar7a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00476:Taar7a APN 10 23992396 unclassified probably benign
IGL02408:Taar7a APN 10 23992602 missense probably benign
PIT4434001:Taar7a UTSW 10 23993421 missense probably benign
R0422:Taar7a UTSW 10 23993274 missense probably benign 0.02
R1029:Taar7a UTSW 10 23992541 missense possibly damaging 0.65
R1742:Taar7a UTSW 10 23993219 missense probably damaging 0.98
R2104:Taar7a UTSW 10 23993061 missense probably damaging 0.99
R2421:Taar7a UTSW 10 23992517 missense probably damaging 1.00
R3907:Taar7a UTSW 10 23992559 missense probably benign 0.25
R4021:Taar7a UTSW 10 23993386 missense probably benign 0.00
R5180:Taar7a UTSW 10 23993148 missense probably damaging 1.00
R5486:Taar7a UTSW 10 23992458 missense probably benign 0.00
R5507:Taar7a UTSW 10 23992631 missense probably damaging 0.98
R5587:Taar7a UTSW 10 23992828 missense probably benign 0.00
R5766:Taar7a UTSW 10 23993362 missense probably benign 0.01
R5861:Taar7a UTSW 10 23992439 missense probably benign
R7201:Taar7a UTSW 10 23992460 missense probably benign 0.04
R7506:Taar7a UTSW 10 23992994 missense possibly damaging 0.50
R8810:Taar7a UTSW 10 23993381 missense probably benign 0.20
R9015:Taar7a UTSW 10 23992835 missense probably damaging 0.97
R9172:Taar7a UTSW 10 23992779 missense probably benign 0.16
R9717:Taar7a UTSW 10 23992901 missense probably benign 0.01
R9720:Taar7a UTSW 10 23992835 missense probably benign 0.10
X0064:Taar7a UTSW 10 23992617 missense probably damaging 1.00
Z1177:Taar7a UTSW 10 23992892 missense probably benign 0.01
Predicted Primers
Posted On 2022-10-06