Incidental Mutation 'R9687:Vmn2r109'
| ID |
728936 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r109
|
| Ensembl Gene |
ENSMUSG00000090572 |
| Gene Name |
vomeronasal 2, receptor 109 |
| Synonyms |
EG627814 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.069)
|
| Stock # |
R9687 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
20760779-20785018 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 20775332 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Lysine
at position 132
(Q132K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132641
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167093]
|
| AlphaFold |
K7N747 |
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000132641
Gene: ENSMUSG00000090572
AA Change: Q132K
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
467 |
1.4e-35 |
PFAM |
|
Pfam:NCD3G
|
510 |
563 |
3.1e-21 |
PFAM |
|
Pfam:7tm_3
|
596 |
831 |
7.4e-52 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 63 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9930111J21Rik1 |
A |
G |
11: 48,839,249 (GRCm39) |
L446P |
probably damaging |
Het |
| Abcc9 |
T |
C |
6: 142,578,889 (GRCm39) |
T927A |
probably benign |
Het |
| Abraxas2 |
A |
G |
7: 132,482,577 (GRCm39) |
T258A |
probably benign |
Het |
| Akna |
A |
T |
4: 63,292,674 (GRCm39) |
C1078* |
probably null |
Het |
| Arhgap24 |
T |
A |
5: 102,994,022 (GRCm39) |
F34L |
probably benign |
Het |
| Cpa5 |
C |
T |
6: 30,614,041 (GRCm39) |
T61I |
probably benign |
Het |
| Crebrf |
A |
G |
17: 26,982,601 (GRCm39) |
*654W |
probably null |
Het |
| Dchs1 |
C |
A |
7: 105,407,191 (GRCm39) |
R2134L |
probably damaging |
Het |
| Dcps |
T |
C |
9: 35,035,978 (GRCm39) |
N303D |
probably damaging |
Het |
| Ddhd1 |
C |
T |
14: 45,848,190 (GRCm39) |
E527K |
probably damaging |
Het |
| Dnah14 |
T |
A |
1: 181,425,978 (GRCm39) |
M174K |
probably benign |
Het |
| Ehd1 |
A |
G |
19: 6,348,330 (GRCm39) |
D436G |
|
Het |
| Entrep1 |
A |
G |
19: 23,957,029 (GRCm39) |
I327T |
probably damaging |
Het |
| Epha8 |
G |
T |
4: 136,665,897 (GRCm39) |
L420M |
probably damaging |
Het |
| Etv1 |
T |
C |
12: 38,911,361 (GRCm39) |
Y396H |
probably damaging |
Het |
| Fbxo11 |
A |
G |
17: 88,316,494 (GRCm39) |
I293T |
|
Het |
| Gcfc2 |
T |
A |
6: 81,918,323 (GRCm39) |
S338T |
probably damaging |
Het |
| Gm10272 |
T |
C |
10: 77,542,764 (GRCm39) |
V102A |
possibly damaging |
Het |
| Gm11110 |
T |
C |
17: 57,410,439 (GRCm39) |
T20A |
unknown |
Het |
| Gna14 |
G |
A |
19: 16,582,350 (GRCm39) |
R206Q |
|
Het |
| Gpm6a |
T |
C |
8: 55,503,209 (GRCm39) |
Y153H |
possibly damaging |
Het |
| Grip1 |
G |
A |
10: 119,874,569 (GRCm39) |
E778K |
possibly damaging |
Het |
| H2-M10.6 |
G |
A |
17: 37,125,147 (GRCm39) |
V313I |
probably benign |
Het |
| Igkv8-19 |
T |
C |
6: 70,318,005 (GRCm39) |
I74V |
probably benign |
Het |
| Kif24 |
A |
G |
4: 41,428,546 (GRCm39) |
L138P |
probably damaging |
Het |
| Kif26a |
A |
G |
12: 112,143,625 (GRCm39) |
E1293G |
probably damaging |
Het |
| Lrp1 |
A |
C |
10: 127,402,562 (GRCm39) |
L2203R |
probably damaging |
Het |
| Ms4a6b |
A |
G |
19: 11,497,806 (GRCm39) |
D35G |
possibly damaging |
Het |
| Myo1h |
A |
T |
5: 114,458,769 (GRCm39) |
D184V |
|
Het |
| Ncdn |
G |
A |
4: 126,642,467 (GRCm39) |
R397W |
probably damaging |
Het |
| Ncor1 |
A |
T |
11: 62,260,193 (GRCm39) |
I519N |
possibly damaging |
Het |
| Obsl1 |
A |
G |
1: 75,479,670 (GRCm39) |
V575A |
probably damaging |
Het |
| Or2y15 |
T |
C |
11: 49,350,518 (GRCm39) |
F4S |
probably benign |
Het |
| Or5m8 |
G |
T |
2: 85,822,220 (GRCm39) |
V20L |
probably benign |
Het |
| Or7a35 |
T |
A |
10: 78,853,843 (GRCm39) |
I229N |
probably damaging |
Het |
| Osbpl5 |
A |
G |
7: 143,247,598 (GRCm39) |
Y747H |
possibly damaging |
Het |
| Pcdh18 |
T |
A |
3: 49,711,036 (GRCm39) |
D93V |
probably damaging |
Het |
| Ppef2 |
T |
A |
5: 92,386,746 (GRCm39) |
D397V |
probably benign |
Het |
| Ppfia4 |
G |
A |
1: 134,245,694 (GRCm39) |
T620I |
probably benign |
Het |
| Ppp1r9a |
T |
C |
6: 4,905,978 (GRCm39) |
S178P |
probably damaging |
Het |
| Ptchd4 |
A |
G |
17: 42,813,467 (GRCm39) |
Y456C |
probably damaging |
Het |
| Pxk |
A |
G |
14: 8,151,567 (GRCm38) |
I461V |
possibly damaging |
Het |
| Rab18 |
T |
A |
18: 6,784,622 (GRCm39) |
N104K |
probably benign |
Het |
| Sars1 |
A |
G |
3: 108,343,221 (GRCm39) |
L90P |
probably benign |
Het |
| Scaf8 |
T |
A |
17: 3,221,410 (GRCm39) |
I299N |
unknown |
Het |
| Sh3bp2 |
C |
T |
5: 34,716,977 (GRCm39) |
P463S |
probably benign |
Het |
| Slc12a3 |
A |
G |
8: 95,075,208 (GRCm39) |
N734S |
possibly damaging |
Het |
| Slc12a7 |
G |
T |
13: 73,938,796 (GRCm39) |
R191L |
probably damaging |
Het |
| Slc7a12 |
A |
G |
3: 14,545,960 (GRCm39) |
Y35C |
possibly damaging |
Het |
| Spmip2 |
G |
A |
3: 79,337,299 (GRCm39) |
D36N |
possibly damaging |
Het |
| Susd4 |
A |
G |
1: 182,722,762 (GRCm39) |
|
probably null |
Het |
| Taar7f |
G |
A |
10: 23,925,727 (GRCm39) |
R107K |
probably benign |
Het |
| Tarm1 |
T |
C |
7: 3,544,457 (GRCm39) |
T237A |
probably benign |
Het |
| Tshr |
C |
A |
12: 91,504,439 (GRCm39) |
A459E |
probably damaging |
Het |
| Tubgcp5 |
G |
T |
7: 55,475,327 (GRCm39) |
|
probably null |
Het |
| Unc13b |
T |
C |
4: 43,174,920 (GRCm39) |
V1916A |
unknown |
Het |
| Unc45b |
A |
G |
11: 82,810,562 (GRCm39) |
D274G |
probably damaging |
Het |
| Vmn1r230 |
T |
A |
17: 21,067,604 (GRCm39) |
Y264* |
probably null |
Het |
| Zbtb20 |
A |
G |
16: 43,430,160 (GRCm39) |
S151G |
possibly damaging |
Het |
| Zbtb22 |
A |
C |
17: 34,136,850 (GRCm39) |
T332P |
probably damaging |
Het |
| Zc3h6 |
A |
G |
2: 128,859,281 (GRCm39) |
D1104G |
probably damaging |
Het |
| Zfp748 |
A |
G |
13: 67,690,471 (GRCm39) |
V263A |
probably benign |
Het |
| Zhx3 |
A |
C |
2: 160,623,678 (GRCm39) |
V163G |
probably benign |
Het |
|
| Other mutations in Vmn2r109 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01313:Vmn2r109
|
APN |
17 |
20,770,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01383:Vmn2r109
|
APN |
17 |
20,761,383 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL01469:Vmn2r109
|
APN |
17 |
20,761,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01762:Vmn2r109
|
APN |
17 |
20,774,654 (GRCm39) |
missense |
probably benign |
|
|
IGL01864:Vmn2r109
|
APN |
17 |
20,761,396 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL02028:Vmn2r109
|
APN |
17 |
20,761,342 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL02074:Vmn2r109
|
APN |
17 |
20,774,603 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02162:Vmn2r109
|
APN |
17 |
20,774,422 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02474:Vmn2r109
|
APN |
17 |
20,761,150 (GRCm39) |
missense |
probably benign |
|
|
IGL02490:Vmn2r109
|
APN |
17 |
20,761,246 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL02604:Vmn2r109
|
APN |
17 |
20,760,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02669:Vmn2r109
|
APN |
17 |
20,774,518 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL02705:Vmn2r109
|
APN |
17 |
20,774,062 (GRCm39) |
missense |
probably benign |
|
|
IGL02745:Vmn2r109
|
APN |
17 |
20,761,512 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4142001:Vmn2r109
|
UTSW |
17 |
20,774,839 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0389:Vmn2r109
|
UTSW |
17 |
20,761,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0470:Vmn2r109
|
UTSW |
17 |
20,773,148 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0570:Vmn2r109
|
UTSW |
17 |
20,760,937 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0855:Vmn2r109
|
UTSW |
17 |
20,761,670 (GRCm39) |
nonsense |
probably null |
|
|
R0882:Vmn2r109
|
UTSW |
17 |
20,774,842 (GRCm39) |
splice site |
probably benign |
|
|
R1241:Vmn2r109
|
UTSW |
17 |
20,775,503 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1587:Vmn2r109
|
UTSW |
17 |
20,761,002 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1931:Vmn2r109
|
UTSW |
17 |
20,774,072 (GRCm39) |
nonsense |
probably null |
|
|
R1957:Vmn2r109
|
UTSW |
17 |
20,784,969 (GRCm39) |
missense |
probably benign |
0.11 |
|
R1962:Vmn2r109
|
UTSW |
17 |
20,774,185 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2020:Vmn2r109
|
UTSW |
17 |
20,761,448 (GRCm39) |
nonsense |
probably null |
|
|
R2073:Vmn2r109
|
UTSW |
17 |
20,784,974 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2436:Vmn2r109
|
UTSW |
17 |
20,774,798 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3123:Vmn2r109
|
UTSW |
17 |
20,761,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3839:Vmn2r109
|
UTSW |
17 |
20,774,704 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4019:Vmn2r109
|
UTSW |
17 |
20,774,074 (GRCm39) |
missense |
probably benign |
|
|
R4428:Vmn2r109
|
UTSW |
17 |
20,773,286 (GRCm39) |
missense |
probably benign |
|
|
R4584:Vmn2r109
|
UTSW |
17 |
20,774,820 (GRCm39) |
nonsense |
probably null |
|
|
R4652:Vmn2r109
|
UTSW |
17 |
20,761,656 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4708:Vmn2r109
|
UTSW |
17 |
20,761,605 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4823:Vmn2r109
|
UTSW |
17 |
20,774,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4831:Vmn2r109
|
UTSW |
17 |
20,761,494 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4907:Vmn2r109
|
UTSW |
17 |
20,770,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5011:Vmn2r109
|
UTSW |
17 |
20,775,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5296:Vmn2r109
|
UTSW |
17 |
20,774,603 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5600:Vmn2r109
|
UTSW |
17 |
20,761,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5602:Vmn2r109
|
UTSW |
17 |
20,760,933 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5652:Vmn2r109
|
UTSW |
17 |
20,760,781 (GRCm39) |
makesense |
probably null |
|
|
R5702:Vmn2r109
|
UTSW |
17 |
20,774,407 (GRCm39) |
missense |
probably benign |
0.42 |
|
R5706:Vmn2r109
|
UTSW |
17 |
20,774,567 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5714:Vmn2r109
|
UTSW |
17 |
20,773,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5832:Vmn2r109
|
UTSW |
17 |
20,761,318 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6008:Vmn2r109
|
UTSW |
17 |
20,760,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6334:Vmn2r109
|
UTSW |
17 |
20,761,440 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6377:Vmn2r109
|
UTSW |
17 |
20,784,796 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6738:Vmn2r109
|
UTSW |
17 |
20,774,785 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R6857:Vmn2r109
|
UTSW |
17 |
20,760,932 (GRCm39) |
missense |
probably benign |
0.45 |
|
R6953:Vmn2r109
|
UTSW |
17 |
20,760,973 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7108:Vmn2r109
|
UTSW |
17 |
20,785,006 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7229:Vmn2r109
|
UTSW |
17 |
20,761,225 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7238:Vmn2r109
|
UTSW |
17 |
20,761,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7244:Vmn2r109
|
UTSW |
17 |
20,760,945 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7292:Vmn2r109
|
UTSW |
17 |
20,761,700 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7354:Vmn2r109
|
UTSW |
17 |
20,761,043 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7357:Vmn2r109
|
UTSW |
17 |
20,761,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7522:Vmn2r109
|
UTSW |
17 |
20,774,665 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7596:Vmn2r109
|
UTSW |
17 |
20,760,942 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7728:Vmn2r109
|
UTSW |
17 |
20,773,117 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7859:Vmn2r109
|
UTSW |
17 |
20,761,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7871:Vmn2r109
|
UTSW |
17 |
20,760,782 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8113:Vmn2r109
|
UTSW |
17 |
20,774,729 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8153:Vmn2r109
|
UTSW |
17 |
20,784,969 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8977:Vmn2r109
|
UTSW |
17 |
20,774,531 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
Z1176:Vmn2r109
|
UTSW |
17 |
20,773,256 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCTGTATTATCAACAAGGGATGTG -3'
(R):5'- TCAACATGTGGTCCAGGCTG -3'
Sequencing Primer
(F):5'- GGATGTGATTCCCAGTTCTGACAC -3'
(R):5'- AACATGTGGTCCAGGCTGTATTTTTC -3'
|
| Posted On |
2022-10-06 |
Incidental Mutation