|Institutional Source||Beutler Lab|
|Gene Name||guanine nucleotide binding protein, alpha 14|
|Synonyms||G alpha 14|
|Essential gene?||Probably non essential (E-score: 0.090)|
|Stock #||R9687 (G1)|
|Chromosomal Location||16435667-16610818 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||G to A at 16604986 bp (GRCm38)|
|Amino Acid Change||Arginine to Glutamine at position 206 (R206Q)|
|Ref Sequence||ENSEMBL: ENSMUSP00000025602 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000025602]|
AA Change: R206Q
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Gna14||
(F):5'- AATGTTCTCCACTGCCTGTG -3'
(R):5'- CTCACTAGCTAGCTTCTTGAAACAC -3'
(F):5'- GTGCAGCACTGTTCTAACAC -3'
(R):5'- GCTAGCTTCTTGAAACACTGAAG -3'