Incidental Mutation 'R9688:Yeats4'
ID 728991
Institutional Source Beutler Lab
Gene Symbol Yeats4
Ensembl Gene ENSMUSG00000020171
Gene Name YEATS domain containing 4
Synonyms 4930573H17Rik, NuBI-1, GAS41, B230215M10Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably essential (E-score: 0.947) question?
Stock # R9688 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 117215221-117224507 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 117215681 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 224 (T224A)
Ref Sequence ENSEMBL: ENSMUSP00000020382 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020382] [ENSMUST00000218887]
AlphaFold Q9CR11
Predicted Effect probably benign
Transcript: ENSMUST00000020382
AA Change: T224A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000020382
Gene: ENSMUSG00000020171
AA Change: T224A

DomainStartEndE-ValueType
Pfam:YEATS 44 124 4.6e-38 PFAM
low complexity region 152 163 N/A INTRINSIC
coiled coil region 178 226 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000218887
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700093K21Rik A G 11: 23,519,067 probably null Het
Abca2 G C 2: 25,434,447 A272P possibly damaging Het
Adarb1 T A 10: 77,311,265 D479V probably damaging Het
Amz2 T C 11: 109,429,939 F162S probably damaging Het
Ano4 A T 10: 89,344,644 M1K probably null Het
Antxr1 G A 6: 87,137,352 R478C probably damaging Het
Apobr T C 7: 126,587,491 S725P probably benign Het
Arap2 A T 5: 62,714,766 D506E probably damaging Het
Ash1l T G 3: 88,984,717 I1301S probably damaging Het
Camk1g T A 1: 193,348,721 R305W probably damaging Het
Ces2g A T 8: 104,964,672 I147F probably benign Het
Cfap61 T C 2: 146,036,838 F505L probably damaging Het
Cndp1 G C 18: 84,637,857 N62K probably benign Het
Cog6 G T 3: 53,009,107 Q214K probably benign Het
Depdc5 T A 5: 32,897,932 Y226* probably null Het
Elp5 T A 11: 69,970,599 I185F probably damaging Het
Ercc6 A C 14: 32,575,798 H1334P probably benign Het
Ern1 T C 11: 106,459,010 T27A possibly damaging Het
Esf1 A T 2: 140,168,175 D80E probably damaging Het
Evpl T C 11: 116,234,160 K159E probably damaging Het
Gbx1 T C 5: 24,526,512 Y102C probably damaging Het
Gjd2 A G 2: 114,011,628 S123P probably benign Het
H2-M11 A G 17: 36,548,162 Y198C probably damaging Het
Hps1 A C 19: 42,766,708 V265G probably benign Het
Ifna16 C A 4: 88,676,637 E74* probably null Het
Inca1 C T 11: 70,688,984 probably null Het
Jag2 A G 12: 112,908,944 V1230A probably benign Het
Jam3 G A 9: 27,098,908 T260M probably benign Het
Klhl5 A T 5: 65,164,587 D652V probably damaging Het
L3mbtl1 A T 2: 162,948,777 I81L possibly damaging Het
Lgalsl C T 11: 20,829,442 A68T probably benign Het
Map3k14 T A 11: 103,239,233 D286V possibly damaging Het
Mdn1 A G 4: 32,745,590 I4083V probably damaging Het
Ms4a5 T C 19: 11,276,694 I136M possibly damaging Het
Naa16 A T 14: 79,335,869 Y820* probably null Het
Nbea G T 3: 55,649,744 N2537K probably benign Het
Ncapd3 A G 9: 27,056,053 S562G probably benign Het
Olfr1093 A C 2: 86,786,661 K310N probably damaging Het
Olfr786 C A 10: 129,437,098 C95* probably null Het
Papd7 A G 13: 69,507,080 L425P probably damaging Het
Pcdhac2 A G 18: 37,144,575 S203G probably benign Het
Pds5a A T 5: 65,654,853 F309I probably benign Het
Pdzd8 G A 19: 59,345,251 L113F probably benign Het
Pex12 T C 11: 83,298,431 Y4C possibly damaging Het
Ppfibp2 A G 7: 107,719,241 D332G probably benign Het
Psg23 A T 7: 18,610,622 W303R probably damaging Het
Pyy T A 11: 102,107,273 D27V probably damaging Het
Rc3h1 A G 1: 160,942,664 Q302R probably damaging Het
Rhoh A G 5: 65,892,313 probably benign Het
Samd9l A G 6: 3,377,087 M58T probably damaging Het
Scaf11 A C 15: 96,415,927 H1324Q probably damaging Het
Serinc2 C A 4: 130,264,340 A105S probably damaging Het
Setx A T 2: 29,146,316 S938C probably damaging Het
Sgo2a A T 1: 58,017,578 T974S probably damaging Het
Sh3rf1 T C 8: 61,226,314 V130A probably benign Het
Slc43a2 T C 11: 75,543,286 F97L probably damaging Het
Slc9a9 C A 9: 95,229,054 Q642K probably benign Het
Soga3 T C 10: 29,196,695 V661A possibly damaging Het
Sox6 G T 7: 115,476,990 D804E probably benign Het
Tbx15 A T 3: 99,326,392 R290S possibly damaging Het
Terf2 A G 8: 107,094,911 S176P probably damaging Het
Ttc6 A T 12: 57,673,816 H956L possibly damaging Het
Tti2 T C 8: 31,154,251 V292A probably damaging Het
Vmn1r29 A T 6: 58,307,754 E153V probably benign Het
Vmn1r55 G T 7: 5,146,670 H251Q probably benign Het
Yipf4 T A 17: 74,499,083 F239Y probably benign Het
Zan T C 5: 137,468,455 D380G probably damaging Het
Zbtb9 T C 17: 26,974,920 F433S probably damaging Het
Zic5 T C 14: 122,464,023 K432R unknown Het
Other mutations in Yeats4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02383:Yeats4 APN 10 117215811 missense probably benign 0.01
R0305:Yeats4 UTSW 10 117215836 missense probably damaging 0.99
R1606:Yeats4 UTSW 10 117217439 missense probably damaging 1.00
R1703:Yeats4 UTSW 10 117215723 missense probably benign
R1907:Yeats4 UTSW 10 117215731 missense probably benign 0.17
R3156:Yeats4 UTSW 10 117222281 missense probably benign 0.11
R3625:Yeats4 UTSW 10 117220368 missense probably benign 0.08
R5687:Yeats4 UTSW 10 117215680 missense probably benign
R7900:Yeats4 UTSW 10 117220559 missense possibly damaging 0.95
R8347:Yeats4 UTSW 10 117217469 missense probably benign 0.26
R8514:Yeats4 UTSW 10 117215755 missense possibly damaging 0.50
R9665:Yeats4 UTSW 10 117217438 nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGCATCGAGTCTTAGAGCACAC -3'
(R):5'- GTCATAAGAGGATGGGCTCAC -3'

Sequencing Primer
(F):5'- ACACATGTGCCCCGGGAG -3'
(R):5'- GCTCACTCAGCTCAGCTC -3'
Posted On 2022-10-06