Incidental Mutation 'R9691:Or2a14'
ID 729157
Institutional Source Beutler Lab
Gene Symbol Or2a14
Ensembl Gene ENSMUSG00000094200
Gene Name olfactory receptor family 2 subfamily A member 14
Synonyms Olfr237-ps1, MOR261-4, Olfr237, GA_x6K02T08UK8-1-481, GA_x6K02T2P3E9-4404793-4403861, Olfr438
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.124) question?
Stock # R9691 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 43130241-43131173 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 43130629 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 130 (H130R)
Ref Sequence ENSEMBL: ENSMUSP00000149261 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095953] [ENSMUST00000215911] [ENSMUST00000216411]
AlphaFold K9J725
Predicted Effect probably benign
Transcript: ENSMUST00000095953
AA Change: H130R

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000093647
Gene: ENSMUSG00000094200
AA Change: H130R

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 8e-61 PFAM
Pfam:7tm_1 40 289 2.6e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215911
AA Change: H130R

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000216411
AA Change: H130R

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak T C 19: 8,989,090 (GRCm39) M3458T possibly damaging Het
Akap9 T G 5: 4,010,491 (GRCm39) L398R probably damaging Het
Anks3 A T 16: 4,759,840 (GRCm39) C635S probably benign Het
Ankzf1 C A 1: 75,175,196 (GRCm39) Q649K probably benign Het
Atp8a2 T C 14: 60,245,829 (GRCm39) E621G probably damaging Het
Bscl2 A G 19: 8,817,110 (GRCm39) T13A probably benign Het
Cd109 T C 9: 78,611,074 (GRCm39) L1230P possibly damaging Het
Celsr2 T A 3: 108,301,551 (GRCm39) S2678C probably damaging Het
Cnot10 A G 9: 114,420,715 (GRCm39) L709P probably damaging Het
Col5a1 G A 2: 27,842,994 (GRCm39) R449Q unknown Het
Cyp3a25 T A 5: 145,931,732 (GRCm39) E125D probably benign Het
Ddx50 T G 10: 62,476,524 (GRCm39) I250L probably benign Het
Dnah10 A G 5: 124,852,249 (GRCm39) N1859S probably damaging Het
Dnajc13 A G 9: 104,042,211 (GRCm39) L2008P probably damaging Het
Dock4 C T 12: 40,686,097 (GRCm39) L111F probably damaging Het
Ffar3 C G 7: 30,555,119 (GRCm39) R67P probably damaging Het
Gdap2 C T 3: 100,109,441 (GRCm39) A486V probably benign Het
Gm45871 G A 18: 90,610,111 (GRCm39) V450M possibly damaging Het
Golgb1 T A 16: 36,718,996 (GRCm39) S342T probably damaging Het
Grip1 G A 10: 119,874,569 (GRCm39) E778K possibly damaging Het
Grm5 T C 7: 87,723,903 (GRCm39) I731T probably damaging Het
Gxylt2 A T 6: 100,760,109 (GRCm39) T215S probably damaging Het
Jakmip2 A T 18: 43,673,685 (GRCm39) I793N probably damaging Het
Kcnc1 C A 7: 46,076,955 (GRCm39) C252* probably null Het
Kdr T A 5: 76,129,521 (GRCm39) D122V probably damaging Het
Kmt2a G A 9: 44,731,557 (GRCm39) P2920L unknown Het
Lrrc31 T C 3: 30,741,617 (GRCm39) E264G probably damaging Het
Mbnl1 A G 3: 60,529,614 (GRCm39) T256A probably benign Het
Myh3 A G 11: 66,991,921 (GRCm39) E1822G possibly damaging Het
Ndst4 A G 3: 125,518,344 (GRCm39) N155S unknown Het
Negr1 T C 3: 156,267,898 (GRCm39) C23R probably damaging Het
Nfia T A 4: 97,671,465 (GRCm39) D58E probably damaging Het
Nrp1 A T 8: 129,202,650 (GRCm39) N545I probably damaging Het
Nrtn T A 17: 57,059,480 (GRCm39) probably benign Het
Or4c100 T C 2: 88,356,421 (GRCm39) F165L probably benign Het
Or5an11 C T 19: 12,246,379 (GRCm39) R262* probably null Het
Pclo G A 5: 14,727,558 (GRCm39) D2139N unknown Het
Phlpp1 C T 1: 106,246,699 (GRCm39) Q630* probably null Het
Pkd1 T C 17: 24,796,812 (GRCm39) V2429A possibly damaging Het
Pramel20 T A 4: 143,299,328 (GRCm39) H330Q probably benign Het
Pramel30 T C 4: 144,056,844 (GRCm39) L9P probably damaging Het
Prkch A G 12: 73,805,730 (GRCm39) K502E probably damaging Het
Rad51ap2 A G 12: 11,509,413 (GRCm39) K930E possibly damaging Het
Reep4 T A 14: 70,785,683 (GRCm39) N204K probably benign Het
Rin2 T C 2: 145,690,764 (GRCm39) L144P probably damaging Het
Scfd2 T C 5: 74,691,611 (GRCm39) S224G possibly damaging Het
Srprb A G 9: 103,069,481 (GRCm39) Y158H probably damaging Het
Thbs4 T A 13: 92,890,896 (GRCm39) H857L probably damaging Het
Tmem184a A G 5: 139,798,790 (GRCm39) L77P possibly damaging Het
Trbv26 G T 6: 41,204,478 (GRCm39) C7F probably benign Het
Trip11 A G 12: 101,850,123 (GRCm39) S1314P probably benign Het
Ttc28 A T 5: 111,431,879 (GRCm39) T1951S probably benign Het
Ttc29 A C 8: 78,972,895 (GRCm39) D115A possibly damaging Het
Upf2 G A 2: 6,032,024 (GRCm39) V857I unknown Het
Vmn2r43 A G 7: 8,247,787 (GRCm39) V792A probably damaging Het
Washc5 A T 15: 59,218,706 (GRCm39) I687N probably damaging Het
Wwc2 G A 8: 48,281,799 (GRCm39) probably benign Het
Xirp2 G A 2: 67,340,539 (GRCm39) E927K possibly damaging Het
Zc3hav1l A G 6: 38,276,112 (GRCm39) F22L probably benign Het
Zfp407 C T 18: 84,578,312 (GRCm39) A934T probably benign Het
Zfp986 T A 4: 145,626,070 (GRCm39) S243R probably benign Het
Zfyve9 T C 4: 108,576,305 (GRCm39) T259A probably benign Het
Other mutations in Or2a14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01362:Or2a14 APN 6 43,130,569 (GRCm39) missense probably damaging 1.00
IGL01658:Or2a14 APN 6 43,130,784 (GRCm39) missense probably damaging 0.99
IGL02826:Or2a14 APN 6 43,130,511 (GRCm39) missense possibly damaging 0.80
R0504:Or2a14 UTSW 6 43,130,395 (GRCm39) missense probably benign
R0839:Or2a14 UTSW 6 43,130,558 (GRCm39) missense probably benign 0.13
R1954:Or2a14 UTSW 6 43,130,911 (GRCm39) missense possibly damaging 0.82
R5238:Or2a14 UTSW 6 43,130,961 (GRCm39) missense probably damaging 1.00
R5534:Or2a14 UTSW 6 43,130,567 (GRCm39) missense probably benign 0.00
R6213:Or2a14 UTSW 6 43,130,821 (GRCm39) missense possibly damaging 0.95
R6382:Or2a14 UTSW 6 43,130,899 (GRCm39) missense probably damaging 1.00
R8261:Or2a14 UTSW 6 43,130,242 (GRCm39) start codon destroyed probably null 1.00
R8497:Or2a14 UTSW 6 43,130,818 (GRCm39) missense probably damaging 1.00
R9080:Or2a14 UTSW 6 43,130,830 (GRCm39) missense possibly damaging 0.94
R9709:Or2a14 UTSW 6 43,130,469 (GRCm39) missense possibly damaging 0.56
Predicted Primers PCR Primer
(F):5'- TTCCAATAATGTCCCCAAGATGC -3'
(R):5'- AGGGGCCCCACTAATATGAAC -3'

Sequencing Primer
(F):5'- CCCAAGATGCTGGCAAATCTTGTG -3'
(R):5'- GCTGCAAAGATAACAACTTGATTGAG -3'
Posted On 2022-10-06