Incidental Mutation 'R9695:Ifi206'
ID 729194
Institutional Source Beutler Lab
Gene Symbol Ifi206
Ensembl Gene ENSMUSG00000037849
Gene Name interferon activated gene 206
Synonyms Pyblhin-C, Gm4955
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.175) question?
Stock # R9695 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 173296051-173318607 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 173301249 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 810 (T810A)
Ref Sequence ENSEMBL: ENSMUSP00000134646 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000160565] [ENSMUST00000169797]
AlphaFold G3UZV2
Predicted Effect unknown
Transcript: ENSMUST00000160565
AA Change: T810A
SMART Domains Protein: ENSMUSP00000134646
Gene: ENSMUSG00000037849
AA Change: T810A

DomainStartEndE-ValueType
PYRIN 6 84 5.7e-21 SMART
low complexity region 97 108 N/A INTRINSIC
internal_repeat_1 154 349 6.25e-15 PROSPERO
internal_repeat_1 342 575 6.25e-15 PROSPERO
Predicted Effect probably benign
Transcript: ENSMUST00000169797
AA Change: T82A

PolyPhen 2 Score 0.044 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000133809
Gene: ENSMUSG00000037849
AA Change: T82A

DomainStartEndE-ValueType
Pfam:HIN 1 142 8.8e-66 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ablim1 T C 19: 57,170,739 (GRCm39) T1A Het
Adgrl1 G A 8: 84,665,060 (GRCm39) R1249Q probably damaging Het
Apeh G A 9: 107,963,483 (GRCm39) R580C probably damaging Het
Armc12 T A 17: 28,749,993 (GRCm39) C46S probably benign Het
Avpr1a C T 10: 122,284,845 (GRCm39) R46C probably damaging Het
Cbln4 C G 2: 171,879,469 (GRCm39) G140R probably damaging Het
Ccdc89 A G 7: 90,076,552 (GRCm39) N254S probably benign Het
Cd96 T A 16: 45,919,410 (GRCm39) I204F probably damaging Het
Cel G T 2: 28,450,961 (GRCm39) L101I probably damaging Het
Crtap A T 9: 114,215,378 (GRCm39) Y170* probably null Het
Ctxn3 A G 18: 57,610,185 (GRCm39) M1V probably null Het
Cwf19l1 G T 19: 44,101,425 (GRCm39) H478N probably damaging Het
Dpysl3 A T 18: 43,571,192 (GRCm39) D27E probably damaging Het
Dsg1b A G 18: 20,532,389 (GRCm39) T478A probably damaging Het
Dvl2 G A 11: 69,899,976 (GRCm39) R590Q possibly damaging Het
Elovl7 C A 13: 108,416,242 (GRCm39) Q211K probably damaging Het
Fech A G 18: 64,600,803 (GRCm39) I233T probably damaging Het
Fsip2 A T 2: 82,806,226 (GRCm39) Q848H probably benign Het
Gna15 A G 10: 81,359,752 (GRCm39) C13R probably damaging Het
Gstt4 A T 10: 75,657,072 (GRCm39) S65T probably benign Het
Heatr1 T C 13: 12,438,624 (GRCm39) V1353A probably damaging Het
Hip1r A T 5: 124,139,916 (GRCm39) K1006N possibly damaging Het
Hspg2 T A 4: 137,265,701 (GRCm39) V1804E probably damaging Het
Ighv1-69 T C 12: 115,586,987 (GRCm39) T49A probably benign Het
Il4i1 A T 7: 44,489,033 (GRCm39) D266V probably damaging Het
Itga3 A T 11: 94,946,520 (GRCm39) probably null Het
Itpr1 A G 6: 108,378,311 (GRCm39) N1279S probably damaging Het
Madd T C 2: 90,992,929 (GRCm39) T997A probably benign Het
Mal C T 2: 127,482,308 (GRCm39) V32I probably benign Het
Map9 T A 3: 82,284,292 (GRCm39) S289T probably benign Het
Mmp15 G T 8: 96,097,414 (GRCm39) R461L possibly damaging Het
Nelfcd T A 2: 174,266,923 (GRCm39) I395N probably benign Het
Neurog2 T A 3: 127,427,694 (GRCm39) V106E probably damaging Het
Nup160 T A 2: 90,538,486 (GRCm39) N761K probably damaging Het
Oasl1 G A 5: 115,074,054 (GRCm39) R321Q probably damaging Het
Oosp2 T C 19: 11,628,994 (GRCm39) T36A Het
Or2a52 A T 6: 43,144,510 (GRCm39) I173L probably benign Het
Or7g22 A G 9: 19,049,171 (GRCm39) N294S probably damaging Het
Or8k30 T C 2: 86,339,100 (GRCm39) V99A probably benign Het
Or9s27 A G 1: 92,516,595 (GRCm39) D181G probably benign Het
Otx2 T G 14: 48,899,952 (GRCm39) S16R probably damaging Het
Phactr2 A G 10: 13,349,908 (GRCm39) S39P unknown Het
Piwil2 A G 14: 70,627,349 (GRCm39) Y797H possibly damaging Het
Plxna4 T G 6: 32,183,056 (GRCm39) Y949S probably benign Het
Prss35 A G 9: 86,637,761 (GRCm39) Y177C probably damaging Het
Rbm19 T C 5: 120,335,986 (GRCm39) I934T probably damaging Het
Rictor T G 15: 6,816,010 (GRCm39) V1094G probably benign Het
Riok1 A G 13: 38,242,676 (GRCm39) T467A possibly damaging Het
Slc15a4 G A 5: 127,694,400 (GRCm39) R12W possibly damaging Het
Slc44a5 T A 3: 153,956,588 (GRCm39) I280K probably damaging Het
Slc9c1 T C 16: 45,368,026 (GRCm39) L205S probably benign Het
Slco2a1 A G 9: 102,962,139 (GRCm39) R604G possibly damaging Het
Slmap T A 14: 26,183,496 (GRCm39) T296S probably damaging Het
Snrk T C 9: 121,995,640 (GRCm39) V473A probably benign Het
Spart A G 3: 55,033,955 (GRCm39) T394A probably benign Het
Stil T C 4: 114,881,378 (GRCm39) S641P probably damaging Het
Syne1 A G 10: 5,268,461 (GRCm39) V2076A probably benign Het
Tcirg1 G A 19: 3,952,360 (GRCm39) A336V probably null Het
Tespa1 T C 10: 130,198,285 (GRCm39) S436P probably benign Het
Thumpd3 G T 6: 113,024,622 (GRCm39) R72L possibly damaging Het
Tmem70 A C 1: 16,735,659 (GRCm39) E43A probably benign Het
Vars1 A G 17: 35,231,564 (GRCm39) D696G possibly damaging Het
Vwa5b2 A T 16: 20,422,975 (GRCm39) H991L probably benign Het
Zfp160 A G 17: 21,245,746 (GRCm39) K99E possibly damaging Het
Zfp759 G A 13: 67,287,198 (GRCm39) V250I possibly damaging Het
Zmym6 T C 4: 127,016,340 (GRCm39) V707A probably benign Het
Other mutations in Ifi206
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01509:Ifi206 APN 1 173,313,142 (GRCm39) missense probably benign 0.00
IGL02044:Ifi206 APN 1 173,308,557 (GRCm39) missense probably benign 0.41
IGL02118:Ifi206 APN 1 173,309,334 (GRCm39) missense probably benign 0.05
IGL02476:Ifi206 APN 1 173,309,132 (GRCm39) missense probably benign 0.02
IGL02824:Ifi206 APN 1 173,309,438 (GRCm39) missense possibly damaging 0.95
IGL03375:Ifi206 APN 1 173,308,344 (GRCm39) missense probably benign 0.06
PIT4142001:Ifi206 UTSW 1 173,308,730 (GRCm39) missense probably benign 0.02
R0069:Ifi206 UTSW 1 173,314,413 (GRCm39) missense probably damaging 1.00
R0741:Ifi206 UTSW 1 173,301,315 (GRCm39) missense probably benign 0.41
R1572:Ifi206 UTSW 1 173,314,419 (GRCm39) missense probably benign 0.10
R1742:Ifi206 UTSW 1 173,309,537 (GRCm39) missense probably benign 0.06
R4109:Ifi206 UTSW 1 173,308,554 (GRCm39) missense probably benign 0.00
R4707:Ifi206 UTSW 1 173,308,432 (GRCm39) missense probably benign 0.00
R4783:Ifi206 UTSW 1 173,308,432 (GRCm39) missense probably benign 0.00
R4785:Ifi206 UTSW 1 173,308,432 (GRCm39) missense probably benign 0.00
R4805:Ifi206 UTSW 1 173,308,952 (GRCm39) missense possibly damaging 0.55
R4918:Ifi206 UTSW 1 173,309,610 (GRCm39) missense possibly damaging 0.73
R5043:Ifi206 UTSW 1 173,314,284 (GRCm39) missense probably damaging 1.00
R5080:Ifi206 UTSW 1 173,301,414 (GRCm39) missense possibly damaging 0.61
R5419:Ifi206 UTSW 1 173,308,797 (GRCm39) missense probably benign 0.05
R5420:Ifi206 UTSW 1 173,308,599 (GRCm39) missense possibly damaging 0.84
R5777:Ifi206 UTSW 1 173,308,928 (GRCm39) missense possibly damaging 0.55
R5988:Ifi206 UTSW 1 173,308,906 (GRCm39) missense possibly damaging 0.90
R6772:Ifi206 UTSW 1 173,308,773 (GRCm39) missense unknown
R6782:Ifi206 UTSW 1 173,308,923 (GRCm39) missense unknown
R6806:Ifi206 UTSW 1 173,309,137 (GRCm39) missense probably benign 0.06
R7042:Ifi206 UTSW 1 173,308,808 (GRCm39) missense
R7091:Ifi206 UTSW 1 173,301,441 (GRCm39) missense unknown
R7292:Ifi206 UTSW 1 173,301,428 (GRCm39) missense unknown
R7429:Ifi206 UTSW 1 173,308,157 (GRCm39) missense
R7499:Ifi206 UTSW 1 173,309,607 (GRCm39) missense
R7772:Ifi206 UTSW 1 173,308,640 (GRCm39) missense
R7853:Ifi206 UTSW 1 173,299,100 (GRCm39) nonsense probably null
R7971:Ifi206 UTSW 1 173,298,976 (GRCm39) missense unknown
R8079:Ifi206 UTSW 1 173,308,724 (GRCm39) missense
R8205:Ifi206 UTSW 1 173,309,450 (GRCm39) missense
R8289:Ifi206 UTSW 1 173,308,032 (GRCm39) missense
R8390:Ifi206 UTSW 1 173,308,511 (GRCm39) missense
R8500:Ifi206 UTSW 1 173,314,311 (GRCm39) missense
R8712:Ifi206 UTSW 1 173,308,074 (GRCm39) missense
R8753:Ifi206 UTSW 1 173,301,223 (GRCm39) missense unknown
R8875:Ifi206 UTSW 1 173,301,353 (GRCm39) missense unknown
R9128:Ifi206 UTSW 1 173,299,022 (GRCm39) missense unknown
R9369:Ifi206 UTSW 1 173,301,489 (GRCm39) missense unknown
R9569:Ifi206 UTSW 1 173,314,209 (GRCm39) missense
R9676:Ifi206 UTSW 1 173,308,718 (GRCm39) missense
R9776:Ifi206 UTSW 1 173,308,075 (GRCm39) missense
X0052:Ifi206 UTSW 1 173,309,535 (GRCm39) missense possibly damaging 0.89
Z1088:Ifi206 UTSW 1 173,301,577 (GRCm39) missense probably damaging 1.00
Z1176:Ifi206 UTSW 1 173,309,614 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- CCATTCCACACCTTAAAATGGG -3'
(R):5'- TGTTTGACATAGCCCTCGAGG -3'

Sequencing Primer
(F):5'- AATGGGAAACTCCACTTTCTGTTTC -3'
(R):5'- TTGACATAGCCCTCGAGGAAAAGTTC -3'
Posted On 2022-10-06