Incidental Mutation 'R9699:Fam174c'
ID 729484
Institutional Source Beutler Lab
Gene Symbol Fam174c
Ensembl Gene ENSMUSG00000035595
Gene Name family with sequence similarity 174, member C
Synonyms 1600002K03Rik
MMRRC Submission
Accession Numbers
Essential gene? Not available question?
Stock # R9699 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 80008778-80010953 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to A at 80010161 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000037758 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041882] [ENSMUST00000041882] [ENSMUST00000054666] [ENSMUST00000105365] [ENSMUST00000154726]
AlphaFold Q9DAZ5
Predicted Effect probably null
Transcript: ENSMUST00000041882
SMART Domains Protein: ENSMUSP00000037758
Gene: ENSMUSG00000035595

DomainStartEndE-ValueType
Pfam:DUF1180 11 108 4.3e-11 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000041882
SMART Domains Protein: ENSMUSP00000037758
Gene: ENSMUSG00000035595

DomainStartEndE-ValueType
Pfam:DUF1180 11 108 4.3e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000054666
SMART Domains Protein: ENSMUSP00000052642
Gene: ENSMUSG00000045193

DomainStartEndE-ValueType
RRM 7 80 1.62e-32 SMART
low complexity region 89 168 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000105365
SMART Domains Protein: ENSMUSP00000101004
Gene: ENSMUSG00000045193

DomainStartEndE-ValueType
RRM 7 80 1.62e-32 SMART
low complexity region 89 168 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000154726
SMART Domains Protein: ENSMUSP00000121214
Gene: ENSMUSG00000045193

DomainStartEndE-ValueType
RRM 7 80 1.62e-32 SMART
low complexity region 89 108 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700066M21Rik G T 1: 57,416,927 (GRCm39) R33L probably benign Het
Abhd16b A T 2: 181,136,518 (GRCm39) R473S probably benign Het
Adcyap1r1 A G 6: 55,474,140 (GRCm39) D492G probably damaging Het
Ano5 A T 7: 51,229,309 (GRCm39) N617I probably damaging Het
Cdh15 A G 8: 123,588,769 (GRCm39) E281G probably benign Het
Clasp2 T A 9: 113,738,614 (GRCm39) probably null Het
Dock8 G A 19: 25,133,388 (GRCm39) probably null Het
Dscaml1 T C 9: 45,654,315 (GRCm39) V1449A probably damaging Het
Ercc6 A G 14: 32,282,703 (GRCm39) D732G probably damaging Het
Fhip2b A T 14: 70,825,179 (GRCm39) S386T possibly damaging Het
Gimap6 T C 6: 48,684,951 (GRCm39) E45G probably benign Het
Glt1d1 C A 5: 127,771,364 (GRCm39) T285K probably damaging Het
Gm14412 A T 2: 177,007,636 (GRCm39) Y86* probably null Het
Grip2 A G 6: 91,742,318 (GRCm39) S912P probably benign Het
Gucy2d T A 7: 98,108,290 (GRCm39) I741N probably damaging Het
Hrh2 A T 13: 54,368,299 (GRCm39) N92Y probably damaging Het
Klrc2 T A 6: 129,637,452 (GRCm39) Q23L possibly damaging Het
Patl2 T C 2: 121,955,591 (GRCm39) D285G probably damaging Het
Prpf40a A G 2: 53,035,735 (GRCm39) V685A probably benign Het
Rspry1 A G 8: 95,380,857 (GRCm39) H511R probably benign Het
Scarb1 G T 5: 125,374,296 (GRCm39) A279E probably damaging Het
Sell A G 1: 163,893,114 (GRCm39) E110G probably damaging Het
Sftpc A T 14: 70,760,143 (GRCm39) I38N probably damaging Het
Shank1 G A 7: 43,962,342 (GRCm39) S71N unknown Het
Slc5a4b C A 10: 75,946,674 (GRCm39) V33F probably damaging Het
Smad7 A G 18: 75,527,161 (GRCm39) S336G probably damaging Het
Tnpo3 C T 6: 29,565,768 (GRCm39) V529I probably benign Het
Trafd1 A G 5: 121,517,727 (GRCm39) V22A probably benign Het
Tssk1 A G 16: 17,712,545 (GRCm39) E110G probably damaging Het
Vmn1r159 A T 7: 22,542,675 (GRCm39) V119D probably damaging Het
Vmn1r191 A G 13: 22,363,355 (GRCm39) F133S probably benign Het
Vwa1 G A 4: 155,857,336 (GRCm39) P154L probably damaging Het
Zfp830 C T 11: 82,655,805 (GRCm39) T203I possibly damaging Het
Zw10 G T 9: 48,966,942 (GRCm39) probably benign Het
Other mutations in Fam174c
AlleleSourceChrCoordTypePredicted EffectPPH Score
R7185:Fam174c UTSW 10 80,008,963 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CACATCTGGCAAGTGCTTTGG -3'
(R):5'- GTGTGGCACTTTCCTCCAAC -3'

Sequencing Primer
(F):5'- GGAAGCATTGCGTGGGTAC -3'
(R):5'- CCAACATCTGTTTCCATTAGAGC -3'
Posted On 2022-10-06