Mutagenetix > Incidental Mutation

Incidental Mutation 'R9699:Vmn1r191'

729486

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r191

Ensembl Gene

ENSMUSG00000095916

Gene Name

vomeronasal 1 receptor 191

Synonyms

V1rh15

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.151) question?

Stock #

R9699 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

22362856-22363752 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 22363355 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 133 (F133S)

Ref Sequence

ENSEMBL: ENSMUSP00000072206 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072369]

AlphaFold

Q8K4D0

Predicted Effect

probably benign
Transcript: ENSMUST00000072369
AA Change: F133S

PolyPhen 2 Score 0.245 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000072206
Gene: ENSMUSG00000095916
AA Change: F133S

Domain	Start	End	E-Value	Type
transmembrane domain	12	34	N/A	INTRINSIC
Pfam:V1R	35	291	4.4e-33	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700066M21Rik	G	T	1: 57,416,927 (GRCm39)	R33L	probably benign	Het
Abhd16b	A	T	2: 181,136,518 (GRCm39)	R473S	probably benign	Het
Adcyap1r1	A	G	6: 55,474,140 (GRCm39)	D492G	probably damaging	Het
Ano5	A	T	7: 51,229,309 (GRCm39)	N617I	probably damaging	Het
Cdh15	A	G	8: 123,588,769 (GRCm39)	E281G	probably benign	Het
Clasp2	T	A	9: 113,738,614 (GRCm39)		probably null	Het
Dock8	G	A	19: 25,133,388 (GRCm39)		probably null	Het
Dscaml1	T	C	9: 45,654,315 (GRCm39)	V1449A	probably damaging	Het
Ercc6	A	G	14: 32,282,703 (GRCm39)	D732G	probably damaging	Het
Fam174c	T	A	10: 80,010,161 (GRCm39)		probably null	Het
Fhip2b	A	T	14: 70,825,179 (GRCm39)	S386T	possibly damaging	Het
Gimap6	T	C	6: 48,684,951 (GRCm39)	E45G	probably benign	Het
Glt1d1	C	A	5: 127,771,364 (GRCm39)	T285K	probably damaging	Het
Gm14412	A	T	2: 177,007,636 (GRCm39)	Y86*	probably null	Het
Grip2	A	G	6: 91,742,318 (GRCm39)	S912P	probably benign	Het
Gucy2d	T	A	7: 98,108,290 (GRCm39)	I741N	probably damaging	Het
Hrh2	A	T	13: 54,368,299 (GRCm39)	N92Y	probably damaging	Het
Klrc2	T	A	6: 129,637,452 (GRCm39)	Q23L	possibly damaging	Het
Patl2	T	C	2: 121,955,591 (GRCm39)	D285G	probably damaging	Het
Prpf40a	A	G	2: 53,035,735 (GRCm39)	V685A	probably benign	Het
Rspry1	A	G	8: 95,380,857 (GRCm39)	H511R	probably benign	Het
Scarb1	G	T	5: 125,374,296 (GRCm39)	A279E	probably damaging	Het
Sell	A	G	1: 163,893,114 (GRCm39)	E110G	probably damaging	Het
Sftpc	A	T	14: 70,760,143 (GRCm39)	I38N	probably damaging	Het
Shank1	G	A	7: 43,962,342 (GRCm39)	S71N	unknown	Het
Slc5a4b	C	A	10: 75,946,674 (GRCm39)	V33F	probably damaging	Het
Smad7	A	G	18: 75,527,161 (GRCm39)	S336G	probably damaging	Het
Tnpo3	C	T	6: 29,565,768 (GRCm39)	V529I	probably benign	Het
Trafd1	A	G	5: 121,517,727 (GRCm39)	V22A	probably benign	Het
Tssk1	A	G	16: 17,712,545 (GRCm39)	E110G	probably damaging	Het
Vmn1r159	A	T	7: 22,542,675 (GRCm39)	V119D	probably damaging	Het
Vwa1	G	A	4: 155,857,336 (GRCm39)	P154L	probably damaging	Het
Zfp830	C	T	11: 82,655,805 (GRCm39)	T203I	possibly damaging	Het
Zw10	G	T	9: 48,966,942 (GRCm39)		probably benign	Het

Other mutations in Vmn1r191

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00233:Vmn1r191	APN	13	22,362,890 (GRCm39)	missense	probably damaging	1.00
IGL01645:Vmn1r191	APN	13	22,363,614 (GRCm39)	missense	probably benign	0.03
IGL02224:Vmn1r191	APN	13	22,363,068 (GRCm39)	missense	probably damaging	1.00
IGL02321:Vmn1r191	APN	13	22,363,068 (GRCm39)	nonsense	probably null
IGL02516:Vmn1r191	APN	13	22,363,710 (GRCm39)	missense	probably benign	0.38
IGL02602:Vmn1r191	APN	13	22,363,635 (GRCm39)	missense	probably damaging	1.00
IGL02630:Vmn1r191	APN	13	22,363,431 (GRCm39)	missense	possibly damaging	0.95
IGL03077:Vmn1r191	APN	13	22,363,316 (GRCm39)	missense	probably benign	0.07
IGL03380:Vmn1r191	APN	13	22,363,055 (GRCm39)	missense	probably damaging	0.99
R0571:Vmn1r191	UTSW	13	22,363,217 (GRCm39)	missense	probably damaging	0.96
R0981:Vmn1r191	UTSW	13	22,363,389 (GRCm39)	missense	probably benign	0.00
R1672:Vmn1r191	UTSW	13	22,363,262 (GRCm39)	missense	probably benign	0.01
R1955:Vmn1r191	UTSW	13	22,362,985 (GRCm39)	missense	possibly damaging	0.79
R1969:Vmn1r191	UTSW	13	22,362,952 (GRCm39)	missense	possibly damaging	0.71
R5059:Vmn1r191	UTSW	13	22,363,163 (GRCm39)	missense	probably damaging	1.00
R6484:Vmn1r191	UTSW	13	22,362,918 (GRCm39)	missense	probably benign	0.00
R6736:Vmn1r191	UTSW	13	22,363,720 (GRCm39)	missense	probably benign	0.14
R7063:Vmn1r191	UTSW	13	22,362,864 (GRCm39)	missense	probably benign	0.08
R7475:Vmn1r191	UTSW	13	22,362,942 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- AGAAATACCATGTAGCCACTGG -3'
(R):5'- TGCCAAAGACAGTAGCAGC -3'

Sequencing Primer
(F):5'- TGGCACCCTGAAACACTG -3'
(R):5'- TGCCAAAGACAGTAGCAGCTTTTG -3'

Posted On

2022-10-06