Incidental Mutation 'R9702:Tigd3'
ID 729641
Institutional Source Beutler Lab
Gene Symbol Tigd3
Ensembl Gene ENSMUSG00000044390
Gene Name tigger transposable element derived 3
Synonyms
MMRRC Submission
Accession Numbers
Essential gene? Possibly essential (E-score: 0.702) question?
Stock # R9702 (G1)
Quality Score 225.009
Status Not validated
Chromosome 19
Chromosomal Location 5941166-5944156 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 5942836 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 98 (T98M)
Ref Sequence ENSEMBL: ENSMUSP00000059302 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055911] [ENSMUST00000118623] [ENSMUST00000136983]
AlphaFold Q7TM95
Predicted Effect probably benign
Transcript: ENSMUST00000025746
SMART Domains Protein: ENSMUSP00000025746
Gene: ENSMUSG00000024826

DomainStartEndE-ValueType
Pfam:Requiem_N 1 40 1.4e-19 PFAM
low complexity region 115 131 N/A INTRINSIC
low complexity region 134 152 N/A INTRINSIC
ZnF_C2H2 165 188 4.47e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000055911
AA Change: T98M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000059302
Gene: ENSMUSG00000044390
AA Change: T98M

DomainStartEndE-ValueType
Pfam:CENP-B_N 6 59 2.5e-15 PFAM
CENPB 73 137 2.96e-7 SMART
Pfam:DDE_1 192 360 7.4e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000118623
SMART Domains Protein: ENSMUSP00000113465
Gene: ENSMUSG00000024826

DomainStartEndE-ValueType
Pfam:Requiem_N 13 84 7.9e-40 PFAM
low complexity region 159 175 N/A INTRINSIC
low complexity region 178 196 N/A INTRINSIC
PDB:3IUF|A 203 263 1e-21 PDB
PHD 286 342 8.64e-9 SMART
RING 287 341 3.83e0 SMART
PHD 343 389 8.9e-11 SMART
RING 344 388 9.75e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000136983
SMART Domains Protein: ENSMUSP00000120125
Gene: ENSMUSG00000024826

DomainStartEndE-ValueType
Pfam:Requiem_N 12 85 6.2e-41 PFAM
low complexity region 159 175 N/A INTRINSIC
low complexity region 178 196 N/A INTRINSIC
ZnF_C2H2 209 232 4.47e-3 SMART
PHD 272 328 8.64e-9 SMART
RING 273 327 3.83e0 SMART
PHD 329 375 8.9e-11 SMART
RING 330 374 9.75e-1 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca6 A G 11: 110,107,378 (GRCm39) Y746H probably damaging Het
Adgrv1 T A 13: 81,684,483 (GRCm39) I1073F possibly damaging Het
Ankrd6 C T 4: 32,810,202 (GRCm39) R493H possibly damaging Het
Apob G T 12: 8,057,559 (GRCm39) A2014S probably damaging Het
Bdnf A T 2: 109,554,117 (GRCm39) M164L possibly damaging Het
Ccdc187 C T 2: 26,172,222 (GRCm39) V287M unknown Het
Cd164 G A 10: 41,404,818 (GRCm39) R192Q probably damaging Het
Cd84 T C 1: 171,700,498 (GRCm39) V205A probably benign Het
Cfap161 T A 7: 83,442,652 (GRCm39) M54L probably benign Het
Crim1 T A 17: 78,681,516 (GRCm39) V990E probably damaging Het
Dsc1 A G 18: 20,227,685 (GRCm39) F518L probably benign Het
Esyt1 G A 10: 128,356,607 (GRCm39) S346L probably damaging Het
Fbxo30 G T 10: 11,166,382 (GRCm39) C368F probably benign Het
Gas2l3 C T 10: 89,249,943 (GRCm39) A392T probably benign Het
Gfra4 T A 2: 130,884,539 (GRCm39) S22C probably benign Het
Gm11992 T G 11: 9,006,568 (GRCm39) V166G probably benign Het
Gp1bb A T 16: 18,439,884 (GRCm39) L70Q probably damaging Het
Gtf2i T C 5: 134,275,415 (GRCm39) T707A probably benign Het
Inpp5f A C 7: 128,278,515 (GRCm39) D435A possibly damaging Het
Kynu T A 2: 43,479,469 (GRCm39) M121K probably damaging Het
Ldb3 A G 14: 34,299,090 (GRCm39) V178A probably benign Het
Lrrc31 A G 3: 30,735,226 (GRCm39) L350P probably damaging Het
Mfsd14b C A 13: 65,221,414 (GRCm39) V293L probably benign Het
Mrps23 C T 11: 88,100,998 (GRCm39) T121M probably damaging Het
Nlrp4c T A 7: 6,068,801 (GRCm39) V234E probably benign Het
Or51f1e T C 7: 102,747,343 (GRCm39) Y132H probably damaging Het
Pign A T 1: 105,485,212 (GRCm39) D782E probably damaging Het
Rab11b C A 17: 33,968,026 (GRCm39) R82L possibly damaging Het
Sema3c T C 5: 17,858,828 (GRCm39) S76P probably damaging Het
Slc28a2b T A 2: 122,354,012 (GRCm39) I546N probably damaging Het
Sobp T C 10: 42,897,944 (GRCm39) N547S probably benign Het
Tox T G 4: 6,697,418 (GRCm39) M462L probably benign Het
Vmn1r158 T A 7: 22,490,065 (GRCm39) Q48L probably benign Het
Vps8 A G 16: 21,462,883 (GRCm39) T1383A probably benign Het
Vwa1 G A 4: 155,857,336 (GRCm39) P154L probably damaging Het
Zfp108 C T 7: 23,960,195 (GRCm39) T262I probably benign Het
Other mutations in Tigd3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0456:Tigd3 UTSW 19 5,942,821 (GRCm39) missense probably damaging 1.00
R0699:Tigd3 UTSW 19 5,941,974 (GRCm39) missense probably benign
R1416:Tigd3 UTSW 19 5,941,753 (GRCm39) missense probably benign
R3945:Tigd3 UTSW 19 5,942,461 (GRCm39) missense probably damaging 0.98
R5945:Tigd3 UTSW 19 5,941,894 (GRCm39) missense probably benign
R6253:Tigd3 UTSW 19 5,942,870 (GRCm39) missense probably damaging 1.00
R7189:Tigd3 UTSW 19 5,943,050 (GRCm39) missense probably benign 0.09
R7956:Tigd3 UTSW 19 5,942,594 (GRCm39) missense possibly damaging 0.88
R8976:Tigd3 UTSW 19 5,941,853 (GRCm39) missense probably benign 0.00
R8979:Tigd3 UTSW 19 5,941,853 (GRCm39) missense probably benign 0.00
R9506:Tigd3 UTSW 19 5,942,860 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGAACTGCAGGAGGAGCTTC -3'
(R):5'- CTGGAACTCTTGGATGAGTCTAAG -3'

Sequencing Primer
(F):5'- CTGCAGGAGGAGCTTCAGGAG -3'
(R):5'- TGAGTCTAAGATGTCCCAGTCAG -3'
Posted On 2022-10-06