Incidental Mutation 'R9703:H2ac19'
ID 729649
Institutional Source Beutler Lab
Gene Symbol H2ac19
Ensembl Gene ENSMUSG00000063954
Gene Name H2A clustered histone 19
Synonyms Hist2h2aa2, H2a-614
MMRRC Submission
Accession Numbers
Essential gene? Not available question?
Stock # R9703 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 96147065-96147592 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 96147557 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Cysteine at position 4 (R4C)
Ref Sequence ENSEMBL: ENSMUSP00000100581 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074976] [ENSMUST00000167403]
AlphaFold Q6GSS7
Predicted Effect probably benign
Transcript: ENSMUST00000074976
AA Change: R4C

PolyPhen 2 Score 0.242 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000100581
Gene: ENSMUSG00000063954
AA Change: R4C

DomainStartEndE-ValueType
H2A 3 123 1.1e-82 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000167403
SMART Domains Protein: ENSMUSP00000135215
Gene: ENSMUSG00000081058

DomainStartEndE-ValueType
H3 34 136 2.12e-75 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 98.2%
Validation Efficiency
MGI Phenotype FUNCTION: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Aug 2015]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam20 T A 8: 41,248,971 (GRCm39) N360K probably damaging Het
Aoc1l2 A G 6: 48,909,629 (GRCm39) T625A probably benign Het
Apob T A 12: 8,030,507 (GRCm39) L82Q probably damaging Het
Arhgap30 T G 1: 171,235,339 (GRCm39) L571R probably damaging Het
Atg9a C T 1: 75,162,431 (GRCm39) C493Y probably damaging Het
Brip1 T C 11: 85,952,830 (GRCm39) T984A possibly damaging Het
Btbd9 A G 17: 30,749,200 (GRCm39) V38A possibly damaging Het
Crocc2 C A 1: 93,130,444 (GRCm39) D908E probably benign Het
Crybg3 C G 16: 59,375,939 (GRCm39) A58P probably damaging Het
Cts7 T C 13: 61,504,350 (GRCm39) N71S probably damaging Het
Ddx46 A G 13: 55,824,635 (GRCm39) Y962C probably damaging Het
Dock10 G A 1: 80,517,540 (GRCm39) R1373C probably damaging Het
Dock9 A T 14: 121,781,989 (GRCm39) *2043R probably null Het
Efs A T 14: 55,156,871 (GRCm39) V388E possibly damaging Het
Esyt1 C T 10: 128,354,796 (GRCm39) probably null Het
Extl3 G T 14: 65,292,103 (GRCm39) R907S probably damaging Het
Fcgbp G A 7: 27,806,400 (GRCm39) V2123M probably damaging Het
Gas2l3 C T 10: 89,249,943 (GRCm39) A392T probably benign Het
Golm1 A T 13: 59,797,433 (GRCm39) D137E probably benign Het
Grxcr2 T C 18: 42,124,988 (GRCm39) D140G possibly damaging Het
Hrh1 G A 6: 114,457,979 (GRCm39) C420Y probably benign Het
Ints13 A T 6: 146,459,063 (GRCm39) L316Q probably damaging Het
Iws1 T A 18: 32,212,738 (GRCm39) D55E probably damaging Het
Kcnrg CACAACAA CACAA 14: 61,845,009 (GRCm39) probably benign Het
Klrc2 G C 6: 129,633,407 (GRCm39) S215* probably null Het
Muc5b A G 7: 141,425,535 (GRCm39) T4727A possibly damaging Het
Nsd3 T C 8: 26,131,228 (GRCm39) S198P probably benign Het
Or2n1b A T 17: 38,459,856 (GRCm39) I126F possibly damaging Het
Or6c214 A T 10: 129,591,286 (GRCm39) I11N possibly damaging Het
Ovch2 T A 7: 107,383,777 (GRCm39) I523F probably damaging Het
Pals1 T A 12: 78,843,850 (GRCm39) I18K probably benign Het
Pcdhb1 T A 18: 37,399,019 (GRCm39) D323E probably damaging Het
Pfkl T A 10: 77,826,142 (GRCm39) probably null Het
Pigc T A 1: 161,798,176 (GRCm39) F53I probably benign Het
Pramel29 T A 4: 143,939,510 (GRCm39) D9V probably damaging Het
Prph2 G A 17: 47,234,447 (GRCm39) A339T unknown Het
Prrc2a T C 17: 35,378,320 (GRCm39) K452E unknown Het
Rab36 T C 10: 74,886,474 (GRCm39) W151R possibly damaging Het
Sdk1 A G 5: 142,100,283 (GRCm39) T1438A possibly damaging Het
Slc25a17 A T 15: 81,224,193 (GRCm39) I55K probably damaging Het
Smg1 A T 7: 117,739,744 (GRCm39) I3401N possibly damaging Het
Smpd3 T A 8: 106,991,713 (GRCm39) H280L probably damaging Het
Srsf10 A G 4: 135,591,153 (GRCm39) H202R probably benign Het
Swap70 C T 7: 109,872,512 (GRCm39) R376C probably damaging Het
Syde1 G T 10: 78,421,557 (GRCm39) L665M probably damaging Het
Tha1 A G 11: 117,761,863 (GRCm39) V126A probably damaging Het
Tln2 T C 9: 67,293,938 (GRCm39) H230R probably damaging Het
Tnc G A 4: 63,889,412 (GRCm39) A1698V probably benign Het
Twist2 C A 1: 91,729,744 (GRCm39) S132R probably damaging Het
Ubr1 C T 2: 120,732,092 (GRCm39) C1170Y probably damaging Het
Vwa1 G A 4: 155,857,336 (GRCm39) P154L probably damaging Het
Predicted Primers PCR Primer
(F):5'- TTTGCCCAGCAGCTTGTTG -3'
(R):5'- AATGAGAGGCTTCTGTCCGC -3'

Sequencing Primer
(F):5'- AGGATCTCGGCCGTTAGGTAC -3'
(R):5'- CGCGCTCCTATTGGCCAC -3'
Posted On 2022-10-06