Incidental Mutation 'R9703:Kcnrg'
ID 729682
Institutional Source Beutler Lab
Gene Symbol Kcnrg
Ensembl Gene ENSMUSG00000046168
Gene Name potassium channel regulator
Synonyms LOC328424, E030012H22Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.234) question?
Stock # R9703 (G1)
Quality Score 217.468
Status Not validated
Chromosome 14
Chromosomal Location 61844906-61850275 bp(+) (GRCm39)
Type of Mutation small deletion (1 aa in frame mutation)
DNA Base Change (assembly) CACAACAA to CACAA at 61845009 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000153429 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039562] [ENSMUST00000051184] [ENSMUST00000165015] [ENSMUST00000225582]
AlphaFold Q2TUM3
Predicted Effect probably benign
Transcript: ENSMUST00000039562
SMART Domains Protein: ENSMUSP00000045009
Gene: ENSMUSG00000035235

DomainStartEndE-ValueType
RING 10 57 1.31e-8 SMART
BBOX 89 131 5.55e-12 SMART
transmembrane domain 316 338 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000051184
SMART Domains Protein: ENSMUSP00000055327
Gene: ENSMUSG00000046168

DomainStartEndE-ValueType
BTB 5 106 8.7e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000165015
SMART Domains Protein: ENSMUSP00000128509
Gene: ENSMUSG00000035235

DomainStartEndE-ValueType
RING 10 57 1.31e-8 SMART
BBOX 89 131 5.55e-12 SMART
transmembrane domain 316 338 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000225582
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 98.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein which regulates the activity of voltage-gated potassium channels. This gene is on chromosome 13 and overlaps the gene for tripartite motif containing 13 on the same strand. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Allele List at MGI

All alleles(1) : Gene trapped(1)
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam20 T A 8: 41,248,971 (GRCm39) N360K probably damaging Het
Aoc1l2 A G 6: 48,909,629 (GRCm39) T625A probably benign Het
Apob T A 12: 8,030,507 (GRCm39) L82Q probably damaging Het
Arhgap30 T G 1: 171,235,339 (GRCm39) L571R probably damaging Het
Atg9a C T 1: 75,162,431 (GRCm39) C493Y probably damaging Het
Brip1 T C 11: 85,952,830 (GRCm39) T984A possibly damaging Het
Btbd9 A G 17: 30,749,200 (GRCm39) V38A possibly damaging Het
Crocc2 C A 1: 93,130,444 (GRCm39) D908E probably benign Het
Crybg3 C G 16: 59,375,939 (GRCm39) A58P probably damaging Het
Cts7 T C 13: 61,504,350 (GRCm39) N71S probably damaging Het
Ddx46 A G 13: 55,824,635 (GRCm39) Y962C probably damaging Het
Dock10 G A 1: 80,517,540 (GRCm39) R1373C probably damaging Het
Dock9 A T 14: 121,781,989 (GRCm39) *2043R probably null Het
Efs A T 14: 55,156,871 (GRCm39) V388E possibly damaging Het
Esyt1 C T 10: 128,354,796 (GRCm39) probably null Het
Extl3 G T 14: 65,292,103 (GRCm39) R907S probably damaging Het
Fcgbp G A 7: 27,806,400 (GRCm39) V2123M probably damaging Het
Gas2l3 C T 10: 89,249,943 (GRCm39) A392T probably benign Het
Golm1 A T 13: 59,797,433 (GRCm39) D137E probably benign Het
Grxcr2 T C 18: 42,124,988 (GRCm39) D140G possibly damaging Het
H2ac19 G A 3: 96,147,557 (GRCm39) R4C probably benign Het
Hrh1 G A 6: 114,457,979 (GRCm39) C420Y probably benign Het
Ints13 A T 6: 146,459,063 (GRCm39) L316Q probably damaging Het
Iws1 T A 18: 32,212,738 (GRCm39) D55E probably damaging Het
Klrc2 G C 6: 129,633,407 (GRCm39) S215* probably null Het
Muc5b A G 7: 141,425,535 (GRCm39) T4727A possibly damaging Het
Nsd3 T C 8: 26,131,228 (GRCm39) S198P probably benign Het
Or2n1b A T 17: 38,459,856 (GRCm39) I126F possibly damaging Het
Or6c214 A T 10: 129,591,286 (GRCm39) I11N possibly damaging Het
Ovch2 T A 7: 107,383,777 (GRCm39) I523F probably damaging Het
Pals1 T A 12: 78,843,850 (GRCm39) I18K probably benign Het
Pcdhb1 T A 18: 37,399,019 (GRCm39) D323E probably damaging Het
Pfkl T A 10: 77,826,142 (GRCm39) probably null Het
Pigc T A 1: 161,798,176 (GRCm39) F53I probably benign Het
Pramel29 T A 4: 143,939,510 (GRCm39) D9V probably damaging Het
Prph2 G A 17: 47,234,447 (GRCm39) A339T unknown Het
Prrc2a T C 17: 35,378,320 (GRCm39) K452E unknown Het
Rab36 T C 10: 74,886,474 (GRCm39) W151R possibly damaging Het
Sdk1 A G 5: 142,100,283 (GRCm39) T1438A possibly damaging Het
Slc25a17 A T 15: 81,224,193 (GRCm39) I55K probably damaging Het
Smg1 A T 7: 117,739,744 (GRCm39) I3401N possibly damaging Het
Smpd3 T A 8: 106,991,713 (GRCm39) H280L probably damaging Het
Srsf10 A G 4: 135,591,153 (GRCm39) H202R probably benign Het
Swap70 C T 7: 109,872,512 (GRCm39) R376C probably damaging Het
Syde1 G T 10: 78,421,557 (GRCm39) L665M probably damaging Het
Tha1 A G 11: 117,761,863 (GRCm39) V126A probably damaging Het
Tln2 T C 9: 67,293,938 (GRCm39) H230R probably damaging Het
Tnc G A 4: 63,889,412 (GRCm39) A1698V probably benign Het
Twist2 C A 1: 91,729,744 (GRCm39) S132R probably damaging Het
Ubr1 C T 2: 120,732,092 (GRCm39) C1170Y probably damaging Het
Vwa1 G A 4: 155,857,336 (GRCm39) P154L probably damaging Het
Other mutations in Kcnrg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00595:Kcnrg APN 14 61,845,359 (GRCm39) missense probably damaging 1.00
IGL01311:Kcnrg APN 14 61,849,274 (GRCm39) missense probably damaging 1.00
D4216:Kcnrg UTSW 14 61,849,242 (GRCm39) nonsense probably null
R1081:Kcnrg UTSW 14 61,845,163 (GRCm39) missense possibly damaging 0.87
R1346:Kcnrg UTSW 14 61,849,144 (GRCm39) missense probably benign 0.31
R3147:Kcnrg UTSW 14 61,845,140 (GRCm39) missense probably damaging 1.00
R4690:Kcnrg UTSW 14 61,849,176 (GRCm39) missense probably damaging 1.00
R4820:Kcnrg UTSW 14 61,845,386 (GRCm39) missense probably benign 0.39
R5068:Kcnrg UTSW 14 61,845,266 (GRCm39) missense probably damaging 1.00
R5914:Kcnrg UTSW 14 61,849,280 (GRCm39) missense probably benign
R7234:Kcnrg UTSW 14 61,845,531 (GRCm39) missense unknown
R8232:Kcnrg UTSW 14 61,845,386 (GRCm39) missense probably benign 0.39
R8821:Kcnrg UTSW 14 61,844,981 (GRCm39) missense possibly damaging 0.55
R9442:Kcnrg UTSW 14 61,845,009 (GRCm39) small deletion probably benign
R9475:Kcnrg UTSW 14 61,845,106 (GRCm39) missense possibly damaging 0.95
R9633:Kcnrg UTSW 14 61,845,009 (GRCm39) small deletion probably benign
R9634:Kcnrg UTSW 14 61,845,009 (GRCm39) small deletion probably benign
Predicted Primers PCR Primer
(F):5'- CTTGCAAACACAGCTATGGATAC -3'
(R):5'- TCCGAGGGTAACAGAAGCTC -3'

Sequencing Primer
(F):5'- GGATACACTATTTGTCTTGACGATAG -3'
(R):5'- GGGTAACAGAAGCTCATGATTTCTC -3'
Posted On 2022-10-06