Incidental Mutation 'R9705:Styk1'
| ID |
729750 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Styk1
|
| Ensembl Gene |
ENSMUSG00000032899 |
| Gene Name |
serine/threonine/tyrosine kinase 1 |
| Synonyms |
|
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.311)
|
| Stock # |
R9705 (G1)
|
| Quality Score |
217.468 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
131276096-131330532 bp(-) (GRCm39) |
| Type of Mutation |
small deletion (4 aa in frame mutation) |
| DNA Base Change (assembly) |
CTCTTCATGATTTTCTT to CTCTT
at 131278612 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112900
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000049150]
[ENSMUST00000121078]
|
| AlphaFold |
Q6J9G1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000049150
|
| SMART Domains |
Protein: ENSMUSP00000044098
Gene: ENSMUSG00000032899
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
31 |
53 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
119 |
387 |
3.2e-31 |
PFAM |
|
Pfam:Pkinase_Tyr
|
119 |
387 |
1.8e-59 |
PFAM |
|
low complexity region
|
399 |
410 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000121078
|
| SMART Domains |
Protein: ENSMUSP00000112900
Gene: ENSMUSG00000032899
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
31 |
53 |
N/A |
INTRINSIC |
|
Pfam:Pkinase_Tyr
|
67 |
298 |
2.5e-53 |
PFAM |
|
Pfam:Pkinase
|
68 |
298 |
5.7e-29 |
PFAM |
|
low complexity region
|
310 |
321 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.7%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 47 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A830018L16Rik |
C |
T |
1: 11,588,913 (GRCm39) |
P110L |
probably damaging |
Het |
| Aff1 |
T |
G |
5: 103,932,276 (GRCm39) |
L298R |
possibly damaging |
Het |
| B4galt1 |
T |
C |
4: 40,853,474 (GRCm39) |
K111R |
probably benign |
Het |
| Brap |
A |
G |
5: 121,801,373 (GRCm39) |
T87A |
probably benign |
Het |
| C1qtnf6 |
T |
A |
15: 78,411,493 (GRCm39) |
Q61L |
probably benign |
Het |
| Ccar2 |
C |
A |
14: 70,380,383 (GRCm39) |
C399F |
probably damaging |
Het |
| Cdh15 |
C |
A |
8: 123,591,024 (GRCm39) |
D424E |
probably damaging |
Het |
| Cemip2 |
G |
A |
19: 21,784,788 (GRCm39) |
V424I |
probably damaging |
Het |
| Col4a4 |
G |
A |
1: 82,465,313 (GRCm39) |
A954V |
unknown |
Het |
| Cul9 |
T |
G |
17: 46,854,226 (GRCm39) |
T159P |
probably damaging |
Het |
| Cyp3a59 |
A |
G |
5: 146,033,120 (GRCm39) |
E164G |
probably benign |
Het |
| Dnah11 |
A |
C |
12: 118,094,770 (GRCm39) |
L766R |
probably damaging |
Het |
| Drd5 |
T |
C |
5: 38,478,027 (GRCm39) |
V340A |
probably damaging |
Het |
| Ephb6 |
G |
A |
6: 41,596,715 (GRCm39) |
E921K |
probably benign |
Het |
| Fam83e |
G |
A |
7: 45,371,921 (GRCm39) |
R106K |
probably benign |
Het |
| Fsip2 |
A |
G |
2: 82,823,634 (GRCm39) |
T6456A |
probably benign |
Het |
| H2ac1 |
A |
G |
13: 24,118,728 (GRCm39) |
N95S |
probably benign |
Het |
| H2-M10.6 |
A |
G |
17: 37,123,642 (GRCm39) |
N112S |
probably benign |
Het |
| Hectd4 |
A |
T |
5: 121,448,744 (GRCm39) |
Y364F |
probably benign |
Het |
| Hoxc9 |
T |
A |
15: 102,890,362 (GRCm39) |
M93K |
possibly damaging |
Het |
| Hsd17b4 |
A |
C |
18: 50,324,791 (GRCm39) |
K668T |
probably benign |
Het |
| Inpp4b |
T |
C |
8: 82,772,890 (GRCm39) |
V728A |
probably benign |
Het |
| Jph3 |
C |
T |
8: 122,508,913 (GRCm39) |
R392W |
probably damaging |
Het |
| Krt79 |
T |
G |
15: 101,839,196 (GRCm39) |
E424D |
probably benign |
Het |
| Mphosph10 |
T |
C |
7: 64,027,031 (GRCm39) |
E594G |
possibly damaging |
Het |
| Mrm2 |
G |
A |
5: 140,316,990 (GRCm39) |
R15W |
probably damaging |
Het |
| Neurl4 |
A |
T |
11: 69,799,679 (GRCm39) |
D994V |
probably damaging |
Het |
| Ngef |
G |
A |
1: 87,431,010 (GRCm39) |
P269L |
probably damaging |
Het |
| Odam |
T |
A |
5: 88,037,228 (GRCm39) |
F141I |
probably benign |
Het |
| Or1j10 |
A |
G |
2: 36,266,962 (GRCm39) |
Y58C |
probably damaging |
Het |
| Or56a3b |
T |
A |
7: 104,770,841 (GRCm39) |
L59Q |
probably damaging |
Het |
| Pck1 |
T |
A |
2: 173,000,170 (GRCm39) |
S534T |
possibly damaging |
Het |
| Pgm3 |
A |
G |
9: 86,437,414 (GRCm39) |
F528L |
probably benign |
Het |
| Pi4ka |
A |
T |
16: 17,099,815 (GRCm39) |
I1936N |
|
Het |
| Ptpn13 |
T |
C |
5: 103,681,221 (GRCm39) |
L807S |
possibly damaging |
Het |
| Ramp2 |
T |
A |
11: 101,137,369 (GRCm39) |
L31Q |
possibly damaging |
Het |
| Rars2 |
A |
T |
4: 34,646,561 (GRCm39) |
K275N |
possibly damaging |
Het |
| Rusc2 |
A |
C |
4: 43,424,936 (GRCm39) |
N1131T |
probably benign |
Het |
| Snapc1 |
G |
T |
12: 74,015,150 (GRCm39) |
K161N |
probably damaging |
Het |
| Spag8 |
G |
A |
4: 43,652,366 (GRCm39) |
H325Y |
possibly damaging |
Het |
| Synpo2l |
C |
T |
14: 20,710,989 (GRCm39) |
V773M |
probably damaging |
Het |
| Syt3 |
A |
G |
7: 44,045,225 (GRCm39) |
D519G |
probably damaging |
Het |
| Tacc2 |
A |
G |
7: 130,361,018 (GRCm39) |
Y459C |
probably damaging |
Het |
| Trp53tg5 |
T |
C |
2: 164,313,208 (GRCm39) |
S156G |
probably benign |
Het |
| Ubb |
A |
G |
11: 62,443,375 (GRCm39) |
Y135C |
possibly damaging |
Het |
| Vmn2r90 |
A |
G |
17: 17,933,039 (GRCm39) |
I200V |
possibly damaging |
Het |
| Zfp27 |
C |
A |
7: 29,595,342 (GRCm39) |
V208F |
possibly damaging |
Het |
|
| Other mutations in Styk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00822:Styk1
|
APN |
6 |
131,278,625 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL01370:Styk1
|
APN |
6 |
131,278,615 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01833:Styk1
|
APN |
6 |
131,279,329 (GRCm39) |
splice site |
probably benign |
|
|
IGL02705:Styk1
|
APN |
6 |
131,289,546 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL03029:Styk1
|
APN |
6 |
131,277,523 (GRCm39) |
missense |
probably benign |
0.27 |
|
conviction
|
UTSW |
6 |
131,289,539 (GRCm39) |
missense |
probably benign |
0.01 |
|
will
|
UTSW |
6 |
131,289,880 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0201:Styk1
|
UTSW |
6 |
131,278,693 (GRCm39) |
splice site |
probably benign |
|
|
R2267:Styk1
|
UTSW |
6 |
131,289,539 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2268:Styk1
|
UTSW |
6 |
131,289,539 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2269:Styk1
|
UTSW |
6 |
131,289,539 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2919:Styk1
|
UTSW |
6 |
131,289,967 (GRCm39) |
start gained |
probably benign |
|
|
R3153:Styk1
|
UTSW |
6 |
131,286,975 (GRCm39) |
nonsense |
probably null |
|
|
R3154:Styk1
|
UTSW |
6 |
131,286,975 (GRCm39) |
nonsense |
probably null |
|
|
R4041:Styk1
|
UTSW |
6 |
131,289,880 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4650:Styk1
|
UTSW |
6 |
131,277,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4739:Styk1
|
UTSW |
6 |
131,277,429 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5079:Styk1
|
UTSW |
6 |
131,278,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5497:Styk1
|
UTSW |
6 |
131,281,670 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5637:Styk1
|
UTSW |
6 |
131,277,381 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6137:Styk1
|
UTSW |
6 |
131,287,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6429:Styk1
|
UTSW |
6 |
131,287,027 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7522:Styk1
|
UTSW |
6 |
131,289,803 (GRCm39) |
splice site |
probably null |
|
|
R8188:Styk1
|
UTSW |
6 |
131,281,848 (GRCm39) |
missense |
probably benign |
0.43 |
|
R9255:Styk1
|
UTSW |
6 |
131,286,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9704:Styk1
|
UTSW |
6 |
131,278,612 (GRCm39) |
small deletion |
probably benign |
|
|
R9712:Styk1
|
UTSW |
6 |
131,278,612 (GRCm39) |
small deletion |
probably benign |
|
|
R9714:Styk1
|
UTSW |
6 |
131,278,612 (GRCm39) |
small deletion |
probably benign |
|
|
R9715:Styk1
|
UTSW |
6 |
131,278,612 (GRCm39) |
small deletion |
probably benign |
|
|
R9725:Styk1
|
UTSW |
6 |
131,278,612 (GRCm39) |
small deletion |
probably benign |
|
|
R9725:Styk1
|
UTSW |
6 |
131,278,610 (GRCm39) |
small deletion |
probably benign |
|
|
R9750:Styk1
|
UTSW |
6 |
131,278,612 (GRCm39) |
small deletion |
probably benign |
|
|
R9751:Styk1
|
UTSW |
6 |
131,278,612 (GRCm39) |
small deletion |
probably benign |
|
|
R9752:Styk1
|
UTSW |
6 |
131,278,612 (GRCm39) |
small deletion |
probably benign |
|
|
R9753:Styk1
|
UTSW |
6 |
131,278,612 (GRCm39) |
small deletion |
probably benign |
|
|
R9771:Styk1
|
UTSW |
6 |
131,278,612 (GRCm39) |
small deletion |
probably benign |
|
|
R9778:Styk1
|
UTSW |
6 |
131,287,992 (GRCm39) |
nonsense |
probably null |
|
|
X0021:Styk1
|
UTSW |
6 |
131,284,032 (GRCm39) |
critical splice donor site |
probably null |
|
|
X0026:Styk1
|
UTSW |
6 |
131,287,902 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTGAACAAACTAAGTGCTCCTG -3'
(R):5'- CCCCATGGTTATGCTTTAGAGG -3'
Sequencing Primer
(F):5'- CTGCACCATAATGGAACTGTG -3'
(R):5'- AGAGGCTGCTTTTCAGGTCACAG -3'
|
| Posted On |
2022-10-06 |
Incidental Mutation