Incidental Mutation 'R9705:Vmn2r90'
| ID |
729773 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r90
|
| Ensembl Gene |
ENSMUSG00000092120 |
| Gene Name |
vomeronasal 2, receptor 90 |
| Synonyms |
EG626942 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.139)
|
| Stock # |
R9705 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
17924203-17954429 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 17933039 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 200
(I200V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126650
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000169805]
[ENSMUST00000231659]
[ENSMUST00000232078]
[ENSMUST00000232113]
|
| AlphaFold |
E9PXJ8 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000169805
AA Change: I200V
PolyPhen 2
Score 0.908 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000126650
Gene: ENSMUSG00000092120
AA Change: I200V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
1.8e-43 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
3e-22 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
9.8e-54 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231659
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232078
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232113
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.7%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 47 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A830018L16Rik |
C |
T |
1: 11,588,913 (GRCm39) |
P110L |
probably damaging |
Het |
| Aff1 |
T |
G |
5: 103,932,276 (GRCm39) |
L298R |
possibly damaging |
Het |
| B4galt1 |
T |
C |
4: 40,853,474 (GRCm39) |
K111R |
probably benign |
Het |
| Brap |
A |
G |
5: 121,801,373 (GRCm39) |
T87A |
probably benign |
Het |
| C1qtnf6 |
T |
A |
15: 78,411,493 (GRCm39) |
Q61L |
probably benign |
Het |
| Ccar2 |
C |
A |
14: 70,380,383 (GRCm39) |
C399F |
probably damaging |
Het |
| Cdh15 |
C |
A |
8: 123,591,024 (GRCm39) |
D424E |
probably damaging |
Het |
| Cemip2 |
G |
A |
19: 21,784,788 (GRCm39) |
V424I |
probably damaging |
Het |
| Col4a4 |
G |
A |
1: 82,465,313 (GRCm39) |
A954V |
unknown |
Het |
| Cul9 |
T |
G |
17: 46,854,226 (GRCm39) |
T159P |
probably damaging |
Het |
| Cyp3a59 |
A |
G |
5: 146,033,120 (GRCm39) |
E164G |
probably benign |
Het |
| Dnah11 |
A |
C |
12: 118,094,770 (GRCm39) |
L766R |
probably damaging |
Het |
| Drd5 |
T |
C |
5: 38,478,027 (GRCm39) |
V340A |
probably damaging |
Het |
| Ephb6 |
G |
A |
6: 41,596,715 (GRCm39) |
E921K |
probably benign |
Het |
| Fam83e |
G |
A |
7: 45,371,921 (GRCm39) |
R106K |
probably benign |
Het |
| Fsip2 |
A |
G |
2: 82,823,634 (GRCm39) |
T6456A |
probably benign |
Het |
| H2ac1 |
A |
G |
13: 24,118,728 (GRCm39) |
N95S |
probably benign |
Het |
| H2-M10.6 |
A |
G |
17: 37,123,642 (GRCm39) |
N112S |
probably benign |
Het |
| Hectd4 |
A |
T |
5: 121,448,744 (GRCm39) |
Y364F |
probably benign |
Het |
| Hoxc9 |
T |
A |
15: 102,890,362 (GRCm39) |
M93K |
possibly damaging |
Het |
| Hsd17b4 |
A |
C |
18: 50,324,791 (GRCm39) |
K668T |
probably benign |
Het |
| Inpp4b |
T |
C |
8: 82,772,890 (GRCm39) |
V728A |
probably benign |
Het |
| Jph3 |
C |
T |
8: 122,508,913 (GRCm39) |
R392W |
probably damaging |
Het |
| Krt79 |
T |
G |
15: 101,839,196 (GRCm39) |
E424D |
probably benign |
Het |
| Mphosph10 |
T |
C |
7: 64,027,031 (GRCm39) |
E594G |
possibly damaging |
Het |
| Mrm2 |
G |
A |
5: 140,316,990 (GRCm39) |
R15W |
probably damaging |
Het |
| Neurl4 |
A |
T |
11: 69,799,679 (GRCm39) |
D994V |
probably damaging |
Het |
| Ngef |
G |
A |
1: 87,431,010 (GRCm39) |
P269L |
probably damaging |
Het |
| Odam |
T |
A |
5: 88,037,228 (GRCm39) |
F141I |
probably benign |
Het |
| Or1j10 |
A |
G |
2: 36,266,962 (GRCm39) |
Y58C |
probably damaging |
Het |
| Or56a3b |
T |
A |
7: 104,770,841 (GRCm39) |
L59Q |
probably damaging |
Het |
| Pck1 |
T |
A |
2: 173,000,170 (GRCm39) |
S534T |
possibly damaging |
Het |
| Pgm3 |
A |
G |
9: 86,437,414 (GRCm39) |
F528L |
probably benign |
Het |
| Pi4ka |
A |
T |
16: 17,099,815 (GRCm39) |
I1936N |
|
Het |
| Ptpn13 |
T |
C |
5: 103,681,221 (GRCm39) |
L807S |
possibly damaging |
Het |
| Ramp2 |
T |
A |
11: 101,137,369 (GRCm39) |
L31Q |
possibly damaging |
Het |
| Rars2 |
A |
T |
4: 34,646,561 (GRCm39) |
K275N |
possibly damaging |
Het |
| Rusc2 |
A |
C |
4: 43,424,936 (GRCm39) |
N1131T |
probably benign |
Het |
| Snapc1 |
G |
T |
12: 74,015,150 (GRCm39) |
K161N |
probably damaging |
Het |
| Spag8 |
G |
A |
4: 43,652,366 (GRCm39) |
H325Y |
possibly damaging |
Het |
| Styk1 |
CTCTTCATGATTTTCTT |
CTCTT |
6: 131,278,612 (GRCm39) |
|
probably benign |
Het |
| Synpo2l |
C |
T |
14: 20,710,989 (GRCm39) |
V773M |
probably damaging |
Het |
| Syt3 |
A |
G |
7: 44,045,225 (GRCm39) |
D519G |
probably damaging |
Het |
| Tacc2 |
A |
G |
7: 130,361,018 (GRCm39) |
Y459C |
probably damaging |
Het |
| Trp53tg5 |
T |
C |
2: 164,313,208 (GRCm39) |
S156G |
probably benign |
Het |
| Ubb |
A |
G |
11: 62,443,375 (GRCm39) |
Y135C |
possibly damaging |
Het |
| Zfp27 |
C |
A |
7: 29,595,342 (GRCm39) |
V208F |
possibly damaging |
Het |
|
| Other mutations in Vmn2r90 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00092:Vmn2r90
|
APN |
17 |
17,953,758 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01330:Vmn2r90
|
APN |
17 |
17,953,542 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01989:Vmn2r90
|
APN |
17 |
17,933,494 (GRCm39) |
nonsense |
probably null |
|
|
IGL02080:Vmn2r90
|
APN |
17 |
17,933,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02112:Vmn2r90
|
APN |
17 |
17,932,465 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02123:Vmn2r90
|
APN |
17 |
17,953,744 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02749:Vmn2r90
|
APN |
17 |
17,947,122 (GRCm39) |
makesense |
probably null |
|
|
IGL03114:Vmn2r90
|
APN |
17 |
17,953,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0131:Vmn2r90
|
UTSW |
17 |
17,932,511 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0131:Vmn2r90
|
UTSW |
17 |
17,932,511 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0132:Vmn2r90
|
UTSW |
17 |
17,932,511 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0184:Vmn2r90
|
UTSW |
17 |
17,947,139 (GRCm39) |
nonsense |
probably null |
|
|
R0379:Vmn2r90
|
UTSW |
17 |
17,948,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1022:Vmn2r90
|
UTSW |
17 |
17,948,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1024:Vmn2r90
|
UTSW |
17 |
17,948,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1897:Vmn2r90
|
UTSW |
17 |
17,953,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1993:Vmn2r90
|
UTSW |
17 |
17,933,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2472:Vmn2r90
|
UTSW |
17 |
17,948,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2508:Vmn2r90
|
UTSW |
17 |
17,954,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2679:Vmn2r90
|
UTSW |
17 |
17,933,131 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R3409:Vmn2r90
|
UTSW |
17 |
17,953,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4693:Vmn2r90
|
UTSW |
17 |
17,953,956 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4797:Vmn2r90
|
UTSW |
17 |
17,932,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5258:Vmn2r90
|
UTSW |
17 |
17,933,114 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5358:Vmn2r90
|
UTSW |
17 |
17,924,412 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5445:Vmn2r90
|
UTSW |
17 |
17,954,386 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5446:Vmn2r90
|
UTSW |
17 |
17,932,464 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5567:Vmn2r90
|
UTSW |
17 |
17,932,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5680:Vmn2r90
|
UTSW |
17 |
17,947,034 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5686:Vmn2r90
|
UTSW |
17 |
17,933,712 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5751:Vmn2r90
|
UTSW |
17 |
17,954,128 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6156:Vmn2r90
|
UTSW |
17 |
17,953,606 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6185:Vmn2r90
|
UTSW |
17 |
17,953,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6450:Vmn2r90
|
UTSW |
17 |
17,953,498 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R6707:Vmn2r90
|
UTSW |
17 |
17,948,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6802:Vmn2r90
|
UTSW |
17 |
17,932,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6913:Vmn2r90
|
UTSW |
17 |
17,924,323 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7070:Vmn2r90
|
UTSW |
17 |
17,924,313 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7237:Vmn2r90
|
UTSW |
17 |
17,924,249 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7503:Vmn2r90
|
UTSW |
17 |
17,933,510 (GRCm39) |
missense |
not run |
|
|
R7698:Vmn2r90
|
UTSW |
17 |
17,953,596 (GRCm39) |
missense |
probably benign |
|
|
R7943:Vmn2r90
|
UTSW |
17 |
17,932,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8072:Vmn2r90
|
UTSW |
17 |
17,947,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8128:Vmn2r90
|
UTSW |
17 |
17,954,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8295:Vmn2r90
|
UTSW |
17 |
17,948,358 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8345:Vmn2r90
|
UTSW |
17 |
17,933,127 (GRCm39) |
nonsense |
probably null |
|
|
R8682:Vmn2r90
|
UTSW |
17 |
17,932,344 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8716:Vmn2r90
|
UTSW |
17 |
17,924,343 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9041:Vmn2r90
|
UTSW |
17 |
17,954,286 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9412:Vmn2r90
|
UTSW |
17 |
17,954,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9607:Vmn2r90
|
UTSW |
17 |
17,953,638 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
Z1088:Vmn2r90
|
UTSW |
17 |
17,953,879 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn2r90
|
UTSW |
17 |
17,933,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAAAACTCTGTAATGGGGTTGTC -3'
(R):5'- GGACCAGACTTTTCCATAATGC -3'
Sequencing Primer
(F):5'- GGTTGTCTTTAAAATGTGGTAAACCC -3'
(R):5'- GCATTTGAAAATGAATTCCAGATGCC -3'
|
| Posted On |
2022-10-06 |
Incidental Mutation