Incidental Mutation 'R9709:Nin'
| ID |
730002 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nin
|
| Ensembl Gene |
ENSMUSG00000021068 |
| Gene Name |
ninein |
| Synonyms |
3110068G20Rik |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9709 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
12 |
| Chromosomal Location |
70058209-70160491 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 70149468 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Glutamine
at position 47
(P47Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000082422
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021468]
[ENSMUST00000085314]
[ENSMUST00000095666]
[ENSMUST00000169074]
[ENSMUST00000220689]
[ENSMUST00000221275]
[ENSMUST00000222237]
[ENSMUST00000222835]
[ENSMUST00000223257]
|
| AlphaFold |
Q61043 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000021468
AA Change: P47Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000021468
Gene: ENSMUSG00000021068
AA Change: P47Q
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000082422
Gene: ENSMUSG00000021068
AA Change: P47Q
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
4.15e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
4.15e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1971 |
2045 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000095666
AA Change: P47Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000093327
Gene: ENSMUSG00000021068
AA Change: P47Q
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000169074
AA Change: P47Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000129648
Gene: ENSMUSG00000021068
AA Change: P47Q
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
7 |
67 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
97 |
108 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
242 |
7.83e-8 |
PROSPERO |
|
low complexity region
|
276 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
336 |
353 |
N/A |
INTRINSIC |
|
coiled coil region
|
358 |
570 |
N/A |
INTRINSIC |
|
coiled coil region
|
625 |
802 |
N/A |
INTRINSIC |
|
coiled coil region
|
834 |
926 |
N/A |
INTRINSIC |
|
coiled coil region
|
957 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1044 |
N/A |
INTRINSIC |
|
low complexity region
|
1047 |
1057 |
N/A |
INTRINSIC |
|
coiled coil region
|
1069 |
1094 |
N/A |
INTRINSIC |
|
coiled coil region
|
1178 |
1325 |
N/A |
INTRINSIC |
|
low complexity region
|
1374 |
1385 |
N/A |
INTRINSIC |
|
coiled coil region
|
1425 |
1806 |
N/A |
INTRINSIC |
|
coiled coil region
|
1980 |
2013 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000220689
AA Change: P47Q
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| Predicted Effect |
|
| Predicted Effect |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000222835
AA Change: P47Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000223257
AA Change: P47Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1810062G17Rik |
T |
C |
3: 36,530,356 (GRCm39) |
S25P |
unknown |
Het |
| 4921539E11Rik |
A |
G |
4: 103,092,678 (GRCm39) |
I268T |
unknown |
Het |
| 4930507D05Rik |
T |
A |
10: 62,285,581 (GRCm39) |
C102S |
unknown |
Het |
| Abca14 |
T |
A |
7: 119,888,739 (GRCm39) |
Y1228* |
probably null |
Het |
| Abca17 |
T |
C |
17: 24,517,934 (GRCm39) |
I792V |
probably benign |
Het |
| Abca6 |
C |
A |
11: 110,102,589 (GRCm39) |
L878F |
probably benign |
Het |
| Adk |
C |
A |
14: 21,126,386 (GRCm39) |
T4N |
probably benign |
Het |
| Ankrd40cl |
G |
A |
11: 94,175,560 (GRCm39) |
S65N |
probably benign |
Het |
| Atg2b |
A |
T |
12: 105,611,140 (GRCm39) |
F1264I |
probably damaging |
Het |
| Atl3 |
T |
G |
19: 7,507,921 (GRCm39) |
S358A |
probably benign |
Het |
| Atp8a2 |
T |
A |
14: 60,271,187 (GRCm39) |
Y248F |
probably damaging |
Het |
| Bcas3 |
T |
C |
11: 85,474,749 (GRCm39) |
V785A |
probably damaging |
Het |
| Cckar |
C |
T |
5: 53,860,201 (GRCm39) |
|
probably null |
Het |
| Cdc42se2 |
A |
G |
11: 54,614,417 (GRCm39) |
F47L |
probably benign |
Het |
| Cfap58 |
T |
C |
19: 47,963,992 (GRCm39) |
L540P |
probably damaging |
Het |
| Copg1 |
A |
G |
6: 87,868,957 (GRCm39) |
E117G |
probably benign |
Het |
| Cstpp1 |
T |
C |
2: 91,112,099 (GRCm39) |
Q250R |
probably benign |
Het |
| Cul2 |
C |
T |
18: 3,431,560 (GRCm39) |
T655M |
probably damaging |
Het |
| Ddi2 |
T |
C |
4: 141,412,429 (GRCm39) |
Q161R |
probably benign |
Het |
| Dffb |
T |
C |
4: 154,059,121 (GRCm39) |
Y52C |
probably damaging |
Het |
| Dll1 |
T |
C |
17: 15,591,198 (GRCm39) |
Q249R |
probably benign |
Het |
| Dnmt3a |
T |
A |
12: 3,957,701 (GRCm39) |
I894N |
probably damaging |
Het |
| Fshr |
G |
A |
17: 89,293,265 (GRCm39) |
T471I |
probably damaging |
Het |
| Gabpb1 |
C |
T |
2: 126,500,488 (GRCm39) |
V4I |
probably benign |
Het |
| Gbp9 |
T |
C |
5: 105,231,542 (GRCm39) |
Q348R |
probably damaging |
Het |
| Gm21149 |
G |
A |
5: 15,677,110 (GRCm39) |
S248F |
unknown |
Het |
| Gpr152 |
C |
A |
19: 4,192,640 (GRCm39) |
H60Q |
probably benign |
Het |
| Hdac9 |
A |
G |
12: 34,362,602 (GRCm39) |
S612P |
probably benign |
Het |
| Hhipl2 |
A |
G |
1: 183,199,747 (GRCm39) |
D102G |
possibly damaging |
Het |
| Hspa9 |
A |
G |
18: 35,073,294 (GRCm39) |
V530A |
possibly damaging |
Het |
| Igfbp7 |
T |
C |
5: 77,549,384 (GRCm39) |
N173S |
unknown |
Het |
| Ighv1-75 |
A |
G |
12: 115,797,791 (GRCm39) |
S44P |
possibly damaging |
Het |
| Iqgap3 |
C |
A |
3: 88,016,176 (GRCm39) |
F986L |
probably damaging |
Het |
| Itgax |
G |
T |
7: 127,735,500 (GRCm39) |
G523W |
probably damaging |
Het |
| Itih3 |
A |
G |
14: 30,637,587 (GRCm39) |
|
probably null |
Het |
| Kcnb2 |
T |
C |
1: 15,780,523 (GRCm39) |
I465T |
probably benign |
Het |
| Kmt2b |
A |
G |
7: 30,279,228 (GRCm39) |
V1478A |
probably damaging |
Het |
| Ky |
A |
T |
9: 102,419,411 (GRCm39) |
I473F |
probably damaging |
Het |
| Lbr |
A |
G |
1: 181,666,034 (GRCm39) |
V25A |
probably damaging |
Het |
| Ldlr |
A |
G |
9: 21,657,135 (GRCm39) |
T751A |
probably benign |
Het |
| Lrrtm4 |
A |
G |
6: 80,786,154 (GRCm39) |
E587G |
probably damaging |
Het |
| Lvrn |
A |
C |
18: 47,006,847 (GRCm39) |
|
probably null |
Het |
| Mast2 |
A |
T |
4: 116,173,044 (GRCm39) |
C594S |
probably damaging |
Het |
| Mast4 |
A |
G |
13: 102,910,711 (GRCm39) |
V644A |
probably damaging |
Het |
| Mcm5 |
T |
C |
8: 75,842,604 (GRCm39) |
Y293H |
probably damaging |
Het |
| Mthfd2 |
A |
T |
6: 83,283,665 (GRCm39) |
V339E |
possibly damaging |
Het |
| Muc4 |
A |
T |
16: 32,590,644 (GRCm39) |
I881F |
|
Het |
| Myo7a |
A |
G |
7: 97,743,536 (GRCm39) |
S372P |
possibly damaging |
Het |
| Nbea |
T |
A |
3: 55,693,879 (GRCm39) |
K2180* |
probably null |
Het |
| Neb |
T |
C |
2: 52,101,507 (GRCm39) |
D4621G |
probably damaging |
Het |
| Nefh |
C |
T |
11: 4,890,042 (GRCm39) |
S859N |
probably benign |
Het |
| Nek2 |
T |
A |
1: 191,563,289 (GRCm39) |
H384Q |
possibly damaging |
Het |
| Nfkb2 |
A |
G |
19: 46,298,782 (GRCm39) |
E645G |
probably benign |
Het |
| Nit1 |
C |
A |
1: 171,171,307 (GRCm39) |
K178N |
probably benign |
Het |
| Nrap |
C |
A |
19: 56,317,452 (GRCm39) |
K1433N |
probably damaging |
Het |
| Nrap |
T |
C |
19: 56,317,453 (GRCm39) |
K1433R |
probably benign |
Het |
| Nup85 |
A |
G |
11: 115,457,463 (GRCm39) |
Y55C |
possibly damaging |
Het |
| Or2a14 |
G |
T |
6: 43,130,469 (GRCm39) |
V77F |
possibly damaging |
Het |
| Pde1b |
A |
G |
15: 103,411,985 (GRCm39) |
K29E |
probably benign |
Het |
| Pheta2 |
G |
T |
15: 82,227,537 (GRCm39) |
D19Y |
probably damaging |
Het |
| Pheta2 |
C |
G |
15: 82,227,535 (GRCm39) |
A18G |
probably damaging |
Het |
| Pik3cg |
A |
T |
12: 32,226,687 (GRCm39) |
Y1067N |
probably benign |
Het |
| Pkd1l1 |
C |
T |
11: 8,799,016 (GRCm39) |
G2249S |
probably damaging |
Het |
| Plppr4 |
T |
A |
3: 117,121,976 (GRCm39) |
T201S |
possibly damaging |
Het |
| Polr1e |
A |
G |
4: 45,018,678 (GRCm39) |
T3A |
probably benign |
Het |
| Polr1has |
A |
T |
17: 37,275,249 (GRCm39) |
R7S |
probably benign |
Het |
| Pou6f2 |
G |
T |
13: 18,414,389 (GRCm39) |
Q129K |
unknown |
Het |
| Ppil4 |
T |
A |
10: 7,675,341 (GRCm39) |
D163E |
probably benign |
Het |
| Pradc1 |
A |
G |
6: 85,424,952 (GRCm39) |
F82L |
probably benign |
Het |
| Psd3 |
T |
C |
8: 68,194,414 (GRCm39) |
K784R |
probably null |
Het |
| Ptgs1 |
C |
A |
2: 36,141,204 (GRCm39) |
S550R |
probably damaging |
Het |
| Pxylp1 |
A |
G |
9: 96,711,030 (GRCm39) |
L153P |
probably damaging |
Het |
| Rgs10 |
A |
C |
7: 127,975,729 (GRCm39) |
F146C |
probably damaging |
Het |
| Rimbp2 |
G |
A |
5: 128,874,875 (GRCm39) |
P239S |
probably damaging |
Het |
| Rp1 |
A |
G |
1: 4,112,255 (GRCm39) |
Y1199H |
unknown |
Het |
| Rrp12 |
A |
T |
19: 41,857,231 (GRCm39) |
M1181K |
probably benign |
Het |
| Rundc3b |
T |
C |
5: 8,570,982 (GRCm39) |
N279S |
probably benign |
Het |
| Sbf2 |
G |
T |
7: 110,027,514 (GRCm39) |
P494Q |
probably damaging |
Het |
| Scnn1b |
A |
G |
7: 121,509,693 (GRCm39) |
T281A |
probably benign |
Het |
| Scube2 |
A |
T |
7: 109,430,971 (GRCm39) |
N409K |
probably damaging |
Het |
| Serpina3m |
A |
C |
12: 104,359,008 (GRCm39) |
D340A |
probably damaging |
Het |
| Sez6 |
G |
A |
11: 77,865,121 (GRCm39) |
E623K |
possibly damaging |
Het |
| Sgpp2 |
T |
C |
1: 78,367,200 (GRCm39) |
I111T |
probably benign |
Het |
| Shprh |
C |
T |
10: 11,038,574 (GRCm39) |
T443I |
possibly damaging |
Het |
| Sis |
T |
A |
3: 72,799,074 (GRCm39) |
Y1726F |
possibly damaging |
Het |
| Slc17a9 |
T |
C |
2: 180,374,321 (GRCm39) |
L129P |
probably damaging |
Het |
| Slc1a5 |
T |
A |
7: 16,527,729 (GRCm39) |
F342I |
probably benign |
Het |
| Slc4a4 |
T |
A |
5: 89,188,205 (GRCm39) |
|
probably null |
Het |
| Slco3a1 |
T |
C |
7: 73,952,957 (GRCm39) |
E534G |
possibly damaging |
Het |
| Smok2b |
A |
T |
17: 13,454,052 (GRCm39) |
I71F |
possibly damaging |
Het |
| Tmbim7 |
A |
T |
5: 3,711,809 (GRCm39) |
H18L |
probably damaging |
Het |
| Tmem151a |
A |
T |
19: 5,131,876 (GRCm39) |
Y443* |
probably null |
Het |
| Tnks1bp1 |
T |
G |
2: 84,902,125 (GRCm39) |
S1674A |
probably benign |
Het |
| Trappc11 |
T |
A |
8: 47,946,348 (GRCm39) |
I1095F |
probably damaging |
Het |
| Trim11 |
A |
G |
11: 58,872,864 (GRCm39) |
R183G |
possibly damaging |
Het |
| Trim29 |
A |
G |
9: 43,231,797 (GRCm39) |
D348G |
probably benign |
Het |
| Ttc28 |
A |
T |
5: 111,433,637 (GRCm39) |
S2224C |
probably damaging |
Het |
| Vps13d |
C |
T |
4: 144,875,915 (GRCm39) |
V1537M |
|
Het |
| Zfp1005 |
T |
A |
2: 150,110,305 (GRCm39) |
C332S |
possibly damaging |
Het |
| Zfp184 |
A |
G |
13: 22,143,665 (GRCm39) |
D457G |
possibly damaging |
Het |
|
| Other mutations in Nin |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00472:Nin
|
APN |
12 |
70,076,862 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL00677:Nin
|
APN |
12 |
70,073,634 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00823:Nin
|
APN |
12 |
70,061,567 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01103:Nin
|
APN |
12 |
70,103,532 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01113:Nin
|
APN |
12 |
70,078,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01420:Nin
|
APN |
12 |
70,092,188 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01556:Nin
|
APN |
12 |
70,089,962 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01663:Nin
|
APN |
12 |
70,090,439 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL02002:Nin
|
APN |
12 |
70,109,473 (GRCm39) |
nonsense |
probably null |
|
|
IGL02030:Nin
|
APN |
12 |
70,092,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02202:Nin
|
APN |
12 |
70,102,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02207:Nin
|
APN |
12 |
70,103,431 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02257:Nin
|
APN |
12 |
70,149,465 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02394:Nin
|
APN |
12 |
70,090,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02531:Nin
|
APN |
12 |
70,067,706 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL03028:Nin
|
APN |
12 |
70,082,044 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL03155:Nin
|
APN |
12 |
70,078,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03197:Nin
|
APN |
12 |
70,073,584 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02835:Nin
|
UTSW |
12 |
70,103,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0131:Nin
|
UTSW |
12 |
70,097,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0131:Nin
|
UTSW |
12 |
70,097,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0132:Nin
|
UTSW |
12 |
70,097,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0211:Nin
|
UTSW |
12 |
70,061,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0211:Nin
|
UTSW |
12 |
70,061,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0734:Nin
|
UTSW |
12 |
70,076,887 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0947:Nin
|
UTSW |
12 |
70,107,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1085:Nin
|
UTSW |
12 |
70,067,736 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1367:Nin
|
UTSW |
12 |
70,090,703 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1452:Nin
|
UTSW |
12 |
70,064,424 (GRCm39) |
nonsense |
probably null |
|
|
R1477:Nin
|
UTSW |
12 |
70,090,958 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1518:Nin
|
UTSW |
12 |
70,061,547 (GRCm39) |
missense |
probably benign |
0.27 |
|
R1566:Nin
|
UTSW |
12 |
70,101,253 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1572:Nin
|
UTSW |
12 |
70,085,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1583:Nin
|
UTSW |
12 |
70,078,512 (GRCm39) |
missense |
probably benign |
|
|
R1584:Nin
|
UTSW |
12 |
70,089,443 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1699:Nin
|
UTSW |
12 |
70,092,337 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1699:Nin
|
UTSW |
12 |
70,077,712 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1765:Nin
|
UTSW |
12 |
70,089,665 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1794:Nin
|
UTSW |
12 |
70,090,569 (GRCm39) |
nonsense |
probably null |
|
|
R1952:Nin
|
UTSW |
12 |
70,077,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2004:Nin
|
UTSW |
12 |
70,072,251 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2025:Nin
|
UTSW |
12 |
70,076,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2060:Nin
|
UTSW |
12 |
70,089,192 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R2213:Nin
|
UTSW |
12 |
70,092,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2224:Nin
|
UTSW |
12 |
70,108,004 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2247:Nin
|
UTSW |
12 |
70,101,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2972:Nin
|
UTSW |
12 |
70,109,487 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3776:Nin
|
UTSW |
12 |
70,085,456 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R3881:Nin
|
UTSW |
12 |
70,089,315 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3930:Nin
|
UTSW |
12 |
70,125,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3959:Nin
|
UTSW |
12 |
70,097,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4229:Nin
|
UTSW |
12 |
70,097,984 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4359:Nin
|
UTSW |
12 |
70,061,712 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4423:Nin
|
UTSW |
12 |
70,089,752 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4461:Nin
|
UTSW |
12 |
70,089,359 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4639:Nin
|
UTSW |
12 |
70,085,375 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4791:Nin
|
UTSW |
12 |
70,090,581 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4839:Nin
|
UTSW |
12 |
70,137,325 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4912:Nin
|
UTSW |
12 |
70,090,837 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5712:Nin
|
UTSW |
12 |
70,089,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5726:Nin
|
UTSW |
12 |
70,124,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5804:Nin
|
UTSW |
12 |
70,092,375 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R5874:Nin
|
UTSW |
12 |
70,077,692 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5992:Nin
|
UTSW |
12 |
70,092,298 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6077:Nin
|
UTSW |
12 |
70,066,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6184:Nin
|
UTSW |
12 |
70,090,511 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6307:Nin
|
UTSW |
12 |
70,061,631 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6315:Nin
|
UTSW |
12 |
70,092,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6326:Nin
|
UTSW |
12 |
70,091,955 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6492:Nin
|
UTSW |
12 |
70,101,308 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6562:Nin
|
UTSW |
12 |
70,102,728 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6578:Nin
|
UTSW |
12 |
70,107,968 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6613:Nin
|
UTSW |
12 |
70,077,728 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7112:Nin
|
UTSW |
12 |
70,149,573 (GRCm39) |
missense |
|
|
|
R7170:Nin
|
UTSW |
12 |
70,091,013 (GRCm39) |
missense |
|
|
|
R7324:Nin
|
UTSW |
12 |
70,090,508 (GRCm39) |
missense |
|
|
|
R7338:Nin
|
UTSW |
12 |
70,090,838 (GRCm39) |
missense |
|
|
|
R7372:Nin
|
UTSW |
12 |
70,102,803 (GRCm39) |
missense |
|
|
|
R7431:Nin
|
UTSW |
12 |
70,124,997 (GRCm39) |
missense |
|
|
|
R7577:Nin
|
UTSW |
12 |
70,109,480 (GRCm39) |
missense |
|
|
|
R7655:Nin
|
UTSW |
12 |
70,089,542 (GRCm39) |
missense |
|
|
|
R7656:Nin
|
UTSW |
12 |
70,089,542 (GRCm39) |
missense |
|
|
|
R7683:Nin
|
UTSW |
12 |
70,124,956 (GRCm39) |
missense |
|
|
|
R7769:Nin
|
UTSW |
12 |
70,090,004 (GRCm39) |
missense |
|
|
|
R7981:Nin
|
UTSW |
12 |
70,089,591 (GRCm39) |
missense |
|
|
|
R8138:Nin
|
UTSW |
12 |
70,089,672 (GRCm39) |
missense |
|
|
|
R8141:Nin
|
UTSW |
12 |
70,076,795 (GRCm39) |
missense |
|
|
|
R8754:Nin
|
UTSW |
12 |
70,077,787 (GRCm39) |
intron |
probably benign |
|
|
R8790:Nin
|
UTSW |
12 |
70,067,793 (GRCm39) |
missense |
|
|
|
R8899:Nin
|
UTSW |
12 |
70,077,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8974:Nin
|
UTSW |
12 |
70,124,932 (GRCm39) |
missense |
|
|
|
R9085:Nin
|
UTSW |
12 |
70,076,786 (GRCm39) |
nonsense |
probably null |
|
|
R9143:Nin
|
UTSW |
12 |
70,137,349 (GRCm39) |
missense |
|
|
|
R9380:Nin
|
UTSW |
12 |
70,074,805 (GRCm39) |
missense |
|
|
|
R9496:Nin
|
UTSW |
12 |
70,102,762 (GRCm39) |
missense |
|
|
|
R9638:Nin
|
UTSW |
12 |
70,067,618 (GRCm39) |
missense |
|
|
|
R9745:Nin
|
UTSW |
12 |
70,089,899 (GRCm39) |
missense |
|
|
|
R9792:Nin
|
UTSW |
12 |
70,094,009 (GRCm39) |
missense |
|
|
|
Z1176:Nin
|
UTSW |
12 |
70,095,938 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1177:Nin
|
UTSW |
12 |
70,101,200 (GRCm39) |
missense |
|
|
|
Z1177:Nin
|
UTSW |
12 |
70,090,869 (GRCm39) |
missense |
|
|
|
| Predicted Primers |
PCR Primer
(F):5'- TTGCCCTTATCACGAGAGC -3'
(R):5'- ATTGTGACCTGTCCCAACCTG -3'
Sequencing Primer
(F):5'- TGCCCTTATCACGAGAGCAAACTAC -3'
(R):5'- CTTCCTTCATGTCCCACACAGG -3'
|
| Posted On |
2022-10-06 |
Incidental Mutation