Incidental Mutation 'R9710:Arhgef2'
| ID |
730045 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgef2
|
| Ensembl Gene |
ENSMUSG00000028059 |
| Gene Name |
Rho/Rac guanine nucleotide exchange factor 2 |
| Synonyms |
Lfc, Lbcl1, LFP40, P40, GEFH1, GEF-H1 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.664)
|
| Stock # |
R9710 (G1)
|
| Quality Score |
157.009 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
88513273-88555359 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 88528576 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 4
(I4T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000029694
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000029694]
[ENSMUST00000107510]
[ENSMUST00000170653]
[ENSMUST00000175779]
[ENSMUST00000175903]
[ENSMUST00000175911]
[ENSMUST00000176243]
[ENSMUST00000176307]
[ENSMUST00000176500]
[ENSMUST00000176539]
[ENSMUST00000176804]
[ENSMUST00000177023]
[ENSMUST00000177303]
[ENSMUST00000177498]
|
| AlphaFold |
Q60875 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000029694
AA Change: I4T
PolyPhen 2
Score 0.428 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000029694
Gene: ENSMUSG00000028059
AA Change: I4T
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
40 |
86 |
4.22e-9 |
SMART |
|
low complexity region
|
90 |
95 |
N/A |
INTRINSIC |
|
low complexity region
|
133 |
146 |
N/A |
INTRINSIC |
|
RhoGEF
|
240 |
432 |
1.86e-58 |
SMART |
|
PH
|
474 |
574 |
9.56e-11 |
SMART |
|
coiled coil region
|
588 |
619 |
N/A |
INTRINSIC |
|
low complexity region
|
812 |
827 |
N/A |
INTRINSIC |
|
coiled coil region
|
829 |
866 |
N/A |
INTRINSIC |
|
low complexity region
|
872 |
888 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107510
|
| SMART Domains |
Protein: ENSMUSP00000103134
Gene: ENSMUSG00000028059
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
13 |
59 |
4.22e-9 |
SMART |
|
low complexity region
|
63 |
68 |
N/A |
INTRINSIC |
|
low complexity region
|
106 |
119 |
N/A |
INTRINSIC |
|
RhoGEF
|
213 |
405 |
1.86e-58 |
SMART |
|
PH
|
447 |
547 |
9.56e-11 |
SMART |
|
coiled coil region
|
561 |
592 |
N/A |
INTRINSIC |
|
low complexity region
|
785 |
800 |
N/A |
INTRINSIC |
|
coiled coil region
|
802 |
839 |
N/A |
INTRINSIC |
|
low complexity region
|
845 |
861 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170653
|
| SMART Domains |
Protein: ENSMUSP00000127843
Gene: ENSMUSG00000028059
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
13 |
59 |
4.22e-9 |
SMART |
|
low complexity region
|
63 |
68 |
N/A |
INTRINSIC |
|
low complexity region
|
104 |
117 |
N/A |
INTRINSIC |
|
RhoGEF
|
211 |
403 |
1.86e-58 |
SMART |
|
PH
|
445 |
545 |
9.56e-11 |
SMART |
|
coiled coil region
|
559 |
590 |
N/A |
INTRINSIC |
|
low complexity region
|
783 |
798 |
N/A |
INTRINSIC |
|
coiled coil region
|
800 |
837 |
N/A |
INTRINSIC |
|
low complexity region
|
843 |
859 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175779
|
| SMART Domains |
Protein: ENSMUSP00000135177
Gene: ENSMUSG00000028059
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
25 |
71 |
4.22e-9 |
SMART |
|
low complexity region
|
75 |
80 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
131 |
N/A |
INTRINSIC |
|
RhoGEF
|
225 |
417 |
1.86e-58 |
SMART |
|
PH
|
459 |
559 |
9.56e-11 |
SMART |
|
coiled coil region
|
573 |
604 |
N/A |
INTRINSIC |
|
low complexity region
|
797 |
812 |
N/A |
INTRINSIC |
|
coiled coil region
|
814 |
851 |
N/A |
INTRINSIC |
|
low complexity region
|
857 |
873 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175903
|
| SMART Domains |
Protein: ENSMUSP00000135168
Gene: ENSMUSG00000028059
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
25 |
71 |
4.22e-9 |
SMART |
|
low complexity region
|
75 |
80 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
131 |
N/A |
INTRINSIC |
|
RhoGEF
|
223 |
415 |
1.86e-58 |
SMART |
|
PH
|
457 |
557 |
9.56e-11 |
SMART |
|
coiled coil region
|
571 |
602 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
810 |
N/A |
INTRINSIC |
|
coiled coil region
|
812 |
849 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
871 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175911
|
| SMART Domains |
Protein: ENSMUSP00000135428
Gene: ENSMUSG00000028059
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
32 |
78 |
4.22e-9 |
SMART |
|
low complexity region
|
82 |
87 |
N/A |
INTRINSIC |
|
low complexity region
|
125 |
138 |
N/A |
INTRINSIC |
|
RhoGEF
|
232 |
424 |
1.86e-58 |
SMART |
|
PH
|
466 |
566 |
9.56e-11 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176243
|
| SMART Domains |
Protein: ENSMUSP00000135771
Gene: ENSMUSG00000028059
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
13 |
59 |
4.22e-9 |
SMART |
|
low complexity region
|
63 |
68 |
N/A |
INTRINSIC |
|
low complexity region
|
104 |
117 |
N/A |
INTRINSIC |
|
Blast:RhoGEF
|
170 |
203 |
1e-14 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176307
|
| SMART Domains |
Protein: ENSMUSP00000134843
Gene: ENSMUSG00000028059
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
13 |
59 |
4.22e-9 |
SMART |
|
low complexity region
|
63 |
68 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176500
|
| SMART Domains |
Protein: ENSMUSP00000134834
Gene: ENSMUSG00000028059
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
25 |
71 |
4.22e-9 |
SMART |
|
low complexity region
|
75 |
80 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
131 |
N/A |
INTRINSIC |
|
RhoGEF
|
225 |
417 |
1.86e-58 |
SMART |
|
PH
|
459 |
559 |
9.56e-11 |
SMART |
|
coiled coil region
|
573 |
604 |
N/A |
INTRINSIC |
|
low complexity region
|
797 |
812 |
N/A |
INTRINSIC |
|
coiled coil region
|
814 |
851 |
N/A |
INTRINSIC |
|
low complexity region
|
857 |
873 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176539
|
| SMART Domains |
Protein: ENSMUSP00000135612
Gene: ENSMUSG00000028059
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
25 |
71 |
4.22e-9 |
SMART |
|
low complexity region
|
75 |
80 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
131 |
N/A |
INTRINSIC |
|
Blast:RhoGEF
|
184 |
253 |
2e-28 |
BLAST |
|
PDB:4D0N|B
|
196 |
255 |
1e-17 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176804
AA Change: I4T
PolyPhen 2
Score 0.121 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000135397
Gene: ENSMUSG00000028059
AA Change: I4T
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
40 |
86 |
4.22e-9 |
SMART |
|
low complexity region
|
90 |
95 |
N/A |
INTRINSIC |
|
low complexity region
|
133 |
146 |
N/A |
INTRINSIC |
|
RhoGEF
|
238 |
430 |
1.86e-58 |
SMART |
|
PH
|
472 |
572 |
9.56e-11 |
SMART |
|
coiled coil region
|
586 |
617 |
N/A |
INTRINSIC |
|
low complexity region
|
810 |
825 |
N/A |
INTRINSIC |
|
coiled coil region
|
827 |
864 |
N/A |
INTRINSIC |
|
low complexity region
|
870 |
886 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177023
|
| SMART Domains |
Protein: ENSMUSP00000134859
Gene: ENSMUSG00000028059
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
25 |
71 |
4.22e-9 |
SMART |
|
low complexity region
|
75 |
80 |
N/A |
INTRINSIC |
|
low complexity region
|
116 |
129 |
N/A |
INTRINSIC |
|
Blast:RhoGEF
|
182 |
208 |
5e-9 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177303
|
| SMART Domains |
Protein: ENSMUSP00000135131
Gene: ENSMUSG00000028059
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
13 |
59 |
4.22e-9 |
SMART |
|
low complexity region
|
63 |
68 |
N/A |
INTRINSIC |
|
low complexity region
|
106 |
119 |
N/A |
INTRINSIC |
|
RhoGEF
|
211 |
403 |
1.86e-58 |
SMART |
|
PH
|
445 |
545 |
9.56e-11 |
SMART |
|
coiled coil region
|
559 |
590 |
N/A |
INTRINSIC |
|
low complexity region
|
783 |
798 |
N/A |
INTRINSIC |
|
coiled coil region
|
800 |
837 |
N/A |
INTRINSIC |
|
low complexity region
|
843 |
859 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177498
|
| SMART Domains |
Protein: ENSMUSP00000134840
Gene: ENSMUSG00000028059
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
25 |
71 |
4.22e-9 |
SMART |
|
low complexity region
|
75 |
80 |
N/A |
INTRINSIC |
|
low complexity region
|
116 |
129 |
N/A |
INTRINSIC |
|
RhoGEF
|
223 |
415 |
1.86e-58 |
SMART |
|
PH
|
457 |
557 |
9.56e-11 |
SMART |
|
coiled coil region
|
571 |
602 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
810 |
N/A |
INTRINSIC |
|
coiled coil region
|
812 |
849 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
871 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.7%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit impaired response to viral infection. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930407I10Rik |
T |
C |
15: 81,946,852 (GRCm39) |
S250P |
probably benign |
Het |
| Ahcyl1 |
T |
A |
3: 107,578,494 (GRCm39) |
I248F |
possibly damaging |
Het |
| Alpk2 |
T |
A |
18: 65,482,646 (GRCm39) |
E454V |
probably damaging |
Het |
| Ank3 |
A |
T |
10: 69,829,070 (GRCm39) |
T2580S |
|
Het |
| Anks1 |
G |
A |
17: 28,128,571 (GRCm39) |
G46R |
possibly damaging |
Het |
| Arhgap45 |
A |
G |
10: 79,857,635 (GRCm39) |
E322G |
probably damaging |
Het |
| C1qtnf4 |
T |
C |
2: 90,720,351 (GRCm39) |
I208T |
probably damaging |
Het |
| Cachd1 |
T |
A |
4: 100,832,092 (GRCm39) |
N751K |
probably benign |
Het |
| Cacna1a |
G |
T |
8: 85,320,808 (GRCm39) |
V1589F |
possibly damaging |
Het |
| Cacnb1 |
T |
C |
11: 97,902,197 (GRCm39) |
H205R |
probably benign |
Het |
| Castor1 |
A |
G |
11: 4,169,015 (GRCm39) |
K61E |
probably benign |
Het |
| Ccdc9b |
G |
T |
2: 118,591,077 (GRCm39) |
A152E |
probably benign |
Het |
| Clvs2 |
C |
A |
10: 33,389,307 (GRCm39) |
R311L |
probably benign |
Het |
| Crim1 |
G |
T |
17: 78,610,504 (GRCm39) |
G320* |
probably null |
Het |
| Crtam |
A |
T |
9: 40,895,671 (GRCm39) |
D218E |
probably benign |
Het |
| Cwc27 |
G |
A |
13: 104,943,158 (GRCm39) |
T128I |
probably damaging |
Het |
| Cyp4a14 |
T |
A |
4: 115,349,347 (GRCm39) |
I238F |
probably benign |
Het |
| D930020B18Rik |
A |
C |
10: 121,503,563 (GRCm39) |
E246A |
probably benign |
Het |
| Dsg1c |
T |
A |
18: 20,410,044 (GRCm39) |
V504E |
probably benign |
Het |
| Enpp6 |
T |
A |
8: 47,518,948 (GRCm39) |
S239T |
probably damaging |
Het |
| Eri2 |
A |
T |
7: 119,384,824 (GRCm39) |
I559N |
probably benign |
Het |
| Fbxo34 |
T |
C |
14: 47,768,724 (GRCm39) |
Y746H |
probably damaging |
Het |
| Galr1 |
A |
T |
18: 82,424,103 (GRCm39) |
L58Q |
probably damaging |
Het |
| Ghdc |
A |
G |
11: 100,658,863 (GRCm39) |
V423A |
probably benign |
Het |
| Glt28d2 |
T |
C |
3: 85,779,059 (GRCm39) |
D138G |
probably benign |
Het |
| Gm266 |
A |
T |
12: 111,451,763 (GRCm39) |
C148S |
probably benign |
Het |
| Gnas |
C |
T |
2: 174,141,132 (GRCm39) |
T493M |
unknown |
Het |
| Hivep2 |
T |
C |
10: 14,015,203 (GRCm39) |
I1790T |
probably damaging |
Het |
| Impg1 |
A |
G |
9: 80,287,276 (GRCm39) |
V390A |
probably benign |
Het |
| Isy1 |
A |
G |
6: 87,796,574 (GRCm39) |
F239L |
possibly damaging |
Het |
| Itgb5 |
A |
G |
16: 33,685,917 (GRCm39) |
T86A |
probably benign |
Het |
| Itpr1 |
T |
C |
6: 108,382,481 (GRCm39) |
C1458R |
possibly damaging |
Het |
| Krt28 |
T |
C |
11: 99,255,921 (GRCm39) |
E446G |
probably damaging |
Het |
| Lama1 |
A |
T |
17: 68,129,404 (GRCm39) |
Q3071L |
|
Het |
| Lasp1 |
A |
G |
11: 97,697,593 (GRCm39) |
|
probably benign |
Het |
| Lmf2 |
T |
C |
15: 89,237,419 (GRCm39) |
K348E |
probably benign |
Het |
| Lrch3 |
G |
T |
16: 32,796,108 (GRCm39) |
E331* |
probably null |
Het |
| Lzic |
T |
A |
4: 149,573,141 (GRCm39) |
F98I |
probably damaging |
Het |
| Map7d1 |
C |
A |
4: 126,127,440 (GRCm39) |
|
probably null |
Het |
| Marchf8 |
C |
T |
6: 116,378,405 (GRCm39) |
T113I |
possibly damaging |
Het |
| Mgrn1 |
A |
T |
16: 4,745,740 (GRCm39) |
K423* |
probably null |
Het |
| Muc20 |
G |
A |
16: 32,615,266 (GRCm39) |
T37I |
possibly damaging |
Het |
| Myh15 |
A |
G |
16: 48,959,044 (GRCm39) |
E972G |
probably damaging |
Het |
| Myocd |
T |
A |
11: 65,087,167 (GRCm39) |
K253N |
probably damaging |
Het |
| Myod1 |
T |
G |
7: 46,026,575 (GRCm39) |
L160R |
probably damaging |
Het |
| Nanog |
T |
C |
6: 122,684,799 (GRCm39) |
S20P |
probably benign |
Het |
| Nat8f2 |
A |
T |
6: 85,844,683 (GRCm39) |
Y226* |
probably null |
Het |
| Nsmf |
A |
G |
2: 24,949,077 (GRCm39) |
K277R |
probably null |
Het |
| Nsrp1 |
C |
T |
11: 76,967,503 (GRCm39) |
G30R |
probably damaging |
Het |
| Nsun6 |
C |
A |
2: 15,003,009 (GRCm39) |
R389L |
probably benign |
Het |
| Obscn |
G |
A |
11: 58,943,397 (GRCm39) |
R4251C |
probably benign |
Het |
| Or10g9 |
A |
T |
9: 39,912,172 (GRCm39) |
M117K |
probably damaging |
Het |
| Or11h4 |
C |
T |
14: 50,974,199 (GRCm39) |
C140Y |
probably benign |
Het |
| Or51h1 |
A |
G |
7: 102,308,441 (GRCm39) |
T138A |
probably damaging |
Het |
| Or5w20 |
G |
A |
2: 87,726,902 (GRCm39) |
D120N |
probably damaging |
Het |
| Pgm1 |
T |
C |
4: 99,843,918 (GRCm39) |
L567P |
probably damaging |
Het |
| Polrmt |
G |
T |
10: 79,576,535 (GRCm39) |
H474N |
probably benign |
Het |
| Ppfia2 |
A |
G |
10: 106,664,885 (GRCm39) |
I374V |
probably benign |
Het |
| Pramel5 |
T |
A |
4: 143,999,545 (GRCm39) |
I181F |
probably benign |
Het |
| Prpf4b |
T |
A |
13: 35,083,870 (GRCm39) |
Y880N |
probably damaging |
Het |
| Ptpn3 |
G |
A |
4: 57,249,957 (GRCm39) |
Q180* |
probably null |
Het |
| Ptprc |
T |
C |
1: 138,008,627 (GRCm39) |
R687G |
probably damaging |
Het |
| Rnaseh2a |
T |
C |
8: 85,684,638 (GRCm39) |
T241A |
probably damaging |
Het |
| Rnf148 |
T |
A |
6: 23,654,802 (GRCm39) |
I65F |
possibly damaging |
Het |
| Rnf213 |
A |
G |
11: 119,331,831 (GRCm39) |
I2348V |
|
Het |
| Rttn |
A |
G |
18: 89,035,334 (GRCm39) |
N736S |
possibly damaging |
Het |
| Ryr3 |
A |
C |
2: 112,633,534 (GRCm39) |
V2093G |
probably damaging |
Het |
| Selenof |
T |
A |
3: 144,283,370 (GRCm39) |
F33L |
probably benign |
Het |
| Sh2d3c |
C |
T |
2: 32,635,889 (GRCm39) |
R238* |
probably null |
Het |
| Slc23a4 |
T |
C |
6: 34,923,235 (GRCm39) |
K543R |
probably benign |
Het |
| Smn1 |
A |
T |
13: 100,272,210 (GRCm39) |
N278I |
possibly damaging |
Het |
| Sox7 |
G |
A |
14: 64,185,509 (GRCm39) |
A182T |
probably benign |
Het |
| Spata31e5 |
T |
A |
1: 28,817,120 (GRCm39) |
Y304F |
probably benign |
Het |
| Sptlc2 |
A |
T |
12: 87,359,533 (GRCm39) |
I501N |
probably benign |
Het |
| Srf |
T |
C |
17: 46,866,271 (GRCm39) |
T162A |
probably benign |
Het |
| Srm |
C |
T |
4: 148,676,039 (GRCm39) |
|
probably benign |
Het |
| Stim1 |
CAGCGCCTGACGGAGC |
CAGC |
7: 102,080,118 (GRCm39) |
|
probably benign |
Het |
| Taar8a |
T |
C |
10: 23,952,714 (GRCm39) |
L106P |
probably damaging |
Het |
| Tcte1 |
A |
G |
17: 45,850,798 (GRCm39) |
H358R |
possibly damaging |
Het |
| Tmem205 |
A |
G |
9: 21,837,587 (GRCm39) |
S20P |
probably damaging |
Het |
| Trav16 |
T |
A |
14: 53,980,910 (GRCm39) |
V33E |
possibly damaging |
Het |
| Trf |
T |
A |
9: 103,103,217 (GRCm39) |
I149F |
probably damaging |
Het |
| Trmt2a |
C |
T |
16: 18,070,041 (GRCm39) |
Q419* |
probably null |
Het |
| Ttc19 |
A |
G |
11: 62,203,997 (GRCm39) |
I319M |
probably benign |
Het |
| Txndc16 |
T |
C |
14: 45,400,467 (GRCm39) |
I345V |
probably benign |
Het |
| Ube3b |
T |
C |
5: 114,553,370 (GRCm39) |
I914T |
probably benign |
Het |
| Ubr3 |
T |
C |
2: 69,727,957 (GRCm39) |
F107L |
possibly damaging |
Het |
| Vmn1r73 |
T |
C |
7: 11,490,407 (GRCm39) |
F75S |
possibly damaging |
Het |
| Vmn2r54 |
A |
T |
7: 12,363,753 (GRCm39) |
M380K |
possibly damaging |
Het |
| Wdr7 |
T |
A |
18: 63,927,317 (GRCm39) |
M989K |
possibly damaging |
Het |
| Zcchc3 |
A |
G |
2: 152,256,385 (GRCm39) |
S105P |
probably benign |
Het |
| Zfp735 |
T |
A |
11: 73,601,806 (GRCm39) |
V250E |
possibly damaging |
Het |
|
| Other mutations in Arhgef2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01913:Arhgef2
|
APN |
3 |
88,539,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02165:Arhgef2
|
APN |
3 |
88,553,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
monument
|
UTSW |
3 |
88,540,955 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0090:Arhgef2
|
UTSW |
3 |
88,546,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0330:Arhgef2
|
UTSW |
3 |
88,549,808 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0414:Arhgef2
|
UTSW |
3 |
88,539,575 (GRCm39) |
splice site |
probably benign |
|
|
R0631:Arhgef2
|
UTSW |
3 |
88,541,743 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1635:Arhgef2
|
UTSW |
3 |
88,546,628 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1688:Arhgef2
|
UTSW |
3 |
88,547,607 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1751:Arhgef2
|
UTSW |
3 |
88,551,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1767:Arhgef2
|
UTSW |
3 |
88,551,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1836:Arhgef2
|
UTSW |
3 |
88,546,766 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1853:Arhgef2
|
UTSW |
3 |
88,540,222 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R1934:Arhgef2
|
UTSW |
3 |
88,537,098 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2155:Arhgef2
|
UTSW |
3 |
88,543,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2206:Arhgef2
|
UTSW |
3 |
88,537,221 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2360:Arhgef2
|
UTSW |
3 |
88,541,723 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3916:Arhgef2
|
UTSW |
3 |
88,540,340 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4090:Arhgef2
|
UTSW |
3 |
88,551,185 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4732:Arhgef2
|
UTSW |
3 |
88,539,247 (GRCm39) |
nonsense |
probably null |
|
|
R4733:Arhgef2
|
UTSW |
3 |
88,539,247 (GRCm39) |
nonsense |
probably null |
|
|
R4837:Arhgef2
|
UTSW |
3 |
88,540,250 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4952:Arhgef2
|
UTSW |
3 |
88,549,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5152:Arhgef2
|
UTSW |
3 |
88,536,875 (GRCm39) |
splice site |
probably null |
|
|
R5194:Arhgef2
|
UTSW |
3 |
88,542,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5250:Arhgef2
|
UTSW |
3 |
88,540,955 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5334:Arhgef2
|
UTSW |
3 |
88,553,636 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5514:Arhgef2
|
UTSW |
3 |
88,550,304 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5560:Arhgef2
|
UTSW |
3 |
88,541,744 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5595:Arhgef2
|
UTSW |
3 |
88,550,283 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5879:Arhgef2
|
UTSW |
3 |
88,550,924 (GRCm39) |
splice site |
probably null |
|
|
R5910:Arhgef2
|
UTSW |
3 |
88,542,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5914:Arhgef2
|
UTSW |
3 |
88,543,176 (GRCm39) |
missense |
probably benign |
|
|
R5918:Arhgef2
|
UTSW |
3 |
88,543,387 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6181:Arhgef2
|
UTSW |
3 |
88,542,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6489:Arhgef2
|
UTSW |
3 |
88,550,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7167:Arhgef2
|
UTSW |
3 |
88,551,179 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7289:Arhgef2
|
UTSW |
3 |
88,543,192 (GRCm39) |
missense |
probably benign |
|
|
R7318:Arhgef2
|
UTSW |
3 |
88,539,610 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7353:Arhgef2
|
UTSW |
3 |
88,542,993 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7402:Arhgef2
|
UTSW |
3 |
88,540,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7441:Arhgef2
|
UTSW |
3 |
88,551,262 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7899:Arhgef2
|
UTSW |
3 |
88,528,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7934:Arhgef2
|
UTSW |
3 |
88,537,221 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8002:Arhgef2
|
UTSW |
3 |
88,554,117 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8254:Arhgef2
|
UTSW |
3 |
88,549,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8297:Arhgef2
|
UTSW |
3 |
88,546,739 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8314:Arhgef2
|
UTSW |
3 |
88,528,600 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8350:Arhgef2
|
UTSW |
3 |
88,553,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8450:Arhgef2
|
UTSW |
3 |
88,553,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8755:Arhgef2
|
UTSW |
3 |
88,536,850 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9632:Arhgef2
|
UTSW |
3 |
88,528,576 (GRCm39) |
missense |
probably benign |
0.43 |
|
V1662:Arhgef2
|
UTSW |
3 |
88,540,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAAAAGGGATCCTCGAACCTGTC -3'
(R):5'- AGCTCAGCTCTCCTAGATCC -3'
Sequencing Primer
(F):5'- GATCCTCGAACCTGTCCCAAGG -3'
(R):5'- TAGATCCCCGCACAGAAGCTG -3'
|
| Posted On |
2022-10-06 |
Incidental Mutation