Mutagenetix > Incidental Mutation

Incidental Mutation 'R9710:Lama1'

730118

Institutional Source

Beutler Lab

Gene Symbol

Lama1

Ensembl Gene

ENSMUSG00000032796

Gene Name

laminin, alpha 1

Synonyms

Lama

MMRRC Submission

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R9710 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

68004254-68129642 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 68129404 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Leucine at position 3071 (Q3071L)

Ref Sequence

ENSEMBL: ENSMUSP00000043957 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035471]

AlphaFold

no structure available at present

Predicted Effect

SMART Domains

Protein: ENSMUSP00000043957
Gene: ENSMUSG00000032796
AA Change: Q3071L

Domain	Start	End	E-Value	Type
low complexity region	3	22	N/A	INTRINSIC
LamNT	23	275	1.2e-131	SMART
EGF_Lam	277	331	1e-5	SMART
EGF_Lam	334	401	6.6e-6	SMART
EGF_Lam	404	458	9.11e-9	SMART
EGF_Lam	461	507	8.12e-6	SMART
LamB	570	702	2.09e-57	SMART
EGF_like	715	746	3.36e0	SMART
EGF_Lam	749	795	7.01e-10	SMART
EGF_Lam	798	853	3.59e-7	SMART
EGF_Lam	856	906	1.53e-10	SMART
EGF_Lam	909	955	1.13e-13	SMART
EGF_Lam	958	1002	1.36e-7	SMART
EGF_Lam	1005	1048	7.29e-8	SMART
EGF_like	1034	1082	4.83e1	SMART
EGF_Lam	1051	1094	1.67e-7	SMART
EGF_Lam	1097	1154	1.32e-5	SMART
LamB	1220	1352	8.7e-46	SMART
Pfam:Laminin_EGF	1367	1397	1.7e-6	PFAM
EGF_Lam	1410	1456	7.12e-11	SMART
EGF_Lam	1459	1513	3.25e-5	SMART
EGF_like	1497	1547	6.41e1	SMART
EGF_Lam	1516	1560	1.71e-13	SMART
Pfam:Laminin_I	1574	1838	1.7e-91	PFAM
low complexity region	2012	2031	N/A	INTRINSIC
low complexity region	2087	2098	N/A	INTRINSIC
LamG	2145	2287	3.66e-30	SMART
LamG	2332	2473	5.98e-35	SMART
LamG	2513	2661	1.11e-29	SMART
low complexity region	2695	2708	N/A	INTRINSIC
LamG	2743	2877	9.72e-35	SMART
LamG	2920	3056	4.63e-41	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014]
PHENOTYPE: Homozygous null mice display embryonic lethality before somite formation with impaired formation of Reichert's membrane. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 92 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930407I10Rik	T	C	15: 81,946,852 (GRCm39)	S250P	probably benign	Het
Ahcyl1	T	A	3: 107,578,494 (GRCm39)	I248F	possibly damaging	Het
Alpk2	T	A	18: 65,482,646 (GRCm39)	E454V	probably damaging	Het
Ank3	A	T	10: 69,829,070 (GRCm39)	T2580S		Het
Anks1	G	A	17: 28,128,571 (GRCm39)	G46R	possibly damaging	Het
Arhgap45	A	G	10: 79,857,635 (GRCm39)	E322G	probably damaging	Het
Arhgef2	T	C	3: 88,528,576 (GRCm39)	I4T	probably benign	Het
C1qtnf4	T	C	2: 90,720,351 (GRCm39)	I208T	probably damaging	Het
Cachd1	T	A	4: 100,832,092 (GRCm39)	N751K	probably benign	Het
Cacna1a	G	T	8: 85,320,808 (GRCm39)	V1589F	possibly damaging	Het
Cacnb1	T	C	11: 97,902,197 (GRCm39)	H205R	probably benign	Het
Castor1	A	G	11: 4,169,015 (GRCm39)	K61E	probably benign	Het
Ccdc9b	G	T	2: 118,591,077 (GRCm39)	A152E	probably benign	Het
Clvs2	C	A	10: 33,389,307 (GRCm39)	R311L	probably benign	Het
Crim1	G	T	17: 78,610,504 (GRCm39)	G320*	probably null	Het
Crtam	A	T	9: 40,895,671 (GRCm39)	D218E	probably benign	Het
Cwc27	G	A	13: 104,943,158 (GRCm39)	T128I	probably damaging	Het
Cyp4a14	T	A	4: 115,349,347 (GRCm39)	I238F	probably benign	Het
D930020B18Rik	A	C	10: 121,503,563 (GRCm39)	E246A	probably benign	Het
Dsg1c	T	A	18: 20,410,044 (GRCm39)	V504E	probably benign	Het
Enpp6	T	A	8: 47,518,948 (GRCm39)	S239T	probably damaging	Het
Eri2	A	T	7: 119,384,824 (GRCm39)	I559N	probably benign	Het
Fbxo34	T	C	14: 47,768,724 (GRCm39)	Y746H	probably damaging	Het
Galr1	A	T	18: 82,424,103 (GRCm39)	L58Q	probably damaging	Het
Ghdc	A	G	11: 100,658,863 (GRCm39)	V423A	probably benign	Het
Glt28d2	T	C	3: 85,779,059 (GRCm39)	D138G	probably benign	Het
Gm266	A	T	12: 111,451,763 (GRCm39)	C148S	probably benign	Het
Gnas	C	T	2: 174,141,132 (GRCm39)	T493M	unknown	Het
Hivep2	T	C	10: 14,015,203 (GRCm39)	I1790T	probably damaging	Het
Impg1	A	G	9: 80,287,276 (GRCm39)	V390A	probably benign	Het
Isy1	A	G	6: 87,796,574 (GRCm39)	F239L	possibly damaging	Het
Itgb5	A	G	16: 33,685,917 (GRCm39)	T86A	probably benign	Het
Itpr1	T	C	6: 108,382,481 (GRCm39)	C1458R	possibly damaging	Het
Krt28	T	C	11: 99,255,921 (GRCm39)	E446G	probably damaging	Het
Lasp1	A	G	11: 97,697,593 (GRCm39)		probably benign	Het
Lmf2	T	C	15: 89,237,419 (GRCm39)	K348E	probably benign	Het
Lrch3	G	T	16: 32,796,108 (GRCm39)	E331*	probably null	Het
Lzic	T	A	4: 149,573,141 (GRCm39)	F98I	probably damaging	Het
Map7d1	C	A	4: 126,127,440 (GRCm39)		probably null	Het
Marchf8	C	T	6: 116,378,405 (GRCm39)	T113I	possibly damaging	Het
Mgrn1	A	T	16: 4,745,740 (GRCm39)	K423*	probably null	Het
Muc20	G	A	16: 32,615,266 (GRCm39)	T37I	possibly damaging	Het
Myh15	A	G	16: 48,959,044 (GRCm39)	E972G	probably damaging	Het
Myocd	T	A	11: 65,087,167 (GRCm39)	K253N	probably damaging	Het
Myod1	T	G	7: 46,026,575 (GRCm39)	L160R	probably damaging	Het
Nanog	T	C	6: 122,684,799 (GRCm39)	S20P	probably benign	Het
Nat8f2	A	T	6: 85,844,683 (GRCm39)	Y226*	probably null	Het
Nsmf	A	G	2: 24,949,077 (GRCm39)	K277R	probably null	Het
Nsrp1	C	T	11: 76,967,503 (GRCm39)	G30R	probably damaging	Het
Nsun6	C	A	2: 15,003,009 (GRCm39)	R389L	probably benign	Het
Obscn	G	A	11: 58,943,397 (GRCm39)	R4251C	probably benign	Het
Or10g9	A	T	9: 39,912,172 (GRCm39)	M117K	probably damaging	Het
Or11h4	C	T	14: 50,974,199 (GRCm39)	C140Y	probably benign	Het
Or51h1	A	G	7: 102,308,441 (GRCm39)	T138A	probably damaging	Het
Or5w20	G	A	2: 87,726,902 (GRCm39)	D120N	probably damaging	Het
Pgm1	T	C	4: 99,843,918 (GRCm39)	L567P	probably damaging	Het
Polrmt	G	T	10: 79,576,535 (GRCm39)	H474N	probably benign	Het
Ppfia2	A	G	10: 106,664,885 (GRCm39)	I374V	probably benign	Het
Pramel5	T	A	4: 143,999,545 (GRCm39)	I181F	probably benign	Het
Prpf4b	T	A	13: 35,083,870 (GRCm39)	Y880N	probably damaging	Het
Ptpn3	G	A	4: 57,249,957 (GRCm39)	Q180*	probably null	Het
Ptprc	T	C	1: 138,008,627 (GRCm39)	R687G	probably damaging	Het
Rnaseh2a	T	C	8: 85,684,638 (GRCm39)	T241A	probably damaging	Het
Rnf148	T	A	6: 23,654,802 (GRCm39)	I65F	possibly damaging	Het
Rnf213	A	G	11: 119,331,831 (GRCm39)	I2348V		Het
Rttn	A	G	18: 89,035,334 (GRCm39)	N736S	possibly damaging	Het
Ryr3	A	C	2: 112,633,534 (GRCm39)	V2093G	probably damaging	Het
Selenof	T	A	3: 144,283,370 (GRCm39)	F33L	probably benign	Het
Sh2d3c	C	T	2: 32,635,889 (GRCm39)	R238*	probably null	Het
Slc23a4	T	C	6: 34,923,235 (GRCm39)	K543R	probably benign	Het
Smn1	A	T	13: 100,272,210 (GRCm39)	N278I	possibly damaging	Het
Sox7	G	A	14: 64,185,509 (GRCm39)	A182T	probably benign	Het
Spata31e5	T	A	1: 28,817,120 (GRCm39)	Y304F	probably benign	Het
Sptlc2	A	T	12: 87,359,533 (GRCm39)	I501N	probably benign	Het
Srf	T	C	17: 46,866,271 (GRCm39)	T162A	probably benign	Het
Srm	C	T	4: 148,676,039 (GRCm39)		probably benign	Het
Stim1	CAGCGCCTGACGGAGC	CAGC	7: 102,080,118 (GRCm39)		probably benign	Het
Taar8a	T	C	10: 23,952,714 (GRCm39)	L106P	probably damaging	Het
Tcte1	A	G	17: 45,850,798 (GRCm39)	H358R	possibly damaging	Het
Tmem205	A	G	9: 21,837,587 (GRCm39)	S20P	probably damaging	Het
Trav16	T	A	14: 53,980,910 (GRCm39)	V33E	possibly damaging	Het
Trf	T	A	9: 103,103,217 (GRCm39)	I149F	probably damaging	Het
Trmt2a	C	T	16: 18,070,041 (GRCm39)	Q419*	probably null	Het
Ttc19	A	G	11: 62,203,997 (GRCm39)	I319M	probably benign	Het
Txndc16	T	C	14: 45,400,467 (GRCm39)	I345V	probably benign	Het
Ube3b	T	C	5: 114,553,370 (GRCm39)	I914T	probably benign	Het
Ubr3	T	C	2: 69,727,957 (GRCm39)	F107L	possibly damaging	Het
Vmn1r73	T	C	7: 11,490,407 (GRCm39)	F75S	possibly damaging	Het
Vmn2r54	A	T	7: 12,363,753 (GRCm39)	M380K	possibly damaging	Het
Wdr7	T	A	18: 63,927,317 (GRCm39)	M989K	possibly damaging	Het
Zcchc3	A	G	2: 152,256,385 (GRCm39)	S105P	probably benign	Het
Zfp735	T	A	11: 73,601,806 (GRCm39)	V250E	possibly damaging	Het

Other mutations in Lama1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00157:Lama1	APN	17	68,122,923 (GRCm39)	missense	probably benign
IGL00336:Lama1	APN	17	68,120,943 (GRCm39)	missense	probably benign	0.07
IGL01066:Lama1	APN	17	68,050,321 (GRCm39)	missense	probably damaging	1.00
IGL01140:Lama1	APN	17	68,109,928 (GRCm39)	missense	probably benign	0.14
IGL01291:Lama1	APN	17	68,045,865 (GRCm39)	missense	probably damaging	1.00
IGL01296:Lama1	APN	17	68,052,046 (GRCm39)	missense	probably benign	0.27
IGL01317:Lama1	APN	17	68,125,696 (GRCm39)	missense	probably damaging	1.00
IGL01490:Lama1	APN	17	68,057,579 (GRCm39)	missense	possibly damaging	0.54
IGL01506:Lama1	APN	17	68,092,065 (GRCm39)	missense	probably benign	0.01
IGL01508:Lama1	APN	17	68,116,356 (GRCm39)	splice site	probably benign
IGL01522:Lama1	APN	17	68,059,769 (GRCm39)	splice site	probably benign
IGL01530:Lama1	APN	17	68,103,785 (GRCm39)	missense	probably benign	0.02
IGL01541:Lama1	APN	17	68,092,065 (GRCm39)	missense	probably benign	0.01
IGL01677:Lama1	APN	17	68,086,143 (GRCm39)	missense	probably benign	0.15
IGL01886:Lama1	APN	17	68,114,792 (GRCm39)	missense	probably benign	0.36
IGL01994:Lama1	APN	17	68,059,434 (GRCm39)	missense	probably benign	0.05
IGL02017:Lama1	APN	17	68,071,720 (GRCm39)	missense	probably benign	0.00
IGL02021:Lama1	APN	17	68,128,621 (GRCm39)	missense	probably damaging	1.00
IGL02026:Lama1	APN	17	68,116,287 (GRCm39)	missense	possibly damaging	0.82
IGL02044:Lama1	APN	17	68,118,485 (GRCm39)	missense	probably benign	0.01
IGL02120:Lama1	APN	17	68,023,784 (GRCm39)	missense	probably damaging	1.00
IGL02425:Lama1	APN	17	68,118,480 (GRCm39)	missense	probably benign	0.45
IGL02549:Lama1	APN	17	68,097,830 (GRCm39)	missense	possibly damaging	0.93
IGL02642:Lama1	APN	17	68,119,361 (GRCm39)	missense	probably benign	0.00
IGL02795:Lama1	APN	17	68,045,889 (GRCm39)	splice site	probably null
IGL02798:Lama1	APN	17	68,102,186 (GRCm39)	splice site	probably benign
IGL02863:Lama1	APN	17	68,111,531 (GRCm39)	missense	probably damaging	0.99
IGL02870:Lama1	APN	17	68,111,531 (GRCm39)	missense	probably damaging	0.99
IGL02876:Lama1	APN	17	68,057,687 (GRCm39)	critical splice donor site	probably null
IGL02885:Lama1	APN	17	68,111,531 (GRCm39)	missense	probably damaging	0.99
IGL02891:Lama1	APN	17	68,111,531 (GRCm39)	missense	probably damaging	0.99
IGL02978:Lama1	APN	17	68,093,076 (GRCm39)	nonsense	probably null
IGL03064:Lama1	APN	17	68,086,099 (GRCm39)	missense	probably benign	0.01
IGL03076:Lama1	APN	17	68,023,794 (GRCm39)	missense	possibly damaging	0.95
IGL03110:Lama1	APN	17	68,105,981 (GRCm39)	missense	probably benign	0.04
IGL03143:Lama1	APN	17	68,111,531 (GRCm39)	missense	probably damaging	0.99
IGL03159:Lama1	APN	17	68,111,531 (GRCm39)	missense	probably damaging	0.99
IGL03268:Lama1	APN	17	68,111,531 (GRCm39)	missense	probably damaging	0.99
ANU05:Lama1	UTSW	17	68,045,865 (GRCm39)	missense	probably damaging	1.00
PIT4472001:Lama1	UTSW	17	68,071,699 (GRCm39)	missense
R0047:Lama1	UTSW	17	68,102,181 (GRCm39)	splice site	probably benign
R0047:Lama1	UTSW	17	68,102,181 (GRCm39)	splice site	probably benign
R0050:Lama1	UTSW	17	68,089,051 (GRCm39)	missense	possibly damaging	0.66
R0096:Lama1	UTSW	17	68,112,408 (GRCm39)	missense	probably benign	0.12
R0096:Lama1	UTSW	17	68,112,408 (GRCm39)	missense	probably benign	0.12
R0111:Lama1	UTSW	17	68,044,493 (GRCm39)	missense	probably damaging	0.98
R0116:Lama1	UTSW	17	68,083,918 (GRCm39)	missense	probably benign	0.10
R0121:Lama1	UTSW	17	68,105,508 (GRCm39)	splice site	probably benign
R0278:Lama1	UTSW	17	68,117,178 (GRCm39)	missense	probably null	0.98
R0281:Lama1	UTSW	17	68,124,564 (GRCm39)	missense	probably damaging	1.00
R0312:Lama1	UTSW	17	68,082,846 (GRCm39)	missense	possibly damaging	0.45
R0419:Lama1	UTSW	17	68,098,605 (GRCm39)	critical splice donor site	probably null
R0512:Lama1	UTSW	17	68,086,129 (GRCm39)	missense	possibly damaging	0.67
R0514:Lama1	UTSW	17	68,071,693 (GRCm39)	missense	probably benign	0.40
R0562:Lama1	UTSW	17	68,122,954 (GRCm39)	missense	probably damaging	1.00
R0632:Lama1	UTSW	17	68,059,363 (GRCm39)	splice site	probably benign
R0645:Lama1	UTSW	17	68,080,707 (GRCm39)	missense	probably benign	0.01
R0712:Lama1	UTSW	17	68,086,037 (GRCm39)	splice site	probably null
R0763:Lama1	UTSW	17	68,079,813 (GRCm39)	missense	probably damaging	0.97
R0941:Lama1	UTSW	17	68,082,860 (GRCm39)	missense	probably benign	0.10
R1025:Lama1	UTSW	17	68,059,893 (GRCm39)	missense	probably benign	0.00
R1084:Lama1	UTSW	17	68,111,464 (GRCm39)	missense	probably benign	0.12
R1103:Lama1	UTSW	17	68,097,942 (GRCm39)	missense	probably damaging	0.98
R1420:Lama1	UTSW	17	68,097,942 (GRCm39)	missense	probably damaging	0.98
R1430:Lama1	UTSW	17	68,089,150 (GRCm39)	missense	possibly damaging	0.95
R1569:Lama1	UTSW	17	68,087,613 (GRCm39)	splice site	probably null
R1575:Lama1	UTSW	17	68,117,404 (GRCm39)	missense	possibly damaging	0.96
R1613:Lama1	UTSW	17	68,114,918 (GRCm39)	missense	probably benign	0.42
R1620:Lama1	UTSW	17	68,074,028 (GRCm39)	missense	probably benign	0.01
R1629:Lama1	UTSW	17	68,112,423 (GRCm39)	missense	probably benign	0.00
R1645:Lama1	UTSW	17	68,044,677 (GRCm39)	missense	probably benign	0.14
R1652:Lama1	UTSW	17	68,114,841 (GRCm39)	missense	probably damaging	0.97
R1674:Lama1	UTSW	17	68,098,239 (GRCm39)	missense	probably benign
R1678:Lama1	UTSW	17	68,117,150 (GRCm39)	missense	possibly damaging	0.56
R1710:Lama1	UTSW	17	68,060,786 (GRCm39)	missense	probably benign	0.00
R1712:Lama1	UTSW	17	68,024,181 (GRCm39)	missense	possibly damaging	0.95
R1737:Lama1	UTSW	17	68,109,916 (GRCm39)	missense	probably benign	0.36
R1757:Lama1	UTSW	17	68,004,378 (GRCm39)	missense	unknown
R1757:Lama1	UTSW	17	68,070,831 (GRCm39)	missense	probably benign	0.40
R1813:Lama1	UTSW	17	68,098,218 (GRCm39)	missense	probably benign
R1896:Lama1	UTSW	17	68,098,218 (GRCm39)	missense	probably benign
R1945:Lama1	UTSW	17	68,052,848 (GRCm39)	missense	probably benign	0.14
R2086:Lama1	UTSW	17	68,124,618 (GRCm39)	missense	probably damaging	1.00
R2149:Lama1	UTSW	17	68,080,860 (GRCm39)	missense	possibly damaging	0.95
R2178:Lama1	UTSW	17	68,076,510 (GRCm39)	missense	probably benign	0.07
R2183:Lama1	UTSW	17	68,098,004 (GRCm39)	missense	probably damaging	0.98
R2197:Lama1	UTSW	17	68,059,936 (GRCm39)	missense	probably benign	0.02
R2213:Lama1	UTSW	17	68,084,029 (GRCm39)	nonsense	probably null
R2260:Lama1	UTSW	17	68,044,502 (GRCm39)	missense	probably damaging	0.96
R2356:Lama1	UTSW	17	68,117,109 (GRCm39)	missense	probably damaging	1.00
R2420:Lama1	UTSW	17	68,057,548 (GRCm39)	missense	probably benign	0.00
R2421:Lama1	UTSW	17	68,057,548 (GRCm39)	missense	probably benign	0.00
R2422:Lama1	UTSW	17	68,057,548 (GRCm39)	missense	probably benign	0.00
R2424:Lama1	UTSW	17	68,105,660 (GRCm39)	missense	probably benign	0.09
R2442:Lama1	UTSW	17	68,075,312 (GRCm39)	missense	probably benign	0.04
R3147:Lama1	UTSW	17	68,044,653 (GRCm39)	missense	probably damaging	0.98
R3414:Lama1	UTSW	17	68,044,598 (GRCm39)	missense	probably damaging	1.00
R3683:Lama1	UTSW	17	68,075,328 (GRCm39)	missense	probably benign	0.40
R3820:Lama1	UTSW	17	68,086,041 (GRCm39)	splice site	probably null
R3821:Lama1	UTSW	17	68,086,041 (GRCm39)	splice site	probably null
R3822:Lama1	UTSW	17	68,086,041 (GRCm39)	splice site	probably null
R4012:Lama1	UTSW	17	68,119,368 (GRCm39)	nonsense	probably null
R4113:Lama1	UTSW	17	68,071,698 (GRCm39)	missense	probably benign	0.01
R4133:Lama1	UTSW	17	68,119,481 (GRCm39)	missense	probably damaging	1.00
R4133:Lama1	UTSW	17	68,057,650 (GRCm39)	missense	probably damaging	0.98
R4259:Lama1	UTSW	17	68,059,413 (GRCm39)	missense	possibly damaging	0.95
R4278:Lama1	UTSW	17	68,098,512 (GRCm39)	missense	probably null	0.00
R4321:Lama1	UTSW	17	68,078,078 (GRCm39)	missense	probably benign	0.03
R4374:Lama1	UTSW	17	68,111,513 (GRCm39)	missense	probably benign	0.00
R4386:Lama1	UTSW	17	68,080,707 (GRCm39)	missense	probably benign	0.01
R4463:Lama1	UTSW	17	68,068,695 (GRCm39)	missense	probably damaging	1.00
R4629:Lama1	UTSW	17	68,112,355 (GRCm39)	critical splice acceptor site	probably null
R4630:Lama1	UTSW	17	68,101,295 (GRCm39)	missense	probably benign	0.00
R4633:Lama1	UTSW	17	68,105,579 (GRCm39)	missense	probably damaging	0.96
R4668:Lama1	UTSW	17	68,059,429 (GRCm39)	missense	probably benign	0.27
R4684:Lama1	UTSW	17	68,080,773 (GRCm39)	missense	possibly damaging	0.88
R4745:Lama1	UTSW	17	68,045,775 (GRCm39)	missense	probably damaging	1.00
R4786:Lama1	UTSW	17	68,080,854 (GRCm39)	missense	possibly damaging	0.77
R4797:Lama1	UTSW	17	68,023,770 (GRCm39)	missense	probably benign	0.04
R4803:Lama1	UTSW	17	68,116,266 (GRCm39)	missense	probably damaging	1.00
R4925:Lama1	UTSW	17	68,101,309 (GRCm39)	missense	probably benign	0.02
R4939:Lama1	UTSW	17	68,044,470 (GRCm39)	missense	possibly damaging	0.91
R4952:Lama1	UTSW	17	68,074,561 (GRCm39)	critical splice donor site	probably null
R4975:Lama1	UTSW	17	68,045,829 (GRCm39)	missense	possibly damaging	0.95
R4977:Lama1	UTSW	17	68,044,677 (GRCm39)	missense	probably damaging	1.00
R5039:Lama1	UTSW	17	68,052,888 (GRCm39)	missense	possibly damaging	0.66
R5047:Lama1	UTSW	17	68,050,276 (GRCm39)	nonsense	probably null
R5195:Lama1	UTSW	17	68,071,795 (GRCm39)	missense	probably benign	0.13
R5230:Lama1	UTSW	17	68,052,078 (GRCm39)	nonsense	probably null
R5236:Lama1	UTSW	17	68,111,487 (GRCm39)	missense	probably benign	0.24
R5254:Lama1	UTSW	17	68,063,711 (GRCm39)	missense	probably benign	0.01
R5345:Lama1	UTSW	17	68,124,558 (GRCm39)	missense	probably benign
R5438:Lama1	UTSW	17	68,107,769 (GRCm39)	missense	possibly damaging	0.92
R5521:Lama1	UTSW	17	68,087,889 (GRCm39)	nonsense	probably null
R5568:Lama1	UTSW	17	68,075,293 (GRCm39)	critical splice acceptor site	probably null
R5645:Lama1	UTSW	17	68,109,943 (GRCm39)	missense	probably damaging	1.00
R5665:Lama1	UTSW	17	68,077,982 (GRCm39)	missense	probably damaging	1.00
R5727:Lama1	UTSW	17	68,122,219 (GRCm39)	missense	possibly damaging	0.81
R5757:Lama1	UTSW	17	68,045,782 (GRCm39)	missense	possibly damaging	0.59
R5795:Lama1	UTSW	17	68,103,722 (GRCm39)	missense	probably benign	0.02
R5857:Lama1	UTSW	17	68,114,838 (GRCm39)	missense	probably damaging	0.99
R5894:Lama1	UTSW	17	68,086,042 (GRCm39)	critical splice acceptor site	probably null
R5974:Lama1	UTSW	17	68,080,722 (GRCm39)	missense	probably benign	0.31
R6032:Lama1	UTSW	17	68,057,638 (GRCm39)	missense	probably benign	0.01
R6032:Lama1	UTSW	17	68,057,638 (GRCm39)	missense	probably benign	0.01
R6120:Lama1	UTSW	17	68,087,612 (GRCm39)	critical splice donor site	probably null
R6219:Lama1	UTSW	17	68,097,851 (GRCm39)	missense	probably benign	0.08
R6224:Lama1	UTSW	17	68,109,982 (GRCm39)	missense	possibly damaging	0.56
R6249:Lama1	UTSW	17	68,105,599 (GRCm39)	missense	probably benign
R6265:Lama1	UTSW	17	68,057,650 (GRCm39)	missense	probably damaging	0.98
R6276:Lama1	UTSW	17	68,091,083 (GRCm39)	splice site	probably null
R6284:Lama1	UTSW	17	68,117,091 (GRCm39)	missense	probably damaging	0.99
R6337:Lama1	UTSW	17	68,093,014 (GRCm39)	missense	probably benign	0.27
R6414:Lama1	UTSW	17	68,053,905 (GRCm39)	critical splice donor site	probably null
R6631:Lama1	UTSW	17	68,081,477 (GRCm39)	missense	probably benign	0.21
R6659:Lama1	UTSW	17	68,125,630 (GRCm39)	missense	probably damaging	1.00
R6660:Lama1	UTSW	17	68,111,495 (GRCm39)	missense	probably benign	0.05
R6677:Lama1	UTSW	17	68,102,228 (GRCm39)	missense	probably benign	0.14
R6763:Lama1	UTSW	17	68,053,868 (GRCm39)	missense	unknown
R6787:Lama1	UTSW	17	68,091,020 (GRCm39)	missense	unknown
R6831:Lama1	UTSW	17	68,063,749 (GRCm39)	missense	possibly damaging	0.89
R6855:Lama1	UTSW	17	68,089,150 (GRCm39)	missense	possibly damaging	0.95
R6910:Lama1	UTSW	17	68,098,459 (GRCm39)	missense	possibly damaging	0.60
R6934:Lama1	UTSW	17	68,081,538 (GRCm39)	missense	probably benign	0.04
R6945:Lama1	UTSW	17	68,120,861 (GRCm39)	missense
R6984:Lama1	UTSW	17	68,086,107 (GRCm39)	missense
R6989:Lama1	UTSW	17	68,060,753 (GRCm39)	missense
R6994:Lama1	UTSW	17	68,060,820 (GRCm39)	missense
R6995:Lama1	UTSW	17	68,060,820 (GRCm39)	missense
R7035:Lama1	UTSW	17	68,088,044 (GRCm39)	missense
R7133:Lama1	UTSW	17	68,089,141 (GRCm39)	missense
R7172:Lama1	UTSW	17	68,111,540 (GRCm39)	missense
R7197:Lama1	UTSW	17	68,044,700 (GRCm39)	nonsense	probably null
R7217:Lama1	UTSW	17	68,071,668 (GRCm39)	missense
R7229:Lama1	UTSW	17	68,059,441 (GRCm39)	missense
R7264:Lama1	UTSW	17	68,050,292 (GRCm39)	missense
R7311:Lama1	UTSW	17	68,074,380 (GRCm39)	missense
R7394:Lama1	UTSW	17	68,024,256 (GRCm39)	missense
R7419:Lama1	UTSW	17	68,024,169 (GRCm39)	missense
R7460:Lama1	UTSW	17	68,074,013 (GRCm39)	missense
R7492:Lama1	UTSW	17	68,124,646 (GRCm39)	missense
R7494:Lama1	UTSW	17	68,118,441 (GRCm39)	missense
R7552:Lama1	UTSW	17	68,044,662 (GRCm39)	missense
R7576:Lama1	UTSW	17	68,089,036 (GRCm39)	missense
R7583:Lama1	UTSW	17	68,068,616 (GRCm39)	missense
R7649:Lama1	UTSW	17	68,044,549 (GRCm39)	missense
R7663:Lama1	UTSW	17	68,087,875 (GRCm39)	missense
R7667:Lama1	UTSW	17	68,087,592 (GRCm39)	missense
R7688:Lama1	UTSW	17	68,068,623 (GRCm39)	missense
R7693:Lama1	UTSW	17	68,124,026 (GRCm39)	missense
R7748:Lama1	UTSW	17	68,057,585 (GRCm39)	missense
R7778:Lama1	UTSW	17	68,111,468 (GRCm39)	missense
R7824:Lama1	UTSW	17	68,111,468 (GRCm39)	missense
R7861:Lama1	UTSW	17	68,116,216 (GRCm39)	missense
R7884:Lama1	UTSW	17	68,076,430 (GRCm39)	missense
R8029:Lama1	UTSW	17	68,124,589 (GRCm39)	missense
R8078:Lama1	UTSW	17	68,098,289 (GRCm39)	missense
R8101:Lama1	UTSW	17	68,052,917 (GRCm39)	missense
R8313:Lama1	UTSW	17	68,057,515 (GRCm39)	missense
R8356:Lama1	UTSW	17	68,044,491 (GRCm39)	missense
R8366:Lama1	UTSW	17	68,125,699 (GRCm39)	missense
R8403:Lama1	UTSW	17	68,052,918 (GRCm39)	missense
R8456:Lama1	UTSW	17	68,044,491 (GRCm39)	missense
R8466:Lama1	UTSW	17	68,120,948 (GRCm39)	missense
R8678:Lama1	UTSW	17	68,124,098 (GRCm39)	missense
R8728:Lama1	UTSW	17	68,125,663 (GRCm39)	missense
R8796:Lama1	UTSW	17	68,117,146 (GRCm39)	missense
R8885:Lama1	UTSW	17	68,080,779 (GRCm39)	missense
R8893:Lama1	UTSW	17	68,112,367 (GRCm39)	missense
R8898:Lama1	UTSW	17	68,128,610 (GRCm39)	missense
R8909:Lama1	UTSW	17	68,079,736 (GRCm39)	missense
R9025:Lama1	UTSW	17	68,119,491 (GRCm39)	missense
R9045:Lama1	UTSW	17	68,060,838 (GRCm39)	missense
R9098:Lama1	UTSW	17	68,111,508 (GRCm39)	missense
R9114:Lama1	UTSW	17	68,128,669 (GRCm39)	missense
R9173:Lama1	UTSW	17	68,076,597 (GRCm39)	missense
R9190:Lama1	UTSW	17	68,111,514 (GRCm39)	missense
R9381:Lama1	UTSW	17	68,044,479 (GRCm39)	missense
R9429:Lama1	UTSW	17	68,118,449 (GRCm39)	missense
R9504:Lama1	UTSW	17	68,128,661 (GRCm39)	missense
R9558:Lama1	UTSW	17	68,124,004 (GRCm39)	missense
R9647:Lama1	UTSW	17	68,024,170 (GRCm39)	missense
R9651:Lama1	UTSW	17	68,101,215 (GRCm39)	missense
R9654:Lama1	UTSW	17	68,101,266 (GRCm39)	missense
R9733:Lama1	UTSW	17	68,116,940 (GRCm39)	missense
RF001:Lama1	UTSW	17	68,059,897 (GRCm39)	missense
RF013:Lama1	UTSW	17	68,088,057 (GRCm39)	missense
V8831:Lama1	UTSW	17	68,059,878 (GRCm39)	missense	probably benign	0.00
X0024:Lama1	UTSW	17	68,045,883 (GRCm39)	missense	probably damaging	1.00
X0028:Lama1	UTSW	17	68,101,305 (GRCm39)	missense	probably benign	0.06
X0028:Lama1	UTSW	17	68,074,417 (GRCm39)	missense	probably benign	0.00
X0066:Lama1	UTSW	17	68,118,561 (GRCm39)	missense	probably damaging	1.00
Z1088:Lama1	UTSW	17	68,117,166 (GRCm39)	missense	probably damaging	1.00
Z1088:Lama1	UTSW	17	68,078,077 (GRCm39)	missense	probably benign	0.25
Z1088:Lama1	UTSW	17	68,059,878 (GRCm39)	missense	probably benign	0.00
Z1176:Lama1	UTSW	17	68,059,878 (GRCm39)	missense	probably benign	0.00
Z1177:Lama1	UTSW	17	68,059,878 (GRCm39)	missense	probably benign	0.00
Z1191:Lama1	UTSW	17	68,105,639 (GRCm39)	missense

Predicted Primers

PCR Primer
(F):5'- CCACTAAACCCACATGTGTTATG -3'
(R):5'- GTCCGTGTGGCTTTAGTTCAAC -3'

Sequencing Primer
(F):5'- CCCACATGTGTTATGATTTGAGAGTC -3'
(R):5'- ACATAAATACAGCATTTTCCTCTGG -3'

Posted On

2022-10-06