Mutagenetix > Incidental Mutation

Incidental Mutation 'R9711:Ugt2b37'

730145

Institutional Source

Beutler Lab

Gene Symbol

Ugt2b37

Ensembl Gene

ENSMUSG00000057425

Gene Name

UDP glucuronosyltransferase 2 family, polypeptide B37

Synonyms

0610033E06Rik

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

R9711 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

87388351-87402647 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 87402532 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 33 (F33S)

Ref Sequence

ENSEMBL: ENSMUSP00000075255 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075858]

AlphaFold

Q8VCN3

Predicted Effect

possibly damaging
Transcript: ENSMUST00000075858
AA Change: F33S

PolyPhen 2 Score 0.848 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000075255
Gene: ENSMUSG00000057425
AA Change: F33S

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:UDPGT	24	527	5.5e-256	PFAM
Pfam:Glyco_tran_28_C	328	449	2.5e-9	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 87 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc12	T	C	8: 87,275,388 (GRCm39)	D430G	probably damaging	Het
Adgrf1	T	C	17: 43,621,580 (GRCm39)	S606P	possibly damaging	Het
Afap1	A	G	5: 36,141,540 (GRCm39)	N475D	probably damaging	Het
Ahnak2	A	G	12: 112,739,468 (GRCm39)	S1535P	possibly damaging	Het
Akt1	G	T	12: 112,624,885 (GRCm39)	H194N	possibly damaging	Het
Api5	T	A	2: 94,251,812 (GRCm39)	Q396L	possibly damaging	Het
Aplp2	T	C	9: 31,083,303 (GRCm39)	N148S	probably benign	Het
Asb3	A	G	11: 31,031,400 (GRCm39)	Y340C	probably damaging	Het
Bbox1	A	T	2: 110,098,581 (GRCm39)	M332K	probably damaging	Het
Cabin1	A	T	10: 75,579,090 (GRCm39)	S449T	probably benign	Het
Carns1	A	G	19: 4,216,007 (GRCm39)	V725A	possibly damaging	Het
Cdkn1b	A	G	6: 134,898,058 (GRCm39)	K59R	possibly damaging	Het
Cdv3	A	T	9: 103,233,539 (GRCm39)	I212K	probably damaging	Het
Clec14a	T	A	12: 58,314,432 (GRCm39)	I397F	probably damaging	Het
Cnnm1	A	G	19: 43,483,469 (GRCm39)	I950V	possibly damaging	Het
Ddi2	A	G	4: 141,422,734 (GRCm39)	M326T	probably benign	Het
Dhx30	T	C	9: 109,914,103 (GRCm39)	T1065A	probably benign	Het
Eif3c	A	T	7: 126,146,674 (GRCm39)	M808K	possibly damaging	Het
Evi2	G	T	11: 79,406,971 (GRCm39)	H201Q	possibly damaging	Het
Exoc4	A	G	6: 33,452,991 (GRCm39)	T494A	unknown	Het
Fam83f	T	A	15: 80,574,819 (GRCm39)	M242K	probably damaging	Het
Fat4	T	C	3: 39,055,374 (GRCm39)	Y4198H	probably benign	Het
Fcgbp	C	A	7: 27,793,000 (GRCm39)	N1001K	probably benign	Het
Gda	G	T	19: 21,400,449 (GRCm39)	A164E	probably damaging	Het
Gm19410	T	C	8: 36,279,493 (GRCm39)	V1786A	possibly damaging	Het
Gm45871	A	G	18: 90,609,069 (GRCm39)	N82S	probably benign	Het
Gnas	T	A	2: 174,141,392 (GRCm39)	S580T	unknown	Het
Gprin1	G	A	13: 54,886,714 (GRCm39)	P520L	probably benign	Het
Gramd4	C	T	15: 86,014,751 (GRCm39)	R433C	probably damaging	Het
Ighv5-12	T	A	12: 113,665,958 (GRCm39)	T47S	probably benign	Het
Itprid1	T	G	6: 55,864,018 (GRCm39)	S115A	probably damaging	Het
Kdm5a	T	A	6: 120,367,658 (GRCm39)	L451Q	probably damaging	Het
Kif12	T	A	4: 63,084,126 (GRCm39)	R624S	probably benign	Het
Lepr	T	A	4: 101,592,851 (GRCm39)	Y155*	probably null	Het
Lnx2	T	A	5: 146,961,376 (GRCm39)	I519F	probably damaging	Het
Marchf7	T	A	2: 60,060,175 (GRCm39)	S101T	probably damaging	Het
Miox	A	G	15: 89,220,785 (GRCm39)	D230G	probably damaging	Het
Morc2a	T	A	11: 3,600,381 (GRCm39)	M1K	probably null	Het
Mtus1	T	C	8: 41,536,222 (GRCm39)	N498S	probably damaging	Het
Mxd1	T	A	6: 86,645,554 (GRCm39)	R46W	probably damaging	Het
Ndufa11	G	C	17: 57,024,843 (GRCm39)	A2P	possibly damaging	Het
Necab2	C	T	8: 120,198,513 (GRCm39)	H362Y	probably damaging	Het
Nphp4	G	A	4: 152,623,434 (GRCm39)	V703I	possibly damaging	Het
Nup54	T	C	5: 92,582,218 (GRCm39)	N31S	unknown	Het
Or13a23-ps1	T	A	7: 140,118,497 (GRCm39)	S22R	probably benign	Het
Or1ad6	T	C	11: 50,860,316 (GRCm39)	L157P	probably damaging	Het
Or1e34	A	T	11: 73,778,696 (GRCm39)	C167*	probably null	Het
Or8b4	A	C	9: 37,830,066 (GRCm39)	T38P	probably damaging	Het
P2rx2	T	C	5: 110,490,388 (GRCm39)	E109G	possibly damaging	Het
Pcdha7	T	C	18: 37,107,409 (GRCm39)	S145P	probably damaging	Het
Pdlim5	A	T	3: 141,948,529 (GRCm39)	V586E	probably damaging	Het
Pex5l	T	C	3: 33,136,204 (GRCm39)	E5G	probably benign	Het
Plch1	T	A	3: 63,615,176 (GRCm39)	D774V	probably damaging	Het
Plekhg3	A	T	12: 76,611,726 (GRCm39)	D335V	possibly damaging	Het
Pop1	A	G	15: 34,530,227 (GRCm39)	H905R	probably benign	Het
Ppm1k	T	C	6: 57,492,720 (GRCm39)	T189A	probably damaging	Het
Pramel13	A	G	4: 144,122,517 (GRCm39)	L9P	probably damaging	Het
Recql5	A	G	11: 115,784,367 (GRCm39)	V911A	probably damaging	Het
Rnf145	T	A	11: 44,415,830 (GRCm39)	L15*	probably null	Het
Rpl13a	A	G	7: 44,776,673 (GRCm39)	V29A	probably benign	Het
Rps6ka5	A	G	12: 100,540,250 (GRCm39)	V491A	probably benign	Het
Setbp1	T	C	18: 78,900,142 (GRCm39)	H1175R	probably benign	Het
Setd5	T	C	6: 113,093,063 (GRCm39)	S372P	probably damaging	Het
Slc1a3	T	C	15: 8,675,177 (GRCm39)	E276G	probably damaging	Het
Slc36a2	T	C	11: 55,070,169 (GRCm39)	N136S	probably benign	Het
Spag1	G	A	15: 36,190,683 (GRCm39)		probably null	Het
Spon1	A	C	7: 113,387,685 (GRCm39)	T81P	probably damaging	Het
Sv2b	A	T	7: 74,856,238 (GRCm39)	D17E	probably benign	Het
Tasor2	A	G	13: 3,649,667 (GRCm39)	V44A	probably benign	Het
Tax1bp1	C	T	6: 52,704,215 (GRCm39)	T65I	probably damaging	Het
Tenm2	C	A	11: 35,915,341 (GRCm39)	K2065N	probably damaging	Het
Ticam2	T	C	18: 46,693,658 (GRCm39)	D143G	probably damaging	Het
Tmem132d	T	C	5: 127,869,579 (GRCm39)	E585G	possibly damaging	Het
Tnfrsf8	C	T	4: 145,019,668 (GRCm39)		probably null	Het
Trim44	C	T	2: 102,230,813 (GRCm39)	G73R	unknown	Het
Trpc3	C	T	3: 36,692,713 (GRCm39)	D760N	possibly damaging	Het
Tspan9	T	A	6: 127,942,715 (GRCm39)	M171L	probably benign	Het
Vav2	A	T	2: 27,159,027 (GRCm39)	V734E	probably damaging	Het
Vmn1r214	A	G	13: 23,218,508 (GRCm39)	M1V	probably null	Het
Vmn1r24	A	T	6: 57,932,804 (GRCm39)	V238E	probably damaging	Het
Vmn2r107	A	G	17: 20,577,262 (GRCm39)	Q420R	probably damaging	Het
Vmn2r31	G	A	7: 7,387,085 (GRCm39)	P829S	probably damaging	Het
Xpo6	A	G	7: 125,712,873 (GRCm39)	F703L	probably benign	Het
Zfp442	T	A	2: 150,250,207 (GRCm39)	H565L	possibly damaging	Het
Zfp950	A	T	19: 61,116,000 (GRCm39)	D2E	probably damaging	Het
Zfp992	T	A	4: 146,551,345 (GRCm39)	S355R	probably damaging	Het
Zwilch	A	T	9: 64,063,303 (GRCm39)	F309Y	probably damaging	Het

Other mutations in Ugt2b37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00401:Ugt2b37	APN	5	87,390,340 (GRCm39)	missense	possibly damaging	0.90
IGL00567:Ugt2b37	APN	5	87,401,933 (GRCm39)	missense	probably damaging	1.00
IGL00787:Ugt2b37	APN	5	87,390,288 (GRCm39)	missense	probably benign	0.00
IGL01560:Ugt2b37	APN	5	87,399,698 (GRCm39)	missense	probably damaging	1.00
IGL01617:Ugt2b37	APN	5	87,399,738 (GRCm39)	missense	probably damaging	1.00
IGL01982:Ugt2b37	APN	5	87,390,291 (GRCm39)	missense	probably damaging	1.00
IGL02299:Ugt2b37	APN	5	87,390,174 (GRCm39)	missense	probably benign	0.00
IGL02323:Ugt2b37	APN	5	87,398,423 (GRCm39)	splice site	probably benign
IGL02326:Ugt2b37	APN	5	87,388,861 (GRCm39)	missense	probably benign	0.25
IGL02516:Ugt2b37	APN	5	87,388,741 (GRCm39)	missense	probably damaging	1.00
IGL03285:Ugt2b37	APN	5	87,388,734 (GRCm39)	missense	probably damaging	1.00
R0076:Ugt2b37	UTSW	5	87,402,080 (GRCm39)	missense	probably benign	0.31
R0141:Ugt2b37	UTSW	5	87,388,842 (GRCm39)	missense	probably damaging	1.00
R0312:Ugt2b37	UTSW	5	87,398,524 (GRCm39)	missense	probably damaging	1.00
R0359:Ugt2b37	UTSW	5	87,398,443 (GRCm39)	missense	probably benign	0.10
R0523:Ugt2b37	UTSW	5	87,399,691 (GRCm39)	missense	possibly damaging	0.91
R1938:Ugt2b37	UTSW	5	87,388,716 (GRCm39)	missense	probably damaging	1.00
R1962:Ugt2b37	UTSW	5	87,402,193 (GRCm39)	missense	probably damaging	1.00
R2496:Ugt2b37	UTSW	5	87,402,569 (GRCm39)	missense	probably damaging	0.97
R3704:Ugt2b37	UTSW	5	87,390,846 (GRCm39)	missense	possibly damaging	0.55
R4430:Ugt2b37	UTSW	5	87,401,951 (GRCm39)	missense	probably benign	0.00
R4825:Ugt2b37	UTSW	5	87,398,498 (GRCm39)	missense	possibly damaging	0.91
R5043:Ugt2b37	UTSW	5	87,399,719 (GRCm39)	nonsense	probably null
R5098:Ugt2b37	UTSW	5	87,390,812 (GRCm39)	missense	probably damaging	1.00
R5174:Ugt2b37	UTSW	5	87,399,739 (GRCm39)	missense	probably benign	0.00
R5522:Ugt2b37	UTSW	5	87,388,759 (GRCm39)	missense	probably benign	0.14
R5879:Ugt2b37	UTSW	5	87,402,265 (GRCm39)	missense	probably benign
R5999:Ugt2b37	UTSW	5	87,402,036 (GRCm39)	missense	probably benign	0.25
R6374:Ugt2b37	UTSW	5	87,390,279 (GRCm39)	missense	probably damaging	1.00
R6454:Ugt2b37	UTSW	5	87,388,836 (GRCm39)	missense	probably damaging	1.00
R6857:Ugt2b37	UTSW	5	87,388,705 (GRCm39)	missense	probably damaging	0.98
R6875:Ugt2b37	UTSW	5	87,390,288 (GRCm39)	missense	probably benign	0.00
R6916:Ugt2b37	UTSW	5	87,402,459 (GRCm39)	missense	probably benign	0.07
R7099:Ugt2b37	UTSW	5	87,388,848 (GRCm39)	missense	probably benign	0.00
R7239:Ugt2b37	UTSW	5	87,402,590 (GRCm39)	missense	probably benign
R7470:Ugt2b37	UTSW	5	87,401,971 (GRCm39)	missense	probably benign	0.24
R7810:Ugt2b37	UTSW	5	87,402,118 (GRCm39)	missense	probably damaging	1.00
R7841:Ugt2b37	UTSW	5	87,398,489 (GRCm39)	missense	probably benign	0.05
R7860:Ugt2b37	UTSW	5	87,402,189 (GRCm39)	missense	probably damaging	1.00
R7861:Ugt2b37	UTSW	5	87,390,299 (GRCm39)	nonsense	probably null
R8200:Ugt2b37	UTSW	5	87,388,750 (GRCm39)	nonsense	probably null
R8211:Ugt2b37	UTSW	5	87,390,235 (GRCm39)	missense	probably benign	0.07
R8282:Ugt2b37	UTSW	5	87,402,440 (GRCm39)	missense	probably benign	0.01
R8312:Ugt2b37	UTSW	5	87,390,799 (GRCm39)	missense	probably benign	0.15
R8520:Ugt2b37	UTSW	5	87,388,714 (GRCm39)	missense	probably benign	0.04
R8688:Ugt2b37	UTSW	5	87,390,240 (GRCm39)	missense	possibly damaging	0.52
R8695:Ugt2b37	UTSW	5	87,390,243 (GRCm39)	missense	probably benign	0.00
R8772:Ugt2b37	UTSW	5	87,402,345 (GRCm39)	missense	probably benign	0.00
R8839:Ugt2b37	UTSW	5	87,402,415 (GRCm39)	missense	probably damaging	1.00
R9087:Ugt2b37	UTSW	5	87,401,996 (GRCm39)	missense	probably benign	0.01
R9139:Ugt2b37	UTSW	5	87,399,636 (GRCm39)	missense	probably benign	0.09
R9424:Ugt2b37	UTSW	5	87,402,217 (GRCm39)	missense	probably damaging	0.99
R9432:Ugt2b37	UTSW	5	87,402,046 (GRCm39)	missense	probably damaging	0.97
R9498:Ugt2b37	UTSW	5	87,402,244 (GRCm39)	missense	probably benign	0.07
R9718:Ugt2b37	UTSW	5	87,390,802 (GRCm39)	missense	probably benign	0.11
R9783:Ugt2b37	UTSW	5	87,388,840 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GTATCTCTTGACAACTCATAAGTCC -3'
(R):5'- AACCTCTGGGCTGAAGCTTC -3'

Sequencing Primer
(F):5'- GTCCACACATTCAAAAGCTGTATG -3'
(R):5'- GCTGAAGCTTCTTGGATAAAAGGTC -3'

Posted On

2022-10-06