Mutagenetix > Incidental Mutation

Incidental Mutation 'R9711:Vmn2r107'

730202

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r107

Ensembl Gene

ENSMUSG00000056910

Gene Name

vomeronasal 2, receptor 107

Synonyms

V2r6

MMRRC Submission

Accession Numbers

Genbank: NM_001104569; MGI: 1316664

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

R9711 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

20345425-20375772 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 20357000 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Arginine at position 420 (Q420R)

Ref Sequence

ENSEMBL: ENSMUSP00000048706 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042090]

AlphaFold

E9PZJ7

Predicted Effect

probably damaging
Transcript: ENSMUST00000042090
AA Change: Q420R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000048706
Gene: ENSMUSG00000056910
AA Change: Q420R

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	466	3.6e-40	PFAM
Pfam:NCD3G	509	562	5.1e-21	PFAM
Pfam:7tm_3	593	830	8e-51	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 87 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc12	T	C	8: 86,548,759	D430G	probably damaging	Het
Adgrf1	T	C	17: 43,310,689	S606P	possibly damaging	Het
Afap1	A	G	5: 35,984,196	N475D	probably damaging	Het
Ahnak2	A	G	12: 112,773,034	S1535P	possibly damaging	Het
Akt1	G	T	12: 112,658,451	H194N	possibly damaging	Het
Api5	T	A	2: 94,421,467	Q396L	possibly damaging	Het
Aplp2	T	C	9: 31,172,007	N148S	probably benign	Het
Asb3	A	G	11: 31,081,400	Y340C	probably damaging	Het
Bbox1	A	T	2: 110,268,236	M332K	probably damaging	Het
Cabin1	A	T	10: 75,743,256	S449T	probably benign	Het
Carns1	A	G	19: 4,166,008	V725A	possibly damaging	Het
Ccdc129	T	G	6: 55,887,033	S115A	probably damaging	Het
Cdkn1b	A	G	6: 134,921,095	K59R	possibly damaging	Het
Cdv3	A	T	9: 103,356,340	I212K	probably damaging	Het
Clec14a	T	A	12: 58,267,646	I397F	probably damaging	Het
Cnnm1	A	G	19: 43,495,030	I950V	possibly damaging	Het
Ddi2	A	G	4: 141,695,423	M326T	probably benign	Het
Dhx30	T	C	9: 110,085,035	T1065A	probably benign	Het
Eif3c	A	T	7: 126,547,502	M808K	possibly damaging	Het
Evi2	G	T	11: 79,516,145	H201Q	possibly damaging	Het
Exoc4	A	G	6: 33,476,056	T494A	unknown	Het
Fam208b	A	G	13: 3,599,667	V44A	probably benign	Het
Fam83f	T	A	15: 80,690,618	M242K	probably damaging	Het
Fat4	T	C	3: 39,001,225	Y4198H	probably benign	Het
Fcgbp	C	A	7: 28,093,575	N1001K	probably benign	Het
Gda	G	T	19: 21,423,085	A164E	probably damaging	Het
Gm19410	T	C	8: 35,812,339	V1786A	possibly damaging	Het
Gm45871	A	G	18: 90,590,945	N82S	probably benign	Het
Gnas	T	A	2: 174,299,599	S580T	unknown	Het
Gprin1	G	A	13: 54,738,901	P520L	probably benign	Het
Gramd4	C	T	15: 86,130,550	R433C	probably damaging	Het
Ighv5-12	T	A	12: 113,702,338	T47S	probably benign	Het
Kdm5a	T	A	6: 120,390,697	L451Q	probably damaging	Het
Kif12	T	A	4: 63,165,889	R624S	probably benign	Het
Lepr	T	A	4: 101,735,654	Y155*	probably null	Het
Lnx2	T	A	5: 147,024,566	I519F	probably damaging	Het
March7	T	A	2: 60,229,831	S101T	probably damaging	Het
Miox	A	G	15: 89,336,582	D230G	probably damaging	Het
Morc2a	T	A	11: 3,650,381	M1K	probably null	Het
Mtus1	T	C	8: 41,083,185	N498S	probably damaging	Het
Mxd1	T	A	6: 86,668,572	R46W	probably damaging	Het
Ndufa11	G	C	17: 56,717,843	A2P	possibly damaging	Het
Necab2	C	T	8: 119,471,774	H362Y	probably damaging	Het
Nphp4	G	A	4: 152,538,977	V703I	possibly damaging	Het
Nup54	T	C	5: 92,434,359	N31S	unknown	Het
Olfr1378	T	C	11: 50,969,489	L157P	probably damaging	Het
Olfr394	A	T	11: 73,887,870	C167*	probably null	Het
Olfr537-ps1	T	A	7: 140,538,584	S22R	probably benign	Het
Olfr878	A	C	9: 37,918,770	T38P	probably damaging	Het
P2rx2	T	C	5: 110,342,522	E109G	possibly damaging	Het
Pcdha7	T	C	18: 36,974,356	S145P	probably damaging	Het
Pdlim5	A	T	3: 142,242,768	V586E	probably damaging	Het
Pex5l	T	C	3: 33,082,055	E5G	probably benign	Het
Plch1	T	A	3: 63,707,755	D774V	probably damaging	Het
Plekhg3	A	T	12: 76,564,952	D335V	possibly damaging	Het
Pop1	A	G	15: 34,530,081	H905R	probably benign	Het
Ppm1k	T	C	6: 57,515,735	T189A	probably damaging	Het
Pramef12	A	G	4: 144,395,947	L9P	probably damaging	Het
Recql5	A	G	11: 115,893,541	V911A	probably damaging	Het
Rnf145	T	A	11: 44,525,003	L15*	probably null	Het
Rpl13a	A	G	7: 45,127,249	V29A	probably benign	Het
Rps6ka5	A	G	12: 100,573,991	V491A	probably benign	Het
Setbp1	T	C	18: 78,856,927	H1175R	probably benign	Het
Setd5	T	C	6: 113,116,102	S372P	probably damaging	Het
Slc1a3	T	C	15: 8,645,693	E276G	probably damaging	Het
Slc36a2	T	C	11: 55,179,343	N136S	probably benign	Het
Spag1	G	A	15: 36,190,537		probably null	Het
Spon1	A	C	7: 113,788,448	T81P	probably damaging	Het
Sv2b	A	T	7: 75,206,490	D17E	probably benign	Het
Tax1bp1	C	T	6: 52,727,230	T65I	probably damaging	Het
Tenm2	C	A	11: 36,024,514	K2065N	probably damaging	Het
Ticam2	T	C	18: 46,560,591	D143G	probably damaging	Het
Tmem132d	T	C	5: 127,792,515	E585G	possibly damaging	Het
Tnfrsf8	C	T	4: 145,293,098		probably null	Het
Trim44	C	T	2: 102,400,468	G73R	unknown	Het
Trpc3	C	T	3: 36,638,564	D760N	possibly damaging	Het
Tspan9	T	A	6: 127,965,752	M171L	probably benign	Het
Ugt2b37	A	G	5: 87,254,673	F33S	possibly damaging	Het
Vav2	A	T	2: 27,269,015	V734E	probably damaging	Het
Vmn1r214	A	G	13: 23,034,338	M1V	probably null	Het
Vmn1r24	A	T	6: 57,955,819	V238E	probably damaging	Het
Vmn2r31	G	A	7: 7,384,086	P829S	probably damaging	Het
Xpo6	A	G	7: 126,113,701	F703L	probably benign	Het
Zfp442	T	A	2: 150,408,287	H565L	possibly damaging	Het
Zfp950	A	T	19: 61,127,562	D2E	probably damaging	Het
Zfp992	T	A	4: 146,466,888	S355R	probably damaging	Het
Zwilch	A	T	9: 64,156,021	F309Y	probably damaging	Het

Other mutations in Vmn2r107

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01402:Vmn2r107	APN	17	20375747	missense	probably damaging	0.98
IGL01768:Vmn2r107	APN	17	20345606	missense	probably benign	0.32
IGL02086:Vmn2r107	APN	17	20357800	missense	probably benign	0.00
IGL02136:Vmn2r107	APN	17	20374906	missense	probably benign	0.02
IGL02266:Vmn2r107	APN	17	20356777	missense	probably damaging	1.00
IGL02285:Vmn2r107	APN	17	20375561	missense	probably damaging	1.00
IGL02724:Vmn2r107	APN	17	20356744	missense	possibly damaging	0.49
IGL02998:Vmn2r107	APN	17	20357755	missense	probably damaging	0.99
IGL03089:Vmn2r107	APN	17	20375712	missense	probably benign	0.05
IGL03284:Vmn2r107	APN	17	20356911	missense	probably benign	0.07
IGL03307:Vmn2r107	APN	17	20356776	missense	probably benign	0.09
IGL03399:Vmn2r107	APN	17	20357958	splice site	probably benign
3-1:Vmn2r107	UTSW	17	20345504	missense	probably benign
BB006:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
BB016:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R0285:Vmn2r107	UTSW	17	20345611	missense	probably benign	0.00
R0455:Vmn2r107	UTSW	17	20374823	splice site	probably benign
R0497:Vmn2r107	UTSW	17	20375132	missense	probably damaging	1.00
R0506:Vmn2r107	UTSW	17	20357759	missense	probably benign
R0621:Vmn2r107	UTSW	17	20374990	missense	probably benign	0.01
R0667:Vmn2r107	UTSW	17	20355654	missense	possibly damaging	0.91
R1118:Vmn2r107	UTSW	17	20356598	missense	probably benign	0.03
R1204:Vmn2r107	UTSW	17	20357769	missense	probably benign
R1237:Vmn2r107	UTSW	17	20356685	nonsense	probably null
R1485:Vmn2r107	UTSW	17	20374847	missense	possibly damaging	0.95
R1783:Vmn2r107	UTSW	17	20356513	missense	possibly damaging	0.51
R1873:Vmn2r107	UTSW	17	20345578	missense	probably benign	0.10
R1974:Vmn2r107	UTSW	17	20355617	splice site	probably null
R2009:Vmn2r107	UTSW	17	20375467	missense	probably benign	0.01
R2029:Vmn2r107	UTSW	17	20375287	missense	probably benign	0.01
R2164:Vmn2r107	UTSW	17	20375642	missense	probably damaging	1.00
R2269:Vmn2r107	UTSW	17	20375555	missense	possibly damaging	0.58
R3087:Vmn2r107	UTSW	17	20360345	missense	probably benign	0.03
R3740:Vmn2r107	UTSW	17	20374889	missense	probably benign	0.00
R3961:Vmn2r107	UTSW	17	20375455	missense	probably damaging	1.00
R4031:Vmn2r107	UTSW	17	20375221	missense	probably benign	0.00
R4270:Vmn2r107	UTSW	17	20355779	missense	probably benign
R4963:Vmn2r107	UTSW	17	20375141	missense	probably damaging	1.00
R5121:Vmn2r107	UTSW	17	20355753	missense	probably benign	0.01
R5640:Vmn2r107	UTSW	17	20375164	missense	probably damaging	1.00
R6007:Vmn2r107	UTSW	17	20375054	missense	probably benign	0.19
R6238:Vmn2r107	UTSW	17	20345587	missense	probably benign	0.43
R6298:Vmn2r107	UTSW	17	20355782	missense	probably benign	0.00
R6467:Vmn2r107	UTSW	17	20375677	missense	probably damaging	0.99
R6726:Vmn2r107	UTSW	17	20375375	missense	probably damaging	0.96
R6782:Vmn2r107	UTSW	17	20356879	missense	probably damaging	1.00
R7299:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7301:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7375:Vmn2r107	UTSW	17	20355876	missense	probably benign
R7448:Vmn2r107	UTSW	17	20375732	missense	probably benign	0.00
R7495:Vmn2r107	UTSW	17	20375009	missense	possibly damaging	0.71
R7589:Vmn2r107	UTSW	17	20375372	missense	probably benign	0.05
R7594:Vmn2r107	UTSW	17	20360373	missense	probably benign	0.03
R7678:Vmn2r107	UTSW	17	20356639	missense	probably benign	0.01
R7929:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R7974:Vmn2r107	UTSW	17	20357008	missense	probably benign	0.00
R8040:Vmn2r107	UTSW	17	20375546	missense	probably damaging	1.00
R8263:Vmn2r107	UTSW	17	20360352	missense	probably damaging	1.00
R8426:Vmn2r107	UTSW	17	20356977	missense	possibly damaging	0.91
R9175:Vmn2r107	UTSW	17	20356789	missense	possibly damaging	0.79
R9537:Vmn2r107	UTSW	17	20374887	missense	probably benign	0.00
R9642:Vmn2r107	UTSW	17	20360399	missense	probably damaging	1.00
X0022:Vmn2r107	UTSW	17	20356968	missense	possibly damaging	0.85

Predicted Primers

PCR Primer
(F):5'- AGACATTTATCTCCCTAAGATGTGG -3'
(R):5'- GCCAGTTTACAACATCATACACTTG -3'

Sequencing Primer
(F):5'- ATCTCCCTAAGATGTGGTATTTGTTC -3'
(R):5'- CATACACTTGAAATTACCCTGACTTC -3'

Posted On

2022-10-06