Incidental Mutation 'R9712:Cux1'
| ID |
730246 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cux1
|
| Ensembl Gene |
ENSMUSG00000029705 |
| Gene Name |
cut-like homeobox 1 |
| Synonyms |
CDP, Cutl1, Cux, Cux-1 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.892)
|
| Stock # |
R9712 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
136276989-136596344 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 136338673 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Lysine
at position 664
(E664K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135086
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000004097]
[ENSMUST00000175918]
[ENSMUST00000175975]
[ENSMUST00000175998]
[ENSMUST00000176172]
[ENSMUST00000176216]
[ENSMUST00000176423]
[ENSMUST00000176745]
[ENSMUST00000176778]
[ENSMUST00000177297]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000004097
AA Change: E573K
PolyPhen 2
Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000004097
Gene: ENSMUSG00000029705
AA Change: E573K
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
low complexity region
|
425 |
436 |
N/A |
INTRINSIC |
|
CUT
|
452 |
538 |
5.06e-39 |
SMART |
|
low complexity region
|
602 |
608 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
642 |
N/A |
INTRINSIC |
|
CUT
|
841 |
929 |
3.31e-43 |
SMART |
|
low complexity region
|
956 |
972 |
N/A |
INTRINSIC |
|
low complexity region
|
990 |
1011 |
N/A |
INTRINSIC |
|
CUT
|
1024 |
1110 |
3.78e-38 |
SMART |
|
HOX
|
1150 |
1212 |
6.32e-15 |
SMART |
|
low complexity region
|
1224 |
1239 |
N/A |
INTRINSIC |
|
low complexity region
|
1317 |
1379 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175918
|
| SMART Domains |
Protein: ENSMUSP00000135606
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
73 |
328 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000175975
AA Change: E651K
PolyPhen 2
Score 0.957 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000135223
Gene: ENSMUSG00000029705
AA Change: E651K
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
169 |
N/A |
INTRINSIC |
|
low complexity region
|
235 |
251 |
N/A |
INTRINSIC |
|
low complexity region
|
277 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
331 |
342 |
N/A |
INTRINSIC |
|
CUT
|
358 |
444 |
5.06e-39 |
SMART |
|
low complexity region
|
508 |
514 |
N/A |
INTRINSIC |
|
low complexity region
|
526 |
548 |
N/A |
INTRINSIC |
|
CUT
|
747 |
835 |
3.31e-43 |
SMART |
|
low complexity region
|
862 |
878 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
917 |
N/A |
INTRINSIC |
|
CUT
|
930 |
1016 |
3.78e-38 |
SMART |
|
HOX
|
1056 |
1118 |
6.32e-15 |
SMART |
|
low complexity region
|
1130 |
1145 |
N/A |
INTRINSIC |
|
low complexity region
|
1223 |
1285 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175998
|
| SMART Domains |
Protein: ENSMUSP00000135816
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
52 |
64 |
N/A |
INTRINSIC |
|
coiled coil region
|
76 |
148 |
N/A |
INTRINSIC |
|
Pfam:CASP_C
|
204 |
430 |
8.6e-72 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176172
AA Change: E664K
PolyPhen 2
Score 0.349 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000135086
Gene: ENSMUSG00000029705
AA Change: E664K
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
99 |
354 |
N/A |
INTRINSIC |
|
low complexity region
|
420 |
436 |
N/A |
INTRINSIC |
|
low complexity region
|
462 |
474 |
N/A |
INTRINSIC |
|
low complexity region
|
516 |
527 |
N/A |
INTRINSIC |
|
CUT
|
543 |
629 |
5.06e-39 |
SMART |
|
low complexity region
|
693 |
699 |
N/A |
INTRINSIC |
|
low complexity region
|
711 |
733 |
N/A |
INTRINSIC |
|
CUT
|
932 |
1020 |
3.31e-43 |
SMART |
|
low complexity region
|
1047 |
1063 |
N/A |
INTRINSIC |
|
low complexity region
|
1081 |
1102 |
N/A |
INTRINSIC |
|
CUT
|
1115 |
1201 |
3.78e-38 |
SMART |
|
HOX
|
1241 |
1303 |
6.32e-15 |
SMART |
|
low complexity region
|
1315 |
1330 |
N/A |
INTRINSIC |
|
low complexity region
|
1408 |
1470 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176216
|
| SMART Domains |
Protein: ENSMUSP00000135054
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
369 |
390 |
9.35e-5 |
PROSPERO |
|
Pfam:CASP_C
|
421 |
647 |
1.2e-71 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176423
|
| SMART Domains |
Protein: ENSMUSP00000135036
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
52 |
64 |
N/A |
INTRINSIC |
|
coiled coil region
|
76 |
148 |
N/A |
INTRINSIC |
|
low complexity region
|
217 |
226 |
N/A |
INTRINSIC |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000135370
Gene: ENSMUSG00000029705
AA Change: E535K
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
363 |
N/A |
INTRINSIC |
|
low complexity region
|
429 |
445 |
N/A |
INTRINSIC |
|
low complexity region
|
471 |
483 |
N/A |
INTRINSIC |
|
low complexity region
|
525 |
536 |
N/A |
INTRINSIC |
|
CUT
|
552 |
638 |
5.06e-39 |
SMART |
|
Blast:CUT
|
641 |
840 |
3e-50 |
BLAST |
|
CUT
|
919 |
1007 |
3.31e-43 |
SMART |
|
low complexity region
|
1034 |
1050 |
N/A |
INTRINSIC |
|
low complexity region
|
1068 |
1089 |
N/A |
INTRINSIC |
|
CUT
|
1102 |
1188 |
3.78e-38 |
SMART |
|
HOX
|
1228 |
1290 |
6.32e-15 |
SMART |
|
low complexity region
|
1302 |
1317 |
N/A |
INTRINSIC |
|
low complexity region
|
1395 |
1457 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176745
|
| SMART Domains |
Protein: ENSMUSP00000135512
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
363 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
367 |
388 |
8.95e-5 |
PROSPERO |
|
Pfam:CASP_C
|
419 |
645 |
1.2e-71 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000176778
AA Change: E656K
PolyPhen 2
Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000135892
Gene: ENSMUSG00000029705
AA Change: E656K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
78 |
86 |
N/A |
INTRINSIC |
|
coiled coil region
|
195 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
519 |
N/A |
INTRINSIC |
|
CUT
|
535 |
621 |
5.06e-39 |
SMART |
|
low complexity region
|
685 |
691 |
N/A |
INTRINSIC |
|
low complexity region
|
703 |
725 |
N/A |
INTRINSIC |
|
CUT
|
924 |
1012 |
3.31e-43 |
SMART |
|
low complexity region
|
1039 |
1055 |
N/A |
INTRINSIC |
|
low complexity region
|
1073 |
1094 |
N/A |
INTRINSIC |
|
CUT
|
1107 |
1193 |
3.78e-38 |
SMART |
|
HOX
|
1233 |
1295 |
6.32e-15 |
SMART |
|
low complexity region
|
1307 |
1322 |
N/A |
INTRINSIC |
|
low complexity region
|
1400 |
1462 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177297
|
| SMART Domains |
Protein: ENSMUSP00000134819
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
369 |
390 |
8.99e-6 |
PROSPERO |
|
Pfam:CASP_C
|
422 |
527 |
1.8e-17 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygotes for a targeted null mutation exhibit delayed lung development and neonatal mortality. Survivors show growth retardation and hair defects. Homozygotes for a partially deleted protein have curly hair, and females tend to lose their litters. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1810055G02Rik |
A |
T |
19: 3,765,784 (GRCm39) |
M20L |
probably benign |
Het |
| Aadacl4fm1 |
C |
T |
4: 144,255,354 (GRCm39) |
A258V |
probably benign |
Het |
| Abca8b |
T |
A |
11: 109,833,163 (GRCm39) |
D1241V |
probably benign |
Het |
| Adam20 |
G |
A |
8: 41,248,490 (GRCm39) |
R200H |
probably benign |
Het |
| Adcy10 |
T |
C |
1: 165,340,681 (GRCm39) |
F229L |
probably damaging |
Het |
| Adsl |
A |
T |
15: 80,839,840 (GRCm39) |
N126I |
probably benign |
Het |
| Ahnak |
GATCTCTAT |
GAT |
19: 8,984,393 (GRCm39) |
|
probably benign |
Het |
| Ahnak |
AGATCTC |
A |
19: 8,984,392 (GRCm39) |
|
probably benign |
Het |
| Aktip |
G |
A |
8: 91,856,355 (GRCm39) |
P41S |
probably damaging |
Het |
| Alkbh3 |
C |
A |
2: 93,811,318 (GRCm39) |
R258L |
probably damaging |
Het |
| Arfgap3 |
A |
G |
15: 83,197,734 (GRCm39) |
Y341H |
probably benign |
Het |
| Arhgef26 |
C |
T |
3: 62,331,034 (GRCm39) |
L583F |
probably damaging |
Het |
| Arhgef40 |
T |
C |
14: 52,226,415 (GRCm39) |
I153T |
probably damaging |
Het |
| Atp1a1 |
T |
C |
3: 101,498,757 (GRCm39) |
S179G |
probably benign |
Het |
| Bok |
T |
C |
1: 93,614,229 (GRCm39) |
S21P |
probably damaging |
Het |
| Ccdc136 |
A |
G |
6: 29,417,441 (GRCm39) |
E754G |
probably benign |
Het |
| Cers3 |
A |
G |
7: 66,423,378 (GRCm39) |
K108E |
probably benign |
Het |
| Cmya5 |
T |
C |
13: 93,201,881 (GRCm39) |
|
probably null |
Het |
| Col19a1 |
T |
C |
1: 24,367,148 (GRCm39) |
E478G |
possibly damaging |
Het |
| Colec10 |
T |
A |
15: 54,323,180 (GRCm39) |
S134R |
possibly damaging |
Het |
| Ctnnb1 |
A |
T |
9: 120,784,895 (GRCm39) |
I514F |
probably damaging |
Het |
| Dars1 |
T |
C |
1: 128,333,199 (GRCm39) |
Q75R |
probably benign |
Het |
| Disp1 |
T |
A |
1: 182,917,379 (GRCm39) |
S16C |
probably damaging |
Het |
| Dnah7a |
A |
T |
1: 53,598,299 (GRCm39) |
V1412E |
probably benign |
Het |
| Ect2l |
C |
T |
10: 18,044,182 (GRCm39) |
V226I |
probably benign |
Het |
| Ep400 |
T |
A |
5: 110,904,509 (GRCm39) |
H30L |
unknown |
Het |
| Ephx4 |
A |
G |
5: 107,567,647 (GRCm39) |
I202V |
probably benign |
Het |
| Exoc3 |
A |
T |
13: 74,341,027 (GRCm39) |
F259Y |
probably damaging |
Het |
| Ezr |
T |
C |
17: 7,020,394 (GRCm39) |
E229G |
probably damaging |
Het |
| Fat1 |
A |
T |
8: 45,470,417 (GRCm39) |
I1472L |
probably benign |
Het |
| Fsd1l |
T |
G |
4: 53,679,972 (GRCm39) |
D223E |
probably benign |
Het |
| Gata6 |
A |
T |
18: 11,059,064 (GRCm39) |
D377V |
possibly damaging |
Het |
| Gm12185 |
A |
T |
11: 48,798,216 (GRCm39) |
M759K |
probably benign |
Het |
| Gm9922 |
C |
T |
14: 101,966,893 (GRCm39) |
A120T |
unknown |
Het |
| Hectd4 |
A |
T |
5: 121,448,744 (GRCm39) |
Y364F |
probably benign |
Het |
| Hnrnph1 |
A |
G |
11: 50,276,696 (GRCm39) |
S465G |
unknown |
Het |
| Ifi204 |
T |
C |
1: 173,576,924 (GRCm39) |
Y559C |
probably damaging |
Het |
| Ift88 |
T |
C |
14: 57,718,853 (GRCm39) |
S613P |
probably damaging |
Het |
| Kif21a |
G |
C |
15: 90,869,528 (GRCm39) |
A441G |
probably damaging |
Het |
| Kif21a |
G |
T |
15: 90,879,715 (GRCm39) |
T191K |
probably benign |
Het |
| Lrit1 |
T |
A |
14: 36,782,084 (GRCm39) |
C252* |
probably null |
Het |
| Ncbp1 |
T |
A |
4: 46,144,837 (GRCm39) |
D29E |
probably benign |
Het |
| Nlrp10 |
A |
T |
7: 108,524,735 (GRCm39) |
D248E |
probably damaging |
Het |
| Nphp4 |
T |
G |
4: 152,631,521 (GRCm39) |
V807G |
probably benign |
Het |
| Nsd1 |
T |
C |
13: 55,393,856 (GRCm39) |
S589P |
possibly damaging |
Het |
| Oas1b |
T |
A |
5: 120,952,550 (GRCm39) |
N80K |
probably damaging |
Het |
| Oprk1 |
T |
A |
1: 5,669,096 (GRCm39) |
C181S |
probably damaging |
Het |
| Oprl1 |
T |
A |
2: 181,360,212 (GRCm39) |
N89K |
probably damaging |
Het |
| Or5w12 |
A |
T |
2: 87,502,105 (GRCm39) |
I202N |
probably benign |
Het |
| Or8k53 |
G |
A |
2: 86,177,583 (GRCm39) |
H176Y |
probably benign |
Het |
| Pdcd11 |
A |
G |
19: 47,117,741 (GRCm39) |
K1697E |
probably damaging |
Het |
| Pdp1 |
G |
A |
4: 11,961,607 (GRCm39) |
H254Y |
probably benign |
Het |
| Pds5b |
A |
T |
5: 150,729,128 (GRCm39) |
D1419V |
possibly damaging |
Het |
| Per1 |
G |
T |
11: 68,991,475 (GRCm39) |
G3V |
probably benign |
Het |
| Pex16 |
C |
A |
2: 92,206,988 (GRCm39) |
N55K |
probably damaging |
Het |
| Phldb2 |
C |
A |
16: 45,595,340 (GRCm39) |
L862F |
probably benign |
Het |
| Pld5 |
T |
A |
1: 175,791,572 (GRCm39) |
D478V |
probably benign |
Het |
| Pms2 |
T |
C |
5: 143,851,614 (GRCm39) |
I177T |
probably damaging |
Het |
| Pou1f1 |
A |
T |
16: 65,326,758 (GRCm39) |
E119D |
probably benign |
Het |
| Ppp2r1a |
A |
C |
17: 21,179,058 (GRCm39) |
E295A |
probably damaging |
Het |
| Qrfprl |
A |
G |
6: 65,433,124 (GRCm39) |
I315V |
probably benign |
Het |
| Rad51ap2 |
A |
T |
12: 11,507,593 (GRCm39) |
N505I |
possibly damaging |
Het |
| Rasal3 |
A |
C |
17: 32,615,536 (GRCm39) |
V434G |
probably damaging |
Het |
| Rasgrf2 |
C |
T |
13: 92,136,092 (GRCm39) |
V6M |
|
Het |
| Rwdd1 |
A |
T |
10: 33,877,152 (GRCm39) |
D197E |
|
Het |
| Scn11a |
A |
T |
9: 119,619,076 (GRCm39) |
C755* |
probably null |
Het |
| Skil |
T |
C |
3: 31,171,009 (GRCm39) |
S443P |
probably benign |
Het |
| Slc12a6 |
T |
C |
2: 112,186,817 (GRCm39) |
C939R |
probably damaging |
Het |
| Slc25a36 |
A |
G |
9: 96,961,230 (GRCm39) |
S269P |
probably benign |
Het |
| Srrm4 |
T |
A |
5: 116,620,452 (GRCm39) |
H92L |
unknown |
Het |
| Styk1 |
CTCTTCATGATTTTCTT |
CTCTT |
6: 131,278,612 (GRCm39) |
|
probably benign |
Het |
| Tbc1d4 |
A |
T |
14: 101,744,846 (GRCm39) |
V260E |
probably benign |
Het |
| Tbc1d8 |
T |
C |
1: 39,424,313 (GRCm39) |
N593D |
probably damaging |
Het |
| Trex1 |
C |
A |
9: 108,887,805 (GRCm39) |
R62L |
probably damaging |
Het |
| Trpm3 |
A |
T |
19: 22,692,716 (GRCm39) |
D269V |
possibly damaging |
Het |
| Trpv4 |
G |
T |
5: 114,771,211 (GRCm39) |
Y439* |
probably null |
Het |
| Ttn |
G |
A |
2: 76,564,592 (GRCm39) |
T28515I |
probably damaging |
Het |
| Ucn2 |
G |
A |
9: 108,815,571 (GRCm39) |
G111D |
probably damaging |
Het |
| Uhrf2 |
A |
G |
19: 30,033,881 (GRCm39) |
I212V |
possibly damaging |
Het |
| Usp24 |
T |
A |
4: 106,204,564 (GRCm39) |
M261K |
probably benign |
Het |
| Vmn1r235 |
A |
T |
17: 21,481,960 (GRCm39) |
D95V |
probably benign |
Het |
| Vwf |
G |
A |
6: 125,601,536 (GRCm39) |
R826Q |
|
Het |
| Zfp1002 |
C |
T |
2: 150,096,496 (GRCm39) |
R311Q |
probably benign |
Het |
| Zfp28 |
T |
C |
7: 6,396,878 (GRCm39) |
C438R |
probably damaging |
Het |
|
| Other mutations in Cux1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00846:Cux1
|
APN |
5 |
136,355,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00966:Cux1
|
APN |
5 |
136,340,345 (GRCm39) |
intron |
probably benign |
|
|
IGL01129:Cux1
|
APN |
5 |
136,333,572 (GRCm39) |
intron |
probably benign |
|
|
IGL01885:Cux1
|
APN |
5 |
136,337,301 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01947:Cux1
|
APN |
5 |
136,303,979 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02259:Cux1
|
APN |
5 |
136,355,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02666:Cux1
|
APN |
5 |
136,304,169 (GRCm39) |
nonsense |
probably null |
|
|
IGL02826:Cux1
|
APN |
5 |
136,336,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03014:Cux1
|
UTSW |
5 |
136,594,379 (GRCm39) |
intron |
probably benign |
|
|
R0047:Cux1
|
UTSW |
5 |
136,392,107 (GRCm39) |
splice site |
probably benign |
|
|
R0047:Cux1
|
UTSW |
5 |
136,392,107 (GRCm39) |
splice site |
probably benign |
|
|
R0057:Cux1
|
UTSW |
5 |
136,285,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0149:Cux1
|
UTSW |
5 |
136,308,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0295:Cux1
|
UTSW |
5 |
136,342,066 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0361:Cux1
|
UTSW |
5 |
136,308,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0533:Cux1
|
UTSW |
5 |
136,336,713 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0630:Cux1
|
UTSW |
5 |
136,315,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0801:Cux1
|
UTSW |
5 |
136,355,783 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0884:Cux1
|
UTSW |
5 |
136,336,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0976:Cux1
|
UTSW |
5 |
136,342,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1073:Cux1
|
UTSW |
5 |
136,281,395 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1222:Cux1
|
UTSW |
5 |
136,304,003 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1518:Cux1
|
UTSW |
5 |
136,337,133 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1686:Cux1
|
UTSW |
5 |
136,304,235 (GRCm39) |
nonsense |
probably null |
|
|
R1687:Cux1
|
UTSW |
5 |
136,341,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1758:Cux1
|
UTSW |
5 |
136,421,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1797:Cux1
|
UTSW |
5 |
136,304,169 (GRCm39) |
missense |
probably benign |
0.22 |
|
R1919:Cux1
|
UTSW |
5 |
136,392,173 (GRCm39) |
nonsense |
probably null |
|
|
R2051:Cux1
|
UTSW |
5 |
136,361,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2339:Cux1
|
UTSW |
5 |
136,315,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3438:Cux1
|
UTSW |
5 |
136,340,414 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3713:Cux1
|
UTSW |
5 |
136,594,397 (GRCm39) |
intron |
probably benign |
|
|
R3800:Cux1
|
UTSW |
5 |
136,344,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3964:Cux1
|
UTSW |
5 |
136,311,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4135:Cux1
|
UTSW |
5 |
136,336,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4198:Cux1
|
UTSW |
5 |
136,315,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4467:Cux1
|
UTSW |
5 |
136,341,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4498:Cux1
|
UTSW |
5 |
136,341,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4622:Cux1
|
UTSW |
5 |
136,337,154 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4623:Cux1
|
UTSW |
5 |
136,337,154 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4651:Cux1
|
UTSW |
5 |
136,596,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4652:Cux1
|
UTSW |
5 |
136,596,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4658:Cux1
|
UTSW |
5 |
136,279,448 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4665:Cux1
|
UTSW |
5 |
136,315,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4704:Cux1
|
UTSW |
5 |
136,278,055 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4867:Cux1
|
UTSW |
5 |
136,303,815 (GRCm39) |
intron |
probably benign |
|
|
R4965:Cux1
|
UTSW |
5 |
136,340,410 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R5090:Cux1
|
UTSW |
5 |
136,342,054 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5155:Cux1
|
UTSW |
5 |
136,594,295 (GRCm39) |
intron |
probably benign |
|
|
R5226:Cux1
|
UTSW |
5 |
136,399,027 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5252:Cux1
|
UTSW |
5 |
136,337,151 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5266:Cux1
|
UTSW |
5 |
136,341,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5399:Cux1
|
UTSW |
5 |
136,281,458 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R5509:Cux1
|
UTSW |
5 |
136,304,171 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5609:Cux1
|
UTSW |
5 |
136,421,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5681:Cux1
|
UTSW |
5 |
136,337,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5993:Cux1
|
UTSW |
5 |
136,392,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6049:Cux1
|
UTSW |
5 |
136,361,564 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6290:Cux1
|
UTSW |
5 |
136,340,412 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6310:Cux1
|
UTSW |
5 |
136,304,018 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6351:Cux1
|
UTSW |
5 |
136,338,646 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6531:Cux1
|
UTSW |
5 |
136,303,973 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6590:Cux1
|
UTSW |
5 |
136,368,971 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6663:Cux1
|
UTSW |
5 |
136,514,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6690:Cux1
|
UTSW |
5 |
136,368,971 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6777:Cux1
|
UTSW |
5 |
136,594,422 (GRCm39) |
intron |
probably benign |
|
|
R6786:Cux1
|
UTSW |
5 |
136,596,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6817:Cux1
|
UTSW |
5 |
136,402,027 (GRCm39) |
splice site |
probably null |
|
|
R6989:Cux1
|
UTSW |
5 |
136,308,502 (GRCm39) |
nonsense |
probably null |
|
|
R7011:Cux1
|
UTSW |
5 |
136,388,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7167:Cux1
|
UTSW |
5 |
136,338,895 (GRCm39) |
splice site |
probably null |
|
|
R7699:Cux1
|
UTSW |
5 |
136,514,593 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7861:Cux1
|
UTSW |
5 |
136,281,458 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7876:Cux1
|
UTSW |
5 |
136,392,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7916:Cux1
|
UTSW |
5 |
136,311,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8023:Cux1
|
UTSW |
5 |
136,402,251 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8154:Cux1
|
UTSW |
5 |
136,281,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8267:Cux1
|
UTSW |
5 |
136,311,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8289:Cux1
|
UTSW |
5 |
136,337,358 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8305:Cux1
|
UTSW |
5 |
136,388,863 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8319:Cux1
|
UTSW |
5 |
136,594,251 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8405:Cux1
|
UTSW |
5 |
136,304,241 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8483:Cux1
|
UTSW |
5 |
136,303,944 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8506:Cux1
|
UTSW |
5 |
136,337,358 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8671:Cux1
|
UTSW |
5 |
136,279,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8680:Cux1
|
UTSW |
5 |
136,336,710 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R8737:Cux1
|
UTSW |
5 |
136,311,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8738:Cux1
|
UTSW |
5 |
136,402,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8793:Cux1
|
UTSW |
5 |
136,594,539 (GRCm39) |
missense |
unknown |
|
|
R8897:Cux1
|
UTSW |
5 |
136,315,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8926:Cux1
|
UTSW |
5 |
136,338,404 (GRCm39) |
intron |
probably benign |
|
|
R8954:Cux1
|
UTSW |
5 |
136,402,203 (GRCm39) |
nonsense |
probably null |
|
|
R9092:Cux1
|
UTSW |
5 |
136,514,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9205:Cux1
|
UTSW |
5 |
136,398,989 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9550:Cux1
|
UTSW |
5 |
136,340,387 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9578:Cux1
|
UTSW |
5 |
136,282,919 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9682:Cux1
|
UTSW |
5 |
136,337,116 (GRCm39) |
missense |
probably benign |
|
|
R9701:Cux1
|
UTSW |
5 |
136,343,169 (GRCm39) |
missense |
probably damaging |
0.97 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTGTGGAATCATACTCAGGGTC -3'
(R):5'- TTGCAGCAATTAGGGATGAGTG -3'
Sequencing Primer
(F):5'- GAATCATACTCAGGGTCACTTTGGAG -3'
(R):5'- CAGCAATTAGGGATGAGTGGGAGAC -3'
|
| Posted On |
2022-10-06 |
Incidental Mutation