Mutagenetix > Incidental Mutation

Incidental Mutation 'R9713:Zfp787'

730309

Institutional Source

Beutler Lab

Gene Symbol

Zfp787

Ensembl Gene

ENSMUSG00000046792

Gene Name

zinc finger protein 787

Synonyms

2210018M03Rik

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.087) question?

Stock #

R9713 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

6134490-6158996 bp(-) (GRCm39)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

A to G at 6146059 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000092468 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094870] [ENSMUST00000207315] [ENSMUST00000207331] [ENSMUST00000207628] [ENSMUST00000207957] [ENSMUST00000208746]

AlphaFold

Q8BIF9

Predicted Effect

probably null
Transcript: ENSMUST00000094870

SMART Domains

Protein: ENSMUSP00000092468
Gene: ENSMUSG00000046792

Domain	Start	End	E-Value	Type
low complexity region	41	65	N/A	INTRINSIC
ZnF_C2H2	66	88	5.67e-5	SMART
ZnF_C2H2	94	116	9.58e-3	SMART
ZnF_C2H2	122	144	1.84e-4	SMART
ZnF_C2H2	150	172	1.3e-4	SMART
ZnF_C2H2	178	200	6.88e-4	SMART
low complexity region	245	277	N/A	INTRINSIC
ZnF_C2H2	280	303	2.36e-2	SMART
ZnF_C2H2	317	339	4.72e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000207315

Predicted Effect

probably benign
Transcript: ENSMUST00000207331

Predicted Effect

probably benign
Transcript: ENSMUST00000207628

Predicted Effect

silent
Transcript: ENSMUST00000207957

Predicted Effect

probably benign
Transcript: ENSMUST00000208746

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.4%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700024B05Rik	A	T	14: 41,820,060 (GRCm39)	I107F	probably benign	Het
Adam20	G	A	8: 41,248,490 (GRCm39)	R200H	probably benign	Het
Ahnak	GATCTCTAT	GAT	19: 8,984,393 (GRCm39)		probably benign	Het
Arfgef3	A	T	10: 18,528,556 (GRCm39)	I277N	probably damaging	Het
Atp11b	A	T	3: 35,885,560 (GRCm39)	Y851F	probably damaging	Het
Cdhr1	A	G	14: 36,801,751 (GRCm39)	S731P	probably damaging	Het
Csf2rb2	A	G	15: 78,176,730 (GRCm39)	S221P	possibly damaging	Het
Dact3	A	T	7: 16,620,292 (GRCm39)	I596F	unknown	Het
Eya4	A	T	10: 23,027,870 (GRCm39)	Y287*	probably null	Het
Folr2	T	C	7: 101,489,809 (GRCm39)	D153G	probably benign	Het
Gal3st2b	A	T	1: 93,866,409 (GRCm39)	I37L	probably benign	Het
H2ac8	G	A	13: 23,755,041 (GRCm39)	P81L	probably damaging	Het
Hectd1	A	G	12: 51,823,328 (GRCm39)	M1027T	probably benign	Het
Hectd4	A	T	5: 121,448,744 (GRCm39)	Y364F	probably benign	Het
Hsd17b2	A	T	8: 118,485,342 (GRCm39)		probably null	Het
Igkv4-74	A	G	6: 69,161,993 (GRCm39)	Y59H	probably damaging	Het
Ilvbl	T	C	10: 78,412,489 (GRCm39)	V70A	probably benign	Het
Klrh1	A	G	6: 129,752,359 (GRCm39)	V52A	possibly damaging	Het
Ly9	A	C	1: 171,428,756 (GRCm39)	I288S	probably damaging	Het
Muc5b	A	G	7: 141,416,678 (GRCm39)	E3208G	probably benign	Het
Myo1b	G	A	1: 51,818,766 (GRCm39)	T503I	possibly damaging	Het
Ntm	T	A	9: 29,090,327 (GRCm39)	I131F	possibly damaging	Het
Odad1	T	G	7: 45,578,562 (GRCm39)	V45G	probably damaging	Het
Or1p4-ps1	A	G	11: 74,208,078 (GRCm39)	T76A	probably damaging	Het
Or51f23c-ps1	T	C	7: 102,431,633 (GRCm39)	*317Q	probably null	Het
Or52ae7	C	T	7: 103,119,914 (GRCm39)	L223F	possibly damaging	Het
Or5b108	A	T	19: 13,168,727 (GRCm39)	Y232F	probably benign	Het
Or8k38	T	C	2: 86,488,041 (GRCm39)	T254A	possibly damaging	Het
Pbrm1	T	C	14: 30,828,123 (GRCm39)	S1317P	probably damaging	Het
Spaca6	T	A	17: 18,058,498 (GRCm39)	Y39*	probably null	Het
Spen	G	A	4: 141,244,331 (GRCm39)	R235C	unknown	Het
Sycp2l	C	A	13: 41,326,183 (GRCm39)	A746D	probably damaging	Het
Tgm3	A	G	2: 129,867,229 (GRCm39)	E158G	possibly damaging	Het
Trim26	A	T	17: 37,168,307 (GRCm39)	D324V	probably damaging	Het
Ttc9b	T	C	7: 27,353,475 (GRCm39)	S42P	probably benign	Het
Ttn	C	A	2: 76,682,434 (GRCm39)	E952*	probably null	Het
Ulk4	C	A	9: 120,873,862 (GRCm39)	E1190*	probably null	Het
Vmn1r85	A	T	7: 12,818,458 (GRCm39)	S229T	probably damaging	Het
Wwc1	C	A	11: 35,766,576 (GRCm39)	A560S	probably benign	Het

Other mutations in Zfp787

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02546:Zfp787	APN	7	6,135,297 (GRCm39)	missense	probably damaging	0.99
IGL02721:Zfp787	APN	7	6,135,463 (GRCm39)	splice site	probably null
cheater	UTSW	7	6,136,039 (GRCm39)	missense	possibly damaging	0.93
R0063:Zfp787	UTSW	7	6,135,322 (GRCm39)	splice site	probably null
R1415:Zfp787	UTSW	7	6,135,694 (GRCm39)	missense	probably damaging	1.00
R1434:Zfp787	UTSW	7	6,135,234 (GRCm39)	missense	probably damaging	0.98
R2042:Zfp787	UTSW	7	6,135,763 (GRCm39)	missense	possibly damaging	0.72
R5657:Zfp787	UTSW	7	6,136,053 (GRCm39)	missense	probably damaging	1.00
R5919:Zfp787	UTSW	7	6,135,834 (GRCm39)	missense	probably damaging	0.98
R6306:Zfp787	UTSW	7	6,135,360 (GRCm39)	missense	probably damaging	1.00
R7273:Zfp787	UTSW	7	6,136,039 (GRCm39)	missense	possibly damaging	0.93
R7316:Zfp787	UTSW	7	6,158,523 (GRCm39)	unclassified	probably benign
R7396:Zfp787	UTSW	7	6,135,106 (GRCm39)	makesense	probably null
R7880:Zfp787	UTSW	7	6,135,190 (GRCm39)	missense	probably benign	0.00
R7979:Zfp787	UTSW	7	6,146,094 (GRCm39)	missense	probably damaging	0.97
R9412:Zfp787	UTSW	7	6,135,946 (GRCm39)	missense	probably damaging	0.98
R9527:Zfp787	UTSW	7	6,136,027 (GRCm39)	missense	probably damaging	0.99
Z1177:Zfp787	UTSW	7	6,135,123 (GRCm39)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- GTGCTCAACAATAGCTAGCTGC -3'
(R):5'- GACTGCCTGCTTTGGAGAGTTC -3'

Sequencing Primer
(F):5'- TAGCTAGCTGCAGATATGACAC -3'
(R):5'- GAGAGTTCTTTGTTCTGTTCAGCACC -3'

Posted On

2022-10-06