Incidental Mutation 'R9715:Or10ad1b'
ID 730415
Institutional Source Beutler Lab
Gene Symbol Or10ad1b
Ensembl Gene ENSMUSG00000059460
Gene Name olfactory receptor family 10 subfamily AD member 1B
Synonyms Olfr286, GA_x6K02T2NBG7-5528233-5529186, EG629524, MOR286-2
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R9715 (G1)
Quality Score 225.009
Status Not validated
Chromosome 15
Chromosomal Location 98124556-98132331 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 98124902 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 210 (D210V)
Ref Sequence ENSEMBL: ENSMUSP00000154601 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073612] [ENSMUST00000205305]
AlphaFold A0A2I3BRI6
Predicted Effect probably damaging
Transcript: ENSMUST00000073612
AA Change: D210V

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000073296
Gene: ENSMUSG00000059460
AA Change: D210V

DomainStartEndE-ValueType
Pfam:7tm_4 37 313 2.6e-52 PFAM
Pfam:7tm_1 47 296 2.4e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000073612
AA Change: D210V

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000205305
AA Change: D208V

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 C T 7: 45,629,359 (GRCm39) V1323I probably damaging Het
Adam20 G A 8: 41,248,490 (GRCm39) R200H probably benign Het
Ahnak GATCTCTAT GAT 19: 8,984,393 (GRCm39) probably benign Het
Cbr3 A G 16: 93,481,941 (GRCm39) D99G probably benign Het
Ccdc17 T A 4: 116,455,090 (GRCm39) L215Q probably damaging Het
Cep350 A G 1: 155,751,107 (GRCm39) Y2022H probably benign Het
Cimip2c G C 5: 30,641,261 (GRCm39) D170H possibly damaging Het
Cnbd2 T C 2: 156,183,547 (GRCm39) S338P probably benign Het
D5Ertd579e A T 5: 36,787,029 (GRCm39) V113D possibly damaging Het
Dhx30 A G 9: 109,916,718 (GRCm39) F570S probably damaging Het
Ephb1 T C 9: 101,848,384 (GRCm39) N679S probably damaging Het
Faxc T C 4: 21,993,307 (GRCm39) I317T probably damaging Het
Fgd5 T C 6: 91,965,290 (GRCm39) Y508H possibly damaging Het
Foxd2 G T 4: 114,765,195 (GRCm39) A275E unknown Het
Fut9 C A 4: 25,620,679 (GRCm39) S45I probably benign Het
Gm5148 T C 3: 37,768,801 (GRCm39) N140D unknown Het
Gpr37l1 C T 1: 135,089,391 (GRCm39) G225S probably damaging Het
Gramd1c G A 16: 43,825,840 (GRCm39) S107L possibly damaging Het
Gtpbp2 A G 17: 46,478,301 (GRCm39) D483G Het
Ik G A 18: 36,886,566 (GRCm39) R346H probably benign Het
Ino80e A T 7: 126,461,098 (GRCm39) Y50N unknown Het
Irag1 A T 7: 110,470,640 (GRCm39) S898T possibly damaging Het
Kbtbd2 A G 6: 56,756,566 (GRCm39) V390A probably benign Het
Limch1 A C 5: 67,156,360 (GRCm39) N276H probably damaging Het
Negr1 T G 3: 156,774,936 (GRCm39) probably null Het
Ngef G A 1: 87,431,010 (GRCm39) P269L probably damaging Het
Nlrp14 G A 7: 106,781,626 (GRCm39) M274I probably benign Het
Nr1d1 T C 11: 98,662,943 (GRCm39) I17V probably benign Het
Or4k35 T C 2: 111,100,623 (GRCm39) I30V probably benign Het
Or5p64 A G 7: 107,855,198 (GRCm39) I49T probably benign Het
Ppip5k2 A G 1: 97,677,312 (GRCm39) V334A Het
Ppp1r9a G A 6: 5,045,936 (GRCm39) V467I probably damaging Het
Ppp2r2c A G 5: 37,097,488 (GRCm39) I225V possibly damaging Het
Ptpro A T 6: 137,345,108 (GRCm39) N38I probably damaging Het
Scn2a C A 2: 65,579,149 (GRCm39) Q1495K possibly damaging Het
Scn7a A T 2: 66,519,902 (GRCm39) Y1001N possibly damaging Het
Sfi1 ACA ACATCTTCCCAAAGCCAGTCA 11: 3,103,382 (GRCm39) probably benign Het
Sh3bgrl2 T A 9: 83,430,513 (GRCm39) M1K probably null Het
Slc25a12 C T 2: 71,109,899 (GRCm39) V516M probably benign Het
Sptbn4 A G 7: 27,091,000 (GRCm39) L1402P probably damaging Het
Styk1 CTCTTCATGATTTTCTT CTCTT 6: 131,278,612 (GRCm39) probably benign Het
Svop A G 5: 114,198,169 (GRCm39) S135P probably benign Het
Sycp2 G T 2: 178,035,957 (GRCm39) D243E probably damaging Het
Tcerg1 T C 18: 42,706,413 (GRCm39) F1030S probably damaging Het
Tecta T A 9: 42,286,596 (GRCm39) N687Y probably damaging Het
Tep1 A T 14: 51,081,759 (GRCm39) H1230Q Het
Tfap2b T C 1: 19,284,373 (GRCm39) S94P probably damaging Het
Tll2 C A 19: 41,092,238 (GRCm39) G533V probably damaging Het
Vmn2r55 A G 7: 12,402,061 (GRCm39) V409A probably damaging Het
Wdr41 A G 13: 95,145,373 (GRCm39) E194G probably damaging Het
Zan G T 5: 137,398,817 (GRCm39) S4182R unknown Het
Zfpl1 T C 19: 6,134,074 (GRCm39) Y40C probably damaging Het
Znrf3 C A 11: 5,232,454 (GRCm39) R257L possibly damaging Het
Other mutations in Or10ad1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02436:Or10ad1b APN 15 98,125,171 (GRCm39) nonsense probably null
IGL02850:Or10ad1b APN 15 98,125,232 (GRCm39) missense probably benign 0.01
R1833:Or10ad1b UTSW 15 98,124,846 (GRCm39) missense probably damaging 1.00
R3879:Or10ad1b UTSW 15 98,125,085 (GRCm39) missense probably damaging 0.98
R4854:Or10ad1b UTSW 15 98,125,425 (GRCm39) missense possibly damaging 0.93
R4866:Or10ad1b UTSW 15 98,125,371 (GRCm39) missense probably damaging 1.00
R5076:Or10ad1b UTSW 15 98,124,642 (GRCm39) missense probably damaging 1.00
R5886:Or10ad1b UTSW 15 98,124,672 (GRCm39) missense possibly damaging 0.83
R7090:Or10ad1b UTSW 15 98,125,083 (GRCm39) missense probably benign 0.00
R9378:Or10ad1b UTSW 15 98,124,920 (GRCm39) missense possibly damaging 0.94
R9405:Or10ad1b UTSW 15 98,124,912 (GRCm39) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- TTTGTCAGGCCCGTGTGTAC -3'
(R):5'- TCATGAGCCAGAAGGTGTGTG -3'

Sequencing Primer
(F):5'- TACTTCGGGGATTCATGTAAGAGAAC -3'
(R):5'- CCAGAAGGTGTGTGTCAGGC -3'
Posted On 2022-10-06