Incidental Mutation 'R9718:Omd'
ID 730626
Institutional Source Beutler Lab
Gene Symbol Omd
Ensembl Gene ENSMUSG00000048368
Gene Name osteomodulin
Synonyms osteoadherin, SLRR2C, OSAD
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R9718 (G1)
Quality Score 225.009
Status Not validated
Chromosome 13
Chromosomal Location 49735938-49746088 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 49743336 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 129 (S129P)
Ref Sequence ENSEMBL: ENSMUSP00000065706 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021818] [ENSMUST00000065494] [ENSMUST00000221170]
AlphaFold O35103
Predicted Effect probably benign
Transcript: ENSMUST00000021818
SMART Domains Protein: ENSMUSP00000021818
Gene: ENSMUSG00000021391

DomainStartEndE-ValueType
coiled coil region 1 34 N/A INTRINSIC
Pfam:CENP-P 102 278 3.9e-89 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000065494
AA Change: S129P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000065706
Gene: ENSMUSG00000048368
AA Change: S129P

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
LRRNT 61 95 3.14e-11 SMART
LRR 115 139 2.15e2 SMART
LRR 140 160 2.2e1 SMART
LRR 162 184 4.21e1 SMART
LRR 185 210 1.01e2 SMART
LRR 211 234 6.96e0 SMART
LRR 235 255 8.49e1 SMART
LRR 256 279 1.76e-1 SMART
LRR 300 322 7.8e1 SMART
Blast:LRR 330 353 6e-8 BLAST
low complexity region 385 391 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000221170
AA Change: S129P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mutation of this gene results in impaired cued contextual conditioning behavior. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9430097D07Rik A C 2: 32,465,247 (GRCm39) probably benign Het
Acvr1c A T 2: 58,206,007 (GRCm39) D34E probably benign Het
Arhgef19 T C 4: 140,976,603 (GRCm39) V455A probably damaging Het
Cbfa2t3 T A 8: 123,364,936 (GRCm39) D282V probably benign Het
Ccl9 T A 11: 83,466,238 (GRCm39) N114I probably benign Het
Cdan1 G T 2: 120,554,650 (GRCm39) A875E probably damaging Het
Celf2 A T 2: 6,726,349 (GRCm39) F61L probably damaging Het
Chd9 T C 8: 91,712,801 (GRCm39) Y875H unknown Het
Ckap5 A T 2: 91,379,177 (GRCm39) K39M probably benign Het
Clcn3 T C 8: 61,390,434 (GRCm39) H169R possibly damaging Het
Csmd3 C A 15: 47,560,083 (GRCm39) V1416F Het
Cyp4v3 A T 8: 45,773,703 (GRCm39) H155Q probably damaging Het
Dhx36 A G 3: 62,379,466 (GRCm39) F874S possibly damaging Het
Dnah14 A T 1: 181,450,544 (GRCm39) Q719L probably benign Het
Evi2 C T 11: 79,406,583 (GRCm39) V331M probably damaging Het
Fcgrt T G 7: 44,744,853 (GRCm39) E205A possibly damaging Het
Fkrp G T 7: 16,545,112 (GRCm39) T250N probably benign Het
Ftdc1 A G 16: 58,434,974 (GRCm39) L117S probably benign Het
Galc G A 12: 98,225,573 (GRCm39) P6S Het
Gm5134 A T 10: 75,828,331 (GRCm39) M304L possibly damaging Het
Haao T C 17: 84,142,215 (GRCm39) E208G probably damaging Het
Hook1 T A 4: 95,904,678 (GRCm39) H553Q probably benign Het
Igdcc3 A G 9: 65,090,280 (GRCm39) probably null Het
Ighv10-3 C T 12: 114,487,254 (GRCm39) V56I probably benign Het
Ighv1-62-1 G T 12: 115,350,705 (GRCm39) A15E probably benign Het
Krtap24-1 T C 16: 88,408,378 (GRCm39) *249W probably null Het
Ktn1 T G 14: 47,910,508 (GRCm39) I318R probably damaging Het
L3mbtl2 A G 15: 81,572,123 (GRCm39) T710A unknown Het
Ldha A T 7: 46,504,456 (GRCm39) Q326L possibly damaging Het
Map4 G A 9: 109,901,774 (GRCm39) probably null Het
Mdfic T A 6: 15,770,514 (GRCm39) H173Q probably damaging Het
Noxred1 T A 12: 87,271,692 (GRCm39) Q159L possibly damaging Het
Or14j3 C T 17: 37,900,914 (GRCm39) G110D probably benign Het
Or52r1c T C 7: 102,735,196 (GRCm39) V152A probably benign Het
Parp16 A G 9: 65,141,009 (GRCm39) Y193C probably damaging Het
Pdzk1 A G 3: 96,763,174 (GRCm39) T201A Het
Phldb2 T A 16: 45,601,756 (GRCm39) H728L possibly damaging Het
Prrt1b A T 2: 29,637,548 (GRCm39) L42Q probably damaging Het
Ptchd4 C T 17: 42,813,641 (GRCm39) T514I probably damaging Het
Pusl1 T C 4: 155,976,094 (GRCm39) D24G probably benign Het
Rai1 G A 11: 60,080,165 (GRCm39) A1410T probably benign Het
Rint1 T A 5: 24,005,721 (GRCm39) H134Q possibly damaging Het
Rnf170 A G 8: 26,619,243 (GRCm39) S156G unknown Het
Rtf1 A G 2: 119,535,986 (GRCm39) D180G possibly damaging Het
Sectm1a G T 11: 120,960,490 (GRCm39) D108E probably damaging Het
Senp7 T A 16: 55,944,277 (GRCm39) D200E probably damaging Het
Sfswap A G 5: 129,616,848 (GRCm39) S431G probably benign Het
Sh3bp4 T A 1: 89,073,472 (GRCm39) D773E probably damaging Het
Shprh T C 10: 11,089,248 (GRCm39) L1662P probably damaging Het
Slx4 G T 16: 3,804,328 (GRCm39) P829T possibly damaging Het
Snapc4 A T 2: 26,268,533 (GRCm39) S43T probably damaging Het
Ssh3 C T 19: 4,312,437 (GRCm39) R636Q probably benign Het
Strn4 G A 7: 16,572,496 (GRCm39) V679M probably damaging Het
Tas2r121 T G 6: 132,677,765 (GRCm39) Y69S probably benign Het
Tcerg1 C T 18: 42,663,836 (GRCm39) T341M unknown Het
Tjp2 A C 19: 24,078,207 (GRCm39) S895R probably damaging Het
Tmem220 G T 11: 66,916,086 (GRCm39) A28S probably damaging Het
Trdv1 G A 14: 54,119,663 (GRCm39) C109Y probably damaging Het
Trpc6 A G 9: 8,634,190 (GRCm39) Y423C probably damaging Het
Ttn T C 2: 76,625,027 (GRCm39) M15184V possibly damaging Het
Ugt2b37 T A 5: 87,390,802 (GRCm39) Y355F probably benign Het
Vnn3 C T 10: 23,745,454 (GRCm39) R468* probably null Het
Washc5 T A 15: 59,217,192 (GRCm39) T792S probably benign Het
Wdfy4 T C 14: 32,847,893 (GRCm39) M820V Het
Zfp961 T A 8: 72,721,933 (GRCm39) C149S possibly damaging Het
Zmat4 G A 8: 24,238,507 (GRCm39) V30M probably damaging Het
Other mutations in Omd
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01976:Omd APN 13 49,743,119 (GRCm39) nonsense probably null
IGL01982:Omd APN 13 49,742,973 (GRCm39) missense possibly damaging 0.88
IGL02678:Omd APN 13 49,745,757 (GRCm39) missense probably benign 0.37
IGL03069:Omd APN 13 49,745,870 (GRCm39) utr 3 prime probably benign
R1036:Omd UTSW 13 49,743,447 (GRCm39) missense probably damaging 1.00
R3954:Omd UTSW 13 49,743,213 (GRCm39) missense probably benign 0.00
R4030:Omd UTSW 13 49,743,125 (GRCm39) missense probably benign 0.08
R4335:Omd UTSW 13 49,743,712 (GRCm39) missense probably benign 0.02
R5095:Omd UTSW 13 49,743,174 (GRCm39) missense possibly damaging 0.95
R5137:Omd UTSW 13 49,743,552 (GRCm39) missense probably benign 0.05
R5400:Omd UTSW 13 49,745,703 (GRCm39) missense probably benign 0.37
R5596:Omd UTSW 13 49,745,814 (GRCm39) missense probably benign 0.16
R5930:Omd UTSW 13 49,743,112 (GRCm39) missense possibly damaging 0.63
R6132:Omd UTSW 13 49,743,843 (GRCm39) missense probably damaging 0.97
R6294:Omd UTSW 13 49,743,467 (GRCm39) missense probably damaging 1.00
R6454:Omd UTSW 13 49,743,345 (GRCm39) missense probably damaging 0.99
R6680:Omd UTSW 13 49,743,004 (GRCm39) missense possibly damaging 0.74
R6704:Omd UTSW 13 49,743,349 (GRCm39) missense probably damaging 1.00
R6932:Omd UTSW 13 49,743,710 (GRCm39) missense probably damaging 1.00
R7427:Omd UTSW 13 49,745,745 (GRCm39) missense possibly damaging 0.68
R7884:Omd UTSW 13 49,743,630 (GRCm39) missense probably damaging 1.00
R7971:Omd UTSW 13 49,743,730 (GRCm39) missense probably benign 0.00
R8129:Omd UTSW 13 49,745,565 (GRCm39) missense probably damaging 0.99
R8399:Omd UTSW 13 49,743,345 (GRCm39) missense possibly damaging 0.50
R8914:Omd UTSW 13 49,745,718 (GRCm39) missense probably damaging 1.00
R8959:Omd UTSW 13 49,745,790 (GRCm39) missense possibly damaging 0.57
R8984:Omd UTSW 13 49,743,576 (GRCm39) missense possibly damaging 0.92
R9415:Omd UTSW 13 49,745,837 (GRCm39) missense probably benign
R9723:Omd UTSW 13 49,743,838 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTGCTAAGGAATGCTTCTGTCC -3'
(R):5'- TAGCAGAGGTCAAGCATAGTCAC -3'

Sequencing Primer
(F):5'- GGAATGCTTCTGTCCAACTAAC -3'
(R):5'- GAGGTCAAGCATAGTCACATTCAC -3'
Posted On 2022-10-06