Incidental Mutation 'R9719:Or1p1'
ID 730674
Institutional Source Beutler Lab
Gene Symbol Or1p1
Ensembl Gene ENSMUSG00000070374
Gene Name olfactory receptor family 1 subfamily P member 1
Synonyms MOR133-3P, Olfr59, IH3, GA_x6K02T2P1NL-4434429-4435400
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R9719 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 74174562-74180472 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 74180146 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 225 (I225L)
Ref Sequence ENSEMBL: ENSMUSP00000148959 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000143976] [ENSMUST00000205790] [ENSMUST00000206659] [ENSMUST00000214048]
AlphaFold B1ARL3
Predicted Effect probably damaging
Transcript: ENSMUST00000143976
AA Change: I225L

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000119877
Gene: ENSMUSG00000070374
AA Change: I225L

DomainStartEndE-ValueType
Pfam:7tm_1 41 237 7.5e-34 PFAM
Pfam:7tm_4 139 237 1.9e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205790
Predicted Effect probably benign
Transcript: ENSMUST00000206659
Predicted Effect probably damaging
Transcript: ENSMUST00000214048
AA Change: I225L

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alppl2 T A 1: 87,016,136 (GRCm39) Q241L probably benign Het
Apob T A 12: 8,065,464 (GRCm39) N4144K probably benign Het
B4gat1 A G 19: 5,090,516 (GRCm39) H413R probably benign Het
Ccdc179 T C 7: 51,664,612 (GRCm39) T28A probably benign Het
Ceacam5 A C 7: 17,491,835 (GRCm39) D735A probably damaging Het
Col18a1 C T 10: 76,949,432 (GRCm39) D27N unknown Het
Colgalt1 A G 8: 72,073,456 (GRCm39) E359G probably benign Het
Crybg2 T A 4: 133,793,148 (GRCm39) I261N probably benign Het
Cyyr1 A T 16: 85,219,203 (GRCm39) L68Q unknown Het
Dgkz T A 2: 91,768,911 (GRCm39) probably null Het
Efcab3 A T 11: 104,867,912 (GRCm39) E3947V unknown Het
Eif2ak2 C A 17: 79,162,783 (GRCm39) D472Y probably damaging Het
Elp2 A G 18: 24,755,539 (GRCm39) T429A possibly damaging Het
Fen1 G A 19: 10,178,016 (GRCm39) H143Y probably benign Het
Gm10518 C A 1: 179,631,113 (GRCm39) R58S unknown Het
Hspa1b T C 17: 35,176,467 (GRCm39) D506G probably damaging Het
Inhca G T 9: 103,132,014 (GRCm39) P569H probably benign Het
Kcna7 A G 7: 45,056,390 (GRCm39) D202G probably benign Het
Krt9 TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC 11: 100,079,903 (GRCm39) probably benign Het
Mal C T 2: 127,498,025 (GRCm39) S10N possibly damaging Het
Mgat2 T A 12: 69,232,115 (GRCm39) W230R probably damaging Het
Myo3a A T 2: 22,436,493 (GRCm39) T883S probably benign Het
Ncaph2 T C 15: 89,249,526 (GRCm39) S277P probably benign Het
Olfm3 G A 3: 114,916,091 (GRCm39) W341* probably null Het
Or13c7e-ps1 A C 4: 43,781,454 (GRCm39) M292R probably damaging Het
Or5b119 A G 19: 13,457,368 (GRCm39) S65P probably damaging Het
Or5d46 T A 2: 88,169,928 (GRCm39) N6K Het
Or5g26 T A 2: 85,494,608 (GRCm39) I57F probably benign Het
Or6z1 C A 7: 6,504,999 (GRCm39) M75I probably benign Het
Pcnx4 T C 12: 72,603,039 (GRCm39) Y434H probably damaging Het
Ptpn14 T A 1: 189,583,484 (GRCm39) M777K probably benign Het
Rasef A G 4: 73,688,102 (GRCm39) I17T possibly damaging Het
Rptor A T 11: 119,781,940 (GRCm39) D1089V probably benign Het
Scel A T 14: 103,809,442 (GRCm39) probably null Het
Scfd2 A T 5: 74,386,004 (GRCm39) L605Q probably damaging Het
Son A G 16: 91,456,440 (GRCm39) E1729G probably damaging Het
Spata31e2 C G 1: 26,722,820 (GRCm39) E787Q probably benign Het
Spout1 A G 2: 30,065,813 (GRCm39) Y243H probably benign Het
Syne1 A G 10: 5,276,601 (GRCm39) F1765S possibly damaging Het
Tet2 A T 3: 133,191,803 (GRCm39) V877E possibly damaging Het
Txn2 T C 15: 77,812,289 (GRCm39) probably benign Het
Vmn1r158 T C 7: 22,489,331 (GRCm39) I293V possibly damaging Het
Vmn1r81 G A 7: 11,994,449 (GRCm39) T53I probably damaging Het
Vps18 T C 2: 119,127,553 (GRCm39) F792S probably damaging Het
Vps25 A G 11: 101,146,853 (GRCm39) D91G probably null Het
Wdr26 G A 1: 181,015,224 (GRCm39) L396F possibly damaging Het
Zfp1005 T A 2: 150,111,304 (GRCm39) C665S possibly damaging Het
Zfp26 T C 9: 20,347,861 (GRCm39) E901G possibly damaging Het
Other mutations in Or1p1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00227:Or1p1 APN 11 74,179,952 (GRCm39) missense probably damaging 1.00
IGL00337:Or1p1 APN 11 74,180,213 (GRCm39) missense probably damaging 0.97
IGL01307:Or1p1 APN 11 74,180,254 (GRCm39) missense possibly damaging 0.88
IGL01488:Or1p1 APN 11 74,179,514 (GRCm39) missense probably damaging 1.00
IGL02583:Or1p1 APN 11 74,180,330 (GRCm39) missense probably damaging 1.00
IGL02839:Or1p1 APN 11 74,180,196 (GRCm39) nonsense probably null
IGL02996:Or1p1 APN 11 74,179,991 (GRCm39) missense probably benign 0.08
R0013:Or1p1 UTSW 11 74,179,877 (GRCm39) missense possibly damaging 0.88
R0077:Or1p1 UTSW 11 74,179,501 (GRCm39) missense probably benign 0.00
R0078:Or1p1 UTSW 11 74,180,092 (GRCm39) missense probably damaging 1.00
R0734:Or1p1 UTSW 11 74,179,772 (GRCm39) missense probably damaging 1.00
R1033:Or1p1 UTSW 11 74,179,492 (GRCm39) missense probably damaging 0.99
R1556:Or1p1 UTSW 11 74,179,762 (GRCm39) missense probably damaging 1.00
R1721:Or1p1 UTSW 11 74,180,126 (GRCm39) missense probably damaging 1.00
R1737:Or1p1 UTSW 11 74,179,637 (GRCm39) missense probably damaging 1.00
R1848:Or1p1 UTSW 11 74,180,039 (GRCm39) missense probably damaging 0.99
R1881:Or1p1 UTSW 11 74,179,492 (GRCm39) missense probably benign 0.08
R2057:Or1p1 UTSW 11 74,179,652 (GRCm39) missense probably damaging 1.00
R2107:Or1p1 UTSW 11 74,180,216 (GRCm39) missense probably damaging 1.00
R4399:Or1p1 UTSW 11 74,179,682 (GRCm39) missense probably damaging 1.00
R4633:Or1p1 UTSW 11 74,180,120 (GRCm39) missense probably benign 0.00
R5593:Or1p1 UTSW 11 74,179,618 (GRCm39) missense possibly damaging 0.65
R5988:Or1p1 UTSW 11 74,179,679 (GRCm39) missense probably benign
R6104:Or1p1 UTSW 11 74,180,192 (GRCm39) missense probably damaging 1.00
R7436:Or1p1 UTSW 11 74,179,511 (GRCm39) missense possibly damaging 0.84
R7506:Or1p1 UTSW 11 74,179,949 (GRCm39) missense possibly damaging 0.96
R7769:Or1p1 UTSW 11 74,179,589 (GRCm39) missense probably damaging 1.00
R8247:Or1p1 UTSW 11 74,180,315 (GRCm39) missense noncoding transcript
R8709:Or1p1 UTSW 11 74,180,054 (GRCm39) missense possibly damaging 0.76
R8900:Or1p1 UTSW 11 74,180,413 (GRCm39) missense probably damaging 0.98
R9010:Or1p1 UTSW 11 74,180,305 (GRCm39) missense probably damaging 1.00
R9147:Or1p1 UTSW 11 74,180,169 (GRCm39) missense probably damaging 0.97
R9148:Or1p1 UTSW 11 74,180,169 (GRCm39) missense probably damaging 0.97
Z1088:Or1p1 UTSW 11 74,179,661 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTGGACCCTTACAACCGTTG -3'
(R):5'- TGTATACATGACAGCTGCTGC -3'

Sequencing Primer
(F):5'- TACAACCGTTGTGGCCATGAC -3'
(R):5'- CTGTGTCCTCTACCACTGAGTTAGAG -3'
Posted On 2022-10-06