Incidental Mutation 'R9720:Or6d14'
ID 730711
Institutional Source Beutler Lab
Gene Symbol Or6d14
Ensembl Gene ENSMUSG00000051046
Gene Name olfactory receptor family 6 subfamily D member 14
Synonyms Olfr214, GA_x54KRFPKN04-58190962-58191900, MOR119-1
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.212) question?
Stock # R9720 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 116533388-116534350 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 116534016 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 210 (V210A)
Ref Sequence ENSEMBL: ENSMUSP00000145465 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060204] [ENSMUST00000122096] [ENSMUST00000203867] [ENSMUST00000214699] [ENSMUST00000215846] [ENSMUST00000217313]
AlphaFold Q8VG27
Predicted Effect possibly damaging
Transcript: ENSMUST00000060204
AA Change: V210A

PolyPhen 2 Score 0.611 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000052730
Gene: ENSMUSG00000051046
AA Change: V210A

DomainStartEndE-ValueType
Pfam:7tm_4 39 316 4.7e-47 PFAM
Pfam:7tm_1 49 298 5.9e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000122096
SMART Domains Protein: ENSMUSP00000145194
Gene: ENSMUSG00000107906

DomainStartEndE-ValueType
DEXDc 57 254 2.4e-59 SMART
HELICc 291 372 6.6e-38 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000203867
AA Change: V210A

PolyPhen 2 Score 0.611 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000145465
Gene: ENSMUSG00000051046
AA Change: V210A

DomainStartEndE-ValueType
Pfam:7tm_4 39 316 4.7e-47 PFAM
Pfam:7tm_1 49 298 5.9e-17 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214699
AA Change: V210A

PolyPhen 2 Score 0.611 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215846
AA Change: V210A

PolyPhen 2 Score 0.611 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217313
AA Change: V210A

PolyPhen 2 Score 0.611 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca T G 11: 84,154,183 (GRCm39) V968G probably damaging Het
Adam33 A G 2: 130,900,236 (GRCm39) V110A Het
Adamts2 T C 11: 50,666,954 (GRCm39) M417T probably damaging Het
Adgrv1 A G 13: 81,740,693 (GRCm39) I145T probably damaging Het
Ampd3 C A 7: 110,377,056 (GRCm39) H16N probably benign Het
Ank3 A T 10: 69,825,335 (GRCm39) S1335C Het
Ankrd26 G A 6: 118,498,902 (GRCm39) S1208L probably damaging Het
Atmin G A 8: 117,681,653 (GRCm39) probably null Het
AU018091 T C 7: 3,209,272 (GRCm39) T323A probably benign Het
Barx2 A G 9: 31,765,407 (GRCm39) probably null Het
Bltp3b T A 10: 89,641,219 (GRCm39) S797T probably benign Het
Brpf3 A G 17: 29,026,330 (GRCm39) I468V probably benign Het
Cacna1g T A 11: 94,302,297 (GRCm39) H1985L probably benign Het
Cass4 T C 2: 172,269,568 (GRCm39) V550A probably benign Het
Ccdc88a A G 11: 29,413,813 (GRCm39) S784G probably benign Het
Cd300ld2 C T 11: 114,903,118 (GRCm39) probably null Het
Cgn G A 3: 94,686,621 (GRCm39) A227V probably benign Het
Clcn7 G T 17: 25,374,471 (GRCm39) R524L probably damaging Het
Cldn22 G A 8: 48,277,786 (GRCm39) A75T probably benign Het
Ddb1 A G 19: 10,585,724 (GRCm39) D146G probably benign Het
Dhx32 C A 7: 133,324,857 (GRCm39) E607* probably null Het
Egfem1 A G 3: 29,716,580 (GRCm39) Y350C probably damaging Het
Eri2 T A 7: 119,386,976 (GRCm39) D181V probably damaging Het
Gabrg2 T C 11: 41,862,673 (GRCm39) N137S probably damaging Het
Gar1 C T 3: 129,620,497 (GRCm39) G197S unknown Het
Ggta1 G T 2: 35,303,418 (GRCm39) D91E probably benign Het
Hap1 T A 11: 100,246,696 (GRCm39) I70F probably benign Het
Hars2 A G 18: 36,920,607 (GRCm39) Y150C probably damaging Het
Igsf9b G A 9: 27,220,810 (GRCm39) V59I probably damaging Het
Il15 T G 8: 83,058,608 (GRCm39) K142Q probably damaging Het
Klhl23 T C 2: 69,654,804 (GRCm39) Y225H possibly damaging Het
Krt6b T A 15: 101,588,226 (GRCm39) I145F probably benign Het
Lgals3bp T A 11: 118,284,083 (GRCm39) T499S probably benign Het
Lrriq4 A G 3: 30,714,077 (GRCm39) N490S probably damaging Het
Ltbr G A 6: 125,284,348 (GRCm39) R365W probably damaging Het
Mical3 A G 6: 120,935,238 (GRCm39) S1763P probably damaging Het
Ncoa6 A G 2: 155,250,304 (GRCm39) V1000A probably damaging Het
Nefm A G 14: 68,358,793 (GRCm39) S414P probably benign Het
Nphs1 T C 7: 30,165,499 (GRCm39) V622A possibly damaging Het
Or6c76 T C 10: 129,612,581 (GRCm39) V281A probably benign Het
Pde4dip T C 3: 97,603,287 (GRCm39) D2234G probably damaging Het
Pde6c A T 19: 38,157,887 (GRCm39) Y637F probably benign Het
Pigg T A 5: 108,467,800 (GRCm39) C266* probably null Het
Pkdrej A T 15: 85,702,497 (GRCm39) D1146E possibly damaging Het
Pkp2 T C 16: 16,087,584 (GRCm39) V756A probably benign Het
Pole C T 5: 110,484,909 (GRCm39) T2245I probably benign Het
Ppm1g A C 5: 31,360,914 (GRCm39) probably null Het
Ppp1r36 A G 12: 76,485,298 (GRCm39) I340M possibly damaging Het
Pvr G A 7: 19,643,121 (GRCm39) R371* probably null Het
Rassf9 G A 10: 102,348,369 (GRCm39) probably benign Het
Rtl1 A C 12: 109,559,882 (GRCm39) N652K possibly damaging Het
Sall4 G C 2: 168,592,160 (GRCm39) S998C probably damaging Het
Sdk1 T C 5: 142,197,796 (GRCm39) Y2150H probably damaging Het
Serpinb3b A T 1: 107,083,669 (GRCm39) I170K probably benign Het
Shank2 A T 7: 143,682,137 (GRCm39) D390V probably damaging Het
Slc39a4 A G 15: 76,500,930 (GRCm39) V11A probably benign Het
Synj2 C T 17: 6,040,584 (GRCm39) T220I probably benign Het
Taar7a A G 10: 23,868,733 (GRCm39) I216T probably benign Het
Tas2r122 G T 6: 132,688,634 (GRCm39) D86E probably benign Het
Tbxa2r T A 10: 81,169,018 (GRCm39) C236S probably benign Het
Trav13d-4 C A 14: 53,995,286 (GRCm39) T80K probably benign Het
Trav6d-5 T A 14: 53,033,077 (GRCm39) C109S probably damaging Het
Trio A G 15: 27,847,495 (GRCm39) M982T probably benign Het
Unc80 A T 1: 66,683,485 (GRCm39) T2176S possibly damaging Het
Ypel1 T C 16: 16,910,890 (GRCm39) T259A probably damaging Het
Zfp120 A T 2: 149,959,197 (GRCm39) I397K probably benign Het
Other mutations in Or6d14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00951:Or6d14 APN 6 116,534,027 (GRCm39) missense probably benign
IGL01837:Or6d14 APN 6 116,533,807 (GRCm39) nonsense probably null
IGL02523:Or6d14 APN 6 116,534,054 (GRCm39) missense probably benign 0.03
R0027:Or6d14 UTSW 6 116,533,910 (GRCm39) missense probably damaging 0.99
R0616:Or6d14 UTSW 6 116,533,889 (GRCm39) missense probably benign 0.00
R1121:Or6d14 UTSW 6 116,534,190 (GRCm39) missense probably damaging 0.99
R1555:Or6d14 UTSW 6 116,533,787 (GRCm39) missense probably damaging 1.00
R1691:Or6d14 UTSW 6 116,533,538 (GRCm39) missense probably benign 0.00
R2196:Or6d14 UTSW 6 116,533,578 (GRCm39) missense probably damaging 0.99
R3080:Or6d14 UTSW 6 116,534,178 (GRCm39) missense probably damaging 0.98
R5416:Or6d14 UTSW 6 116,534,166 (GRCm39) missense probably damaging 1.00
R5706:Or6d14 UTSW 6 116,534,074 (GRCm39) missense probably damaging 1.00
R6848:Or6d14 UTSW 6 116,533,736 (GRCm39) missense probably damaging 0.98
R7425:Or6d14 UTSW 6 116,533,398 (GRCm39) missense possibly damaging 0.95
R8059:Or6d14 UTSW 6 116,533,434 (GRCm39) missense possibly damaging 0.47
R8349:Or6d14 UTSW 6 116,534,289 (GRCm39) missense probably damaging 0.99
R8449:Or6d14 UTSW 6 116,534,289 (GRCm39) missense probably damaging 0.99
R8551:Or6d14 UTSW 6 116,534,289 (GRCm39) missense probably damaging 0.99
R8552:Or6d14 UTSW 6 116,534,289 (GRCm39) missense probably damaging 0.99
R8553:Or6d14 UTSW 6 116,534,289 (GRCm39) missense probably damaging 0.99
R8555:Or6d14 UTSW 6 116,534,289 (GRCm39) missense probably damaging 0.99
R8988:Or6d14 UTSW 6 116,534,255 (GRCm39) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- AGCCATTTGCAAGCCTCTGC -3'
(R):5'- ATTCAAGCCTGCTCACTTGC -3'

Sequencing Primer
(F):5'- TGCGCTACCCAGCCATCATG -3'
(R):5'- CGGTTTCACATATATAAACACACAGC -3'
Posted On 2022-10-06